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The map label for this gene is glyA

Identifier: 187918462

GI number: 187918462

Start: 633821

End: 635074

Strand: Direct

Name: glyA

Synonym: BH0601

Alternate gene names: 187918462

Gene position: 633821-635074 (Clockwise)

Preceding gene: 187918461

Following gene: 187918463

Centisome position: 68.72

GC content: 35.09

Gene sequence:

>1254_bases
ATGATAGATAGCATTTTATTTGATTTAATTGAAAGGGAAGTTAAGAGGGAGAAAGAAAATATTGAATTAATTGCTTCAGA
AAATTTTGTCTCATCAGATGTAAGAAGGGCTGTTGGAAGTATTTTGACTAATAAATATGCTGAGGGTTATCCTTCAAAGA
GATATTATGGTGGATGCTTTGTTGTTGATGATATTGAAAGTTTGGCTATATCACGGGCAAGAGAGCTTTTTGGTGCAAAT
TATGCCAATGTCCAACCTCATAGTGGTTCTCAAGCTAATATGGCTGCTATAATGGCACTTATTAAGCCTGGGGATAGAAT
TCTTGGAATGGAATTGTCTCATGGTGGTCATTTAACCCATGGTAGTAAAGTTAGTTTTTCTGGGATGTTCTTTGACGCAT
ATTCTTATGGAGTGTCAAGGGAATCTGAGATGATTGATTATGATGATGTTAGAAAAATAGCTAAAGAATGTAGACCCAAT
TTAATAATTGCTGGTGCTTCTTCTTATTCAAGGGAAATTGATTTTAAAAAATTTCGTGAGATAGCGGATGAAGTTTCAGC
TTATCTTTTGTGTGATGTTGCCCATACAGCAGGTCTTATTGCTACAGGTTTTCATAATTCTCCTATTGATGTTGCACATT
TAACTACAAGTACTACCCATAAGACTTTAAGGGGGCCTAGAGGAGGATTAATTCTTGCAGGTAGGGAATCTAGTATAATA
GTAAATTATAATAATAAAGAGAGAAGACTGGAGGATGCTGTTAATTCTTGTGTTTTTCCAGGAACCCAGGGTGGACCCTT
AATGCATGTTATTGCAGGTAAAGCAGTGGCTTTTAGAGAAGCTTTGATGGAGGATTTTAAGGATTATATTTCTAGGGTCA
TAAGTAATACCAAAGCTATGGCTGAGTGTTTTATTTCAGAAGGTTTTAGGATAGTTAGTGGTGGAACGGATAATCATTTG
TTTTTAGTTGACCTTGGTATTTTGGGTATTACGGGAGCTGATGCTGAGAAGGTTCTTGAAAGAGTAAACATTACTCTTAA
TAAGAACGCAATTCCTTTTGATTCAAAGAATCCTTCTGTAACTTCTGGTATTCGAATTGGTGCTGCTGCTATTACTTCAA
GAGGTTTAAATAGAGATGATTCTATTAGAGTTGCTCATTTTGTTATTAGGGCTTTAAAGACTAAATCCGAAGATGAGCTT
AAAAAAATAAAACGAGACGTCATAGAATTTATTAGCAGTTTTGATATGCCTTAA

Upstream 100 bases:

>100_bases
TTGGCTGATGAATATTTTGACCTAGTATTGTTTAAATATAAAAGCTTGACAAATAGTAATTATTCTTTGAATTATAGGAT
TACTTTGGAGGAAAATATTA

Downstream 100 bases:

>100_bases
TTTTGATTTGCAGGTTGTTTATTTAGGTGTCTAATTTGTTTCAAATTTTCTTGTTGTTATTGCCATTTATTTTAATTCTT
AGTCCCTTTCTTTTAAGTGT

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MIDSILFDLIEREVKREKENIELIASENFVSSDVRRAVGSILTNKYAEGYPSKRYYGGCFVVDDIESLAISRARELFGAN
YANVQPHSGSQANMAAIMALIKPGDRILGMELSHGGHLTHGSKVSFSGMFFDAYSYGVSRESEMIDYDDVRKIAKECRPN
LIIAGASSYSREIDFKKFREIADEVSAYLLCDVAHTAGLIATGFHNSPIDVAHLTTSTTHKTLRGPRGGLILAGRESSII
VNYNNKERRLEDAVNSCVFPGTQGGPLMHVIAGKAVAFREALMEDFKDYISRVISNTKAMAECFISEGFRIVSGGTDNHL
FLVDLGILGITGADAEKVLERVNITLNKNAIPFDSKNPSVTSGIRIGAAAITSRGLNRDDSIRVAHFVIRALKTKSEDEL
KKIKRDVIEFISSFDMP

Sequences:

>Translated_417_residues
MIDSILFDLIEREVKREKENIELIASENFVSSDVRRAVGSILTNKYAEGYPSKRYYGGCFVVDDIESLAISRARELFGAN
YANVQPHSGSQANMAAIMALIKPGDRILGMELSHGGHLTHGSKVSFSGMFFDAYSYGVSRESEMIDYDDVRKIAKECRPN
LIIAGASSYSREIDFKKFREIADEVSAYLLCDVAHTAGLIATGFHNSPIDVAHLTTSTTHKTLRGPRGGLILAGRESSII
VNYNNKERRLEDAVNSCVFPGTQGGPLMHVIAGKAVAFREALMEDFKDYISRVISNTKAMAECFISEGFRIVSGGTDNHL
FLVDLGILGITGADAEKVLERVNITLNKNAIPFDSKNPSVTSGIRIGAAAITSRGLNRDDSIRVAHFVIRALKTKSEDEL
KKIKRDVIEFISSFDMP
>Mature_417_residues
MIDSILFDLIEREVKREKENIELIASENFVSSDVRRAVGSILTNKYAEGYPSKRYYGGCFVVDDIESLAISRARELFGAN
YANVQPHSGSQANMAAIMALIKPGDRILGMELSHGGHLTHGSKVSFSGMFFDAYSYGVSRESEMIDYDDVRKIAKECRPN
LIIAGASSYSREIDFKKFREIADEVSAYLLCDVAHTAGLIATGFHNSPIDVAHLTTSTTHKTLRGPRGGLILAGRESSII
VNYNNKERRLEDAVNSCVFPGTQGGPLMHVIAGKAVAFREALMEDFKDYISRVISNTKAMAECFISEGFRIVSGGTDNHL
FLVDLGILGITGADAEKVLERVNITLNKNAIPFDSKNPSVTSGIRIGAAAITSRGLNRDDSIRVAHFVIRALKTKSEDEL
KKIKRDVIEFISSFDMP

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI19923315, Length=448, Percent_Identity=43.0803571428571, Blast_Score=351, Evalue=7e-97,
Organism=Homo sapiens, GI261862352, Length=448, Percent_Identity=43.0803571428571, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI261862350, Length=448, Percent_Identity=43.0803571428571, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI261862348, Length=448, Percent_Identity=43.0803571428571, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI261862346, Length=448, Percent_Identity=42.4107142857143, Blast_Score=335, Evalue=4e-92,
Organism=Homo sapiens, GI22547186, Length=402, Percent_Identity=45.0248756218905, Blast_Score=328, Evalue=7e-90,
Organism=Homo sapiens, GI22547189, Length=400, Percent_Identity=41, Blast_Score=285, Evalue=5e-77,
Organism=Escherichia coli, GI1788902, Length=413, Percent_Identity=53.7530266343826, Blast_Score=425, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI25144732, Length=450, Percent_Identity=42.2222222222222, Blast_Score=338, Evalue=3e-93,
Organism=Caenorhabditis elegans, GI25144729, Length=450, Percent_Identity=42.2222222222222, Blast_Score=338, Evalue=4e-93,
Organism=Saccharomyces cerevisiae, GI6319739, Length=403, Percent_Identity=42.9280397022332, Blast_Score=336, Evalue=5e-93,
Organism=Saccharomyces cerevisiae, GI6323087, Length=403, Percent_Identity=44.4168734491315, Blast_Score=335, Evalue=7e-93,
Organism=Drosophila melanogaster, GI24640005, Length=451, Percent_Identity=44.3458980044346, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI221329721, Length=451, Percent_Identity=44.3458980044346, Blast_Score=363, Evalue=1e-100,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA_BORHD (B2S0U9)

Other databases:

- EMBL:   CP000048
- RefSeq:   YP_001884025.1
- ProteinModelPortal:   B2S0U9
- EnsemblBacteria:   EBBORT00000006582
- GeneID:   6276467
- GenomeReviews:   CP000048_GR
- KEGG:   bhr:BH0601
- GeneTree:   EBGT00050000007055
- HOGENOM:   HBG301263
- OMA:   ELSHGGH
- ProtClustDB:   PRK00011
- BioCyc:   BHER314723:BH0601-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 45831; Mature: 45831

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDSILFDLIEREVKREKENIELIASENFVSSDVRRAVGSILTNKYAEGYPSKRYYGGCF
CHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCEE
VVDDIESLAISRARELFGANYANVQPHSGSQANMAAIMALIKPGDRILGMELSHGGHLTH
EECCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCC
GSKVSFSGMFFDAYSYGVSRESEMIDYDDVRKIAKECRPNLIIAGASSYSREIDFKKFRE
CCCEEECEEEEHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHH
IADEVSAYLLCDVAHTAGLIATGFHNSPIDVAHLTTSTTHKTLRGPRGGLILAGRESSII
HHHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEEECCHHHHHHCCCCCCEEEECCCCEEE
VNYNNKERRLEDAVNSCVFPGTQGGPLMHVIAGKAVAFREALMEDFKDYISRVISNTKAM
EEECCHHHHHHHHHHHCCCCCCCCCCEEEEHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AECFISEGFRIVSGGTDNHLFLVDLGILGITGADAEKVLERVNITLNKNAIPFDSKNPSV
HHHHHHCCCEEEECCCCCEEEEEEECEEECCCCCHHHHHHHHCEEECCCCCCCCCCCCCC
TSGIRIGAAAITSRGLNRDDSIRVAHFVIRALKTKSEDELKKIKRDVIEFISSFDMP
CCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIDSILFDLIEREVKREKENIELIASENFVSSDVRRAVGSILTNKYAEGYPSKRYYGGCF
CHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCEE
VVDDIESLAISRARELFGANYANVQPHSGSQANMAAIMALIKPGDRILGMELSHGGHLTH
EECCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCC
GSKVSFSGMFFDAYSYGVSRESEMIDYDDVRKIAKECRPNLIIAGASSYSREIDFKKFRE
CCCEEECEEEEHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHH
IADEVSAYLLCDVAHTAGLIATGFHNSPIDVAHLTTSTTHKTLRGPRGGLILAGRESSII
HHHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEEECCHHHHHHCCCCCCEEEECCCCEEE
VNYNNKERRLEDAVNSCVFPGTQGGPLMHVIAGKAVAFREALMEDFKDYISRVISNTKAM
EEECCHHHHHHHHHHHCCCCCCCCCCEEEEHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AECFISEGFRIVSGGTDNHLFLVDLGILGITGADAEKVLERVNITLNKNAIPFDSKNPSV
HHHHHHCCCEEEECCCCCEEEEEEECEEECCCCCHHHHHHHHCEEECCCCCCCCCCCCCC
TSGIRIGAAAITSRGLNRDDSIRVAHFVIRALKTKSEDELKKIKRDVIEFISSFDMP
CCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA