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The map label for this gene is pyrG [H]

Identifier: 187918439

GI number: 187918439

Start: 598705

End: 600369

Strand: Direct

Name: pyrG [H]

Synonym: BH0575

Alternate gene names: 187918439

Gene position: 598705-600369 (Clockwise)

Preceding gene: 187918438

Following gene: 187918440

Centisome position: 64.91

GC content: 33.45

Gene sequence:

>1665_bases
GTGTTTTTAAGCATTGATATTGGTTGTTTGAACTTATTTTTTTGGAGGGTATTAATGATAGATAATCTAAAAATTTTGGT
AGTAACAGGTGGTGTAATTTCTGGGATAGGTAAAGGAGTTACATCAGCAAGTATAGCACGGTTATTCAAGGATAATTTGA
GGATAACACCAATTAAATGTGATGGTTATTTAAATACTGACCCTGGAACTATTAATCCTGTTGAGCATGGAGAGGTTTTT
GTTCTTGATGATGGCGGAGAAGTTGATATGGATTTTGGTCATTATGAGAGATTTTTAAATCTAAATTCTAAGTCTAATTG
GAACATTACGATGGGTAAAATATATAAAAATATTCTTGAAAATGAGAGACATGGAAAATATTTAGGTAGAACTGTACAGC
TTATTCCCCATGTTACTGATGAGATTAGGGATACAATTTTTAAGATTGCCAAAGAGGAGTGCAGTGAACTTTTAGTAATT
GAGATTGGTGGTACTGTAGGGGATATGGAAAATATTTTGTTTATTGAAACAATGAGACAGATAAGATATGAGATTGGGAG
TGATAATATTGCTTTTGTGCACTTAACTTATATCCCAAATCCTGCTGGGATAAATGAGCAAAAGTCTAAGCCTACTCAGC
AGAGTGTCAAGACTTTAAATAAAGCTGGCATTTTTCCAGATTTAATTATTGCAAGAAGTTCTCAACTTTTGACAAAGCAG
ATAAGACAAAAAATAGCAATGTTTTGTAATGTTGATGCTGAGTCCATTGTTGATAATACTGATGTTTCAACTATTTATGA
AATACCCATATCTTTTTATAAACAGGGATTACACGAAATTTTGGGTTCAAAATTAAAAATAAATGTTAAACCTAAGGTGG
ATGGGCTTGAGCGATTAGTAGGTATAATAAAGAGAAATTTTGCCTCTCCTCGTAAAGTTGTCAATATTGCTATTTGTGGT
AAATATACTGAGCTTGGTGATTCTTATGCATCAATATTTGAGTCTTTAACCCATGTATCTGCTAATTTAGATCTTTTAGT
TAAGACAATTGTAATTGATAGCACTAATTTTGATGAAGGGATGTTAAAGGGTATAGATGGTATAGTAGTGCCTGGTGGAT
TTGGGGGTAGGGGATATGAAGGTAAAATGCGTGCAATTAAATATGCACGGGAGAATAATATTCCTTTTCTTGGCATTTGT
CTTGGCATGCAACTTGCAGTAATTGAGTTTGCTCGTAATGTTTGTGGAATACTTGATGCTGATACTGAGGAGACTTTATT
TGAAGGTAATTCTGCATTCAGTTCTATTAGTCCTGTTATTCACTTATTGCCTGAGCAAAAGGAACTGAAAGATAAGGGTG
CAACAATGCGACTTGGAGGCTATCCTGTTTTGTTAAAGAAGGATACGCTTGCTTTTAAACTTTATGGAAGTGAGATGATC
GTTGAGAGATTTAGGCATAGGTATGAAGTTAATAATGATTATCTCGATTTGTTTAATAAGCATGGATTTGTTGTGTCTGG
ATTTTCTGAAGATTCCCGAATAGTAAAAATAATGGAAATTCCAAAAAATAAGTTTTTTGTGGCTTGTCAATTTCATCCTG
AGCTTATTACAAGACTTGAAAGCCCGTCTAAACTTTTTGTAGGCTTAGTAAAAGCATGTCTTTGA

Upstream 100 bases:

>100_bases
ATTTTTAAAGAGAGCAGGAGAATATTATTCTTAAATTTATAAATCTTTTTGTAATTATATGTTACCTCAAACAATTATGG
TGTTAAAGATTTTGATTTAA

Downstream 100 bases:

>100_bases
TTTTACTAAGTCATTTATTGATTGGTTTATTTAATGTATTTCATAGATTTAAGAGTAGGTATATTCTTTTTGGATTTATT
AAGGGGGATAAGATGAAGGA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 554; Mature: 554

Protein sequence:

>554_residues
MFLSIDIGCLNLFFWRVLMIDNLKILVVTGGVISGIGKGVTSASIARLFKDNLRITPIKCDGYLNTDPGTINPVEHGEVF
VLDDGGEVDMDFGHYERFLNLNSKSNWNITMGKIYKNILENERHGKYLGRTVQLIPHVTDEIRDTIFKIAKEECSELLVI
EIGGTVGDMENILFIETMRQIRYEIGSDNIAFVHLTYIPNPAGINEQKSKPTQQSVKTLNKAGIFPDLIIARSSQLLTKQ
IRQKIAMFCNVDAESIVDNTDVSTIYEIPISFYKQGLHEILGSKLKINVKPKVDGLERLVGIIKRNFASPRKVVNIAICG
KYTELGDSYASIFESLTHVSANLDLLVKTIVIDSTNFDEGMLKGIDGIVVPGGFGGRGYEGKMRAIKYARENNIPFLGIC
LGMQLAVIEFARNVCGILDADTEETLFEGNSAFSSISPVIHLLPEQKELKDKGATMRLGGYPVLLKKDTLAFKLYGSEMI
VERFRHRYEVNNDYLDLFNKHGFVVSGFSEDSRIVKIMEIPKNKFFVACQFHPELITRLESPSKLFVGLVKACL

Sequences:

>Translated_554_residues
MFLSIDIGCLNLFFWRVLMIDNLKILVVTGGVISGIGKGVTSASIARLFKDNLRITPIKCDGYLNTDPGTINPVEHGEVF
VLDDGGEVDMDFGHYERFLNLNSKSNWNITMGKIYKNILENERHGKYLGRTVQLIPHVTDEIRDTIFKIAKEECSELLVI
EIGGTVGDMENILFIETMRQIRYEIGSDNIAFVHLTYIPNPAGINEQKSKPTQQSVKTLNKAGIFPDLIIARSSQLLTKQ
IRQKIAMFCNVDAESIVDNTDVSTIYEIPISFYKQGLHEILGSKLKINVKPKVDGLERLVGIIKRNFASPRKVVNIAICG
KYTELGDSYASIFESLTHVSANLDLLVKTIVIDSTNFDEGMLKGIDGIVVPGGFGGRGYEGKMRAIKYARENNIPFLGIC
LGMQLAVIEFARNVCGILDADTEETLFEGNSAFSSISPVIHLLPEQKELKDKGATMRLGGYPVLLKKDTLAFKLYGSEMI
VERFRHRYEVNNDYLDLFNKHGFVVSGFSEDSRIVKIMEIPKNKFFVACQFHPELITRLESPSKLFVGLVKACL
>Mature_554_residues
MFLSIDIGCLNLFFWRVLMIDNLKILVVTGGVISGIGKGVTSASIARLFKDNLRITPIKCDGYLNTDPGTINPVEHGEVF
VLDDGGEVDMDFGHYERFLNLNSKSNWNITMGKIYKNILENERHGKYLGRTVQLIPHVTDEIRDTIFKIAKEECSELLVI
EIGGTVGDMENILFIETMRQIRYEIGSDNIAFVHLTYIPNPAGINEQKSKPTQQSVKTLNKAGIFPDLIIARSSQLLTKQ
IRQKIAMFCNVDAESIVDNTDVSTIYEIPISFYKQGLHEILGSKLKINVKPKVDGLERLVGIIKRNFASPRKVVNIAICG
KYTELGDSYASIFESLTHVSANLDLLVKTIVIDSTNFDEGMLKGIDGIVVPGGFGGRGYEGKMRAIKYARENNIPFLGIC
LGMQLAVIEFARNVCGILDADTEETLFEGNSAFSSISPVIHLLPEQKELKDKGATMRLGGYPVLLKKDTLAFKLYGSEMI
VERFRHRYEVNNDYLDLFNKHGFVVSGFSEDSRIVKIMEIPKNKFFVACQFHPELITRLESPSKLFVGLVKACL

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI28559085, Length=565, Percent_Identity=41.2389380530973, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI28559083, Length=565, Percent_Identity=41.2389380530973, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI221316689, Length=565, Percent_Identity=41.2389380530973, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI148491070, Length=555, Percent_Identity=39.4594594594595, Blast_Score=408, Evalue=1e-114,
Organism=Escherichia coli, GI1789142, Length=542, Percent_Identity=42.8044280442804, Blast_Score=421, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI25148299, Length=605, Percent_Identity=36.5289256198347, Blast_Score=384, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6322563, Length=563, Percent_Identity=40.3197158081705, Blast_Score=415, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6319432, Length=562, Percent_Identity=40.3914590747331, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24664469, Length=554, Percent_Identity=39.8916967509025, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI21357815, Length=498, Percent_Identity=38.3534136546185, Blast_Score=358, Evalue=7e-99,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 61956; Mature: 61956

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLSIDIGCLNLFFWRVLMIDNLKILVVTGGVISGIGKGVTSASIARLFKDNLRITPIKC
CEEEEEHHHHHHHHHHHHHHCCCEEEEEECHHHHHHCCCCHHHHHHHHHHCCCEEEEEEE
DGYLNTDPGTINPVEHGEVFVLDDGGEVDMDFGHYERFLNLNSKSNWNITMGKIYKNILE
CCEECCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHEECCCCCCCCEEHHHHHHHHHC
NERHGKYLGRTVQLIPHVTDEIRDTIFKIAKEECSELLVIEIGGTVGDMENILFIETMRQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHH
IRYEIGSDNIAFVHLTYIPNPAGINEQKSKPTQQSVKTLNKAGIFPDLIIARSSQLLTKQ
HHHHCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHCCHHHHHHH
IRQKIAMFCNVDAESIVDNTDVSTIYEIPISFYKQGLHEILGSKLKINVKPKVDGLERLV
HHHHHHHHCCCCHHHHCCCCCCHHEEECCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHH
GIIKRNFASPRKVVNIAICGKYTELGDSYASIFESLTHVSANLDLLVKTIVIDSTNFDEG
HHHHHCCCCCCCEEEEEEECCHHHHCHHHHHHHHHHHHHCCCHHEEEEEEEEECCCCCHH
MLKGIDGIVVPGGFGGRGYEGKMRAIKYARENNIPFLGICLGMQLAVIEFARNVCGILDA
HHCCCCCEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCCCC
DTEETLFEGNSAFSSISPVIHLLPEQKELKDKGATMRLGGYPVLLKKDTLAFKLYGSEMI
CCHHHHHCCCCHHHHHHHHHHHCCCHHHHHCCCCEEEECCEEEEEECCCEEEEEECHHHH
VERFRHRYEVNNDYLDLFNKHGFVVSGFSEDSRIVKIMEIPKNKFFVACQFHPELITRLE
HHHHHHHHCCCCHHHHHHCCCCCEEECCCCCCCEEEEEECCCCCEEEEEEECHHHHHHCC
SPSKLFVGLVKACL
CCHHHHHHHHHHHC
>Mature Secondary Structure
MFLSIDIGCLNLFFWRVLMIDNLKILVVTGGVISGIGKGVTSASIARLFKDNLRITPIKC
CEEEEEHHHHHHHHHHHHHHCCCEEEEEECHHHHHHCCCCHHHHHHHHHHCCCEEEEEEE
DGYLNTDPGTINPVEHGEVFVLDDGGEVDMDFGHYERFLNLNSKSNWNITMGKIYKNILE
CCEECCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHEECCCCCCCCEEHHHHHHHHHC
NERHGKYLGRTVQLIPHVTDEIRDTIFKIAKEECSELLVIEIGGTVGDMENILFIETMRQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHH
IRYEIGSDNIAFVHLTYIPNPAGINEQKSKPTQQSVKTLNKAGIFPDLIIARSSQLLTKQ
HHHHCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHCCHHHHHHH
IRQKIAMFCNVDAESIVDNTDVSTIYEIPISFYKQGLHEILGSKLKINVKPKVDGLERLV
HHHHHHHHCCCCHHHHCCCCCCHHEEECCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHH
GIIKRNFASPRKVVNIAICGKYTELGDSYASIFESLTHVSANLDLLVKTIVIDSTNFDEG
HHHHHCCCCCCCEEEEEEECCHHHHCHHHHHHHHHHHHHCCCHHEEEEEEEEECCCCCHH
MLKGIDGIVVPGGFGGRGYEGKMRAIKYARENNIPFLGICLGMQLAVIEFARNVCGILDA
HHCCCCCEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCCCC
DTEETLFEGNSAFSSISPVIHLLPEQKELKDKGATMRLGGYPVLLKKDTLAFKLYGSEMI
CCHHHHHCCCCHHHHHHHHHHHCCCHHHHHCCCCEEEECCEEEEEECCCEEEEEECHHHH
VERFRHRYEVNNDYLDLFNKHGFVVSGFSEDSRIVKIMEIPKNKFFVACQFHPELITRLE
HHHHHHHHCCCCHHHHHHCCCCCEEECCCCCCCEEEEEECCCCCEEEEEEECHHHHHHCC
SPSKLFVGLVKACL
CCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA