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The map label for this gene is prs [H]

Identifier: 187918407

GI number: 187918407

Start: 562375

End: 563595

Strand: Direct

Name: prs [H]

Synonym: BH0544

Alternate gene names: 187918407

Gene position: 562375-563595 (Clockwise)

Preceding gene: 187918406

Following gene: 187918408

Centisome position: 60.97

GC content: 30.47

Gene sequence:

>1221_bases
TTGAGTTTGCTTATTAAAAAATCAATAGGAATTATTGCCTGTCCTGGTGGGAGGGTATTTGCAGATAAAATAATGGAAGA
GCTAAAGAAAATATTTTTAGATACTGAGAGTAAAGTTATTGAAAAAATTTCGCAAACTTCTCATTGTTTAAAAGAAGATG
TTTTAAAACTTGAAGGAATTTTGTCTCCTTTTTTAGAAGGGTTTGGATTTTCTAACTCAAGATTTGATGAGGCTATGGAA
ATTCCTGTGAGTTTTGTTAAGTTTGCTAATGGTGAATTTAAAGCAGAAATTTTAAAAACCATAAGAAATAAAGATATTTT
TATTGTGCAAGATGTTTCTAATACTTATCCAGTTAATGTAAATAATAATGAAAAAGTAGTAATGACAATTAATGATCATT
TAATGAATTTGATGACTACAATAGATGCCTGCAAGCAGGCTAAGGCTAATTCTGTGAGCGTTATTGTTCCTTCTTATCCT
TACTCAAGGCAAGATAAGAAGCATTCAAGAGAAGGATTAACAGCAAGTCTTGTTGGGAGGTTTCTGGAGGAATTAGGAGT
TAAGCATATTTTAACATTAGACATTCATTCAAAAGCTATTGAAAATGTTTTTAGAAAAACGTATTTTGAGAATTTAAATG
CATCTTATGAAATTTTTGATGCTTTAGCTGAATTAATAGATATTAGAGATTCAAATTTAGTAGTTGTTTCTCCTGATACG
GGAGCTGTTAATAGGAACAAGTTTTTTGCATCTAGTCTTAAAAGGCCCTTAGCTTTGCTTTATAAGGAAAGGGATTATTC
AAAGGTAACACACAATGTTAATGATTCTAATATTTCTGTTACTAAGCTTTTAGGAGATGTTGAGGGTAAGAATGTTTTTA
TGAGTGATGATATGTTGGCTACTGGTGGGACTTTTATTAAGGCTGTGAAACTGTTAAAAAGTATGGGAGCTAAAAAGATT
ATATGTGCAATAAGTCTGCCATTTTTTAATGGGAATGCAATTAGATATTTTGATAAAGCTTATGAGGAAGGCTATTTTTA
TAAGATAATTGGAACAAATGCCGTTTATCATGATGATAGACTTATTAGTAAACCTTGGTATTATGAAGCTAATGTTGCGC
ATCTTTTTGCAGGTGCAATTTTTGCAATTCACAATAGGGTTAGTTTGCAAAAAATTCTTGATAGAAGTCATGATATTCAA
GCTTTAATTTCTAAGAGTTAG

Upstream 100 bases:

>100_bases
CTTTATAGATCTTTCTTAAGCTTGTGTGAATTATTTGAATTAATGTACAATAAGATGACAATAAAATAAAGATTTTCTGT
CAAAATAGGGAGTTTGAAAA

Downstream 100 bases:

>100_bases
TTTGATGGATGTACTCAGTATTGATATTGGTACTAGTACTTTGAAATCTGCTTTAGTTAATTCTCATCATGGGGTTTTAG
AGAGTTTTGATGTAAATTAT

Product: phosphoribosylpyrophosphate synthetase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MSLLIKKSIGIIACPGGRVFADKIMEELKKIFLDTESKVIEKISQTSHCLKEDVLKLEGILSPFLEGFGFSNSRFDEAME
IPVSFVKFANGEFKAEILKTIRNKDIFIVQDVSNTYPVNVNNNEKVVMTINDHLMNLMTTIDACKQAKANSVSVIVPSYP
YSRQDKKHSREGLTASLVGRFLEELGVKHILTLDIHSKAIENVFRKTYFENLNASYEIFDALAELIDIRDSNLVVVSPDT
GAVNRNKFFASSLKRPLALLYKERDYSKVTHNVNDSNISVTKLLGDVEGKNVFMSDDMLATGGTFIKAVKLLKSMGAKKI
ICAISLPFFNGNAIRYFDKAYEEGYFYKIIGTNAVYHDDRLISKPWYYEANVAHLFAGAIFAIHNRVSLQKILDRSHDIQ
ALISKS

Sequences:

>Translated_406_residues
MSLLIKKSIGIIACPGGRVFADKIMEELKKIFLDTESKVIEKISQTSHCLKEDVLKLEGILSPFLEGFGFSNSRFDEAME
IPVSFVKFANGEFKAEILKTIRNKDIFIVQDVSNTYPVNVNNNEKVVMTINDHLMNLMTTIDACKQAKANSVSVIVPSYP
YSRQDKKHSREGLTASLVGRFLEELGVKHILTLDIHSKAIENVFRKTYFENLNASYEIFDALAELIDIRDSNLVVVSPDT
GAVNRNKFFASSLKRPLALLYKERDYSKVTHNVNDSNISVTKLLGDVEGKNVFMSDDMLATGGTFIKAVKLLKSMGAKKI
ICAISLPFFNGNAIRYFDKAYEEGYFYKIIGTNAVYHDDRLISKPWYYEANVAHLFAGAIFAIHNRVSLQKILDRSHDIQ
ALISKS
>Mature_405_residues
SLLIKKSIGIIACPGGRVFADKIMEELKKIFLDTESKVIEKISQTSHCLKEDVLKLEGILSPFLEGFGFSNSRFDEAMEI
PVSFVKFANGEFKAEILKTIRNKDIFIVQDVSNTYPVNVNNNEKVVMTINDHLMNLMTTIDACKQAKANSVSVIVPSYPY
SRQDKKHSREGLTASLVGRFLEELGVKHILTLDIHSKAIENVFRKTYFENLNASYEIFDALAELIDIRDSNLVVVSPDTG
AVNRNKFFASSLKRPLALLYKERDYSKVTHNVNDSNISVTKLLGDVEGKNVFMSDDMLATGGTFIKAVKLLKSMGAKKII
CAISLPFFNGNAIRYFDKAYEEGYFYKIIGTNAVYHDDRLISKPWYYEANVAHLFAGAIFAIHNRVSLQKILDRSHDIQA
LISKS

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=300, Percent_Identity=31, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4506127, Length=300, Percent_Identity=31.3333333333333, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI84875539, Length=303, Percent_Identity=30.6930693069307, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI28557709, Length=300, Percent_Identity=31, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI4506133, Length=331, Percent_Identity=25.3776435045317, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI194018537, Length=323, Percent_Identity=26.9349845201238, Blast_Score=105, Evalue=9e-23,
Organism=Escherichia coli, GI1787458, Length=311, Percent_Identity=29.2604501607717, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17554704, Length=318, Percent_Identity=31.1320754716981, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI25149168, Length=318, Percent_Identity=31.1320754716981, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17554702, Length=322, Percent_Identity=30.1242236024845, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI71989924, Length=318, Percent_Identity=30.188679245283, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17570245, Length=289, Percent_Identity=25.9515570934256, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319403, Length=317, Percent_Identity=30.9148264984227, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6320946, Length=313, Percent_Identity=30.0319488817891, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6321776, Length=296, Percent_Identity=28.3783783783784, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6322667, Length=195, Percent_Identity=29.2307692307692, Blast_Score=96, Evalue=9e-21,
Organism=Drosophila melanogaster, GI21355239, Length=300, Percent_Identity=32.6666666666667, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI45551540, Length=327, Percent_Identity=30.2752293577982, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI281362873, Length=337, Percent_Identity=27.299703264095, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24651454, Length=337, Percent_Identity=27.299703264095, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24651458, Length=337, Percent_Identity=27.299703264095, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24651456, Length=337, Percent_Identity=27.299703264095, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI45552010, Length=356, Percent_Identity=25.8426966292135, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24651462, Length=356, Percent_Identity=25.8426966292135, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24651464, Length=356, Percent_Identity=25.8426966292135, Blast_Score=95, Evalue=7e-20,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 45680; Mature: 45549

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLIKKSIGIIACPGGRVFADKIMEELKKIFLDTESKVIEKISQTSHCLKEDVLKLEGI
CCEEEECCCCEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LSPFLEGFGFSNSRFDEAMEIPVSFVKFANGEFKAEILKTIRNKDIFIVQDVSNTYPVNV
HHHHHHHCCCCCCHHHHHHHCCHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCCCEEE
NNNEKVVMTINDHLMNLMTTIDACKQAKANSVSVIVPSYPYSRQDKKHSREGLTASLVGR
CCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHCCCCHHHHHH
FLEELGVKHILTLDIHSKAIENVFRKTYFENLNASYEIFDALAELIDIRDSNLVVVSPDT
HHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEECCCC
GAVNRNKFFASSLKRPLALLYKERDYSKVTHNVNDSNISVTKLLGDVEGKNVFMSDDMLA
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCEEHHHHHCCCCCCEEEECCCCCC
TGGTFIKAVKLLKSMGAKKIICAISLPFFNGNAIRYFDKAYEEGYFYKIIGTNAVYHDDR
CCHHHHHHHHHHHHCCCCEEEEEEEECEECCCEEHHHHHHHCCCCEEEEEECCEEEECCC
LISKPWYYEANVAHLFAGAIFAIHNRVSLQKILDRSHDIQALISKS
CCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCC
>Mature Secondary Structure 
SLLIKKSIGIIACPGGRVFADKIMEELKKIFLDTESKVIEKISQTSHCLKEDVLKLEGI
CEEEECCCCEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LSPFLEGFGFSNSRFDEAMEIPVSFVKFANGEFKAEILKTIRNKDIFIVQDVSNTYPVNV
HHHHHHHCCCCCCHHHHHHHCCHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCCCEEE
NNNEKVVMTINDHLMNLMTTIDACKQAKANSVSVIVPSYPYSRQDKKHSREGLTASLVGR
CCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHCCCCHHHHHH
FLEELGVKHILTLDIHSKAIENVFRKTYFENLNASYEIFDALAELIDIRDSNLVVVSPDT
HHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEECCCC
GAVNRNKFFASSLKRPLALLYKERDYSKVTHNVNDSNISVTKLLGDVEGKNVFMSDDMLA
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCEEHHHHHCCCCCCEEEECCCCCC
TGGTFIKAVKLLKSMGAKKIICAISLPFFNGNAIRYFDKAYEEGYFYKIIGTNAVYHDDR
CCHHHHHHHHHHHHCCCCEEEEEEEECEECCCEEHHHHHHHCCCCEEEEEECCEEEECCC
LISKPWYYEANVAHLFAGAIFAIHNRVSLQKILDRSHDIQALISKS
CCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]