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The map label for this gene is dnaX [H]

Identifier: 187918326

GI number: 187918326

Start: 486982

End: 488634

Strand: Direct

Name: dnaX [H]

Synonym: BH0461

Alternate gene names: 187918326

Gene position: 486982-488634 (Clockwise)

Preceding gene: 187918324

Following gene: 187918327

Centisome position: 52.8

GC content: 30.61

Gene sequence:

>1653_bases
ATGATATCTGCAAGAGGTACTGCCATTAAGAGGCGTCCTAGAGATTTTAATTCTCTTGAGGGGCAAGATTTTGTTGTTGA
GACCTTAAAACATTCAATAGAGAATAACAGAATAGCAAATGCTTATATATTTTCAGGACCACGAGGAGTTGGCAAGACTT
CTTCTGCAAGGGCTTTTGCACGGTGTTTAAATTGTCAGGCAGGACCAACAATTATGCCTTGTGGTGTGTGTTTCAGTTGT
AAATCTATTGATAATGATAATAGTCTTGATATTATCGAGATTGATGGTGCTTCAAATACTTCTGTTCAAGATGTTAGACA
AATTAAAGAAGAAATAATGTTTCCTCCTGCCAGTTCTAAGTATAGGGTTTACATTATTGATGAAGTACATATGCTTTCAA
ATTCTGCTTTCAATGCTCTTTTAAAAACAATTGAAGAACCCCCTAGTTATATTGTTTTTATTTTTGCTACGACAGAGGTA
CATAAACTTCCAGATACAATAAAGAGCAGGTGTCAGCATTTTAATTTTAGGCTTTTACCTTTAGAGAAGATTTATGAGAT
GTTAAAGCATGTTTGCCTTGAAGATAACATTAAATATGAGGATGAGGCTTTAAGGTGGATTGCTTATAAGAGTGGAGGGA
GCGTAAGGGATGCTTATACTCTCTTCGATCAAATTGTGTCATTAAGTAATTCTGACATTAATTTTGAACAAATCAAATCT
AAGATGGGATTGACCAGTGATGAATTTTTAGAAAAATTGGCATTAAGCATTCTTAATGATGATTTAAAGGAATTGCTTTG
TGTTTTAGATGCTGTATTTTTAACAGGGATTTCATGTGAGCAATTTCTTCTTGATGCAATTGAGTTTTTTAGAGAGATAT
TATTTCTGAAATTAGACATTAAAAATCTTATGTTTATTGGTATTAAACTTAAGAGTTTAAAAGAAAAATTATCAAGTTTT
GATTTGAATCATGTTGAGAGAAGTATTAGTGTATTACTTGAGACTTATAGGAATTTGCAGTTTTCAGTAAGTCCTAAATA
TGAACTTGAGATTAGTTTTATTAAGATACTTAGGCTTAAAGATTATGTACCTAGTCATTTTTTAATTAAGCAAATTCAAG
ATATCGAAGCTAAGGTACTTGATGAGGTTAGTTTTGATGTAAATGATGTTGATGTTGATACTGATTTAAAATCAGAATTA
GGTAATATTCCTTCAGTAGATCCAGTAAAATTGGGTTTAAGTAAAATTGATACCGCATTAAAGACTGAAGTTAAAGATTC
TAGGCGTATTGATTTTGCTGATGGTGATGATATTGATGAGATTTTTATAGAGACAAAAGATAGTTTTGATAAGGTAGATG
ATAATGATAAAATTAAAGAAAGTTTTATTTATTTAGTATCTAAGTATGTTCAAACTTTAGTATATTCAGGAGAAGTTTTG
ATTGACAATGGTGTGCTTTATTATAAAATTTTTAGTGGATTTGAGTATAATCAGCTTCAAGCTTATCAGAATGAAATAAG
AGCTGAATTTTGTAAAGAATTTCCTAGATTGAATGTTATATTTCAGAAGCAGTTTAAGGATAATGATGATGAGTTTGATA
ATGAGGTGCTTAAGATCAAAAACATTTTTGGAGCAAGTGAGGTGAAAGATTAG

Upstream 100 bases:

>100_bases
TACATATTGTAAAAGAATAATGTTTTTATTGTTTTAATGCTTTTGATTTTGTGTAATTTAAGGTTTAAGTGAGATTTTTA
TTGGTGTATGGGGAGATGGG

Downstream 100 bases:

>100_bases
GATATGGCAGTAAATCCATTAGATTTTTTAAAAAATATGACAAGCTTTAAAGATAATATTGATAATCTTAAAAAAGAAAT
GTCTCAAATTGTTGTCTGTG

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MISARGTAIKRRPRDFNSLEGQDFVVETLKHSIENNRIANAYIFSGPRGVGKTSSARAFARCLNCQAGPTIMPCGVCFSC
KSIDNDNSLDIIEIDGASNTSVQDVRQIKEEIMFPPASSKYRVYIIDEVHMLSNSAFNALLKTIEEPPSYIVFIFATTEV
HKLPDTIKSRCQHFNFRLLPLEKIYEMLKHVCLEDNIKYEDEALRWIAYKSGGSVRDAYTLFDQIVSLSNSDINFEQIKS
KMGLTSDEFLEKLALSILNDDLKELLCVLDAVFLTGISCEQFLLDAIEFFREILFLKLDIKNLMFIGIKLKSLKEKLSSF
DLNHVERSISVLLETYRNLQFSVSPKYELEISFIKILRLKDYVPSHFLIKQIQDIEAKVLDEVSFDVNDVDVDTDLKSEL
GNIPSVDPVKLGLSKIDTALKTEVKDSRRIDFADGDDIDEIFIETKDSFDKVDDNDKIKESFIYLVSKYVQTLVYSGEVL
IDNGVLYYKIFSGFEYNQLQAYQNEIRAEFCKEFPRLNVIFQKQFKDNDDEFDNEVLKIKNIFGASEVKD

Sequences:

>Translated_550_residues
MISARGTAIKRRPRDFNSLEGQDFVVETLKHSIENNRIANAYIFSGPRGVGKTSSARAFARCLNCQAGPTIMPCGVCFSC
KSIDNDNSLDIIEIDGASNTSVQDVRQIKEEIMFPPASSKYRVYIIDEVHMLSNSAFNALLKTIEEPPSYIVFIFATTEV
HKLPDTIKSRCQHFNFRLLPLEKIYEMLKHVCLEDNIKYEDEALRWIAYKSGGSVRDAYTLFDQIVSLSNSDINFEQIKS
KMGLTSDEFLEKLALSILNDDLKELLCVLDAVFLTGISCEQFLLDAIEFFREILFLKLDIKNLMFIGIKLKSLKEKLSSF
DLNHVERSISVLLETYRNLQFSVSPKYELEISFIKILRLKDYVPSHFLIKQIQDIEAKVLDEVSFDVNDVDVDTDLKSEL
GNIPSVDPVKLGLSKIDTALKTEVKDSRRIDFADGDDIDEIFIETKDSFDKVDDNDKIKESFIYLVSKYVQTLVYSGEVL
IDNGVLYYKIFSGFEYNQLQAYQNEIRAEFCKEFPRLNVIFQKQFKDNDDEFDNEVLKIKNIFGASEVKD
>Mature_550_residues
MISARGTAIKRRPRDFNSLEGQDFVVETLKHSIENNRIANAYIFSGPRGVGKTSSARAFARCLNCQAGPTIMPCGVCFSC
KSIDNDNSLDIIEIDGASNTSVQDVRQIKEEIMFPPASSKYRVYIIDEVHMLSNSAFNALLKTIEEPPSYIVFIFATTEV
HKLPDTIKSRCQHFNFRLLPLEKIYEMLKHVCLEDNIKYEDEALRWIAYKSGGSVRDAYTLFDQIVSLSNSDINFEQIKS
KMGLTSDEFLEKLALSILNDDLKELLCVLDAVFLTGISCEQFLLDAIEFFREILFLKLDIKNLMFIGIKLKSLKEKLSSF
DLNHVERSISVLLETYRNLQFSVSPKYELEISFIKILRLKDYVPSHFLIKQIQDIEAKVLDEVSFDVNDVDVDTDLKSEL
GNIPSVDPVKLGLSKIDTALKTEVKDSRRIDFADGDDIDEIFIETKDSFDKVDDNDKIKESFIYLVSKYVQTLVYSGEVL
IDNGVLYYKIFSGFEYNQLQAYQNEIRAEFCKEFPRLNVIFQKQFKDNDDEFDNEVLKIKNIFGASEVKD

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=231, Percent_Identity=25.5411255411255, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI31881687, Length=231, Percent_Identity=25.5411255411255, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1786676, Length=361, Percent_Identity=34.0720221606648, Blast_Score=244, Evalue=9e-66,
Organism=Caenorhabditis elegans, GI17554730, Length=289, Percent_Identity=24.9134948096886, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322528, Length=297, Percent_Identity=22.8956228956229, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324039, Length=292, Percent_Identity=26.3698630136986, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324478, Length=249, Percent_Identity=22.4899598393574, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI18859927, Length=254, Percent_Identity=25.9842519685039, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 63012; Mature: 63012

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISARGTAIKRRPRDFNSLEGQDFVVETLKHSIENNRIANAYIFSGPRGVGKTSSARAFA
CCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHH
RCLNCQAGPTIMPCGVCFSCKSIDNDNSLDIIEIDGASNTSVQDVRQIKEEIMFPPASSK
HHHCCCCCCCEEECCCEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCC
YRVYIIDEVHMLSNSAFNALLKTIEEPPSYIVFIFATTEVHKLPDTIKSRCQHFNFRLLP
EEEEEEECHHHHHHHHHHHHHHHHCCCCCEEEEEEEECHHHHCHHHHHHHHHHCCEEEEC
LEKIYEMLKHVCLEDNIKYEDEALRWIAYKSGGSVRDAYTLFDQIVSLSNSDINFEQIKS
HHHHHHHHHHHHHCCCCCCCHHHEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHH
KMGLTSDEFLEKLALSILNDDLKELLCVLDAVFLTGISCEQFLLDAIEFFREILFLKLDI
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCH
KNLMFIGIKLKSLKEKLSSFDLNHVERSISVLLETYRNLQFSVSPKYELEISFIKILRLK
HHEEEEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEEECCCEEEEEHHHHHHHHH
DYVPSHFLIKQIQDIEAKVLDEVSFDVNDVDVDTDLKSELGNIPSVDPVKLGLSKIDTAL
HCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHH
KTEVKDSRRIDFADGDDIDEIFIETKDSFDKVDDNDKIKESFIYLVSKYVQTLVYSGEVL
HHHHCCCCEECCCCCCCHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEE
IDNGVLYYKIFSGFEYNQLQAYQNEIRAEFCKEFPRLNVIFQKQFKDNDDEFDNEVLKIK
EECCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCCHHHHHHHHHH
NIFGASEVKD
HHCCCCCCCC
>Mature Secondary Structure
MISARGTAIKRRPRDFNSLEGQDFVVETLKHSIENNRIANAYIFSGPRGVGKTSSARAFA
CCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHH
RCLNCQAGPTIMPCGVCFSCKSIDNDNSLDIIEIDGASNTSVQDVRQIKEEIMFPPASSK
HHHCCCCCCCEEECCCEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCC
YRVYIIDEVHMLSNSAFNALLKTIEEPPSYIVFIFATTEVHKLPDTIKSRCQHFNFRLLP
EEEEEEECHHHHHHHHHHHHHHHHCCCCCEEEEEEEECHHHHCHHHHHHHHHHCCEEEEC
LEKIYEMLKHVCLEDNIKYEDEALRWIAYKSGGSVRDAYTLFDQIVSLSNSDINFEQIKS
HHHHHHHHHHHHHCCCCCCCHHHEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHH
KMGLTSDEFLEKLALSILNDDLKELLCVLDAVFLTGISCEQFLLDAIEFFREILFLKLDI
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCH
KNLMFIGIKLKSLKEKLSSFDLNHVERSISVLLETYRNLQFSVSPKYELEISFIKILRLK
HHEEEEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEEECCCEEEEEHHHHHHHHH
DYVPSHFLIKQIQDIEAKVLDEVSFDVNDVDVDTDLKSELGNIPSVDPVKLGLSKIDTAL
HCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHH
KTEVKDSRRIDFADGDDIDEIFIETKDSFDKVDDNDKIKESFIYLVSKYVQTLVYSGEVL
HHHHCCCCEECCCCCCCHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEE
IDNGVLYYKIFSGFEYNQLQAYQNEIRAEFCKEFPRLNVIFQKQFKDNDDEFDNEVLKIK
EECCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCCHHHHHHHHHH
NIFGASEVKD
HHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]