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The map label for this gene is fba [H]

Identifier: 187918311

GI number: 187918311

Start: 468727

End: 469806

Strand: Direct

Name: fba [H]

Synonym: BH0445

Alternate gene names: 187918311

Gene position: 468727-469806 (Clockwise)

Preceding gene: 187918310

Following gene: 187918312

Centisome position: 50.82

GC content: 36.02

Gene sequence:

>1080_bases
GTGGGTGTGTTAGATAAGATTAAGCCTGGAGTGGTTTATGGTAAAGACCTGCATACTTTATATGAAATATGCAAGAGTGA
AGGATTTGCGATTCCTGCAATTAATTGTGTAGGCACAAATTCAATTAATGCTGTTTTGGAAGCAGCTAAAGAAATTAATT
CTCCTATTATGATACAGTTTTCAAATAGTGGTTCTGCTTTTGTTTGTGGTAAGGGACTCAAGGTTGAAAAACCTCAGGGA
ACTTCTATACTTGGAGCCATTTCTGGTGCTATGCATGTTCATTTGCTGGCAGAGTATTATGGAGTGCCTGTTGTGCTTCA
TACAGATCACTGTGCAAAGAAATTAATTCCTTGGGTTGAGGGACTCTTAGAGTATGGGGAGAAATATTATCAAGAGCATA
AAAGACCTTTGTTTTCCTCACATATGTTAGATTTATCTGAAGAGCCAATTAAAGAGAATATTGAGATATCAAAAAAATTT
TTAGAGCGAATGTCCAAGATCGAAATGTTTTTGGAAATTGAGCTTGGAATTACTGGTGGTGAGGAAGATGGCGTTGATAA
TTCAGATAGAGCACAGCATGAGTTATTCTCAACTCCTGAGGATATTTACTATGGGTATTCTGAACTTATGAAAGTTAGTC
CTAATTTTCAAATTGCAGCGGCTTTTGGAAATGTTCATGGGGTTTATAAGCCTGGGAATGTTCAACTTACTCCTAAAGTA
TTAAGAGACGGACAAAATTATGTTATATCAAAGATTAATTCAAGCAATCCAAAACCTGTTTCATATGTATTTCATGGGGG
TTCTGGATCTACAATGGAAGAGATCCATGAAGCACTCTCTTATGGTGTTGTTAAAATGAACATTGACACAGACGCTCAGT
GGGCTGCTTGGGAAGGTTTATTAAATTATTACAAGAAAAATGAAAATAGATTACAAGGGCAGCTTGGTGATGGTAGTGAT
GCTGATGTTCCAAATAAAAAATTTTATGATCCAAGAGTGTGGCTTAGAGAATCTGAGATTAGCATGAAGGAACGTGTAAA
GCTTGCTTGCAAGAACCTTAATAATATTAATAGAAATTGA

Upstream 100 bases:

>100_bases
AGATTTTGTTTTTTAAAAGTAGAGTCAATTTTGGGTTTTAAGGTATATAATAAAAATATATTAAAATATATGTCAATTTA
TGAGGAAGGAGGTATTGTAG

Downstream 100 bases:

>100_bases
GATAAGTGTAATTAAGAATTTGAGTTTTGTCGCCTAAAGAGGCGACTTTTTTATTTATGTGTGTTTATGTATAATAAATG
TACGTCTTATTATATTTAAT

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MGVLDKIKPGVVYGKDLHTLYEICKSEGFAIPAINCVGTNSINAVLEAAKEINSPIMIQFSNSGSAFVCGKGLKVEKPQG
TSILGAISGAMHVHLLAEYYGVPVVLHTDHCAKKLIPWVEGLLEYGEKYYQEHKRPLFSSHMLDLSEEPIKENIEISKKF
LERMSKIEMFLEIELGITGGEEDGVDNSDRAQHELFSTPEDIYYGYSELMKVSPNFQIAAAFGNVHGVYKPGNVQLTPKV
LRDGQNYVISKINSSNPKPVSYVFHGGSGSTMEEIHEALSYGVVKMNIDTDAQWAAWEGLLNYYKKNENRLQGQLGDGSD
ADVPNKKFYDPRVWLRESEISMKERVKLACKNLNNINRN

Sequences:

>Translated_359_residues
MGVLDKIKPGVVYGKDLHTLYEICKSEGFAIPAINCVGTNSINAVLEAAKEINSPIMIQFSNSGSAFVCGKGLKVEKPQG
TSILGAISGAMHVHLLAEYYGVPVVLHTDHCAKKLIPWVEGLLEYGEKYYQEHKRPLFSSHMLDLSEEPIKENIEISKKF
LERMSKIEMFLEIELGITGGEEDGVDNSDRAQHELFSTPEDIYYGYSELMKVSPNFQIAAAFGNVHGVYKPGNVQLTPKV
LRDGQNYVISKINSSNPKPVSYVFHGGSGSTMEEIHEALSYGVVKMNIDTDAQWAAWEGLLNYYKKNENRLQGQLGDGSD
ADVPNKKFYDPRVWLRESEISMKERVKLACKNLNNINRN
>Mature_358_residues
GVLDKIKPGVVYGKDLHTLYEICKSEGFAIPAINCVGTNSINAVLEAAKEINSPIMIQFSNSGSAFVCGKGLKVEKPQGT
SILGAISGAMHVHLLAEYYGVPVVLHTDHCAKKLIPWVEGLLEYGEKYYQEHKRPLFSSHMLDLSEEPIKENIEISKKFL
ERMSKIEMFLEIELGITGGEEDGVDNSDRAQHELFSTPEDIYYGYSELMKVSPNFQIAAAFGNVHGVYKPGNVQLTPKVL
RDGQNYVISKINSSNPKPVSYVFHGGSGSTMEEIHEALSYGVVKMNIDTDAQWAAWEGLLNYYKKNENRLQGQLGDGSDA
DVPNKKFYDPRVWLRESEISMKERVKLACKNLNNINRN

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789293, Length=355, Percent_Identity=61.6901408450704, Blast_Score=477, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6322790, Length=359, Percent_Identity=46.5181058495822, Blast_Score=345, Evalue=7e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006411
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 40056; Mature: 39925

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVLDKIKPGVVYGKDLHTLYEICKSEGFAIPAINCVGTNSINAVLEAAKEINSPIMIQF
CCCCHHCCCCEEECCHHHHHHHHHHCCCCEECEEEECCCCHHHHHHHHHHHCCCCEEEEE
SNSGSAFVCGKGLKVEKPQGTSILGAISGAMHVHLLAEYYGVPVVLHTDHCAKKLIPWVE
CCCCCEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHH
GLLEYGEKYYQEHKRPLFSSHMLDLSEEPIKENIEISKKFLERMSKIEMFLEIELGITGG
HHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEECCC
EEDGVDNSDRAQHELFSTPEDIYYGYSELMKVSPNFQIAAAFGNVHGVYKPGNVQLTPKV
CCCCCCCCHHHHHHHHCCHHHHHHCHHHHHCCCCCEEEEEEECCCCCEECCCCEEECHHH
LRDGQNYVISKINSSNPKPVSYVFHGGSGSTMEEIHEALSYGVVKMNIDTDAQWAAWEGL
HHCCCCEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHCCEEEEECCCCCHHHHHHHH
LNYYKKNENRLQGQLGDGSDADVPNKKFYDPRVWLRESEISMKERVKLACKNLNNINRN
HHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GVLDKIKPGVVYGKDLHTLYEICKSEGFAIPAINCVGTNSINAVLEAAKEINSPIMIQF
CCCHHCCCCEEECCHHHHHHHHHHCCCCEECEEEECCCCHHHHHHHHHHHCCCCEEEEE
SNSGSAFVCGKGLKVEKPQGTSILGAISGAMHVHLLAEYYGVPVVLHTDHCAKKLIPWVE
CCCCCEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHH
GLLEYGEKYYQEHKRPLFSSHMLDLSEEPIKENIEISKKFLERMSKIEMFLEIELGITGG
HHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEECCC
EEDGVDNSDRAQHELFSTPEDIYYGYSELMKVSPNFQIAAAFGNVHGVYKPGNVQLTPKV
CCCCCCCCHHHHHHHHCCHHHHHHCHHHHHCCCCCEEEEEEECCCCCEECCCCEEECHHH
LRDGQNYVISKINSSNPKPVSYVFHGGSGSTMEEIHEALSYGVVKMNIDTDAQWAAWEGL
HHCCCCEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHCCEEEEECCCCCHHHHHHHH
LNYYKKNENRLQGQLGDGSDADVPNKKFYDPRVWLRESEISMKERVKLACKNLNNINRN
HHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9403685; 2738156 [H]