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The map label for this gene is mtnN [H]

Identifier: 187918242

GI number: 187918242

Start: 387707

End: 388420

Strand: Direct

Name: mtnN [H]

Synonym: BH0375

Alternate gene names: 187918242

Gene position: 387707-388420 (Clockwise)

Preceding gene: 187918240

Following gene: 187918243

Centisome position: 42.04

GC content: 29.69

Gene sequence:

>714_bases
ATGATTTTAATAACATCTGCAATGGATGAAGAATCGACAGAGATAAATAAGATTATCGAAAACAAAGAAGAAGTTATATT
AGATGAGTATTCGGGTGGGAAAAAAATTTATAAGGGAGAAATTGCGGGTCACAAGGTAATCTCTTTAACTACTGGCATTG
GAAAAGTAAATGCCGCTATGTGGAATAGCTATATTATATCAAGATATAAAATCACTCATATAATTAATTCAGGAACTGCT
GGGGGGATTAAAGAATCTACAAATCTTAAAATAACAGACATAATAGTATCATCAGAAACGGCATTTCATGATTTTAATTT
AACTAAATTTGGACATAAAATAGGGCAAGTACCGGGCTTTCCACAAAAATTTAAAGCAGATGAAAATTTATTAAGCAAAA
TTATTAATATTACCCAAGATAAATTTAAAAATATTAATGTTCATATTGGTCTAATACTTACAGGTGATCAATTTATTGGA
GACGAAAAACAATTAGAAGAAATTAAAAATAACTTTGCAGATGCTTTAGCTGTAGAGATGGAAAGTGCTGCGGTTGCCCA
AGTAGCATATACATTCAAAATACCTTTTATTATCATTCGTTCTATATCTGATTTACTAAACATCAAAGATAATCACATAG
ATTTCAATAAGTTCTTACAAGATGCATCAATGAACTCAGCCAAGATGGTAAGAGAACTCATTAAACTCATATAA

Upstream 100 bases:

>100_bases
ACCTAAAACAGAAACGGGAGTAAAAAAAATACTAAGACAAGATGAAATAGAATTTATTTTAAAAAAATATGGCTTAAAGG
AAATGTAAAAGGAGAAAAGT

Downstream 100 bases:

>100_bases
TTTATATACAAAGGTGATAATATGCTCAATAATAATCTAACATCAACATCTGAAGCCGTATCTGAAGGACATCCGGATAA
GATTGCGGATCAAATTTCTG

Product: 5'-methylthioadenosine nucleosidase

Products: NA

Alternate protein names: MTA/SAH nucleosidase; MTAN; 5'-methylthioadenosine nucleosidase; MTA nucleosidase; S-adenosylhomocysteine nucleosidase; AdoHcy nucleosidase; SAH nucleosidase; SRH nucleosidase [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MILITSAMDEESTEINKIIENKEEVILDEYSGGKKIYKGEIAGHKVISLTTGIGKVNAAMWNSYIISRYKITHIINSGTA
GGIKESTNLKITDIIVSSETAFHDFNLTKFGHKIGQVPGFPQKFKADENLLSKIINITQDKFKNINVHIGLILTGDQFIG
DEKQLEEIKNNFADALAVEMESAAVAQVAYTFKIPFIIIRSISDLLNIKDNHIDFNKFLQDASMNSAKMVRELIKLI

Sequences:

>Translated_237_residues
MILITSAMDEESTEINKIIENKEEVILDEYSGGKKIYKGEIAGHKVISLTTGIGKVNAAMWNSYIISRYKITHIINSGTA
GGIKESTNLKITDIIVSSETAFHDFNLTKFGHKIGQVPGFPQKFKADENLLSKIINITQDKFKNINVHIGLILTGDQFIG
DEKQLEEIKNNFADALAVEMESAAVAQVAYTFKIPFIIIRSISDLLNIKDNHIDFNKFLQDASMNSAKMVRELIKLI
>Mature_237_residues
MILITSAMDEESTEINKIIENKEEVILDEYSGGKKIYKGEIAGHKVISLTTGIGKVNAAMWNSYIISRYKITHIINSGTA
GGIKESTNLKITDIIVSSETAFHDFNLTKFGHKIGQVPGFPQKFKADENLLSKIINITQDKFKNINVHIGLILTGDQFIG
DEKQLEEIKNNFADALAVEMESAAVAQVAYTFKIPFIIIRSISDLLNIKDNHIDFNKFLQDASMNSAKMVRELIKLI

Specific function: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively [H]

COG id: COG0775

COG function: function code F; Nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/UDP phosphorylase family. MtnN subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786354, Length=234, Percent_Identity=40.1709401709402, Blast_Score=165, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010049
- InterPro:   IPR018017
- InterPro:   IPR000845 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =3.2.2.9 [H]

Molecular weight: Translated: 26450; Mature: 26450

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILITSAMDEESTEINKIIENKEEVILDEYSGGKKIYKGEIAGHKVISLTTGIGKVNAAM
CEEEECCCCCCHHHHHHHHCCCHHEEEECCCCCCEEEECCCCCCEEEEEECCCCHHHHHH
WNSYIISRYKITHIINSGTAGGIKESTNLKITDIIVSSETAFHDFNLTKFGHKIGQVPGF
HHHHHHHHEEEEEEEECCCCCCCCCCCCEEEEEEEEECCCCEECCCHHHHHHHHCCCCCC
PQKFKADENLLSKIINITQDKFKNINVHIGLILTGDQFIGDEKQLEEIKNNFADALAVEM
CHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEEEECCHHCCCHHHHHHHHHHHHHHHHHHH
ESAAVAQVAYTFKIPFIIIRSISDLLNIKDNHIDFNKFLQDASMNSAKMVRELIKLI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHC
>Mature Secondary Structure
MILITSAMDEESTEINKIIENKEEVILDEYSGGKKIYKGEIAGHKVISLTTGIGKVNAAM
CEEEECCCCCCHHHHHHHHCCCHHEEEECCCCCCEEEECCCCCCEEEEEECCCCHHHHHH
WNSYIISRYKITHIINSGTAGGIKESTNLKITDIIVSSETAFHDFNLTKFGHKIGQVPGF
HHHHHHHHEEEEEEEECCCCCCCCCCCCEEEEEEEEECCCCEECCCHHHHHHHHCCCCCC
PQKFKADENLLSKIINITQDKFKNINVHIGLILTGDQFIGDEKQLEEIKNNFADALAVEM
CHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEEEECCHHCCCHHHHHHHHHHHHHHHHHHH
ESAAVAQVAYTFKIPFIIIRSISDLLNIKDNHIDFNKFLQDASMNSAKMVRELIKLI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]