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The map label for this gene is gds [H]

Identifier: 187918188

GI number: 187918188

Start: 324419

End: 325465

Strand: Direct

Name: gds [H]

Synonym: BH0314

Alternate gene names: 187918188

Gene position: 324419-325465 (Clockwise)

Preceding gene: 187918137

Following gene: 187918189

Centisome position: 35.17

GC content: 28.65

Gene sequence:

>1047_bases
ATGCAAAATAAATCATTTTTGGATAAGATCGAAAAAAATATTAATTATATATTCTCAAAAGATCACTTTCTCAATTTATT
TAAAGATAAAGATTTAAAGCTAAAACTTAATATACAAGAAAGCACAATAAAGACCATTAAAGCCCCAGCTATTGAAATAA
TAAATAGAGGGGGAAAGAGAATAAGACCAATGCTAATGATTTTACTAGCATATGCACTAGGATATAACAACAGCAATACC
AAGAATCTATACAAACTAAGCATGCTACTTGAATTACCTCATTCTGGAAGTCTAATTATTGATGATATAGAAGATGGTGC
CATTAAAAGAAGGGGCAAGCCTGCTATTCACTTGATTTACGGACTAGATAATAGTATTAATACAGCAAATTTAATTTACT
TTCTGCCTGCAAAATTAATACAAACTGCAAATTTAAAAACAAGTCAACAACTATTAATTTATGAAAATTTCTTCACCACT
CTCTCAAATCTTCACCTAGGACAAGGAATTGACATCGCATTTCATAATGGAACATATATTCCAAACGTCGAAGAATATAT
ATCTTTAGTTGAACTTAAGACAAGTTCACTTTTTGGAATGGCTGGATTTTTAGCTGGAATACTTACAAACAATGAAAATA
AAGCAAAAAATCTTTACAACACATTCATGAAGCTTGGAACCTGTTTTCAAATAATAGACGATATTAAAAATATTAAAGAT
GGAATTAATGGCAAAGAATTTGGAGATGACTTAATTGAAGGGAAAAAAAGTCTGCCCATAATATATTTTTTAAAAGAGAA
ACAATTTGATAGGCAAATCATTCAAGAGTTAAGCAAAATTAAAAATAAACCTATAGATGAATCAAGAGAAGAAATATTAA
AATTTAGCAATATGATCAACTCATCAAGTGCCATACAAGCGGCCTCAACTCTTGCAATATCGTACCTTAATAAATTTATA
GAAGAGTTTAACTCATACGCATTGATCAACAAATATAAAGATATGATAATGGACATTGTAGAGAAAATAAAAGAGGAAAA
TTTATGA

Upstream 100 bases:

>100_bases
CCTTCTTTTTTAGCTTTTTGTGAATACTTATCAACAACATTATACATATTGATTCTCTTCAATACACTCAATCATTATAC
TTTTTATTATAATTATTATT

Downstream 100 bases:

>100_bases
AAAAATATGCAATAATTCTAGTCTGGATGAACATCATTGCTCCTATTTATGCAACAATTCCTACAGAAGATATAAATAGC
AATAAAATAATAGATGAGCT

Product: dimethylallyltransferase

Products: NA

Alternate protein names: GGPP synthase; GGPS; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyltranstransferase; Geranyltranstransferase [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MQNKSFLDKIEKNINYIFSKDHFLNLFKDKDLKLKLNIQESTIKTIKAPAIEIINRGGKRIRPMLMILLAYALGYNNSNT
KNLYKLSMLLELPHSGSLIIDDIEDGAIKRRGKPAIHLIYGLDNSINTANLIYFLPAKLIQTANLKTSQQLLIYENFFTT
LSNLHLGQGIDIAFHNGTYIPNVEEYISLVELKTSSLFGMAGFLAGILTNNENKAKNLYNTFMKLGTCFQIIDDIKNIKD
GINGKEFGDDLIEGKKSLPIIYFLKEKQFDRQIIQELSKIKNKPIDESREEILKFSNMINSSSAIQAASTLAISYLNKFI
EEFNSYALINKYKDMIMDIVEKIKEENL

Sequences:

>Translated_348_residues
MQNKSFLDKIEKNINYIFSKDHFLNLFKDKDLKLKLNIQESTIKTIKAPAIEIINRGGKRIRPMLMILLAYALGYNNSNT
KNLYKLSMLLELPHSGSLIIDDIEDGAIKRRGKPAIHLIYGLDNSINTANLIYFLPAKLIQTANLKTSQQLLIYENFFTT
LSNLHLGQGIDIAFHNGTYIPNVEEYISLVELKTSSLFGMAGFLAGILTNNENKAKNLYNTFMKLGTCFQIIDDIKNIKD
GINGKEFGDDLIEGKKSLPIIYFLKEKQFDRQIIQELSKIKNKPIDESREEILKFSNMINSSSAIQAASTLAISYLNKFI
EEFNSYALINKYKDMIMDIVEKIKEENL
>Mature_348_residues
MQNKSFLDKIEKNINYIFSKDHFLNLFKDKDLKLKLNIQESTIKTIKAPAIEIINRGGKRIRPMLMILLAYALGYNNSNT
KNLYKLSMLLELPHSGSLIIDDIEDGAIKRRGKPAIHLIYGLDNSINTANLIYFLPAKLIQTANLKTSQQLLIYENFFTT
LSNLHLGQGIDIAFHNGTYIPNVEEYISLVELKTSSLFGMAGFLAGILTNNENKAKNLYNTFMKLGTCFQIIDDIKNIKD
GINGKEFGDDLIEGKKSLPIIYFLKEKQFDRQIIQELSKIKNKPIDESREEILKFSNMINSSSAIQAASTLAISYLNKFI
EEFNSYALINKYKDMIMDIVEKIKEENL

Specific function: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI4758430, Length=237, Percent_Identity=33.7552742616034, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI83700220, Length=237, Percent_Identity=33.7552742616034, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1789578, Length=234, Percent_Identity=30.7692307692308, Blast_Score=91, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6325188, Length=227, Percent_Identity=36.5638766519824, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI281365769, Length=227, Percent_Identity=31.2775330396476, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24660002, Length=227, Percent_Identity=31.2775330396476, Blast_Score=105, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.1; =2.5.1.29; =2.5.1.10 [H]

Molecular weight: Translated: 39714; Mature: 39714

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS00052 RIBOSOMAL_S7 ; PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNKSFLDKIEKNINYIFSKDHFLNLFKDKDLKLKLNIQESTIKTIKAPAIEIINRGGKR
CCCHHHHHHHHHHHHEEECCHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCHH
IRPMLMILLAYALGYNNSNTKNLYKLSMLLELPHSGSLIIDDIEDGAIKRRGKPAIHLIY
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHCCCCCEEEEEE
GLDNSINTANLIYFLPAKLIQTANLKTSQQLLIYENFFTTLSNLHLGQGIDIAFHNGTYI
ECCCCCCHHHHHEEHHHHHHHHCCCCCCCHHEEHHHHHHHHHHCCCCCCCEEEEECCCCC
PNVEEYISLVELKTSSLFGMAGFLAGILTNNENKAKNLYNTFMKLGTCFQIIDDIKNIKD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GINGKEFGDDLIEGKKSLPIIYFLKEKQFDRQIIQELSKIKNKPIDESREEILKFSNMIN
CCCCHHCCHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHC
SSSAIQAASTLAISYLNKFIEEFNSYALINKYKDMIMDIVEKIKEENL
CCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQNKSFLDKIEKNINYIFSKDHFLNLFKDKDLKLKLNIQESTIKTIKAPAIEIINRGGKR
CCCHHHHHHHHHHHHEEECCHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCHH
IRPMLMILLAYALGYNNSNTKNLYKLSMLLELPHSGSLIIDDIEDGAIKRRGKPAIHLIY
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHCCCCCEEEEEE
GLDNSINTANLIYFLPAKLIQTANLKTSQQLLIYENFFTTLSNLHLGQGIDIAFHNGTYI
ECCCCCCHHHHHEEHHHHHHHHCCCCCCCHHEEHHHHHHHHHHCCCCCCCEEEEECCCCC
PNVEEYISLVELKTSSLFGMAGFLAGILTNNENKAKNLYNTFMKLGTCFQIIDDIKNIKD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GINGKEFGDDLIEGKKSLPIIYFLKEKQFDRQIIQELSKIKNKPIDESREEILKFSNMIN
CCCCHHCCHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHC
SSSAIQAASTLAISYLNKFIEEFNSYALINKYKDMIMDIVEKIKEENL
CCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8899719; 11427726 [H]