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The map label for this gene is rppH [H]

Identifier: 187736500

GI number: 187736500

Start: 2454651

End: 2455127

Strand: Reverse

Name: rppH [H]

Synonym: Amuc_2021

Alternate gene names: 187736500

Gene position: 2455127-2454651 (Counterclockwise)

Preceding gene: 187736503

Following gene: 187736489

Centisome position: 92.16

GC content: 54.93

Gene sequence:

>477_bases
ATGGAAAGATTGTATCGTCCGAATGTTGCGGGGATGATGGTCCGGCAGGACGGGAAATTGTTGATTTGCGAGCGTTCCGG
GCAGAAAGGAGCCTGGCAGTTTCCCCAGGGCGGAATTGACCCGGGGGAAACGGCTTTGGAAGCCGTGCGGCGCGAGATTG
GGGAGGAAGTGGGGTTTTTGCCGTCCCAGTATAATATTGTGGAATCCCGGAAGGGGTATCGTTACGATTATCCGCCGGAG
GTGCTGGAGTATGTTCGTGAAAAGCGGCGGCAGCCTTTTGTTGGGCAGGCGCAGGAGTATTTCCTGTGCTGGCTGCATGC
GGACGCTCCGGAACCCGTCCTGGATGACCGGGAGTTTTGCGATTACAAGTGGATAGCCCCAGCCGAATTTAAGCTGGAGT
GGCTGCCGGAGTTTAAAAAGAAAGTTTACGCCAGGGTTCTGGAAGATTTCTTTAATGTCCGGGCGCGGGATAAGTAA

Upstream 100 bases:

>100_bases
GGGGGGGAAATCTGTGAAAGGATTTTTTTGCCCGTTTTCAACGGGTTTATGGAAGGAACATGGCTGGAAATGCGGAAAAG
GGTATGTTAATGAACAGGGC

Downstream 100 bases:

>100_bases
AGTGGCTCAGCAGGTCATGTGCGGCGGAAACGGGGTCCATTTTGTCCCCCGCCACCATGTTTTCCAGAATGGGCATGCGG
GACGCTACGGCGGGGTGCTG

Product: NUDIX hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase [H]

Number of amino acids: Translated: 158; Mature: 158

Protein sequence:

>158_residues
MERLYRPNVAGMMVRQDGKLLICERSGQKGAWQFPQGGIDPGETALEAVRREIGEEVGFLPSQYNIVESRKGYRYDYPPE
VLEYVREKRRQPFVGQAQEYFLCWLHADAPEPVLDDREFCDYKWIAPAEFKLEWLPEFKKKVYARVLEDFFNVRARDK

Sequences:

>Translated_158_residues
MERLYRPNVAGMMVRQDGKLLICERSGQKGAWQFPQGGIDPGETALEAVRREIGEEVGFLPSQYNIVESRKGYRYDYPPE
VLEYVREKRRQPFVGQAQEYFLCWLHADAPEPVLDDREFCDYKWIAPAEFKLEWLPEFKKKVYARVLEDFFNVRARDK
>Mature_158_residues
MERLYRPNVAGMMVRQDGKLLICERSGQKGAWQFPQGGIDPGETALEAVRREIGEEVGFLPSQYNIVESRKGYRYDYPPE
VLEYVREKRRQPFVGQAQEYFLCWLHADAPEPVLDDREFCDYKWIAPAEFKLEWLPEFKKKVYARVLEDFFNVRARDK

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1789194, Length=153, Percent_Identity=34.640522875817, Blast_Score=82, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 18702; Mature: 18702

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERLYRPNVAGMMVRQDGKLLICERSGQKGAWQFPQGGIDPGETALEAVRREIGEEVGFL
CCCCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
PSQYNIVESRKGYRYDYPPEVLEYVREKRRQPFVGQAQEYFLCWLHADAPEPVLDDREFC
CCCCCHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCCCCC
DYKWIAPAEFKLEWLPEFKKKVYARVLEDFFNVRARDK
CEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MERLYRPNVAGMMVRQDGKLLICERSGQKGAWQFPQGGIDPGETALEAVRREIGEEVGFL
CCCCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
PSQYNIVESRKGYRYDYPPEVLEYVREKRRQPFVGQAQEYFLCWLHADAPEPVLDDREFC
CCCCCHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCCCCC
DYKWIAPAEFKLEWLPEFKKKVYARVLEDFFNVRARDK
CEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA