Click here to switch to the map view.

The map label for this gene is pgi [H]

Identifier: 187736457

GI number: 187736457

Start: 2399524

End: 2401071

Strand: Reverse

Name: pgi [H]

Synonym: Amuc_1975

Alternate gene names: 187736457

Gene position: 2401071-2399524 (Counterclockwise)

Preceding gene: 187736458

Following gene: 187736456

Centisome position: 90.13

GC content: 60.79

Gene sequence:

>1548_bases
ATGACCATCATGAGCTTATACGCAAAACAACTCGTTCGCTACCCTGAACTGGGCATTTCCCTTGATTTTTCAAAACTTCC
GCTGGACGACGCATTCCTGTCTTCCATGCAGGGACGGATAGACAGGGCGTTTGCCGACATGAAGGCGCTGGAATCCGGCG
CCATCGCCAATCCGGATGAAAAACGCATGGTGGGGCACTACTGGCTGCGCAACTCCTCCCTGGCTCCCACGCCGGAATTG
AAAGCCGCCATTGACGGCCCCCTGGCGGACGTCAAAGCCTTCGGACGGGACGTTCTGGACGGCAAAATAACGCCTCCCCG
CGCGGAACAATATTCCGCCGCCCTCGTCATCGGCATCGGCGGTTCCGCTCTTGGCCCGGAGCTGGTGGCGGATGCCATTC
CGGCGGCAGGGCTGGACATGTTCTTTCTGGACAACACGGATCCGGACGGCATGTACCGGGTGCTGGAATCCCTCCCTCTG
GAAGAAACGCTTGTCATTGTCATTTCCAAATCTGGCGGCACGCCGGAAACCCGCAACGGCATGCTGGTGGCCCAGGACTT
CTTCAGGAAGAACGGGCTGGAATTCGCACCCCAGGCGGTCGCCGTCACGGGAACGGGTTCCCGGCTGGACAAAACGGCTG
AGGCGGAAGGCTGGCTCAGGCGTTTCCCGATGGAAGACTGGGTGGGCGGCCGCACCTCCGTCATGTCCGTGGTAGGGCTG
GTTCCCGCCGTGCTTCAGGGCGTGAACGTGGATGATCTGCTGGAAGGCGCGCGCCTGATGGACGAAAAGACCCGCCGGGA
CTGCGTGAAATGCAACGCCTCCATGAAACTGGCGCTGGCCTGGTACAAGGCCACCGGCGGCAAGGGGGAAAAGGATATGG
TGGTTCTCCCTTATAAGGATGCCCTGGTGCTCTTCTCCAAATACCTCCAGCAGCTCATTATGGAATCCCTCGGCAAGCGG
CTGGACCTGGAGGGCAACGAAGTCTGCCAGGGCATTTCCGTGTACGGCAACAAGGGCTCCACGGATCAGCATGCCTATGT
GCAGCAGCTCCGTGACGGCGTGAACAACTTCTTCGCCACCTTCATTGAAGTGCGCGAATGTTCCGCGGATGCGGTGGAAG
TGGAAGCGGGCGCCACCTGCGGAGACTTCCTCCAGGGCTTCCTGCGCGGCACCCGCCAGGCTCTGGCGGAATCCGGCCGT
TCCTCCATCACCATTTCCATCCCGGAGGTGAACGCCAAAACGCTTGGCATGCTGATTGCTCTGTTTGAGCGCGCCGTCTC
CTTCTATGCTTCCCTGGTCAACATCAACGCCTACCACCAGCCCGGCGTGGAAGCCGGCAAAAAAGCGGCGGGTTCCTTCC
TGGCCCTGCTGGGCAGGGTAAGGGGGGCTCTGGGAACCGCCCCGGAAACCGCCGCCCAGATGGCTGCCCGGCTGGATGCG
GACCAGGAAGCCGTGTACCATTGCCTCGTGCATATAGCTTCCGGTGATTCCTCCGTCAAGTGGGTTCAGGCTGACTGTGC
GGATGAAGACACCTTCTGCAAGGCATAA

Upstream 100 bases:

>100_bases
CATGGCCAAAGCCCGGGAATGGTTCCAGAAAGCGGCGGACCAGGGCGACGTGCAGGCCAAAAGCATCCTGAAAAAACTCC
GGTAACCCTTTTTCCAATCC

Downstream 100 bases:

>100_bases
AAAACAGGGCATATTATTTCCGGCGGACGCTTATCCGGTTGATAAGCGTCCGTTTTTCTTTTCCGGACAGCCATGAAAAG
AAACTCGCTGCGCTTTTCTT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 515; Mature: 514

Protein sequence:

>515_residues
MTIMSLYAKQLVRYPELGISLDFSKLPLDDAFLSSMQGRIDRAFADMKALESGAIANPDEKRMVGHYWLRNSSLAPTPEL
KAAIDGPLADVKAFGRDVLDGKITPPRAEQYSAALVIGIGGSALGPELVADAIPAAGLDMFFLDNTDPDGMYRVLESLPL
EETLVIVISKSGGTPETRNGMLVAQDFFRKNGLEFAPQAVAVTGTGSRLDKTAEAEGWLRRFPMEDWVGGRTSVMSVVGL
VPAVLQGVNVDDLLEGARLMDEKTRRDCVKCNASMKLALAWYKATGGKGEKDMVVLPYKDALVLFSKYLQQLIMESLGKR
LDLEGNEVCQGISVYGNKGSTDQHAYVQQLRDGVNNFFATFIEVRECSADAVEVEAGATCGDFLQGFLRGTRQALAESGR
SSITISIPEVNAKTLGMLIALFERAVSFYASLVNINAYHQPGVEAGKKAAGSFLALLGRVRGALGTAPETAAQMAARLDA
DQEAVYHCLVHIASGDSSVKWVQADCADEDTFCKA

Sequences:

>Translated_515_residues
MTIMSLYAKQLVRYPELGISLDFSKLPLDDAFLSSMQGRIDRAFADMKALESGAIANPDEKRMVGHYWLRNSSLAPTPEL
KAAIDGPLADVKAFGRDVLDGKITPPRAEQYSAALVIGIGGSALGPELVADAIPAAGLDMFFLDNTDPDGMYRVLESLPL
EETLVIVISKSGGTPETRNGMLVAQDFFRKNGLEFAPQAVAVTGTGSRLDKTAEAEGWLRRFPMEDWVGGRTSVMSVVGL
VPAVLQGVNVDDLLEGARLMDEKTRRDCVKCNASMKLALAWYKATGGKGEKDMVVLPYKDALVLFSKYLQQLIMESLGKR
LDLEGNEVCQGISVYGNKGSTDQHAYVQQLRDGVNNFFATFIEVRECSADAVEVEAGATCGDFLQGFLRGTRQALAESGR
SSITISIPEVNAKTLGMLIALFERAVSFYASLVNINAYHQPGVEAGKKAAGSFLALLGRVRGALGTAPETAAQMAARLDA
DQEAVYHCLVHIASGDSSVKWVQADCADEDTFCKA
>Mature_514_residues
TIMSLYAKQLVRYPELGISLDFSKLPLDDAFLSSMQGRIDRAFADMKALESGAIANPDEKRMVGHYWLRNSSLAPTPELK
AAIDGPLADVKAFGRDVLDGKITPPRAEQYSAALVIGIGGSALGPELVADAIPAAGLDMFFLDNTDPDGMYRVLESLPLE
ETLVIVISKSGGTPETRNGMLVAQDFFRKNGLEFAPQAVAVTGTGSRLDKTAEAEGWLRRFPMEDWVGGRTSVMSVVGLV
PAVLQGVNVDDLLEGARLMDEKTRRDCVKCNASMKLALAWYKATGGKGEKDMVVLPYKDALVLFSKYLQQLIMESLGKRL
DLEGNEVCQGISVYGNKGSTDQHAYVQQLRDGVNNFFATFIEVRECSADAVEVEAGATCGDFLQGFLRGTRQALAESGRS
SITISIPEVNAKTLGMLIALFERAVSFYASLVNINAYHQPGVEAGKKAAGSFLALLGRVRGALGTAPETAAQMAARLDAD
QEAVYHCLVHIASGDSSVKWVQADCADEDTFCKA

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=496, Percent_Identity=27.8225806451613, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI296080693, Length=488, Percent_Identity=26.2295081967213, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1790457, Length=514, Percent_Identity=29.5719844357977, Blast_Score=148, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI71996703, Length=480, Percent_Identity=27.9166666666667, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI71996708, Length=480, Percent_Identity=27.9166666666667, Blast_Score=138, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6319673, Length=485, Percent_Identity=28.0412371134021, Blast_Score=130, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24651916, Length=497, Percent_Identity=29.5774647887324, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24651914, Length=497, Percent_Identity=29.5774647887324, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI17737445, Length=497, Percent_Identity=29.5774647887324, Blast_Score=150, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 55474; Mature: 55343

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIMSLYAKQLVRYPELGISLDFSKLPLDDAFLSSMQGRIDRAFADMKALESGAIANPDE
CCHHHHHHHHHHHCCCCCCEECHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
KRMVGHYWLRNSSLAPTPELKAAIDGPLADVKAFGRDVLDGKITPPRAEQYSAALVIGIG
HHHHHHHHEECCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECC
GSALGPELVADAIPAAGLDMFFLDNTDPDGMYRVLESLPLEETLVIVISKSGGTPETRNG
CCCCCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCC
MLVAQDFFRKNGLEFAPQAVAVTGTGSRLDKTAEAEGWLRRFPMEDWVGGRTSVMSVVGL
EEEEHHHHHCCCCCCCCCEEEEECCCHHHCCHHHHHHHHHHCCHHHHCCCHHHHHHHHHH
VPAVLQGVNVDDLLEGARLMDEKTRRDCVKCNASMKLALAWYKATGGKGEKDMVVLPYKD
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCEEEECCHH
ALVLFSKYLQQLIMESLGKRLDLEGNEVCQGISVYGNKGSTDQHAYVQQLRDGVNNFFAT
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHEECCCCCCHHHHHHHHHHHHHHHHHHH
FIEVRECSADAVEVEAGATCGDFLQGFLRGTRQALAESGRSSITISIPEVNAKTLGMLIA
HHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHH
LFERAVSFYASLVNINAYHQPGVEAGKKAAGSFLALLGRVRGALGTAPETAAQMAARLDA
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
DQEAVYHCLVHIASGDSSVKWVQADCADEDTFCKA
HHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
TIMSLYAKQLVRYPELGISLDFSKLPLDDAFLSSMQGRIDRAFADMKALESGAIANPDE
CHHHHHHHHHHHCCCCCCEECHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
KRMVGHYWLRNSSLAPTPELKAAIDGPLADVKAFGRDVLDGKITPPRAEQYSAALVIGIG
HHHHHHHHEECCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECC
GSALGPELVADAIPAAGLDMFFLDNTDPDGMYRVLESLPLEETLVIVISKSGGTPETRNG
CCCCCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCC
MLVAQDFFRKNGLEFAPQAVAVTGTGSRLDKTAEAEGWLRRFPMEDWVGGRTSVMSVVGL
EEEEHHHHHCCCCCCCCCEEEEECCCHHHCCHHHHHHHHHHCCHHHHCCCHHHHHHHHHH
VPAVLQGVNVDDLLEGARLMDEKTRRDCVKCNASMKLALAWYKATGGKGEKDMVVLPYKD
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCEEEECCHH
ALVLFSKYLQQLIMESLGKRLDLEGNEVCQGISVYGNKGSTDQHAYVQQLRDGVNNFFAT
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHEECCCCCCHHHHHHHHHHHHHHHHHHH
FIEVRECSADAVEVEAGATCGDFLQGFLRGTRQALAESGRSSITISIPEVNAKTLGMLIA
HHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHH
LFERAVSFYASLVNINAYHQPGVEAGKKAAGSFLALLGRVRGALGTAPETAAQMAARLDA
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
DQEAVYHCLVHIASGDSSVKWVQADCADEDTFCKA
HHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA