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The map label for this gene is yfhQ [H]

Identifier: 187736454

GI number: 187736454

Start: 2394351

End: 2395376

Strand: Direct

Name: yfhQ [H]

Synonym: Amuc_1972

Alternate gene names: 187736454

Gene position: 2394351-2395376 (Clockwise)

Preceding gene: 187736453

Following gene: 187736455

Centisome position: 89.87

GC content: 59.84

Gene sequence:

>1026_bases
ATGACTGACGGCACCCCCCATTTTAACATCCATGCTTTCCGGAACGCGCTGGTAGAATGGTTCAGGCGCGAAGGGAGGGA
TTACCCGTGGCGGCGGACAACGGATCCGTGGCACATCCTTGTTTCCGAGCTGATGCTGCAGCAGACTACCATTCCCACCG
TTTTGGGAAGATATGACAGATGGATGCGCCAGTTCCCCACTCCGGCGCATCTGGCTGCCGTGGACGAACAGACGGCCCTG
CGCTCCTGGGAAGGGTTGGGCTATTACCGCCGCGTGCGTTCCCTCCAGGCCATCGCCAGGGAAATCGTCAACGAATTCGG
AGGGCGGTTCCCGGACAATGCGGAAGGGCTGAAACGCCTGCCGGGCATCGGCCCCTACACGTCGGGAGCGCTCCTCTCCT
TCGCCTTCAACAAGGCGGCTCCCATTGTAGACGCCAATGTCGCGCGCGTCCTGGCCCGCATTGACAATTATTCCGTTCCC
GTGGATTCCACGGAAGGCCAGAAATACCTGTGGAGCCGCGCGGAAAGCCTGGTGGATCCGGAACATGCCCGTGAATTCAA
TTCAGCCATCATGGAACTTGGGCAAACCTGCTGCAGCATCAGTTCTCCAGACTGCCTGCTGTGCCCCGTGCGCCCCTTCT
GCTCTGCGGAACGGCCGGAAACGCTTCCCGTCAAAAATCCCAAGCCTCAAGTCACCCGGGTGGAACACCACGATATTCTT
TACATCCGCGGCAAATCCGTCCTGCTGGCCAAATGCCCGGAAGGCAAGCGCCATGCCGGCATGTACCGCTTCCCCCAGAG
GGAGGACGAGCACACCCTTTCCCTGCCCCATGTCCTGAAACAAACCTACAGCATTACCCGCTACAGGGTGACCCGCTACA
TCCACCATGTGACGGATACGCCTCTCCTCAGGGAAGGAGAGGAATTCGTGCCGTTGGACAAAATCCACGGGCTGCCCATG
GCCTCACCGGACCGCAAGGCACTGAACTCCCCCACCCTCGGCAAACTGCTGGACCATATCAGATGA

Upstream 100 bases:

>100_bases
GGCCTTTCCATGCTGGTTCACCAGGGGGCCCTTTCCTTTGAACGCTGGTTCGGCATCAAGCCGGATATTTCCGCCATGCG
CCAGGCTCTTGAACAAAAGC

Downstream 100 bases:

>100_bases
ATGACAGATTGACGCCGGAACTTGTCCTCTCCGCCTATTGCCAGGGGTGTTTTCCCATGGCGGACCCGGAAACGGGAGAA
ATCTCCTTTTACGAACCGGA

Product: HhH-GPD family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MTDGTPHFNIHAFRNALVEWFRREGRDYPWRRTTDPWHILVSELMLQQTTIPTVLGRYDRWMRQFPTPAHLAAVDEQTAL
RSWEGLGYYRRVRSLQAIAREIVNEFGGRFPDNAEGLKRLPGIGPYTSGALLSFAFNKAAPIVDANVARVLARIDNYSVP
VDSTEGQKYLWSRAESLVDPEHAREFNSAIMELGQTCCSISSPDCLLCPVRPFCSAERPETLPVKNPKPQVTRVEHHDIL
YIRGKSVLLAKCPEGKRHAGMYRFPQREDEHTLSLPHVLKQTYSITRYRVTRYIHHVTDTPLLREGEEFVPLDKIHGLPM
ASPDRKALNSPTLGKLLDHIR

Sequences:

>Translated_341_residues
MTDGTPHFNIHAFRNALVEWFRREGRDYPWRRTTDPWHILVSELMLQQTTIPTVLGRYDRWMRQFPTPAHLAAVDEQTAL
RSWEGLGYYRRVRSLQAIAREIVNEFGGRFPDNAEGLKRLPGIGPYTSGALLSFAFNKAAPIVDANVARVLARIDNYSVP
VDSTEGQKYLWSRAESLVDPEHAREFNSAIMELGQTCCSISSPDCLLCPVRPFCSAERPETLPVKNPKPQVTRVEHHDIL
YIRGKSVLLAKCPEGKRHAGMYRFPQREDEHTLSLPHVLKQTYSITRYRVTRYIHHVTDTPLLREGEEFVPLDKIHGLPM
ASPDRKALNSPTLGKLLDHIR
>Mature_340_residues
TDGTPHFNIHAFRNALVEWFRREGRDYPWRRTTDPWHILVSELMLQQTTIPTVLGRYDRWMRQFPTPAHLAAVDEQTALR
SWEGLGYYRRVRSLQAIAREIVNEFGGRFPDNAEGLKRLPGIGPYTSGALLSFAFNKAAPIVDANVARVLARIDNYSVPV
DSTEGQKYLWSRAESLVDPEHAREFNSAIMELGQTCCSISSPDCLLCPVRPFCSAERPETLPVKNPKPQVTRVEHHDILY
IRGKSVLLAKCPEGKRHAGMYRFPQREDEHTLSLPHVLKQTYSITRYRVTRYIHHVTDTPLLREGEEFVPLDKIHGLPMA
SPDRKALNSPTLGKLLDHIR

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298654, Length=219, Percent_Identity=43.37899543379, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI115298652, Length=219, Percent_Identity=43.37899543379, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI115298648, Length=219, Percent_Identity=43.37899543379, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI115298650, Length=219, Percent_Identity=43.37899543379, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI190358497, Length=219, Percent_Identity=43.37899543379, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI6912520, Length=219, Percent_Identity=43.37899543379, Blast_Score=185, Evalue=6e-47,
Organism=Escherichia coli, GI1789331, Length=341, Percent_Identity=33.4310850439883, Blast_Score=177, Evalue=6e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 39027; Mature: 38896

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDGTPHFNIHAFRNALVEWFRREGRDYPWRRTTDPWHILVSELMLQQTTIPTVLGRYDR
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
WMRQFPTPAHLAAVDEQTALRSWEGLGYYRRVRSLQAIAREIVNEFGGRFPDNAEGLKRL
HHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHC
PGIGPYTSGALLSFAFNKAAPIVDANVARVLARIDNYSVPVDSTEGQKYLWSRAESLVDP
CCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCH
EHAREFNSAIMELGQTCCSISSPDCLLCPVRPFCSAERPETLPVKNPKPQVTRVEHHDIL
HHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHCCCCCCCCCCCCCCCCCCEEECCCCEE
YIRGKSVLLAKCPEGKRHAGMYRFPQREDEHTLSLPHVLKQTYSITRYRVTRYIHHVTDT
EEECCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
PLLREGEEFVPLDKIHGLPMASPDRKALNSPTLGKLLDHIR
CHHHCCCCCCCHHHHCCCCCCCCCHHHCCCCCHHHHHHHCC
>Mature Secondary Structure 
TDGTPHFNIHAFRNALVEWFRREGRDYPWRRTTDPWHILVSELMLQQTTIPTVLGRYDR
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
WMRQFPTPAHLAAVDEQTALRSWEGLGYYRRVRSLQAIAREIVNEFGGRFPDNAEGLKRL
HHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHC
PGIGPYTSGALLSFAFNKAAPIVDANVARVLARIDNYSVPVDSTEGQKYLWSRAESLVDP
CCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCH
EHAREFNSAIMELGQTCCSISSPDCLLCPVRPFCSAERPETLPVKNPKPQVTRVEHHDIL
HHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHCCCCCCCCCCCCCCCCCCEEECCCCEE
YIRGKSVLLAKCPEGKRHAGMYRFPQREDEHTLSLPHVLKQTYSITRYRVTRYIHHVTDT
EEECCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
PLLREGEEFVPLDKIHGLPMASPDRKALNSPTLGKLLDHIR
CHHHCCCCCCCHHHHCCCCCCCCCHHHCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]