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The map label for this gene is aroA

Identifier: 187736377

GI number: 187736377

Start: 2299826

End: 2301133

Strand: Reverse

Name: aroA

Synonym: Amuc_1894

Alternate gene names: 187736377

Gene position: 2301133-2299826 (Counterclockwise)

Preceding gene: 187736382

Following gene: 187736374

Centisome position: 86.38

GC content: 61.47

Gene sequence:

>1308_bases
ATGAACCTTCATTCCCATTCCATTTCCTCCCTGCAAGGGGCACTGACCGTGCCCGGAGACAAAAGCATTTCCCACCGCGC
CGCCATTCTGGGAGGCCTGGCGGAAGGAGTGACGGAAGTGGATAATTTTCTATGCAGTGAAGATTGCCTGAATACCCTGC
GCGCCATGGAGCAGCTAGGCGCCAAAGTGGATGTGCTGGAAGAACGGCAGGGATACGGCCCCGTCCGCTTCCGAATTACG
GGCGTCGCCATGAGCCCCAAGGCTCCTGAACGGCCCATTGACTGCGGCAATTCCGGCACGGGCATGAGGCTGCTGGCCGG
GATGCTGGCCGCCTGCCCCTTTGATTCGGAAATGTTTGGGGACGCTTCCCTGAGCTCCCGCCCCATGGGCCGCATCATGC
AGCCTCTGGAACAGATGGGAGCGCGGATTGAAGCCCGGGGAGCCAAACCGGGCTGTGCTCCGCTGAGCATTCACGGCGGG
CGGGTGCACCCCATTTCCTACACGCTTCCCATGGCCAGCGCCCAGGTTAAAAGCGCCATTCTATTGGCGGGCATGTTTGC
GGACGGAACCACCACCGTGCGCCAGCCGGCCGTCACCCGCGACCATACAGAACGCCTGTTCCGCCATTTCGGCGTTCCCT
GCACCGTGGATGGACTTACCGTCGGAACCTGCGGGCCAGCTCTCCCCGTCGCCCATGATTTGACAGTCCCGGCAGATATT
TCCTCCGCAGCCTTCTGGATGGTGGCCGCCGCCAGCCGTCCGGGTTCCCGCCTGACGTTGCGCCAGGTAGGGCTGAACAA
GACGCGGAACGCCGTCATCAGCGCTCTGCAGCGGATGGGCGCGCGAATGGACATCGTGCCCACTTCTCCGGAAGATGCCG
GCGAACCATACGGCGATATTACCGTGTACGGTTCGGATTCCCTGCACGGCACCAGCCTCCTCCCGGAAGAAATACCCAAC
CTCATTGACGAGATACCTATCCTGGCCGTAGCGGGAGCCCTGGGCCGGGGAGACTTCATCGTCCGAAACGCCCGCGAATT
ACGCGTCAAGGAAACGGACCGCATCGCCACCACGGCGGCCAACCTCCGGCTCATGGGCGTGGATGTGGAAGAATTTGACG
ATGGCATGGTTGTTCACGGCGGCACTCCCCTGAAGGGAACGGAATTATCCAGTTATGGGGACCACCGCATCGCCATGAGC
TTCCTGGTGGCCGGACTCAGCGCACAGGGAGAAACCGTAGTGACGGATGCGGAATGCATCAATACGTCCTATCCCGGTTT
TGAACGGGATCTGGCTCAGTTCCTGTAA

Upstream 100 bases:

>100_bases
CGGAAAATCAACTCCATTCTGGAATGCTCCCTGATGCCTCCGCCCATCTCGTAATTGGCTTGATTCTGCATCCGATACAG
GGTAGTTCTTCCGGAAACTC

Downstream 100 bases:

>100_bases
AAAACGCAAGATTCCAGCCGGATTTCACCCCGTCCATGGAATAATGCCGGAAGCAGAAAAGAATCTTGCGGCATTCCGGC
CATATTATGCTTCCCGTTCC

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MNLHSHSISSLQGALTVPGDKSISHRAAILGGLAEGVTEVDNFLCSEDCLNTLRAMEQLGAKVDVLEERQGYGPVRFRIT
GVAMSPKAPERPIDCGNSGTGMRLLAGMLAACPFDSEMFGDASLSSRPMGRIMQPLEQMGARIEARGAKPGCAPLSIHGG
RVHPISYTLPMASAQVKSAILLAGMFADGTTTVRQPAVTRDHTERLFRHFGVPCTVDGLTVGTCGPALPVAHDLTVPADI
SSAAFWMVAAASRPGSRLTLRQVGLNKTRNAVISALQRMGARMDIVPTSPEDAGEPYGDITVYGSDSLHGTSLLPEEIPN
LIDEIPILAVAGALGRGDFIVRNARELRVKETDRIATTAANLRLMGVDVEEFDDGMVVHGGTPLKGTELSSYGDHRIAMS
FLVAGLSAQGETVVTDAECINTSYPGFERDLAQFL

Sequences:

>Translated_435_residues
MNLHSHSISSLQGALTVPGDKSISHRAAILGGLAEGVTEVDNFLCSEDCLNTLRAMEQLGAKVDVLEERQGYGPVRFRIT
GVAMSPKAPERPIDCGNSGTGMRLLAGMLAACPFDSEMFGDASLSSRPMGRIMQPLEQMGARIEARGAKPGCAPLSIHGG
RVHPISYTLPMASAQVKSAILLAGMFADGTTTVRQPAVTRDHTERLFRHFGVPCTVDGLTVGTCGPALPVAHDLTVPADI
SSAAFWMVAAASRPGSRLTLRQVGLNKTRNAVISALQRMGARMDIVPTSPEDAGEPYGDITVYGSDSLHGTSLLPEEIPN
LIDEIPILAVAGALGRGDFIVRNARELRVKETDRIATTAANLRLMGVDVEEFDDGMVVHGGTPLKGTELSSYGDHRIAMS
FLVAGLSAQGETVVTDAECINTSYPGFERDLAQFL
>Mature_435_residues
MNLHSHSISSLQGALTVPGDKSISHRAAILGGLAEGVTEVDNFLCSEDCLNTLRAMEQLGAKVDVLEERQGYGPVRFRIT
GVAMSPKAPERPIDCGNSGTGMRLLAGMLAACPFDSEMFGDASLSSRPMGRIMQPLEQMGARIEARGAKPGCAPLSIHGG
RVHPISYTLPMASAQVKSAILLAGMFADGTTTVRQPAVTRDHTERLFRHFGVPCTVDGLTVGTCGPALPVAHDLTVPADI
SSAAFWMVAAASRPGSRLTLRQVGLNKTRNAVISALQRMGARMDIVPTSPEDAGEPYGDITVYGSDSLHGTSLLPEEIPN
LIDEIPILAVAGALGRGDFIVRNARELRVKETDRIATTAANLRLMGVDVEEFDDGMVVHGGTPLKGTELSSYGDHRIAMS
FLVAGLSAQGETVVTDAECINTSYPGFERDLAQFL

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family

Homologues:

Organism=Escherichia coli, GI1787137, Length=444, Percent_Identity=28.1531531531532, Blast_Score=121, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320332, Length=473, Percent_Identity=25.7928118393235, Blast_Score=103, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROA_AKKM8 (B2UN97)

Other databases:

- EMBL:   CP001071
- RefSeq:   YP_001878489.1
- GeneID:   6273816
- GenomeReviews:   CP001071_GR
- KEGG:   amu:Amuc_1894
- HOGENOM:   HBG646626
- OMA:   SKPETQR
- GO:   GO:0005737
- HAMAP:   MF_00210
- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792
- Gene3D:   G3DSA:3.65.10.10
- PIRSF:   PIRSF000505
- TIGRFAMs:   TIGR01356

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.19

Molecular weight: Translated: 46106; Mature: 46106

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00104 EPSP_SYNTHASE_1; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLHSHSISSLQGALTVPGDKSISHRAAILGGLAEGVTEVDNFLCSEDCLNTLRAMEQLG
CCCCCCCHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
AKVDVLEERQGYGPVRFRITGVAMSPKAPERPIDCGNSGTGMRLLAGMLAACPFDSEMFG
CCEEEHHHHCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHCC
DASLSSRPMGRIMQPLEQMGARIEARGAKPGCAPLSIHGGRVHPISYTLPMASAQVKSAI
CCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCEEEECCCEECEEEEECCCCHHHHHHHH
LLAGMFADGTTTVRQPAVTRDHTERLFRHFGVPCTVDGLTVGTCGPALPVAHDLTVPADI
HHEEECCCCCCHHCCCCCCHHHHHHHHHHCCCCEEECCEEECCCCCCCCCCCCCCCCCCC
SSAAFWMVAAASRPGSRLTLRQVGLNKTRNAVISALQRMGARMDIVPTSPEDAGEPYGDI
CHHHEEEEEECCCCCCEEEHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCE
TVYGSDSLHGTSLLPEEIPNLIDEIPILAVAGALGRGDFIVRNARELRVKETDRIATTAA
EEEECCCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCEEEECHHHHCCCHHHHHHEEEC
NLRLMGVDVEEFDDGMVVHGGTPLKGTELSSYGDHRIAMSFLVAGLSAQGETVVTDAECI
CEEEEECCHHHCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECHHHH
NTSYPGFERDLAQFL
CCCCCCHHHHHHHHC
>Mature Secondary Structure
MNLHSHSISSLQGALTVPGDKSISHRAAILGGLAEGVTEVDNFLCSEDCLNTLRAMEQLG
CCCCCCCHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
AKVDVLEERQGYGPVRFRITGVAMSPKAPERPIDCGNSGTGMRLLAGMLAACPFDSEMFG
CCEEEHHHHCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHCC
DASLSSRPMGRIMQPLEQMGARIEARGAKPGCAPLSIHGGRVHPISYTLPMASAQVKSAI
CCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCEEEECCCEECEEEEECCCCHHHHHHHH
LLAGMFADGTTTVRQPAVTRDHTERLFRHFGVPCTVDGLTVGTCGPALPVAHDLTVPADI
HHEEECCCCCCHHCCCCCCHHHHHHHHHHCCCCEEECCEEECCCCCCCCCCCCCCCCCCC
SSAAFWMVAAASRPGSRLTLRQVGLNKTRNAVISALQRMGARMDIVPTSPEDAGEPYGDI
CHHHEEEEEECCCCCCEEEHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCE
TVYGSDSLHGTSLLPEEIPNLIDEIPILAVAGALGRGDFIVRNARELRVKETDRIATTAA
EEEECCCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCEEEECHHHHCCCHHHHHHEEEC
NLRLMGVDVEEFDDGMVVHGGTPLKGTELSSYGDHRIAMSFLVAGLSAQGETVVTDAECI
CEEEEECCHHHCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECHHHH
NTSYPGFERDLAQFL
CCCCCCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA