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The map label for this gene is fhs [H]

Identifier: 187736343

GI number: 187736343

Start: 2262706

End: 2264379

Strand: Reverse

Name: fhs [H]

Synonym: Amuc_1860

Alternate gene names: 187736343

Gene position: 2264379-2262706 (Counterclockwise)

Preceding gene: 187736344

Following gene: 187736342

Centisome position: 85.0

GC content: 57.83

Gene sequence:

>1674_bases
ATGCCCATGAACCTTCTTGCCAAAAGAGGGGGCTTCCGTCATCATGTGCGCATGGTTACACCTGCATTCTCCGACTGTAT
CAACAAGCTGGGCGTCGATGAAAAAGACGTCATTCCCTTCGGCCGCAACAAGGCCAAAATTTCCCTGGACGTATTGGACA
AGCCGGCAACCCCCGGCAAACTCATCCTGGTATCCGCCATCACTCCCACCCCATCCGGAGAAGGCAAAACCACCGTTTCC
ATCGGCTTGGCGCAGGGATTGCAGGCCATCGGCAAAAAAGTCTGCCTGGCGCTCCGGCAACCTTCCATGGGACCGGTGTT
CGGCCGCAAGGGCGGAGCTACCGGAGGCGGCAAAAGCTCCCTGACGCCGGCAGAGGAAATCAACATGCATTTCACAGGGG
ACTTCCACGCCATTACATCCGCCCACAACCTCATCAGCGCCATCATTGATAACGCCATGTTCTTCCACACGCTGAACATT
GACGAACGCAAAGTCATATGGAAGCGGGTCATGGACATGAACGACCGTTCCCTGCGTTCCATCATCGTGGGGCTCAACAA
GCAGGGGTTCCCCCGAGAAACAGGCTTCGATATCACCCCGGCTTCGGAAATCATGGCGTGCCTGTGCCTTGCCACTTCCT
ACAAGGACATGGAAGAACGCATCAACCGCATCGTGATCGGATTCACGACGGATGACAAGCCCGTATTCGCAAGGGAACTG
GGCATTACCGGTTCCGTCATGTCCCTGCTGAAAGATGCCCTGATGCCCAATCTGGTTCAATCCGTGGAAGGAGTGCCCTG
TTTCCTGCACGGCGGCCCGTTTGCCAACATTGCCCACGGCTGCAACTCCGTGCTGGCCACCAGGATGGCCCTGCATTTTG
GGGACTATGCCGTCACGGAAGCCGGATTCGCGTTTGACCTGGGTGCAGAGAAATTCCTGGATATCAAATGCCGCCAGTCC
GGACTGGATCCGGCGGCCATTGTCATCGTAGCTACGGCACGCGCGCTGAAAATGCACGGGGGAACTGCCCTTGCGGATCT
GAAAAACACGGATGTGGATGCGCTGAAAAAAGGCCTTGCCAACCTGGATGCGCATCTGGACGCTGCCGCCCACTACAAAC
GCCCCGTTGTGGTCGCCGTCAACAAATTCTTTGACGACTCCCGGGAAGAACTGGACGCTATCGTGAAACACTGCGCGGAA
CGCGGTATTCCCTGCGCCATTGCGGATATCTTCTCCCAGGGAGGAGAAGGAGGCAAAGACCTGGCCCAAATGGTTGTGGA
AGCTGCGGACAGGAGTTCCGCCCCTTTCAAGCCCCTCTATGAATCCGCCCTGCCGGTGGAAGAAAAACTCAACATCATTG
CCCGCAACATTTACGGGGCGGACGGTGTGGAATTGACAGCCGCCGCCAAAAAGAAGCTGGCCCAGTTTGAAGCCAGCCGC
CTGACGGACCTTCCCATCTGCATGGCAAAAACCCAGAACTCCCTTTCCGACAACGGACGCCTCCGAGGACGCCCCACCGG
CTTCACCATCACCGTGCGCGACTTTGAAATCGCCAACGGGGCCGGCTTCCTGGTGGCCCTCTGCGGGGAAATCATGCGCA
TGCCCGCCCTTCCCGTCTCACCGAACGCCATGCACATCTACCTGGATGACAAGGGCAACGTCCAGGGGCTCTGA

Upstream 100 bases:

>100_bases
TATTTCCGGAGGTTCTCCCGGAGTTGCATGGATATCCGGGGAATGTCGCGGGACAGGAAGAAGGCGGCCCTTTCCCTCTC
ATTGATTCATCCGGTCCGGA

Downstream 100 bases:

>100_bases
AAAATATCACCAACCGCGCCGCACGCCATGAAAATCGCCATTCTGGGAGCCGGAGCCCTGGGTTGCTATTACGGAGCCAG
ACTTCAGGAATCGGGGCAGG

Product: Formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MPMNLLAKRGGFRHHVRMVTPAFSDCINKLGVDEKDVIPFGRNKAKISLDVLDKPATPGKLILVSAITPTPSGEGKTTVS
IGLAQGLQAIGKKVCLALRQPSMGPVFGRKGGATGGGKSSLTPAEEINMHFTGDFHAITSAHNLISAIIDNAMFFHTLNI
DERKVIWKRVMDMNDRSLRSIIVGLNKQGFPRETGFDITPASEIMACLCLATSYKDMEERINRIVIGFTTDDKPVFAREL
GITGSVMSLLKDALMPNLVQSVEGVPCFLHGGPFANIAHGCNSVLATRMALHFGDYAVTEAGFAFDLGAEKFLDIKCRQS
GLDPAAIVIVATARALKMHGGTALADLKNTDVDALKKGLANLDAHLDAAAHYKRPVVVAVNKFFDDSREELDAIVKHCAE
RGIPCAIADIFSQGGEGGKDLAQMVVEAADRSSAPFKPLYESALPVEEKLNIIARNIYGADGVELTAAAKKKLAQFEASR
LTDLPICMAKTQNSLSDNGRLRGRPTGFTITVRDFEIANGAGFLVALCGEIMRMPALPVSPNAMHIYLDDKGNVQGL

Sequences:

>Translated_557_residues
MPMNLLAKRGGFRHHVRMVTPAFSDCINKLGVDEKDVIPFGRNKAKISLDVLDKPATPGKLILVSAITPTPSGEGKTTVS
IGLAQGLQAIGKKVCLALRQPSMGPVFGRKGGATGGGKSSLTPAEEINMHFTGDFHAITSAHNLISAIIDNAMFFHTLNI
DERKVIWKRVMDMNDRSLRSIIVGLNKQGFPRETGFDITPASEIMACLCLATSYKDMEERINRIVIGFTTDDKPVFAREL
GITGSVMSLLKDALMPNLVQSVEGVPCFLHGGPFANIAHGCNSVLATRMALHFGDYAVTEAGFAFDLGAEKFLDIKCRQS
GLDPAAIVIVATARALKMHGGTALADLKNTDVDALKKGLANLDAHLDAAAHYKRPVVVAVNKFFDDSREELDAIVKHCAE
RGIPCAIADIFSQGGEGGKDLAQMVVEAADRSSAPFKPLYESALPVEEKLNIIARNIYGADGVELTAAAKKKLAQFEASR
LTDLPICMAKTQNSLSDNGRLRGRPTGFTITVRDFEIANGAGFLVALCGEIMRMPALPVSPNAMHIYLDDKGNVQGL
>Mature_556_residues
PMNLLAKRGGFRHHVRMVTPAFSDCINKLGVDEKDVIPFGRNKAKISLDVLDKPATPGKLILVSAITPTPSGEGKTTVSI
GLAQGLQAIGKKVCLALRQPSMGPVFGRKGGATGGGKSSLTPAEEINMHFTGDFHAITSAHNLISAIIDNAMFFHTLNID
ERKVIWKRVMDMNDRSLRSIIVGLNKQGFPRETGFDITPASEIMACLCLATSYKDMEERINRIVIGFTTDDKPVFARELG
ITGSVMSLLKDALMPNLVQSVEGVPCFLHGGPFANIAHGCNSVLATRMALHFGDYAVTEAGFAFDLGAEKFLDIKCRQSG
LDPAAIVIVATARALKMHGGTALADLKNTDVDALKKGLANLDAHLDAAAHYKRPVVVAVNKFFDDSREELDAIVKHCAER
GIPCAIADIFSQGGEGGKDLAQMVVEAADRSSAPFKPLYESALPVEEKLNIIARNIYGADGVELTAAAKKKLAQFEASRL
TDLPICMAKTQNSLSDNGRLRGRPTGFTITVRDFEIANGAGFLVALCGEIMRMPALPVSPNAMHIYLDDKGNVQGL

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=600, Percent_Identity=41.6666666666667, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI36796743, Length=617, Percent_Identity=40.5186385737439, Blast_Score=381, Evalue=1e-106,
Organism=Homo sapiens, GI310124614, Length=105, Percent_Identity=35.2380952380952, Blast_Score=68, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17568737, Length=593, Percent_Identity=43.8448566610455, Blast_Score=423, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17568739, Length=593, Percent_Identity=43.8448566610455, Blast_Score=423, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6321643, Length=609, Percent_Identity=40.0656814449918, Blast_Score=395, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6319558, Length=639, Percent_Identity=38.1846635367762, Blast_Score=392, Evalue=1e-110,
Organism=Drosophila melanogaster, GI62472483, Length=600, Percent_Identity=39.8333333333333, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI45551871, Length=600, Percent_Identity=39.8333333333333, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24645718, Length=600, Percent_Identity=39.8333333333333, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI17137370, Length=600, Percent_Identity=39.8333333333333, Blast_Score=402, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 59797; Mature: 59666

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMNLLAKRGGFRHHVRMVTPAFSDCINKLGVDEKDVIPFGRNKAKISLDVLDKPATPGK
CCCHHHHHCCCCCEEEEEECHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCC
LILVSAITPTPSGEGKTTVSIGLAQGLQAIGKKVCLALRQPSMGPVFGRKGGATGGGKSS
EEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
LTPAEEINMHFTGDFHAITSAHNLISAIIDNAMFFHTLNIDERKVIWKRVMDMNDRSLRS
CCCHHHCCEEECCCHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCHHHHH
IIVGLNKQGFPRETGFDITPASEIMACLCLATSYKDMEERINRIVIGFTTDDKPVFAREL
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHH
GITGSVMSLLKDALMPNLVQSVEGVPCFLHGGPFANIAHGCNSVLATRMALHFGDYAVTE
CCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHC
AGFAFDLGAEKFLDIKCRQSGLDPAAIVIVATARALKMHGGTALADLKNTDVDALKKGLA
CCCEEECCCCHHEEEEHHCCCCCCEEEEEEEHHHHHHCCCCEEEECCCCCCHHHHHHHHH
NLDAHLDAAAHYKRPVVVAVNKFFDDSREELDAIVKHCAERGIPCAIADIFSQGGEGGKD
HHHHHHHHHHHCCCCEEEEEHHHHCCCHHHHHHHHHHHHHCCCCEEHHHHHHCCCCCHHH
LAQMVVEAADRSSAPFKPLYESALPVEEKLNIIARNIYGADGVELTAAAKKKLAQFEASR
HHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHH
LTDLPICMAKTQNSLSDNGRLRGRPTGFTITVRDFEIANGAGFLVALCGEIMRMPALPVS
CCCCCEEHHHCCCCCCCCCEECCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHCCCCCCC
PNAMHIYLDDKGNVQGL
CCEEEEEECCCCCCCCC
>Mature Secondary Structure 
PMNLLAKRGGFRHHVRMVTPAFSDCINKLGVDEKDVIPFGRNKAKISLDVLDKPATPGK
CCHHHHHCCCCCEEEEEECHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCC
LILVSAITPTPSGEGKTTVSIGLAQGLQAIGKKVCLALRQPSMGPVFGRKGGATGGGKSS
EEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
LTPAEEINMHFTGDFHAITSAHNLISAIIDNAMFFHTLNIDERKVIWKRVMDMNDRSLRS
CCCHHHCCEEECCCHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCHHHHH
IIVGLNKQGFPRETGFDITPASEIMACLCLATSYKDMEERINRIVIGFTTDDKPVFAREL
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHH
GITGSVMSLLKDALMPNLVQSVEGVPCFLHGGPFANIAHGCNSVLATRMALHFGDYAVTE
CCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHC
AGFAFDLGAEKFLDIKCRQSGLDPAAIVIVATARALKMHGGTALADLKNTDVDALKKGLA
CCCEEECCCCHHEEEEHHCCCCCCEEEEEEEHHHHHHCCCCEEEECCCCCCHHHHHHHHH
NLDAHLDAAAHYKRPVVVAVNKFFDDSREELDAIVKHCAERGIPCAIADIFSQGGEGGKD
HHHHHHHHHHHCCCCEEEEEHHHHCCCHHHHHHHHHHHHHCCCCEEHHHHHHCCCCCHHH
LAQMVVEAADRSSAPFKPLYESALPVEEKLNIIARNIYGADGVELTAAAKKKLAQFEASR
HHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHH
LTDLPICMAKTQNSLSDNGRLRGRPTGFTITVRDFEIANGAGFLVALCGEIMRMPALPVS
CCCCCEEHHHCCCCCCCCCEECCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHCCCCCCC
PNAMHIYLDDKGNVQGL
CCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA