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The map label for this gene is fucK [H]

Identifier: 187736317

GI number: 187736317

Start: 2223466

End: 2224890

Strand: Reverse

Name: fucK [H]

Synonym: Amuc_1830

Alternate gene names: 187736317

Gene position: 2224890-2223466 (Counterclockwise)

Preceding gene: 187736318

Following gene: 187736316

Centisome position: 83.51

GC content: 59.23

Gene sequence:

>1425_bases
ATGTACTCCCTCTGCTTGGACTGCGGCGCGACTAATGTGCGCGCCATGGTTGTGGATAAACAAGGCGTCATTGTGGGGAA
GGCCTCACAGCCGAACGCCACGCTGCCCGGTGAGGAAAATCCGGAATTTCACGTCTGGGATGCCGACCGGATTTTCAGAC
AGCTCTCCGAATGTGCCGTGAAAGCCCTGGAAGGACTAAATGCGGAACAGGTGACGGCCGTCACGATTACCACCTTTGGC
GTGGACGGCGCGCTGGTGGATGACGCCGGCAACCTGCTCTATCCTGTCATATCCTGGAAATGCCCCCGCACGGCGGAGGT
CATGAAAAACATCGGCAAATATATCTCCCAGGAGGAACTTAACCGTATCTCCGGCGTGGGGGCCTTTGCTTTCAACACCA
TTTACAAACTCGTCTGGCTCAGGGAAAACCACCCGGAACTTCTGGAAAAAGCCCATGCGTGGCTCTTCATCTCCAACCTG
CTGGCCTACAAGCTCACCGGCATCATGGCGACAGACCGGACCATGGCAGGGACCTCCCAGCTCACGGATCTGGAAACGGG
AGATTTTTCCGAATTCATTTTGAACCGCCTCGGTTTGAGCCGCGGCCTCTTCCCCCCCATCGTGGATGCAGGGGAAACCA
TTGGCCTCCTTACGCCGGAAGCGGCAGACGCGATGAATCTCCCGGCCCTGGCGGGCATTCCCGTTATCTCCGCCGGGCAC
GACACCCAGTTCGCCATTTTCGGTTCCGGAGCAGACAAGAACCAGCCCGTCCTTTCCTCCGGAACATGGGAAATCCTGAT
GGCGCGCTCCGCACAGGCTAGGCTGGCCCGGGAAGATTATGAAGACGGCGCCACGGCGGAATTCGACGCGGAATCCGGCC
TTCTTAACCCCGGGCTCCAATGGCTGGGCTCCGGCATTATCGAATGGGTGAAAGCAGCCTGCTTTCACGGGGAATCCTAT
GATACCATGGATGCGGAAGCGGCCGCCGTCCCACCCGGCTGCGACGGCGTGACAATGGTTCCGGACTTCCTGGCTTCCGG
AGACCGGAAAGGCTCCATCAACGGACTGGTGCTGGGAAGAACACGCGGCCATATCTACCGCGCCGCCATGGAGGCTCTCA
CCTGGCGGCTGAAATCCCGCCTGCGCCGTTTGGAATCCGTGGGCGGCTTCAAAAGCGAATTCCTCATCCTGGTGGGCGGA
GGCGCCAGAAACAGAGTTTGGACCCAGATGAGGGCGGACATTCTCCGGATTCCCGTCAAAGTCTCTGAAGTGTCAGAAAG
TACGGTATTGGGAGCATCCATGTTTGCCTTTGCGGGCGCCGGGGTGTACTCTACGCCGGAGCAGGCCCGGGCCGCCTTCG
GCATCGCCTACCGGACATATATGCCGGGTTCCCAGGAAGCCGCCTACGAAAAGTTCAACCAATAA

Upstream 100 bases:

>100_bases
GGACAGCACAGAAATCCCTAAAATGCTCATTTCTATTAACAAACCAACTCAACAAGCTCAGCCGGATTCCTATTAACTTT
TCACTATTAAATCTTAACTC

Downstream 100 bases:

>100_bases
CACGCTACTAAATATGTCAGAAGACTGGTCAATCTCCCCTCCCCTGCCGGACAAAGTGTTCCCATGGGAAAAATACAACC
CCGTCACGCGGGAGGAAGTG

Product: L-fuculokinase

Products: NA

Alternate protein names: L-fuculose kinase [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MYSLCLDCGATNVRAMVVDKQGVIVGKASQPNATLPGEENPEFHVWDADRIFRQLSECAVKALEGLNAEQVTAVTITTFG
VDGALVDDAGNLLYPVISWKCPRTAEVMKNIGKYISQEELNRISGVGAFAFNTIYKLVWLRENHPELLEKAHAWLFISNL
LAYKLTGIMATDRTMAGTSQLTDLETGDFSEFILNRLGLSRGLFPPIVDAGETIGLLTPEAADAMNLPALAGIPVISAGH
DTQFAIFGSGADKNQPVLSSGTWEILMARSAQARLAREDYEDGATAEFDAESGLLNPGLQWLGSGIIEWVKAACFHGESY
DTMDAEAAAVPPGCDGVTMVPDFLASGDRKGSINGLVLGRTRGHIYRAAMEALTWRLKSRLRRLESVGGFKSEFLILVGG
GARNRVWTQMRADILRIPVKVSEVSESTVLGASMFAFAGAGVYSTPEQARAAFGIAYRTYMPGSQEAAYEKFNQ

Sequences:

>Translated_474_residues
MYSLCLDCGATNVRAMVVDKQGVIVGKASQPNATLPGEENPEFHVWDADRIFRQLSECAVKALEGLNAEQVTAVTITTFG
VDGALVDDAGNLLYPVISWKCPRTAEVMKNIGKYISQEELNRISGVGAFAFNTIYKLVWLRENHPELLEKAHAWLFISNL
LAYKLTGIMATDRTMAGTSQLTDLETGDFSEFILNRLGLSRGLFPPIVDAGETIGLLTPEAADAMNLPALAGIPVISAGH
DTQFAIFGSGADKNQPVLSSGTWEILMARSAQARLAREDYEDGATAEFDAESGLLNPGLQWLGSGIIEWVKAACFHGESY
DTMDAEAAAVPPGCDGVTMVPDFLASGDRKGSINGLVLGRTRGHIYRAAMEALTWRLKSRLRRLESVGGFKSEFLILVGG
GARNRVWTQMRADILRIPVKVSEVSESTVLGASMFAFAGAGVYSTPEQARAAFGIAYRTYMPGSQEAAYEKFNQ
>Mature_474_residues
MYSLCLDCGATNVRAMVVDKQGVIVGKASQPNATLPGEENPEFHVWDADRIFRQLSECAVKALEGLNAEQVTAVTITTFG
VDGALVDDAGNLLYPVISWKCPRTAEVMKNIGKYISQEELNRISGVGAFAFNTIYKLVWLRENHPELLEKAHAWLFISNL
LAYKLTGIMATDRTMAGTSQLTDLETGDFSEFILNRLGLSRGLFPPIVDAGETIGLLTPEAADAMNLPALAGIPVISAGH
DTQFAIFGSGADKNQPVLSSGTWEILMARSAQARLAREDYEDGATAEFDAESGLLNPGLQWLGSGIIEWVKAACFHGESY
DTMDAEAAAVPPGCDGVTMVPDFLASGDRKGSINGLVLGRTRGHIYRAAMEALTWRLKSRLRRLESVGGFKSEFLILVGG
GARNRVWTQMRADILRIPVKVSEVSESTVLGASMFAFAGAGVYSTPEQARAAFGIAYRTYMPGSQEAAYEKFNQ

Specific function: Fucose metabolism; second step. [C]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Escherichia coli, GI1789168, Length=469, Percent_Identity=52.2388059701493, Blast_Score=498, Evalue=1e-142,
Organism=Escherichia coli, GI1787789, Length=494, Percent_Identity=23.4817813765182, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1790005, Length=496, Percent_Identity=23.7903225806452, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI1790361, Length=492, Percent_Identity=24.1869918699187, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1789987, Length=429, Percent_Identity=26.5734265734266, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1790338, Length=405, Percent_Identity=24.9382716049383, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1789138, Length=311, Percent_Identity=24.4372990353698, Blast_Score=82, Evalue=7e-17,
Organism=Drosophila melanogaster, GI17864214, Length=427, Percent_Identity=25.0585480093677, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24654573, Length=423, Percent_Identity=25.0591016548463, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR013450 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.51 [H]

Molecular weight: Translated: 51251; Mature: 51251

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSLCLDCGATNVRAMVVDKQGVIVGKASQPNATLPGEENPEFHVWDADRIFRQLSECAV
CCEEEEECCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHH
KALEGLNAEQVTAVTITTFGVDGALVDDAGNLLYPVISWKCPRTAEVMKNIGKYISQEEL
HHHHCCCCCCEEEEEEEEECCCCEEECCCCCEEEHHHCCCCCCHHHHHHHHHHHHCHHHH
NRISGVGAFAFNTIYKLVWLRENHPELLEKAHAWLFISNLLAYKLTGIMATDRTMAGTSQ
HHHHCCHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCH
LTDLETGDFSEFILNRLGLSRGLFPPIVDAGETIGLLTPEAADAMNLPALAGIPVISAGH
HCCCCCCCHHHHHHHHHCCCCCCCCCHHCCCCEEEEECCCCCCCCCCCCCCCCCEEECCC
DTQFAIFGSGADKNQPVLSSGTWEILMARSAQARLAREDYEDGATAEFDAESGLLNPGLQ
CCEEEEEECCCCCCCCEECCCCEEEEEECCHHHHHHHHHCCCCCCEEECCCCCCCCCCHH
WLGSGIIEWVKAACFHGESYDTMDAEAAAVPPGCDGVTMVPDFLASGDRKGSINGLVLGR
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCEEEEEC
TRGHIYRAAMEALTWRLKSRLRRLESVGGFKSEFLILVGGGARNRVWTQMRADILRIPVK
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCEE
VSEVSESTVLGASMFAFAGAGVYSTPEQARAAFGIAYRTYMPGSQEAAYEKFNQ
HHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHEEEEECCCCCHHHHHHHHCC
>Mature Secondary Structure
MYSLCLDCGATNVRAMVVDKQGVIVGKASQPNATLPGEENPEFHVWDADRIFRQLSECAV
CCEEEEECCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHH
KALEGLNAEQVTAVTITTFGVDGALVDDAGNLLYPVISWKCPRTAEVMKNIGKYISQEEL
HHHHCCCCCCEEEEEEEEECCCCEEECCCCCEEEHHHCCCCCCHHHHHHHHHHHHCHHHH
NRISGVGAFAFNTIYKLVWLRENHPELLEKAHAWLFISNLLAYKLTGIMATDRTMAGTSQ
HHHHCCHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCH
LTDLETGDFSEFILNRLGLSRGLFPPIVDAGETIGLLTPEAADAMNLPALAGIPVISAGH
HCCCCCCCHHHHHHHHHCCCCCCCCCHHCCCCEEEEECCCCCCCCCCCCCCCCCEEECCC
DTQFAIFGSGADKNQPVLSSGTWEILMARSAQARLAREDYEDGATAEFDAESGLLNPGLQ
CCEEEEEECCCCCCCCEECCCCEEEEEECCHHHHHHHHHCCCCCCEEECCCCCCCCCCHH
WLGSGIIEWVKAACFHGESYDTMDAEAAAVPPGCDGVTMVPDFLASGDRKGSINGLVLGR
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCEEEEEC
TRGHIYRAAMEALTWRLKSRLRRLESVGGFKSEFLILVGGGARNRVWTQMRADILRIPVK
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCEE
VSEVSESTVLGASMFAFAGAGVYSTPEQARAAFGIAYRTYMPGSQEAAYEKFNQ
HHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHEEEEECCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]