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The map label for this gene is patB [H]

Identifier: 187736285

GI number: 187736285

Start: 2185074

End: 2186279

Strand: Direct

Name: patB [H]

Synonym: Amuc_1798

Alternate gene names: 187736285

Gene position: 2185074-2186279 (Clockwise)

Preceding gene: 187736284

Following gene: 187736286

Centisome position: 82.02

GC content: 57.21

Gene sequence:

>1206_bases
ATGAAGTACGATTTTGATACTGTTGTTCCGCGCCGCGGCACGAATTCCTACAAGTGGGATTCCATGCCCCGGGAGGATAT
TCTGCCCATGTGGGTGGCAGACATGGATTTCCGTACGGCTCCGGCGGTGACGGACGCCATCCGGAAGAGGGCCGAGCACG
GCATTTTCGGTTATACACGGGTTCCGGATTCCTATTATGAGGCGGTTACAAACTGGTTTGAACGCCGCCACGGCTGGAAG
ATTAATCCGGAATGGATGATTTATACCACGGGGGTGGTTCCCGCGCTGTCTGCCGTCATACGGGCCCTGACGGTCCCTGG
GGACAAGGTGCTGGTCCAGACGCCTGTATATAATTGCTTTTTTTCCTCCATCCGCAATAACGGATGCGTGGCGGAAACCT
GCCCTCTGAAATATGAGAACGGCAGATATGCGCTGGATGCGGAGGAGCTGGAACGGAAAGCCTCCGATCCCGCCGTCAAG
CTGATGCTCCTGTGCAATCCCCATAATCCAGCCGGGCGCGTCTGGACGAGGGAAGAATTGGAGGAGATGGCCGCCATTTG
CCGGAGAAACGGCGTTTTCATAGTGGCTGACGAGATTCATTGCGAACTGACGTATCCGGGCCATCCCTATACGCCGTTCG
CCTCCCTCTCCGAGGACGCCCTGCACCATTCCGTCACCTGTATTTCCCCCAGCAAGGCGTTTAATCTGGCGGGCATTCAG
ATAGCCAATATCGTCGCGGCGGATGAAGAAGTCCGGAAGAGGATTGACAAGGCTATCAACATCAATGAGGTGTGTGACGT
CAATTCTTTTGCCGTAGATGCCCTGGAAGCGGCTTATAACGGAGGGGAGGACTGGTTGGAGGAACTGAAGCTCTACCTTT
ACGGGAATTACGAGATTGTCCGGGATATGCTGGCAGAACGTCTGCCGCAGCTCCGTGTGGTGCCGCTGGAGGGAACGTAC
CTGGTCTGGATAGATTGTTCCGCTCTGGGGCTTCCCTCCGCAGAGATTGTCCGCCTGCTGGAAGAGGAGGGTCGGGTGCT
CGTCAACGGCGGGGAAATGTACGGGGAAACGGCGGGGTGCTTCATTCGCCTGAACGTCGCCTGTCCCAGGAAGCTGCTGC
TTGAGGGGCTGGAAAGAATCATCCGCACGCTGTGCGGCCGCATTTCCGGAACACGGACGTGCCCGTCGGGCCCTGCAGGC
TCTTAA

Upstream 100 bases:

>100_bases
TTGTTGCGGAAGAGTACGGGGATATTATTCTGGACGAGCATTGCAAGGCTCCTGCCAATTGCTCCATTGAAACGGGAAAA
GCCCAATCCGGAGAAGCCGC

Downstream 100 bases:

>100_bases
CAGGGAGAACAGTTATTAATCATCAACAATCAAGTTGCCATGGAAAATAAGATGACGAGAAGAACATGGCTCCAGTCTTC
CACCGCAGCCCTGGCATGCC

Product: aminotransferase class I and II

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MKYDFDTVVPRRGTNSYKWDSMPREDILPMWVADMDFRTAPAVTDAIRKRAEHGIFGYTRVPDSYYEAVTNWFERRHGWK
INPEWMIYTTGVVPALSAVIRALTVPGDKVLVQTPVYNCFFSSIRNNGCVAETCPLKYENGRYALDAEELERKASDPAVK
LMLLCNPHNPAGRVWTREELEEMAAICRRNGVFIVADEIHCELTYPGHPYTPFASLSEDALHHSVTCISPSKAFNLAGIQ
IANIVAADEEVRKRIDKAININEVCDVNSFAVDALEAAYNGGEDWLEELKLYLYGNYEIVRDMLAERLPQLRVVPLEGTY
LVWIDCSALGLPSAEIVRLLEEEGRVLVNGGEMYGETAGCFIRLNVACPRKLLLEGLERIIRTLCGRISGTRTCPSGPAG
S

Sequences:

>Translated_401_residues
MKYDFDTVVPRRGTNSYKWDSMPREDILPMWVADMDFRTAPAVTDAIRKRAEHGIFGYTRVPDSYYEAVTNWFERRHGWK
INPEWMIYTTGVVPALSAVIRALTVPGDKVLVQTPVYNCFFSSIRNNGCVAETCPLKYENGRYALDAEELERKASDPAVK
LMLLCNPHNPAGRVWTREELEEMAAICRRNGVFIVADEIHCELTYPGHPYTPFASLSEDALHHSVTCISPSKAFNLAGIQ
IANIVAADEEVRKRIDKAININEVCDVNSFAVDALEAAYNGGEDWLEELKLYLYGNYEIVRDMLAERLPQLRVVPLEGTY
LVWIDCSALGLPSAEIVRLLEEEGRVLVNGGEMYGETAGCFIRLNVACPRKLLLEGLERIIRTLCGRISGTRTCPSGPAG
S
>Mature_401_residues
MKYDFDTVVPRRGTNSYKWDSMPREDILPMWVADMDFRTAPAVTDAIRKRAEHGIFGYTRVPDSYYEAVTNWFERRHGWK
INPEWMIYTTGVVPALSAVIRALTVPGDKVLVQTPVYNCFFSSIRNNGCVAETCPLKYENGRYALDAEELERKASDPAVK
LMLLCNPHNPAGRVWTREELEEMAAICRRNGVFIVADEIHCELTYPGHPYTPFASLSEDALHHSVTCISPSKAFNLAGIQ
IANIVAADEEVRKRIDKAININEVCDVNSFAVDALEAAYNGGEDWLEELKLYLYGNYEIVRDMLAERLPQLRVVPLEGTY
LVWIDCSALGLPSAEIVRLLEEEGRVLVNGGEMYGETAGCFIRLNVACPRKLLLEGLERIIRTLCGRISGTRTCPSGPAG
S

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713254, Length=280, Percent_Identity=23.9285714285714, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI56713256, Length=280, Percent_Identity=23.9285714285714, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI95147551, Length=274, Percent_Identity=23.7226277372263, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI169881279, Length=274, Percent_Identity=23.7226277372263, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4507369, Length=389, Percent_Identity=23.1362467866324, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1787909, Length=388, Percent_Identity=31.9587628865979, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1788722, Length=392, Percent_Identity=25, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1786816, Length=326, Percent_Identity=25.4601226993865, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788627, Length=179, Percent_Identity=26.2569832402235, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994476, Length=269, Percent_Identity=24.1635687732342, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17567369, Length=163, Percent_Identity=28.8343558282209, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71994472, Length=269, Percent_Identity=24.1635687732342, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17567663, Length=310, Percent_Identity=25.1612903225806, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322401, Length=292, Percent_Identity=26.3698630136986, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI28573069, Length=205, Percent_Identity=26.8292682926829, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24646114, Length=205, Percent_Identity=26.8292682926829, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28573067, Length=205, Percent_Identity=26.8292682926829, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28573065, Length=205, Percent_Identity=26.8292682926829, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI18859735, Length=395, Percent_Identity=22.7848101265823, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44992; Mature: 44992

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYDFDTVVPRRGTNSYKWDSMPREDILPMWVADMDFRTAPAVTDAIRKRAEHGIFGYTR
CCCCCCCCCCCCCCCCCCCCCCCHHHCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEC
VPDSYYEAVTNWFERRHGWKINPEWMIYTTGVVPALSAVIRALTVPGDKVLVQTPVYNCF
CCHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCEEEEECCHHHHH
FSSIRNNGCVAETCPLKYENGRYALDAEELERKASDPAVKLMLLCNPHNPAGRVWTREEL
HHHHCCCCCEEEECCCEECCCCEEECHHHHHHCCCCCEEEEEEEECCCCCCCCCCCHHHH
EEMAAICRRNGVFIVADEIHCELTYPGHPYTPFASLSEDALHHSVTCISPSKAFNLAGIQ
HHHHHHHHCCCEEEEEECEEEEEECCCCCCCCCCCCCHHHHHCEEEEECCCCCCEECCEE
IANIVAADEEVRKRIDKAININEVCDVNSFAVDALEAAYNGGEDWLEELKLYLYGNYEIV
EEHEECCCHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHCCCHHHHHHHHEEEECCHHHH
RDMLAERLPQLRVVPLEGTYLVWIDCSALGLPSAEIVRLLEEEGRVLVNGGEMYGETAGC
HHHHHHHCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEECCHHCCCCCCE
FIRLNVACPRKLLLEGLERIIRTLCGRISGTRTCPSGPAGS
EEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MKYDFDTVVPRRGTNSYKWDSMPREDILPMWVADMDFRTAPAVTDAIRKRAEHGIFGYTR
CCCCCCCCCCCCCCCCCCCCCCCHHHCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEC
VPDSYYEAVTNWFERRHGWKINPEWMIYTTGVVPALSAVIRALTVPGDKVLVQTPVYNCF
CCHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCEEEEECCHHHHH
FSSIRNNGCVAETCPLKYENGRYALDAEELERKASDPAVKLMLLCNPHNPAGRVWTREEL
HHHHCCCCCEEEECCCEECCCCEEECHHHHHHCCCCCEEEEEEEECCCCCCCCCCCHHHH
EEMAAICRRNGVFIVADEIHCELTYPGHPYTPFASLSEDALHHSVTCISPSKAFNLAGIQ
HHHHHHHHCCCEEEEEECEEEEEECCCCCCCCCCCCCHHHHHCEEEEECCCCCCEECCEE
IANIVAADEEVRKRIDKAININEVCDVNSFAVDALEAAYNGGEDWLEELKLYLYGNYEIV
EEHEECCCHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHCCCHHHHHHHHEEEECCHHHH
RDMLAERLPQLRVVPLEGTYLVWIDCSALGLPSAEIVRLLEEEGRVLVNGGEMYGETAGC
HHHHHHHCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEECCHHCCCCCCE
FIRLNVACPRKLLLEGLERIIRTLCGRISGTRTCPSGPAGS
EEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]