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The map label for this gene is htrA [H]

Identifier: 187736278

GI number: 187736278

Start: 2179025

End: 2179789

Strand: Reverse

Name: htrA [H]

Synonym: Amuc_1791

Alternate gene names: 187736278

Gene position: 2179789-2179025 (Counterclockwise)

Preceding gene: 187736279

Following gene: 187736277

Centisome position: 81.82

GC content: 58.82

Gene sequence:

>765_bases
ATGACCCCGGCTCTCCGGAATCCCTGTTTTTCCGCTATTCTCTGCGGCACAGCGCTGCTGGCCCCGCCAGCGCCGGCTCA
GTCCGCTGATGGAGCCGGTCTTCTGGCTTCCACCCCGCAATCCGTAGAAGATTTGCAGCGGATTGAACGCCAGCTTCAGC
AAATGCTTCCCCGGGTGCTTCCCGCCCTGGTCTGCATTGAATTAAACAACGGCAGCGGCTCCGGCATCCTGGTTTCGGAA
AAAGGCCTGGTCTTTTCAGCGGCCCACGTTGTGGACAAGAAAGGAACCACGCTCAAAATCATCCTGCCGGATGGAACGCG
CCTTCCGGGAAAAACCACGGCGCAAAACAGCAATTCGGACGCAGGCATGGCCAAAATCACATCCCAATTGAACAAAAAAC
TGCCCTGCGTGGAAAAAGCGGAAAAAATGCCTCGTGTGGGGGACTGGGTGTTCGCGCTGGGGCACGGCGGGGGGCTGGAC
CGGAAACGCGGCCCGATGGTGCGCCTGGGGAGGGTGGTTTCCCTCAAGAACGGCGTCATTCAGACGGACTGCAAGTTGAT
TCGCGGGGATTCCGGCGGCCCTCTTTTCAACCTGGATGGAAAGCTGATTGGCATTCACAGCAGGGTCGGTTCCGGTCTGG
AAGACAATCTGCACGTGCCCATGAAAGATTTCGACGCTCTGACGGAGGAGACAGCGGAAGGAAAGACCTCCCTGACGCCG
CCACCGGAACAGGACAGCCAGCCATTCTCCACTCAGCCATCATGA

Upstream 100 bases:

>100_bases
TATCGGCGTGTATTACCATGATTCCCTGGTGGGCGGCGGACAGGAGGACCAGCAGCAGAAGACGGAAACTTCCGTCTCTG
GGCAATAATCACCGGCAATC

Downstream 100 bases:

>100_bases
AATTTCCTTTCTGCGTCTGCCTGTCTCCCCTGGTTTTCGCCCTGTTCCACCCCGCTCTGGCGGAAGGAAATAACGGAAGC
CTGGATTTTGAACAGAGAAT

Product: peptidase S1 and S6 chymotrypsin/Hap

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MTPALRNPCFSAILCGTALLAPPAPAQSADGAGLLASTPQSVEDLQRIERQLQQMLPRVLPALVCIELNNGSGSGILVSE
KGLVFSAAHVVDKKGTTLKIILPDGTRLPGKTTAQNSNSDAGMAKITSQLNKKLPCVEKAEKMPRVGDWVFALGHGGGLD
RKRGPMVRLGRVVSLKNGVIQTDCKLIRGDSGGPLFNLDGKLIGIHSRVGSGLEDNLHVPMKDFDALTEETAEGKTSLTP
PPEQDSQPFSTQPS

Sequences:

>Translated_254_residues
MTPALRNPCFSAILCGTALLAPPAPAQSADGAGLLASTPQSVEDLQRIERQLQQMLPRVLPALVCIELNNGSGSGILVSE
KGLVFSAAHVVDKKGTTLKIILPDGTRLPGKTTAQNSNSDAGMAKITSQLNKKLPCVEKAEKMPRVGDWVFALGHGGGLD
RKRGPMVRLGRVVSLKNGVIQTDCKLIRGDSGGPLFNLDGKLIGIHSRVGSGLEDNLHVPMKDFDALTEETAEGKTSLTP
PPEQDSQPFSTQPS
>Mature_253_residues
TPALRNPCFSAILCGTALLAPPAPAQSADGAGLLASTPQSVEDLQRIERQLQQMLPRVLPALVCIELNNGSGSGILVSEK
GLVFSAAHVVDKKGTTLKIILPDGTRLPGKTTAQNSNSDAGMAKITSQLNKKLPCVEKAEKMPRVGDWVFALGHGGGLDR
KRGPMVRLGRVVSLKNGVIQTDCKLIRGDSGGPLFNLDGKLIGIHSRVGSGLEDNLHVPMKDFDALTEETAEGKTSLTPP
PEQDSQPFSTQPS

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=185, Percent_Identity=32.972972972973, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI24308541, Length=190, Percent_Identity=30, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI22129776, Length=188, Percent_Identity=31.3829787234043, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1786356, Length=172, Percent_Identity=33.7209302325581, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1789629, Length=211, Percent_Identity=29.8578199052133, Blast_Score=68, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24646839, Length=174, Percent_Identity=30.4597701149425, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 26803; Mature: 26672

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPALRNPCFSAILCGTALLAPPAPAQSADGAGLLASTPQSVEDLQRIERQLQQMLPRVL
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHH
PALVCIELNNGSGSGILVSEKGLVFSAAHVVDKKGTTLKIILPDGTRLPGKTTAQNSNSD
HEEEEEEECCCCCCEEEEECCCCEEEHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCC
AGMAKITSQLNKKLPCVEKAEKMPRVGDWVFALGHGGGLDRKRGPMVRLGRVVSLKNGVI
HHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHEEHHCCCEE
QTDCKLIRGDSGGPLFNLDGKLIGIHSRVGSGLEDNLHVPMKDFDALTEETAEGKTSLTP
ECCCEEEECCCCCCEEECCCCEEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
PPEQDSQPFSTQPS
CCCCCCCCCCCCCC
>Mature Secondary Structure 
TPALRNPCFSAILCGTALLAPPAPAQSADGAGLLASTPQSVEDLQRIERQLQQMLPRVL
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHH
PALVCIELNNGSGSGILVSEKGLVFSAAHVVDKKGTTLKIILPDGTRLPGKTTAQNSNSD
HEEEEEEECCCCCCEEEEECCCCEEEHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCC
AGMAKITSQLNKKLPCVEKAEKMPRVGDWVFALGHGGGLDRKRGPMVRLGRVVSLKNGVI
HHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHEEHHCCCEE
QTDCKLIRGDSGGPLFNLDGKLIGIHSRVGSGLEDNLHVPMKDFDALTEETAEGKTSLTP
ECCCEEEECCCCCCEEECCCCEEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
PPEQDSQPFSTQPS
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]