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The map label for this gene is hisC [C]

Identifier: 187736236

GI number: 187736236

Start: 2129266

End: 2131158

Strand: Reverse

Name: hisC [C]

Synonym: Amuc_1749

Alternate gene names: 187736236

Gene position: 2131158-2129266 (Counterclockwise)

Preceding gene: 187736239

Following gene: 187736235

Centisome position: 80.0

GC content: 52.61

Gene sequence:

>1893_bases
ATGCAGGCGATCATTTTAGCGGCCGGAATGGGAAAAAGACTGGGAGCGCTCACCCGGAACAATACCAAGTGCATGATCCA
GGTCAACGGAGTGACGCTGATAGAACGCATGATGAGACAATTGGACCGCCTTTCCCCGTCTCTGGAAAAAATCGTGATTG
TTACGGGTTATGAGGGGGAAAAACTCAAAACCTTCCTTTCCCAGCTGGACATTTCCACCCCTGTGGAATATGTGGACAAT
CCCCTGTACGCCAGCACCAACAATATTTATTCCCTGTACCTGGCCAAGGAACACCTGCTTCAGGACGATACGCTGCTCTT
TGAATCCGACCTGATTTTTGAAGACTCCGTTATTGATGCCCTGCTCCGCCATCCCTACCCCAGCCTTGCTCTCGTCGCCA
AATTTGAAAGCTGGATGGACGGCACGGTCGTCACTCTGGATGAAGACGACAACATCAGGCAATTCATTCCCGGCAGCAAA
TTCTCCTACAAGAAAAAGACGGAATATTTTAAAACAGTCAATATTTACAAATTCAGCAGGGAATTCTCCCGGACCCATTA
CGTCCCCTTTCTTACAGCCTACAGCAAAGCCCTGGGCAATAATGAATATTACGAACAGGTGCTGCGGGTCATCGCCCTGC
TGGACAAGCCGGAAATCAAGGCGCTGCGCCTCGGCGGCGAAGCATGGTATGAAATAGACGACATCCAGGATCTGGACATC
GCAGCCTCCATATTCACCCCGGACAGGGAAGAACACCTGCGCCTGATGGAATCCCGGTACGGAGGCTACTGGCGCTATCC
CCGCATCAGGGATTTCTGTTACCTGGTCAATCCCTATTTCCCCAACAAACGCCTCATGTCCGAACTCAAGGCGAATTTTG
AACGCCTAGTGAGGGAATACCCGTCCGGAATGAGAGTCAACAGCCTGCTGGCGGCAAAATACTTCGGCATCAGCCAGGAA
TACATCTGCATCGGCAACGGCGCGGCGGAACTCATTAAGGCGCTCATGTCCCGCCTGGAAGGGAAAATGGGGGTCATCTA
CCCTACCTTTGAAGAATACCCCAACCGGGTGAAACCGGATATGGTGGTTCCCTTCCATACCGCTTCCCGGAATTTCACTT
ATACGGCGGACGACCTGATGGAATTCTTTTCCGGGAAAGACATCGGTACCCTGCTCCTCGTCAATCCGGGAAACCCTTCC
GGATTCTTCCTGCCGAAAGGCGATGTGCTACGCCTCTGCCTGTGGACAAAAACCCGCGGCATCCGCCTGATCGTGGATGA
ATCCTTTGTAGACTTCTCCTGCGGAATGCCGGACAATACGCTGCTGAAAGACGGCATCCTGGAAGAATATCCCCACCTGG
CCGTGGTAAAAAGCATTTCCAAATCCTACGGCGTTCCGGGCCTCCGCCTGGGTGTTCTGGCCTCCGCAGACAGGGAATTG
GCGGCATGGATAAAAAAAGACGTTTCCATCTGGAACATCAATTCCATCGCGGAATTCTACATGCAAATCTTCGGGAAATA
CGAGCAATCCTACGTGCGCGCGTGCAACCGTTTCATGAAGGAACGGGACCGCTTCATGCAGAAACTCTCCCGCGTGCCTT
TCCTGAACGTTTTCCCCTCCCAGGCAAACTATTTCATGTGCGAGGTCAAGCCCCCCATGAAAGCCCGCTCCCTGACCGGC
CTTCTGCTGAAAAACCACTCCATCCTTGTTAAGGACTGTAGCCGGAAAAAAGGATTTGAAGGCAGAGAATTCATCCGTAT
CGCCGTCAGAGACGCAACCGACAATGATGCCCTGGTCCGGGCCATGCATGCAGAAACCGGCTCGGAACCGTCTTCTACTT
GTCCCACTAACGGAGAATCCCCTTTTTCATCCTGTTCCACTTCAGCCTCCTGA

Upstream 100 bases:

>100_bases
ACATATTCTTACAGAAATTTTTACTTTGACGGCGGATGCTCAATCCGTTAAACATAGTTCCCGGTTCTTTCTCAGGTTCT
GAAGACAAATTAGAATACTT

Downstream 100 bases:

>100_bases
TGAATACAATTTCCACTCCTGTCATAGGCATTTGCGGCGGCGGCAACCTGGCCCATGCCATGGCGGGATGGCTGGGTACA
CGCGGCCTACATGTCAATAT

Product: aminotransferase class I and II

Products: 2-Oxoglutarate; L-Histidinol phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 630; Mature: 630

Protein sequence:

>630_residues
MQAIILAAGMGKRLGALTRNNTKCMIQVNGVTLIERMMRQLDRLSPSLEKIVIVTGYEGEKLKTFLSQLDISTPVEYVDN
PLYASTNNIYSLYLAKEHLLQDDTLLFESDLIFEDSVIDALLRHPYPSLALVAKFESWMDGTVVTLDEDDNIRQFIPGSK
FSYKKKTEYFKTVNIYKFSREFSRTHYVPFLTAYSKALGNNEYYEQVLRVIALLDKPEIKALRLGGEAWYEIDDIQDLDI
AASIFTPDREEHLRLMESRYGGYWRYPRIRDFCYLVNPYFPNKRLMSELKANFERLVREYPSGMRVNSLLAAKYFGISQE
YICIGNGAAELIKALMSRLEGKMGVIYPTFEEYPNRVKPDMVVPFHTASRNFTYTADDLMEFFSGKDIGTLLLVNPGNPS
GFFLPKGDVLRLCLWTKTRGIRLIVDESFVDFSCGMPDNTLLKDGILEEYPHLAVVKSISKSYGVPGLRLGVLASADREL
AAWIKKDVSIWNINSIAEFYMQIFGKYEQSYVRACNRFMKERDRFMQKLSRVPFLNVFPSQANYFMCEVKPPMKARSLTG
LLLKNHSILVKDCSRKKGFEGREFIRIAVRDATDNDALVRAMHAETGSEPSSTCPTNGESPFSSCSTSAS

Sequences:

>Translated_630_residues
MQAIILAAGMGKRLGALTRNNTKCMIQVNGVTLIERMMRQLDRLSPSLEKIVIVTGYEGEKLKTFLSQLDISTPVEYVDN
PLYASTNNIYSLYLAKEHLLQDDTLLFESDLIFEDSVIDALLRHPYPSLALVAKFESWMDGTVVTLDEDDNIRQFIPGSK
FSYKKKTEYFKTVNIYKFSREFSRTHYVPFLTAYSKALGNNEYYEQVLRVIALLDKPEIKALRLGGEAWYEIDDIQDLDI
AASIFTPDREEHLRLMESRYGGYWRYPRIRDFCYLVNPYFPNKRLMSELKANFERLVREYPSGMRVNSLLAAKYFGISQE
YICIGNGAAELIKALMSRLEGKMGVIYPTFEEYPNRVKPDMVVPFHTASRNFTYTADDLMEFFSGKDIGTLLLVNPGNPS
GFFLPKGDVLRLCLWTKTRGIRLIVDESFVDFSCGMPDNTLLKDGILEEYPHLAVVKSISKSYGVPGLRLGVLASADREL
AAWIKKDVSIWNINSIAEFYMQIFGKYEQSYVRACNRFMKERDRFMQKLSRVPFLNVFPSQANYFMCEVKPPMKARSLTG
LLLKNHSILVKDCSRKKGFEGREFIRIAVRDATDNDALVRAMHAETGSEPSSTCPTNGESPFSSCSTSAS
>Mature_630_residues
MQAIILAAGMGKRLGALTRNNTKCMIQVNGVTLIERMMRQLDRLSPSLEKIVIVTGYEGEKLKTFLSQLDISTPVEYVDN
PLYASTNNIYSLYLAKEHLLQDDTLLFESDLIFEDSVIDALLRHPYPSLALVAKFESWMDGTVVTLDEDDNIRQFIPGSK
FSYKKKTEYFKTVNIYKFSREFSRTHYVPFLTAYSKALGNNEYYEQVLRVIALLDKPEIKALRLGGEAWYEIDDIQDLDI
AASIFTPDREEHLRLMESRYGGYWRYPRIRDFCYLVNPYFPNKRLMSELKANFERLVREYPSGMRVNSLLAAKYFGISQE
YICIGNGAAELIKALMSRLEGKMGVIYPTFEEYPNRVKPDMVVPFHTASRNFTYTADDLMEFFSGKDIGTLLLVNPGNPS
GFFLPKGDVLRLCLWTKTRGIRLIVDESFVDFSCGMPDNTLLKDGILEEYPHLAVVKSISKSYGVPGLRLGVLASADREL
AAWIKKDVSIWNINSIAEFYMQIFGKYEQSYVRACNRFMKERDRFMQKLSRVPFLNVFPSQANYFMCEVKPPMKARSLTG
LLLKNHSILVKDCSRKKGFEGREFIRIAVRDATDNDALVRAMHAETGSEPSSTCPTNGESPFSSCSTSAS

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To Rhizobium NGR234A y4qD [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=303, Percent_Identity=24.7524752475248, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322075, Length=300, Percent_Identity=24, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.9 [C]

Molecular weight: Translated: 71910; Mature: 71910

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAIILAAGMGKRLGALTRNNTKCMIQVNGVTLIERMMRQLDRLSPSLEKIVIVTGYEGE
CCEEEEECCCCCHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCEEEEEEECCCCH
KLKTFLSQLDISTPVEYVDNPLYASTNNIYSLYLAKEHLLQDDTLLFESDLIFEDSVIDA
HHHHHHHHCCCCCCHHHHCCCCEECCCCEEEEEEEHHHHCCCCCEEEECCCEECHHHHHH
LLRHPYPSLALVAKFESWMDGTVVTLDEDDNIRQFIPGSKFSYKKKTEYFKTVNIYKFSR
HHHCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCCCCHHHHHHHHEEEHEEHHH
EFSRTHYVPFLTAYSKALGNNEYYEQVLRVIALLDKPEIKALRLGGEAWYEIDDIQDLDI
HHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCCCCCE
AASIFTPDREEHLRLMESRYGGYWRYPRIRDFCYLVNPYFPNKRLMSELKANFERLVREY
EEEECCCCHHHHHHHHHHHCCCEECCCCHHCEEEEECCCCCCHHHHHHHHHHHHHHHHHC
PSGMRVNSLLAAKYFGISQEYICIGNGAAELIKALMSRLEGKMGVIYPTFEEYPNRVKPD
CCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEECHHHCCCCCCCC
MVVPFHTASRNFTYTADDLMEFFSGKDIGTLLLVNPGNPSGFFLPKGDVLRLCLWTKTRG
EEEEEECCCCCCEECHHHHHHHHCCCCCCEEEEEECCCCCCEECCCCCEEEEEEEECCCC
IRLIVDESFVDFSCGMPDNTLLKDGILEEYPHLAVVKSISKSYGVPGLRLGVLASADREL
EEEEEECCCEEEECCCCCCCHHHCCHHHHCCHHHHHHHHHHHCCCCCEEEEEEECCCHHH
AAWIKKDVSIWNINSIAEFYMQIFGKYEQSYVRACNRFMKERDRFMQKLSRVPFLNVFPS
HHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
QANYFMCEVKPPMKARSLTGLLLKNHSILVKDCSRKKGFEGREFIRIAVRDATDNDALVR
CCCEEEEECCCCCHHHHHHHHEECCCCEEEEECCCCCCCCCCEEEEEEEECCCCCHHHHH
AMHAETGSEPSSTCPTNGESPFSSCSTSAS
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQAIILAAGMGKRLGALTRNNTKCMIQVNGVTLIERMMRQLDRLSPSLEKIVIVTGYEGE
CCEEEEECCCCCHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCEEEEEEECCCCH
KLKTFLSQLDISTPVEYVDNPLYASTNNIYSLYLAKEHLLQDDTLLFESDLIFEDSVIDA
HHHHHHHHCCCCCCHHHHCCCCEECCCCEEEEEEEHHHHCCCCCEEEECCCEECHHHHHH
LLRHPYPSLALVAKFESWMDGTVVTLDEDDNIRQFIPGSKFSYKKKTEYFKTVNIYKFSR
HHHCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCCCCHHHHHHHHEEEHEEHHH
EFSRTHYVPFLTAYSKALGNNEYYEQVLRVIALLDKPEIKALRLGGEAWYEIDDIQDLDI
HHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCCCCCE
AASIFTPDREEHLRLMESRYGGYWRYPRIRDFCYLVNPYFPNKRLMSELKANFERLVREY
EEEECCCCHHHHHHHHHHHCCCEECCCCHHCEEEEECCCCCCHHHHHHHHHHHHHHHHHC
PSGMRVNSLLAAKYFGISQEYICIGNGAAELIKALMSRLEGKMGVIYPTFEEYPNRVKPD
CCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEECHHHCCCCCCCC
MVVPFHTASRNFTYTADDLMEFFSGKDIGTLLLVNPGNPSGFFLPKGDVLRLCLWTKTRG
EEEEEECCCCCCEECHHHHHHHHCCCCCCEEEEEECCCCCCEECCCCCEEEEEEEECCCC
IRLIVDESFVDFSCGMPDNTLLKDGILEEYPHLAVVKSISKSYGVPGLRLGVLASADREL
EEEEEECCCEEEECCCCCCCHHHCCHHHHCCHHHHHHHHHHHCCCCCEEEEEEECCCHHH
AAWIKKDVSIWNINSIAEFYMQIFGKYEQSYVRACNRFMKERDRFMQKLSRVPFLNVFPS
HHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
QANYFMCEVKPPMKARSLTGLLLKNHSILVKDCSRKKGFEGREFIRIAVRDATDNDALVR
CCCEEEEECCCCCHHHHHHHHEECCCCEEEEECCCCCCCCCCEEEEEEEECCCCCHHHHH
AMHAETGSEPSSTCPTNGESPFSSCSTSAS
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-Glutamate; 3-(Imidazol-4-yl)-2-oxopropyl phosphate [C]

Specific reaction: L-Glutamate + 3-(Imidazol-4-yl)-2-oxopropyl phosphate --> 2-Oxoglutarate + L-Histidinol phosphate [C]

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]