Definition | Akkermansia muciniphila ATCC BAA-835, complete genome. |
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Accession | NC_010655 |
Length | 2,664,102 |
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The map label for this gene is hemB [H]
Identifier: 187736217
GI number: 187736217
Start: 2111470
End: 2112465
Strand: Reverse
Name: hemB [H]
Synonym: Amuc_1730
Alternate gene names: 187736217
Gene position: 2112465-2111470 (Counterclockwise)
Preceding gene: 187736218
Following gene: 187736216
Centisome position: 79.29
GC content: 60.34
Gene sequence:
>996_bases ATGATGAATCTACCGATACGGCCTCGCCGCAACAGAAAATCCGCCAACATCCGGGGCCTTATCCGGGAAACCTCCCTTTC CCCGGAACACCTCATCTATCCCGTCTTCGTCCATGAAGGGACCGGGAACCAGCCCATCCCCTCCCTGCCGGGCTGCACGC GCTGGAGCGTCAAGGGACTGGTGGAAGAAGCCAAACGCCTGATGGATCTGGGCATCCGGACGCTGGATCTTTTTCCAGCC ATTCCGGATGAGAAAAAAACGCCGGACGCCTGCGAAGCCTGCAACCCTGACGGCCTCATCCCGCGCACCATTTACGCGCT CAAAAGCGAAGTGCCGGGCATCACCGTCATGACGGACGTAGCCCTGGATCCCTACAATTCCGACGGCCATGACGGCCTGG TGGAATTCCGCTCCGACGGAACGATGGAAATCCTTAACGACGATTCCGTGGAGGTTCTCTGCCGCCAGGCATTGTGCCAC GCGGATGCCGGGGCGGATATCGTCTCCCCCAGCGACATGATGGACGGCCGCGTGGCCGCCATCCGCGCCACCCTGGATTC CGAAGCCCTGGACGATGTCTCCATCATGGCCTATACCGCCAAGTACGCCAGCGCTCTGTACGGGCCGTTCCGCGGAGCTC TGGAGAGCGCACCCAAGGAAGGGGATAAAAAAACCTACCAGATGGATCCCGGCAACATCCGGGAAGCCCTTAGGGAAGCG CAGCTGGATGAAGCTGAGGGAGCGGACATCCTGATGGTGAAACCCGCCACATTGTATCTGGACGTTATGGCCGCCATGCG GAAGCAGGTGACCCTTCCCATAGCCGCCTACCATGTCAGCGGGGAGTACCTGATGATCAAGTCCGCCGCAGCTTCCGGCT GGCTGGATGAACGGGAAACAGTTCTGGAGACTCTAATATCCATCCGGCGCGCCGGGGCCGATATGATCCTTACGTATTAC GCCCCCCAGGCCGCCGAATGGCTTCAACAACGCTGA
Upstream 100 bases:
>100_bases CGATGCGGAACAGCCGCTGGAACTGGAGGCCCCCAAGGCTCCCTGATCATATCCGTCCCGGAACGCCATGCCTTCCTAAA AACCTTTTCATTACCACACC
Downstream 100 bases:
>100_bases CGCCGCACGGCCACCGTACCGGAGGTGGACGTACGGGTCAGAACACCGCCCTCCGCATGTCCACCTCCACGAAAATCATT GTCGGCATCGTGATCGTCGT
Product: delta-aminolevulinic acid dehydratase
Products: NA
Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]
Number of amino acids: Translated: 331; Mature: 331
Protein sequence:
>331_residues MMNLPIRPRRNRKSANIRGLIRETSLSPEHLIYPVFVHEGTGNQPIPSLPGCTRWSVKGLVEEAKRLMDLGIRTLDLFPA IPDEKKTPDACEACNPDGLIPRTIYALKSEVPGITVMTDVALDPYNSDGHDGLVEFRSDGTMEILNDDSVEVLCRQALCH ADAGADIVSPSDMMDGRVAAIRATLDSEALDDVSIMAYTAKYASALYGPFRGALESAPKEGDKKTYQMDPGNIREALREA QLDEAEGADILMVKPATLYLDVMAAMRKQVTLPIAAYHVSGEYLMIKSAAASGWLDERETVLETLISIRRAGADMILTYY APQAAEWLQQR
Sequences:
>Translated_331_residues MMNLPIRPRRNRKSANIRGLIRETSLSPEHLIYPVFVHEGTGNQPIPSLPGCTRWSVKGLVEEAKRLMDLGIRTLDLFPA IPDEKKTPDACEACNPDGLIPRTIYALKSEVPGITVMTDVALDPYNSDGHDGLVEFRSDGTMEILNDDSVEVLCRQALCH ADAGADIVSPSDMMDGRVAAIRATLDSEALDDVSIMAYTAKYASALYGPFRGALESAPKEGDKKTYQMDPGNIREALREA QLDEAEGADILMVKPATLYLDVMAAMRKQVTLPIAAYHVSGEYLMIKSAAASGWLDERETVLETLISIRRAGADMILTYY APQAAEWLQQR >Mature_331_residues MMNLPIRPRRNRKSANIRGLIRETSLSPEHLIYPVFVHEGTGNQPIPSLPGCTRWSVKGLVEEAKRLMDLGIRTLDLFPA IPDEKKTPDACEACNPDGLIPRTIYALKSEVPGITVMTDVALDPYNSDGHDGLVEFRSDGTMEILNDDSVEVLCRQALCH ADAGADIVSPSDMMDGRVAAIRATLDSEALDDVSIMAYTAKYASALYGPFRGALESAPKEGDKKTYQMDPGNIREALREA QLDEAEGADILMVKPATLYLDVMAAMRKQVTLPIAAYHVSGEYLMIKSAAASGWLDERETVLETLISIRRAGADMILTYY APQAAEWLQQR
Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]
COG id: COG0113
COG function: function code H; Delta-aminolevulinic acid dehydratase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the ALADH family [H]
Homologues:
Organism=Homo sapiens, GI189083849, Length=333, Percent_Identity=40.5405405405405, Blast_Score=229, Evalue=2e-60, Organism=Escherichia coli, GI87081728, Length=328, Percent_Identity=46.3414634146341, Blast_Score=256, Evalue=1e-69, Organism=Saccharomyces cerevisiae, GI6321398, Length=319, Percent_Identity=38.2445141065831, Blast_Score=192, Evalue=9e-50, Organism=Drosophila melanogaster, GI21358291, Length=299, Percent_Identity=39.1304347826087, Blast_Score=210, Evalue=1e-54,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001731 - InterPro: IPR013785 [H]
Pfam domain/function: PF00490 ALAD [H]
EC number: =4.2.1.24 [H]
Molecular weight: Translated: 36371; Mature: 36371
Theoretical pI: Translated: 4.65; Mature: 4.65
Prosite motif: PS00169 D_ALA_DEHYDRATASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 4.2 %Met (Translated Protein) 5.7 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 4.2 %Met (Mature Protein) 5.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MMNLPIRPRRNRKSANIRGLIRETSLSPEHLIYPVFVHEGTGNQPIPSLPGCTRWSVKGL CCCCCCCCCCCCCCCCHHEEHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHH VEEAKRLMDLGIRTLDLFPAIPDEKKTPDACEACNPDGLIPRTIYALKSEVPGITVMTDV HHHHHHHHHCCCHHEECCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEE ALDPYNSDGHDGLVEFRSDGTMEILNDDSVEVLCRQALCHADAGADIVSPSDMMDGRVAA EECCCCCCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEE IRATLDSEALDDVSIMAYTAKYASALYGPFRGALESAPKEGDKKTYQMDPGNIREALREA EEEHHCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHH QLDEAEGADILMVKPATLYLDVMAAMRKQVTLPIAAYHVSGEYLMIKSAAASGWLDERET CCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEECCCCCCCHHHHH VLETLISIRRAGADMILTYYAPQAAEWLQQR HHHHHHHHHHCCCCEEEEEECCHHHHHHHCC >Mature Secondary Structure MMNLPIRPRRNRKSANIRGLIRETSLSPEHLIYPVFVHEGTGNQPIPSLPGCTRWSVKGL CCCCCCCCCCCCCCCCHHEEHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHH VEEAKRLMDLGIRTLDLFPAIPDEKKTPDACEACNPDGLIPRTIYALKSEVPGITVMTDV HHHHHHHHHCCCHHEECCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEE ALDPYNSDGHDGLVEFRSDGTMEILNDDSVEVLCRQALCHADAGADIVSPSDMMDGRVAA EECCCCCCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEE IRATLDSEALDDVSIMAYTAKYASALYGPFRGALESAPKEGDKKTYQMDPGNIREALREA EEEHHCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHH QLDEAEGADILMVKPATLYLDVMAAMRKQVTLPIAAYHVSGEYLMIKSAAASGWLDERET CCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEECCCCCCCHHHHH VLETLISIRRAGADMILTYYAPQAAEWLQQR HHHHHHHHHHCCCCEEEEEECCHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 10192388; 10684935; 10871362 [H]