Definition Akkermansia muciniphila ATCC BAA-835, complete genome.
Accession NC_010655
Length 2,664,102

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The map label for this gene is hemB [H]

Identifier: 187736217

GI number: 187736217

Start: 2111470

End: 2112465

Strand: Reverse

Name: hemB [H]

Synonym: Amuc_1730

Alternate gene names: 187736217

Gene position: 2112465-2111470 (Counterclockwise)

Preceding gene: 187736218

Following gene: 187736216

Centisome position: 79.29

GC content: 60.34

Gene sequence:

>996_bases
ATGATGAATCTACCGATACGGCCTCGCCGCAACAGAAAATCCGCCAACATCCGGGGCCTTATCCGGGAAACCTCCCTTTC
CCCGGAACACCTCATCTATCCCGTCTTCGTCCATGAAGGGACCGGGAACCAGCCCATCCCCTCCCTGCCGGGCTGCACGC
GCTGGAGCGTCAAGGGACTGGTGGAAGAAGCCAAACGCCTGATGGATCTGGGCATCCGGACGCTGGATCTTTTTCCAGCC
ATTCCGGATGAGAAAAAAACGCCGGACGCCTGCGAAGCCTGCAACCCTGACGGCCTCATCCCGCGCACCATTTACGCGCT
CAAAAGCGAAGTGCCGGGCATCACCGTCATGACGGACGTAGCCCTGGATCCCTACAATTCCGACGGCCATGACGGCCTGG
TGGAATTCCGCTCCGACGGAACGATGGAAATCCTTAACGACGATTCCGTGGAGGTTCTCTGCCGCCAGGCATTGTGCCAC
GCGGATGCCGGGGCGGATATCGTCTCCCCCAGCGACATGATGGACGGCCGCGTGGCCGCCATCCGCGCCACCCTGGATTC
CGAAGCCCTGGACGATGTCTCCATCATGGCCTATACCGCCAAGTACGCCAGCGCTCTGTACGGGCCGTTCCGCGGAGCTC
TGGAGAGCGCACCCAAGGAAGGGGATAAAAAAACCTACCAGATGGATCCCGGCAACATCCGGGAAGCCCTTAGGGAAGCG
CAGCTGGATGAAGCTGAGGGAGCGGACATCCTGATGGTGAAACCCGCCACATTGTATCTGGACGTTATGGCCGCCATGCG
GAAGCAGGTGACCCTTCCCATAGCCGCCTACCATGTCAGCGGGGAGTACCTGATGATCAAGTCCGCCGCAGCTTCCGGCT
GGCTGGATGAACGGGAAACAGTTCTGGAGACTCTAATATCCATCCGGCGCGCCGGGGCCGATATGATCCTTACGTATTAC
GCCCCCCAGGCCGCCGAATGGCTTCAACAACGCTGA

Upstream 100 bases:

>100_bases
CGATGCGGAACAGCCGCTGGAACTGGAGGCCCCCAAGGCTCCCTGATCATATCCGTCCCGGAACGCCATGCCTTCCTAAA
AACCTTTTCATTACCACACC

Downstream 100 bases:

>100_bases
CGCCGCACGGCCACCGTACCGGAGGTGGACGTACGGGTCAGAACACCGCCCTCCGCATGTCCACCTCCACGAAAATCATT
GTCGGCATCGTGATCGTCGT

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MMNLPIRPRRNRKSANIRGLIRETSLSPEHLIYPVFVHEGTGNQPIPSLPGCTRWSVKGLVEEAKRLMDLGIRTLDLFPA
IPDEKKTPDACEACNPDGLIPRTIYALKSEVPGITVMTDVALDPYNSDGHDGLVEFRSDGTMEILNDDSVEVLCRQALCH
ADAGADIVSPSDMMDGRVAAIRATLDSEALDDVSIMAYTAKYASALYGPFRGALESAPKEGDKKTYQMDPGNIREALREA
QLDEAEGADILMVKPATLYLDVMAAMRKQVTLPIAAYHVSGEYLMIKSAAASGWLDERETVLETLISIRRAGADMILTYY
APQAAEWLQQR

Sequences:

>Translated_331_residues
MMNLPIRPRRNRKSANIRGLIRETSLSPEHLIYPVFVHEGTGNQPIPSLPGCTRWSVKGLVEEAKRLMDLGIRTLDLFPA
IPDEKKTPDACEACNPDGLIPRTIYALKSEVPGITVMTDVALDPYNSDGHDGLVEFRSDGTMEILNDDSVEVLCRQALCH
ADAGADIVSPSDMMDGRVAAIRATLDSEALDDVSIMAYTAKYASALYGPFRGALESAPKEGDKKTYQMDPGNIREALREA
QLDEAEGADILMVKPATLYLDVMAAMRKQVTLPIAAYHVSGEYLMIKSAAASGWLDERETVLETLISIRRAGADMILTYY
APQAAEWLQQR
>Mature_331_residues
MMNLPIRPRRNRKSANIRGLIRETSLSPEHLIYPVFVHEGTGNQPIPSLPGCTRWSVKGLVEEAKRLMDLGIRTLDLFPA
IPDEKKTPDACEACNPDGLIPRTIYALKSEVPGITVMTDVALDPYNSDGHDGLVEFRSDGTMEILNDDSVEVLCRQALCH
ADAGADIVSPSDMMDGRVAAIRATLDSEALDDVSIMAYTAKYASALYGPFRGALESAPKEGDKKTYQMDPGNIREALREA
QLDEAEGADILMVKPATLYLDVMAAMRKQVTLPIAAYHVSGEYLMIKSAAASGWLDERETVLETLISIRRAGADMILTYY
APQAAEWLQQR

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=333, Percent_Identity=40.5405405405405, Blast_Score=229, Evalue=2e-60,
Organism=Escherichia coli, GI87081728, Length=328, Percent_Identity=46.3414634146341, Blast_Score=256, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6321398, Length=319, Percent_Identity=38.2445141065831, Blast_Score=192, Evalue=9e-50,
Organism=Drosophila melanogaster, GI21358291, Length=299, Percent_Identity=39.1304347826087, Blast_Score=210, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36371; Mature: 36371

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNLPIRPRRNRKSANIRGLIRETSLSPEHLIYPVFVHEGTGNQPIPSLPGCTRWSVKGL
CCCCCCCCCCCCCCCCHHEEHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHH
VEEAKRLMDLGIRTLDLFPAIPDEKKTPDACEACNPDGLIPRTIYALKSEVPGITVMTDV
HHHHHHHHHCCCHHEECCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEE
ALDPYNSDGHDGLVEFRSDGTMEILNDDSVEVLCRQALCHADAGADIVSPSDMMDGRVAA
EECCCCCCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEE
IRATLDSEALDDVSIMAYTAKYASALYGPFRGALESAPKEGDKKTYQMDPGNIREALREA
EEEHHCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHH
QLDEAEGADILMVKPATLYLDVMAAMRKQVTLPIAAYHVSGEYLMIKSAAASGWLDERET
CCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEECCCCCCCHHHHH
VLETLISIRRAGADMILTYYAPQAAEWLQQR
HHHHHHHHHHCCCCEEEEEECCHHHHHHHCC
>Mature Secondary Structure
MMNLPIRPRRNRKSANIRGLIRETSLSPEHLIYPVFVHEGTGNQPIPSLPGCTRWSVKGL
CCCCCCCCCCCCCCCCHHEEHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHH
VEEAKRLMDLGIRTLDLFPAIPDEKKTPDACEACNPDGLIPRTIYALKSEVPGITVMTDV
HHHHHHHHHCCCHHEECCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEE
ALDPYNSDGHDGLVEFRSDGTMEILNDDSVEVLCRQALCHADAGADIVSPSDMMDGRVAA
EECCCCCCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEE
IRATLDSEALDDVSIMAYTAKYASALYGPFRGALESAPKEGDKKTYQMDPGNIREALREA
EEEHHCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHH
QLDEAEGADILMVKPATLYLDVMAAMRKQVTLPIAAYHVSGEYLMIKSAAASGWLDERET
CCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEECCCCCCCHHHHH
VLETLISIRRAGADMILTYYAPQAAEWLQQR
HHHHHHHHHHCCCCEEEEEECCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]