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The map label for this gene is cobDQ [H]

Identifier: 187736170

GI number: 187736170

Start: 2040750

End: 2043326

Strand: Reverse

Name: cobDQ [H]

Synonym: Amuc_1683

Alternate gene names: 187736170

Gene position: 2043326-2040750 (Counterclockwise)

Preceding gene: 187736174

Following gene: 187736169

Centisome position: 76.7

GC content: 61.66

Gene sequence:

>2577_bases
ATGAACGTTTTTTCACATGGCGGAGATTTAAAATCCCTGGCGGAGGATGCCTGCCGCCCGGAACGGGATATTTTGGACTT
CAGCGTCAACCTGAGGCCGGAAGGTATGCCGGAGTTCATCGTTTCAGCATTGTGGAAGGCCATGGAAAACGCAGTACCCT
ACCCTTCTCCGGATGCGGCGGATCTGCGGGAACTGGCGGCGGTTCATTACGGGCTTCCTTCCGGCTGCTTCGTATTTGGA
AACGGGGCCAATGAACTCATCCACGCTCTTCCGCGCGCATTAAACCTTAAACAGGCCGTCATTCCGGAACCCGCTTTTTC
CGAATACAGGCTGGCCTGCCTGCGCCACGGCACGGATATTCTTTCCATCCGGACGGAGGAACGGAATTCCTTCCTCCCGT
CTCTTTGCCGTCTGGAGGAACAGGCCGCAGACGGAAGCGCTGTTTTTCTGGCAAATCCCAGCAATCCGTCCGGCGGCCTG
CTGGACGCAGCGGCCCTGCACAGGGTTGTCCAGAGCCGCCCCGAAGTCCTCTGGATCATTGACGAATCTTTCATGGATTA
CGCACAAGGAGCGGAATCGCTGCTCCATGAAGCAGCCCTCCTTCCCAACCTGGTGGTTCTGCGCTCCCTGACCAAATTTT
ACGGCATGGCCGGCGTCCGGTGCGGTTTTTCCATCTGTGCCGCTCCGCTCGCGGAGCGGCTGCGGCGATCCCTGCCCGCC
TGGAACGTGAATGCCTTTGCGACGGCAGCGGTGAAGGCCGTGCTGGCACAACCCTCCTCCTGGGCAGACAGGGAACGCGC
CCGGAACCGGGAACGCCGGGACGACCTGTTCCGCAGGCTCTCCTCCCTGCCGGGCGCCGCCGTACTCCCGTCCGAGGCCA
ACTTCCTGCTCTTCCGCCTGGCGGGGGCGCCTCATGGCCTGGCAGCCCGGCTCCTGAAAAAATACGGCATCGCACTGCGC
GACTGTTCCAATTATCCGGGTCTGGAAACGGGCTGCTGGTTGCGCTCCGGCGTCCGCACGCCGGAGGAACACGCCCTGCT
GGCGGAAGCTCTGCGCGCCGAACTGGCGGGAAACGGCCCCTCCATTATCCGTAAGGCTCCCAAACCGGCCCTGATGATTC
AGGGCACCTGCTCCGATGCAGGAAAAAGCGTTCTCACGGCAGCCCTGTGCCGCATTTTCCTTCAGGACGGCTATCACGTG
GCACCGTTCAAGGCGCAGAACATGGCTCTCAACTCCGGCGTAACTGCGCTGGGAGAGGAAATGGGCCGCGCCCAGCTGGT
GCAGGCCCAGGCCTGCCGCATTGATCCGGATGCCAGAATGAACCCCATTCTTCTCAAGCCCCATTCCAATACCGGCTCCC
AGGTGATCGTGATGGGGCGCCCCGTAGGCCGCATGGACGCGCGGGAATACTTCACGGCTAAAAGGCGCTTCTGGCCGGAC
GTATGCAAAGCATACGATTCCCTGGCGGACGAATATGAACTCCTCTGCCTGGAAGGGGCCGGAAGCCCCGGAGAAATCAA
TCTGAAATCAGCAGACGTGGTCAACATGAACATGGCCCGCTACGCGCGTGCCAGAGTCCTGCTCGCCGGGGACATTGACC
GTGGCGGAGTGTACGCCTCCTTTCTGGGAACGTGGATGACATTCGCCCCGTGGGAAAAAGAACTGCTGGCGGGGTTCGTG
GTCAACAAATTTCGAGGAGATCCGGATCTGCTGGCCCCGGCGCACAGCTACATGCGGAATCGTACGGGCAAGCCTGTGCT
GGGCGTCATCCCGATGATGCGGGACATCAACATTCCGGAAGAAGACCGCGCCACGCTGCCCCCTGGCCACGGGGAGCACG
GGAAACATGCGGATTGCCTGGATGTGGCCGTAGTCATGCCCGCCCACGTCTCCAACTTCACGGACTTCGCCCCTCTGGCG
GCGGAGCCGGACGTCCGGCTCCGCCAGGTGCGGACACGGGAGGAATGGGGAAATCCGGACCTGGTCATTCTGCCCGGCAC
TAAAAGCGTGGCTGCGGACCTGGCTTCTCTCCGTTCCGCCGGGCTGGAAGAACCCATCCGCCGTCATGCCGAAAAGGGAA
AGTGGCTTCTGGGCGTCTGCGGAGGGCTGCAAATGCTGGGGACGGACATTCTGGACCCGCTGCACATGGAATCCCCGGAG
GAGCGCACGCCAGGACTGGGGCTGCTGGAACTTTCCACCACCTTCTCTTCAGCCAAAACCCTGATCAACGTGCGCCGGGC
AAGCACGCCGCTGCCTGTTCCCGCCGCAGGTTATGAAATCCACCATGGCGTCACCAGCCATCAAGAATCCAGCCCCCCCG
TCATGTTCCGGGAAGACGGCTCCCCCTGCGGCTACGGCAAAGGCCGTATCTGGGCCACGTATCTGCACGGCATGCTGGAC
GGAGACCAATTCCGCCGCGCATTCATCAACATGGTCAGGAAAGATTCAGGGCTGAAAGCCAACCCAGCCCTGCACACCGC
CTATGACCTGGACGGAGCGCTGGACCGCCTGGCGGACGTGGTCCGGAAACATCTGGACCTGAAAACCATTTACCGAGCTC
TCCAACTAAAACGCTGA

Upstream 100 bases:

>100_bases
GCGAAGCTTCCGGCTACGTGGAATTCCGAACTTGCAAGGCGCTTCCTTTCTTTCTCCGGCGCGGGCAGCCCTTCGGTACG
CCGGTTCCAATTACTGTGGC

Downstream 100 bases:

>100_bases
CCCATGTTCCCGTGCCCGTTCATCCTGCCTGCGGCCTTCCTGCTGGATATTCTGGCGGGAGAACCGCCCAACAGGTTTCA
TCCCGTCTGTCTGATCGGCC

Product: cobyric acid synthase CobQ

Products: NA

Alternate protein names: Putative threonine-phosphate decarboxylase; L-threonine-O-3-phosphate decarboxylase; Cobyric acid synthase [H]

Number of amino acids: Translated: 858; Mature: 858

Protein sequence:

>858_residues
MNVFSHGGDLKSLAEDACRPERDILDFSVNLRPEGMPEFIVSALWKAMENAVPYPSPDAADLRELAAVHYGLPSGCFVFG
NGANELIHALPRALNLKQAVIPEPAFSEYRLACLRHGTDILSIRTEERNSFLPSLCRLEEQAADGSAVFLANPSNPSGGL
LDAAALHRVVQSRPEVLWIIDESFMDYAQGAESLLHEAALLPNLVVLRSLTKFYGMAGVRCGFSICAAPLAERLRRSLPA
WNVNAFATAAVKAVLAQPSSWADRERARNRERRDDLFRRLSSLPGAAVLPSEANFLLFRLAGAPHGLAARLLKKYGIALR
DCSNYPGLETGCWLRSGVRTPEEHALLAEALRAELAGNGPSIIRKAPKPALMIQGTCSDAGKSVLTAALCRIFLQDGYHV
APFKAQNMALNSGVTALGEEMGRAQLVQAQACRIDPDARMNPILLKPHSNTGSQVIVMGRPVGRMDAREYFTAKRRFWPD
VCKAYDSLADEYELLCLEGAGSPGEINLKSADVVNMNMARYARARVLLAGDIDRGGVYASFLGTWMTFAPWEKELLAGFV
VNKFRGDPDLLAPAHSYMRNRTGKPVLGVIPMMRDINIPEEDRATLPPGHGEHGKHADCLDVAVVMPAHVSNFTDFAPLA
AEPDVRLRQVRTREEWGNPDLVILPGTKSVAADLASLRSAGLEEPIRRHAEKGKWLLGVCGGLQMLGTDILDPLHMESPE
ERTPGLGLLELSTTFSSAKTLINVRRASTPLPVPAAGYEIHHGVTSHQESSPPVMFREDGSPCGYGKGRIWATYLHGMLD
GDQFRRAFINMVRKDSGLKANPALHTAYDLDGALDRLADVVRKHLDLKTIYRALQLKR

Sequences:

>Translated_858_residues
MNVFSHGGDLKSLAEDACRPERDILDFSVNLRPEGMPEFIVSALWKAMENAVPYPSPDAADLRELAAVHYGLPSGCFVFG
NGANELIHALPRALNLKQAVIPEPAFSEYRLACLRHGTDILSIRTEERNSFLPSLCRLEEQAADGSAVFLANPSNPSGGL
LDAAALHRVVQSRPEVLWIIDESFMDYAQGAESLLHEAALLPNLVVLRSLTKFYGMAGVRCGFSICAAPLAERLRRSLPA
WNVNAFATAAVKAVLAQPSSWADRERARNRERRDDLFRRLSSLPGAAVLPSEANFLLFRLAGAPHGLAARLLKKYGIALR
DCSNYPGLETGCWLRSGVRTPEEHALLAEALRAELAGNGPSIIRKAPKPALMIQGTCSDAGKSVLTAALCRIFLQDGYHV
APFKAQNMALNSGVTALGEEMGRAQLVQAQACRIDPDARMNPILLKPHSNTGSQVIVMGRPVGRMDAREYFTAKRRFWPD
VCKAYDSLADEYELLCLEGAGSPGEINLKSADVVNMNMARYARARVLLAGDIDRGGVYASFLGTWMTFAPWEKELLAGFV
VNKFRGDPDLLAPAHSYMRNRTGKPVLGVIPMMRDINIPEEDRATLPPGHGEHGKHADCLDVAVVMPAHVSNFTDFAPLA
AEPDVRLRQVRTREEWGNPDLVILPGTKSVAADLASLRSAGLEEPIRRHAEKGKWLLGVCGGLQMLGTDILDPLHMESPE
ERTPGLGLLELSTTFSSAKTLINVRRASTPLPVPAAGYEIHHGVTSHQESSPPVMFREDGSPCGYGKGRIWATYLHGMLD
GDQFRRAFINMVRKDSGLKANPALHTAYDLDGALDRLADVVRKHLDLKTIYRALQLKR
>Mature_858_residues
MNVFSHGGDLKSLAEDACRPERDILDFSVNLRPEGMPEFIVSALWKAMENAVPYPSPDAADLRELAAVHYGLPSGCFVFG
NGANELIHALPRALNLKQAVIPEPAFSEYRLACLRHGTDILSIRTEERNSFLPSLCRLEEQAADGSAVFLANPSNPSGGL
LDAAALHRVVQSRPEVLWIIDESFMDYAQGAESLLHEAALLPNLVVLRSLTKFYGMAGVRCGFSICAAPLAERLRRSLPA
WNVNAFATAAVKAVLAQPSSWADRERARNRERRDDLFRRLSSLPGAAVLPSEANFLLFRLAGAPHGLAARLLKKYGIALR
DCSNYPGLETGCWLRSGVRTPEEHALLAEALRAELAGNGPSIIRKAPKPALMIQGTCSDAGKSVLTAALCRIFLQDGYHV
APFKAQNMALNSGVTALGEEMGRAQLVQAQACRIDPDARMNPILLKPHSNTGSQVIVMGRPVGRMDAREYFTAKRRFWPD
VCKAYDSLADEYELLCLEGAGSPGEINLKSADVVNMNMARYARARVLLAGDIDRGGVYASFLGTWMTFAPWEKELLAGFV
VNKFRGDPDLLAPAHSYMRNRTGKPVLGVIPMMRDINIPEEDRATLPPGHGEHGKHADCLDVAVVMPAHVSNFTDFAPLA
AEPDVRLRQVRTREEWGNPDLVILPGTKSVAADLASLRSAGLEEPIRRHAEKGKWLLGVCGGLQMLGTDILDPLHMESPE
ERTPGLGLLELSTTFSSAKTLINVRRASTPLPVPAAGYEIHHGVTSHQESSPPVMFREDGSPCGYGKGRIWATYLHGMLD
GDQFRRAFINMVRKDSGLKANPALHTAYDLDGALDRLADVVRKHLDLKTIYRALQLKR

Specific function: Catalyzes two activities which are involved in the adenosylcobalamin biosynthesis:decarboxylates L-threonine-O-3- phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cob

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=307, Percent_Identity=26.7100977198697, Blast_Score=83, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6322075, Length=300, Percent_Identity=27.3333333333333, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2; PF01656 CbiA; PF07685 GATase_3 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 93816; Mature: 93816

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVFSHGGDLKSLAEDACRPERDILDFSVNLRPEGMPEFIVSALWKAMENAVPYPSPDAA
CCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCHH
DLRELAAVHYGLPSGCFVFGNGANELIHALPRALNLKQAVIPEPAFSEYRLACLRHGTDI
HHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHCCCCE
LSIRTEERNSFLPSLCRLEEQAADGSAVFLANPSNPSGGLLDAAALHRVVQSRPEVLWII
EEEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEE
DESFMDYAQGAESLLHEAALLPNLVVLRSLTKFYGMAGVRCGFSICAAPLAERLRRSLPA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
WNVNAFATAAVKAVLAQPSSWADRERARNRERRDDLFRRLSSLPGAAVLPSEANFLLFRL
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCEEEEEE
AGAPHGLAARLLKKYGIALRDCSNYPGLETGCWLRSGVRTPEEHALLAEALRAELAGNGP
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCH
SIIRKAPKPALMIQGTCSDAGKSVLTAALCRIFLQDGYHVAPFKAQNMALNSGVTALGEE
HHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEHHCCHHHHHHH
MGRAQLVQAQACRIDPDARMNPILLKPHSNTGSQVIVMGRPVGRMDAREYFTAKRRFWPD
HHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCHH
VCKAYDSLADEYELLCLEGAGSPGEINLKSADVVNMNMARYARARVLLAGDIDRGGVYAS
HHHHHHHHCCCEEEEEEECCCCCCEEEECCCCEECHHHHHHHHHEEEEEECCCCCCHHHH
FLGTWMTFAPWEKELLAGFVVNKFRGDPDLLAPAHSYMRNRTGKPVLGVIPMMRDINIPE
HHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCC
EDRATLPPGHGEHGKHADCLDVAVVMPAHVSNFTDFAPLAAEPDVRLRQVRTREEWGNPD
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
LVILPGTKSVAADLASLRSAGLEEPIRRHAEKGKWLLGVCGGLQMLGTDILDPLHMESPE
EEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEHHCCHHHHHHHHCCCCCCCCCC
ERTPGLGLLELSTTFSSAKTLINVRRASTPLPVPAAGYEIHHGVTSHQESSPPVMFREDG
CCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCCCCEEEECCC
SPCGYGKGRIWATYLHGMLDGDQFRRAFINMVRKDSGLKANPALHTAYDLDGALDRLADV
CCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCEEHHCCHHHHHHHHHH
VRKHLDLKTIYRALQLKR
HHHHCCHHHHHHHHHCCC
>Mature Secondary Structure
MNVFSHGGDLKSLAEDACRPERDILDFSVNLRPEGMPEFIVSALWKAMENAVPYPSPDAA
CCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCHH
DLRELAAVHYGLPSGCFVFGNGANELIHALPRALNLKQAVIPEPAFSEYRLACLRHGTDI
HHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHCCCCE
LSIRTEERNSFLPSLCRLEEQAADGSAVFLANPSNPSGGLLDAAALHRVVQSRPEVLWII
EEEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEE
DESFMDYAQGAESLLHEAALLPNLVVLRSLTKFYGMAGVRCGFSICAAPLAERLRRSLPA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
WNVNAFATAAVKAVLAQPSSWADRERARNRERRDDLFRRLSSLPGAAVLPSEANFLLFRL
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCEEEEEE
AGAPHGLAARLLKKYGIALRDCSNYPGLETGCWLRSGVRTPEEHALLAEALRAELAGNGP
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCH
SIIRKAPKPALMIQGTCSDAGKSVLTAALCRIFLQDGYHVAPFKAQNMALNSGVTALGEE
HHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEHHCCHHHHHHH
MGRAQLVQAQACRIDPDARMNPILLKPHSNTGSQVIVMGRPVGRMDAREYFTAKRRFWPD
HHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCHH
VCKAYDSLADEYELLCLEGAGSPGEINLKSADVVNMNMARYARARVLLAGDIDRGGVYAS
HHHHHHHHCCCEEEEEEECCCCCCEEEECCCCEECHHHHHHHHHEEEEEECCCCCCHHHH
FLGTWMTFAPWEKELLAGFVVNKFRGDPDLLAPAHSYMRNRTGKPVLGVIPMMRDINIPE
HHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCC
EDRATLPPGHGEHGKHADCLDVAVVMPAHVSNFTDFAPLAAEPDVRLRQVRTREEWGNPD
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
LVILPGTKSVAADLASLRSAGLEEPIRRHAEKGKWLLGVCGGLQMLGTDILDPLHMESPE
EEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEHHCCHHHHHHHHCCCCCCCCCC
ERTPGLGLLELSTTFSSAKTLINVRRASTPLPVPAAGYEIHHGVTSHQESSPPVMFREDG
CCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCCCCEEEECCC
SPCGYGKGRIWATYLHGMLDGDQFRRAFINMVRKDSGLKANPALHTAYDLDGALDRLADV
CCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCEEHHCCHHHHHHHHHH
VRKHLDLKTIYRALQLKR
HHHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12712204 [H]