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The map label for this gene is speA [H]

Identifier: 187736146

GI number: 187736146

Start: 2004200

End: 2006137

Strand: Direct

Name: speA [H]

Synonym: Amuc_1658

Alternate gene names: 187736146

Gene position: 2004200-2006137 (Clockwise)

Preceding gene: 187736145

Following gene: 187736151

Centisome position: 75.23

GC content: 56.19

Gene sequence:

>1938_bases
ATGGCAGCAGCTAAAGAAGGCATCAAGCAGAAAGTCCGCGGGTGGAGTCACCATGATTCCGCAGATTTGTACGGCATTGA
CGATTGGGGGAACGGTTATTTTCGCATCAGCAAAAAGGGAGAGGTTACCGTACGCCTGAATGACGAGGATGGAGGAAAGA
AGGATGTCAGCCTGTGCGATTTGCTGGAGGGGCTGAAGGAGCGTGGGACTACCGTTCCCGTTCTGTTCCGGTTCCGGGAT
TTGCTGCGCAGCCGTATTGCGGAGCTGAACGACAGTTTCCGGAAAGCAATCAAGGAGGCGGGGTACCAGGGTAAGTACCA
GGGCGTTTACCCAATCAAGGTGAACCAGCAGCGCCAGGTGGTGGAGGAGATTGCGGAGTTCGGCACCAAGTATGATTATG
GTCTGGAGGCCGGTTCCAAGCCGGAGCTGATAGCCGCCATGGCCCATATGCACAATCCGAATGCCTATCTGATTTGCAAC
GGGTACAAGGATGACGAGTTTATTGACCTGGCGTTGACGGCCCAGAAGATGGGGCTGAATATTTTTATCGTGCTGGAAAT
GCCTTCCGAGCTGGACGTTATTCTGGAGCGCGCCAGAAGGATGGATATCCGCCCTAATCTGGGCGTGCGCGTCAAGCTGG
CGGCCAAGGGGTCCGGATTATGGCAGGAATCCGCGGGGGATAAGTCCGTTTTCGGGCTGAACGCAGCCCAGGTGGTGGAT
GTGGTGGATAAGCTGAAGCAGGTGGATGCGCTGGACTGCCTGAAGCTGCTCCATTATCATCAGGGGTCCCAGATTCCAAA
TATTTCCGTGGTGCGCGAGGGGCTGACGGAGGCGGTCCGCATTTACGTGGACCTGGTGAAGGAGGGCGCCCCTCTGGGCA
CGCTGGACATGGGCGGCGGCCTGGCCGTGGATTATGACGGTTCCAAGACGAATTTCCATTCTTCCTGCAATTATTCCATT
GCGGAGTTTGCCCGTGACGTGGTGGAGGTTGTGGGAGACATGTGTTCCAAGTACGGGGTTCCCCATCCCACGCTGGTGAC
GGAGTCCGGACGGGCCGTAGTGGCCTATTATTCCGTGCTGGTGTTCAACGTGCTGGATGTGACGAGCGCTCCGGGCGAGG
AACCTCCGCCCGAGCTTCCGGATGACGCTCCGGAGCTGTTGAAGGCTTTTGCGGACACGGACCGGACGCTGGCCAGGAAG
AATATGCAGGAGTGCTATAATGACGCCTGTTATTACCGGGATCAGTTGAGAGCCCAGTTTTTTTACGGGAACGCCACCCT
GCGGCAGCGCGGGCTGGGAGAGGCTTATTATTGGCATATCCTGAGCCGCATTTCCCGCATGCTGGCGGAGATGGAGACCA
TTCCGGAGGATCTCAGGGAGCTTTCCTGCTCCATGGTGGACTTTTATTACGGCAATTTTTCACTGTTCCAGTCTCTTCCG
GATTCCTGGGCCATCCGCCAGCTTTTCCCCGTGATGCCTCTGCACCGTTTGAATGAACGGCCCACGAATAAGGCCGTGCT
GGCAGACATCACGTGCGATTGCGACGGAAAGATAGACCATTTCATTGACCGTGAGGACGTGGCAACCGCCCTCCCCCTGC
ATGCCATCAAACCCGGCGAGGACGATTATTACATAGGCGTATTCCTGGTAGGAGCCTATCAGGAGACCTTGGGGGATTTG
CATAACCTGCTGGGAGATACGAATGTGGTTGGCGTGCATCTGGAAGGCGGCCGCCCCGTTTATACCCATGAAGTGGAGGG
CGATACGGTGTCCGATGTCCTTTCCTACGTGGAGTATGATCCCAAGGAGTTGATCAACAAGTTCCGCACGTTTGCGGAGC
AAGCCGTAGCCGAGGGGAAAATATCTCCGTCCGAACGCCGGAGAGCCTTGGAAGTGTTCCGTTCCGGATTGAATGGATAC
ACTTATTACGAACTGTAG

Upstream 100 bases:

>100_bases
CCGTTCAGAGAAAAGACGGTTCCGTGGAGACGGTGCGCCGTTTTTCCTATGAAGATTTTGAGGCCCGCCTGGGCTAGAAT
ATTTGACCAGACAGATTGAC

Downstream 100 bases:

>100_bases
GAAACGGTCTTGTCTTTTGCTTCAACAGGGAGCGTTTGTCCCGTGCCGGCGCGTTTTCCTTTGTTGCGGATCAGGAGACC
GGCGGTTCTTCCGGCGGTTT

Product: arginine decarboxylase

Products: NA

Alternate protein names: ADC [H]

Number of amino acids: Translated: 645; Mature: 644

Protein sequence:

>645_residues
MAAAKEGIKQKVRGWSHHDSADLYGIDDWGNGYFRISKKGEVTVRLNDEDGGKKDVSLCDLLEGLKERGTTVPVLFRFRD
LLRSRIAELNDSFRKAIKEAGYQGKYQGVYPIKVNQQRQVVEEIAEFGTKYDYGLEAGSKPELIAAMAHMHNPNAYLICN
GYKDDEFIDLALTAQKMGLNIFIVLEMPSELDVILERARRMDIRPNLGVRVKLAAKGSGLWQESAGDKSVFGLNAAQVVD
VVDKLKQVDALDCLKLLHYHQGSQIPNISVVREGLTEAVRIYVDLVKEGAPLGTLDMGGGLAVDYDGSKTNFHSSCNYSI
AEFARDVVEVVGDMCSKYGVPHPTLVTESGRAVVAYYSVLVFNVLDVTSAPGEEPPPELPDDAPELLKAFADTDRTLARK
NMQECYNDACYYRDQLRAQFFYGNATLRQRGLGEAYYWHILSRISRMLAEMETIPEDLRELSCSMVDFYYGNFSLFQSLP
DSWAIRQLFPVMPLHRLNERPTNKAVLADITCDCDGKIDHFIDREDVATALPLHAIKPGEDDYYIGVFLVGAYQETLGDL
HNLLGDTNVVGVHLEGGRPVYTHEVEGDTVSDVLSYVEYDPKELINKFRTFAEQAVAEGKISPSERRRALEVFRSGLNGY
TYYEL

Sequences:

>Translated_645_residues
MAAAKEGIKQKVRGWSHHDSADLYGIDDWGNGYFRISKKGEVTVRLNDEDGGKKDVSLCDLLEGLKERGTTVPVLFRFRD
LLRSRIAELNDSFRKAIKEAGYQGKYQGVYPIKVNQQRQVVEEIAEFGTKYDYGLEAGSKPELIAAMAHMHNPNAYLICN
GYKDDEFIDLALTAQKMGLNIFIVLEMPSELDVILERARRMDIRPNLGVRVKLAAKGSGLWQESAGDKSVFGLNAAQVVD
VVDKLKQVDALDCLKLLHYHQGSQIPNISVVREGLTEAVRIYVDLVKEGAPLGTLDMGGGLAVDYDGSKTNFHSSCNYSI
AEFARDVVEVVGDMCSKYGVPHPTLVTESGRAVVAYYSVLVFNVLDVTSAPGEEPPPELPDDAPELLKAFADTDRTLARK
NMQECYNDACYYRDQLRAQFFYGNATLRQRGLGEAYYWHILSRISRMLAEMETIPEDLRELSCSMVDFYYGNFSLFQSLP
DSWAIRQLFPVMPLHRLNERPTNKAVLADITCDCDGKIDHFIDREDVATALPLHAIKPGEDDYYIGVFLVGAYQETLGDL
HNLLGDTNVVGVHLEGGRPVYTHEVEGDTVSDVLSYVEYDPKELINKFRTFAEQAVAEGKISPSERRRALEVFRSGLNGY
TYYEL
>Mature_644_residues
AAAKEGIKQKVRGWSHHDSADLYGIDDWGNGYFRISKKGEVTVRLNDEDGGKKDVSLCDLLEGLKERGTTVPVLFRFRDL
LRSRIAELNDSFRKAIKEAGYQGKYQGVYPIKVNQQRQVVEEIAEFGTKYDYGLEAGSKPELIAAMAHMHNPNAYLICNG
YKDDEFIDLALTAQKMGLNIFIVLEMPSELDVILERARRMDIRPNLGVRVKLAAKGSGLWQESAGDKSVFGLNAAQVVDV
VDKLKQVDALDCLKLLHYHQGSQIPNISVVREGLTEAVRIYVDLVKEGAPLGTLDMGGGLAVDYDGSKTNFHSSCNYSIA
EFARDVVEVVGDMCSKYGVPHPTLVTESGRAVVAYYSVLVFNVLDVTSAPGEEPPPELPDDAPELLKAFADTDRTLARKN
MQECYNDACYYRDQLRAQFFYGNATLRQRGLGEAYYWHILSRISRMLAEMETIPEDLRELSCSMVDFYYGNFSLFQSLPD
SWAIRQLFPVMPLHRLNERPTNKAVLADITCDCDGKIDHFIDREDVATALPLHAIKPGEDDYYIGVFLVGAYQETLGDLH
NLLGDTNVVGVHLEGGRPVYTHEVEGDTVSDVLSYVEYDPKELINKFRTFAEQAVAEGKISPSERRRALEVFRSGLNGYT
YYEL

Specific function: Catalyzes the biosynthesis of agmatine from arginine [H]

COG id: COG1166

COG function: function code E; Arginine decarboxylase (spermidine biosynthesis)

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789307, Length=629, Percent_Identity=41.1764705882353, Blast_Score=481, Evalue=1e-137,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002985
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.19 [H]

Molecular weight: Translated: 72252; Mature: 72120

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAAKEGIKQKVRGWSHHDSADLYGIDDWGNGYFRISKKGEVTVRLNDEDGGKKDVSLCD
CCCHHHHHHHHHCCCCCCCCCCEEEECCCCCCEEEEECCCEEEEEECCCCCCCCHHHHHH
LLEGLKERGTTVPVLFRFRDLLRSRIAELNDSFRKAIKEAGYQGKYQGVYPIKVNQQRQV
HHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECHHHHH
VEEIAEFGTKYDYGLEAGSKPELIAAMAHMHNPNAYLICNGYKDDEFIDLALTAQKMGLN
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEHHHCCCE
IFIVLEMPSELDVILERARRMDIRPNLGVRVKLAAKGSGLWQESAGDKSVFGLNAAQVVD
EEEEEECCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEECCCHHHHHH
VVDKLKQVDALDCLKLLHYHQGSQIPNISVVREGLTEAVRIYVDLVKEGAPLGTLDMGGG
HHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCC
LAVDYDGSKTNFHSSCNYSIAEFARDVVEVVGDMCSKYGVPHPTLVTESGRAVVAYYSVL
EEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHH
VFNVLDVTSAPGEEPPPELPDDAPELLKAFADTDRTLARKNMQECYNDACYYRDQLRAQF
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCEEE
FYGNATLRQRGLGEAYYWHILSRISRMLAEMETIPEDLRELSCSMVDFYYGNFSLFQSLP
EECCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCC
DSWAIRQLFPVMPLHRLNERPTNKAVLADITCDCDGKIDHFIDREDVATALPLHAIKPGE
CHHHHHHHHHCCCHHHCCCCCCCCEEEEEEEECCCCCHHHHCCHHHHHHHCCCCCCCCCC
DDYYIGVFLVGAYQETLGDLHNLLGDTNVVGVHLEGGRPVYTHEVEGDTVSDVLSYVEYD
CCEEEEEEEEHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHCCC
PKELINKFRTFAEQAVAEGKISPSERRRALEVFRSGLNGYTYYEL
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEC
>Mature Secondary Structure 
AAAKEGIKQKVRGWSHHDSADLYGIDDWGNGYFRISKKGEVTVRLNDEDGGKKDVSLCD
CCHHHHHHHHHCCCCCCCCCCEEEECCCCCCEEEEECCCEEEEEECCCCCCCCHHHHHH
LLEGLKERGTTVPVLFRFRDLLRSRIAELNDSFRKAIKEAGYQGKYQGVYPIKVNQQRQV
HHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECHHHHH
VEEIAEFGTKYDYGLEAGSKPELIAAMAHMHNPNAYLICNGYKDDEFIDLALTAQKMGLN
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEHHHCCCE
IFIVLEMPSELDVILERARRMDIRPNLGVRVKLAAKGSGLWQESAGDKSVFGLNAAQVVD
EEEEEECCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEECCCHHHHHH
VVDKLKQVDALDCLKLLHYHQGSQIPNISVVREGLTEAVRIYVDLVKEGAPLGTLDMGGG
HHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCC
LAVDYDGSKTNFHSSCNYSIAEFARDVVEVVGDMCSKYGVPHPTLVTESGRAVVAYYSVL
EEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHH
VFNVLDVTSAPGEEPPPELPDDAPELLKAFADTDRTLARKNMQECYNDACYYRDQLRAQF
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCEEE
FYGNATLRQRGLGEAYYWHILSRISRMLAEMETIPEDLRELSCSMVDFYYGNFSLFQSLP
EECCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCC
DSWAIRQLFPVMPLHRLNERPTNKAVLADITCDCDGKIDHFIDREDVATALPLHAIKPGE
CHHHHHHHHHCCCHHHCCCCCCCCEEEEEEEECCCCCHHHHCCHHHHHHHCCCCCCCCCC
DDYYIGVFLVGAYQETLGDLHNLLGDTNVVGVHLEGGRPVYTHEVEGDTVSDVLSYVEYD
CCEEEEEEEEHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHCCC
PKELINKFRTFAEQAVAEGKISPSERRRALEVFRSGLNGYTYYEL
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292 [H]