Definition Akkermansia muciniphila ATCC BAA-835, complete genome.
Accession NC_010655
Length 2,664,102

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The map label for this gene is ilvB [H]

Identifier: 187736138

GI number: 187736138

Start: 1991873

End: 1993726

Strand: Direct

Name: ilvB [H]

Synonym: Amuc_1650

Alternate gene names: 187736138

Gene position: 1991873-1993726 (Clockwise)

Preceding gene: 187736137

Following gene: 187736139

Centisome position: 74.77

GC content: 57.23

Gene sequence:

>1854_bases
ATGAGCACAAACGACAAAACATCATCCGCCCCGACGAAAACCCGCATGACAGGAGCTGAAGTGCTCGTGGAATGCCTCGT
GCGTGAAGGTGTAGACGTCGTCTTTGCCTATCCTGGCGGCGCCAGCATGCCGATTCATCAGGCCCTGAGCCATCAGCCCA
AGATACGGACCATCCTGCCCCGCCATGAACAGGGCGGGGCATTCGGCGCGGAAGGCTATGGCCGCGTTACGGGCAAGGTG
GGCGTTTGCATTTCCACTTCCGGCCCCGGCGCCACCAACATGATTACCTCCATTGCGGATGCTTATCTGGACTCCACGCC
TCTGGTGGCGATTACGGCTCAGGTCATGCGCTCCTTGATTGGACGCGGCGCCTTCCAGGAAACAGACGTATTCGGCATGA
CCGCCCCTATCGTGAAGCACAGCTATCTGGTGACGGAACCGGAAGAACTGCCCCGTATCATCAAGGAAGCCTTCTACATC
GCTTCCACGGGCCGTCCGGGCCCTGTGCTGATTGACATGCCCAAGGACGTGCAGGAGGCCGTGTTCACACCGGACTTTGA
CATGGAGATGGATATTCCCGGCTACAACCCCGTGCTGCCCGTCCCTGCGGACAAGCTGGAAGAACTCATCCCGTTGATTG
AAAACGCCAGGCGGCCTGTCATTTACGCCGGCGGCGGCATCATTTCTGCGGAAGCTTCCGGGGATCTTCTGGAATTTGCG
GAACGTTCCCAGATTCCTGTGGCGACCACCCTGATGGGCATTGGCGCCATGCCGGAAACCCACCCTCTTTCCCTGCGTTG
GCTGGGCATGCACGGAGCCGTGTTTGCGAATAACGCCGTGAATGAAGCGGATCTGGTTATTGCCCTGGGCGCCCGGTTTG
ACGACCGCGTAACAGGCGCCGTCAATATGTTCTGTCCGGAATCCACGATCGTTCACATTGATATCGACGCCAGCGAGATC
AATAAAAACAAGAAGGTGGCGTATCCCATCCGCGCAAACGTGAAGGACGCCCTCCAGGTGCTCAACTCCGCTCTGGCCGC
AAAAGGCTGGGAGCGCAAATCCTCCGGCTACACCCGCACTCCTGAATGGTTCGGCGTGATTGACAGTTGGAAAAAACAGT
ACCCCTTCTCCTATGAGGACCGCAAGGGGTATATCGCCCCGCAGGCTGTCATTGAGGAGCTCTACCGCCAGACGGCGGAC
AAGGACCCCATCATCTGCACGGGGGTGGGCCAGCATCAGATGTTTGCCGCTCAATTCTTCAAATTTGACAAGCCCCGCCG
TCTGGCCACTTCCGGCGGTTTGGGAACCATGGGCTATGGACTTCCCGCCTCCATGGGAGCGTGCCTGGCTTATCCGGACA
GACTGGTCGTGAATATTGACGGGGACGGTTCCATGCTCATGAATATTCAGGAGCTGGCAACCATTCATGTGGAGCGTCTG
CCCGTCAAATGCATTATTCTGAACAACCAGCACCTGGGCATGGTGGTCCAATGGGAAGATTTGAAGTATGATTCCAACCG
GGCCCAAACCTTCCTGGCGGACCCGCACGACAATTATGATCCTACCCATAAAACGGAAGATGTCATCTACCCGAACTATC
CGCTTATTTGTGCCGGATTCGGCGTCAAGTGCGAGCGTGTGCTTCGCATAGAGGAGCTTCCGGCGGCTATCACCCGGATG
ATTGAATCCCCTGAGGCCTATGTCCTGGACGTCATGGTTCCCCATGATGTGCATGTGCTGCCGATGATTCTGGGGGGCAT
GAGCTACAAGGATGTGATTCTGGAACGTATTGCCGGGGATGGTTCCGCCAAAAAGGCGTCTGAACTGGGCAAGGAAATCC
CGACTGCCCTGTAA

Upstream 100 bases:

>100_bases
TTCTCCATGCCCTTCTTCCTTTTAAGGAAAAGGCTTCACATTGCGCCCGGAATGCGTTAGAACCTTTTTTCCTATTGAAC
AAATAAAATATTATTTGCAC

Downstream 100 bases:

>100_bases
GAGCGAGGCAAGCTTCTTCTATTGAGCCTTAAACAGGAGCCGTCCGTAAGGGCGGCTCCTGTTGCATGGCGGCGCAAGTG
GAATGCAGGTCAGTTGACTG

Product: acetolactate synthase, large subunit, biosynthetic type

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]

Number of amino acids: Translated: 617; Mature: 616

Protein sequence:

>617_residues
MSTNDKTSSAPTKTRMTGAEVLVECLVREGVDVVFAYPGGASMPIHQALSHQPKIRTILPRHEQGGAFGAEGYGRVTGKV
GVCISTSGPGATNMITSIADAYLDSTPLVAITAQVMRSLIGRGAFQETDVFGMTAPIVKHSYLVTEPEELPRIIKEAFYI
ASTGRPGPVLIDMPKDVQEAVFTPDFDMEMDIPGYNPVLPVPADKLEELIPLIENARRPVIYAGGGIISAEASGDLLEFA
ERSQIPVATTLMGIGAMPETHPLSLRWLGMHGAVFANNAVNEADLVIALGARFDDRVTGAVNMFCPESTIVHIDIDASEI
NKNKKVAYPIRANVKDALQVLNSALAAKGWERKSSGYTRTPEWFGVIDSWKKQYPFSYEDRKGYIAPQAVIEELYRQTAD
KDPIICTGVGQHQMFAAQFFKFDKPRRLATSGGLGTMGYGLPASMGACLAYPDRLVVNIDGDGSMLMNIQELATIHVERL
PVKCIILNNQHLGMVVQWEDLKYDSNRAQTFLADPHDNYDPTHKTEDVIYPNYPLICAGFGVKCERVLRIEELPAAITRM
IESPEAYVLDVMVPHDVHVLPMILGGMSYKDVILERIAGDGSAKKASELGKEIPTAL

Sequences:

>Translated_617_residues
MSTNDKTSSAPTKTRMTGAEVLVECLVREGVDVVFAYPGGASMPIHQALSHQPKIRTILPRHEQGGAFGAEGYGRVTGKV
GVCISTSGPGATNMITSIADAYLDSTPLVAITAQVMRSLIGRGAFQETDVFGMTAPIVKHSYLVTEPEELPRIIKEAFYI
ASTGRPGPVLIDMPKDVQEAVFTPDFDMEMDIPGYNPVLPVPADKLEELIPLIENARRPVIYAGGGIISAEASGDLLEFA
ERSQIPVATTLMGIGAMPETHPLSLRWLGMHGAVFANNAVNEADLVIALGARFDDRVTGAVNMFCPESTIVHIDIDASEI
NKNKKVAYPIRANVKDALQVLNSALAAKGWERKSSGYTRTPEWFGVIDSWKKQYPFSYEDRKGYIAPQAVIEELYRQTAD
KDPIICTGVGQHQMFAAQFFKFDKPRRLATSGGLGTMGYGLPASMGACLAYPDRLVVNIDGDGSMLMNIQELATIHVERL
PVKCIILNNQHLGMVVQWEDLKYDSNRAQTFLADPHDNYDPTHKTEDVIYPNYPLICAGFGVKCERVLRIEELPAAITRM
IESPEAYVLDVMVPHDVHVLPMILGGMSYKDVILERIAGDGSAKKASELGKEIPTAL
>Mature_616_residues
STNDKTSSAPTKTRMTGAEVLVECLVREGVDVVFAYPGGASMPIHQALSHQPKIRTILPRHEQGGAFGAEGYGRVTGKVG
VCISTSGPGATNMITSIADAYLDSTPLVAITAQVMRSLIGRGAFQETDVFGMTAPIVKHSYLVTEPEELPRIIKEAFYIA
STGRPGPVLIDMPKDVQEAVFTPDFDMEMDIPGYNPVLPVPADKLEELIPLIENARRPVIYAGGGIISAEASGDLLEFAE
RSQIPVATTLMGIGAMPETHPLSLRWLGMHGAVFANNAVNEADLVIALGARFDDRVTGAVNMFCPESTIVHIDIDASEIN
KNKKVAYPIRANVKDALQVLNSALAAKGWERKSSGYTRTPEWFGVIDSWKKQYPFSYEDRKGYIAPQAVIEELYRQTADK
DPIICTGVGQHQMFAAQFFKFDKPRRLATSGGLGTMGYGLPASMGACLAYPDRLVVNIDGDGSMLMNIQELATIHVERLP
VKCIILNNQHLGMVVQWEDLKYDSNRAQTFLADPHDNYDPTHKTEDVIYPNYPLICAGFGVKCERVLRIEELPAAITRMI
ESPEAYVLDVMVPHDVHVLPMILGGMSYKDVILERIAGDGSAKKASELGKEIPTAL

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=503, Percent_Identity=24.4532803180915, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI21361361, Length=519, Percent_Identity=22.5433526011561, Blast_Score=131, Evalue=2e-30,
Organism=Escherichia coli, GI87081685, Length=586, Percent_Identity=40.1023890784983, Blast_Score=439, Evalue=1e-124,
Organism=Escherichia coli, GI1790104, Length=598, Percent_Identity=40.8026755852843, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1786717, Length=572, Percent_Identity=32.5174825174825, Blast_Score=280, Evalue=3e-76,
Organism=Escherichia coli, GI1788716, Length=487, Percent_Identity=26.8993839835729, Blast_Score=165, Evalue=8e-42,
Organism=Escherichia coli, GI1787096, Length=577, Percent_Identity=24.9566724436742, Blast_Score=149, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17542570, Length=550, Percent_Identity=26.3636363636364, Blast_Score=156, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17531299, Length=581, Percent_Identity=25.3012048192771, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17531301, Length=581, Percent_Identity=25.3012048192771, Blast_Score=135, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6323755, Length=601, Percent_Identity=40.5990016638935, Blast_Score=424, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6321524, Length=512, Percent_Identity=22.8515625, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323073, Length=513, Percent_Identity=23.1968810916179, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6320816, Length=495, Percent_Identity=23.4343434343434, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323163, Length=498, Percent_Identity=24.0963855421687, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19922626, Length=557, Percent_Identity=23.8779174147217, Blast_Score=139, Evalue=8e-33,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 67308; Mature: 67177

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTNDKTSSAPTKTRMTGAEVLVECLVREGVDVVFAYPGGASMPIHQALSHQPKIRTILP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHCCCCCEEEECC
RHEQGGAFGAEGYGRVTGKVGVCISTSGPGATNMITSIADAYLDSTPLVAITAQVMRSLI
CCCCCCCCCCCCCCEEECEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
GRGAFQETDVFGMTAPIVKHSYLVTEPEELPRIIKEAFYIASTGRPGPVLIDMPKDVQEA
CCCCCCCCCCCCCCHHHHHCCEEEECHHHHHHHHHHHHEEEECCCCCCEEEECCCHHHHH
VFTPDFDMEMDIPGYNPVLPVPADKLEELIPLIENARRPVIYAGGGIISAEASGDLLEFA
HCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCHHHHHH
ERSQIPVATTLMGIGAMPETHPLSLRWLGMHGAVFANNAVNEADLVIALGARFDDRVTGA
HHCCCCHHHHHHHCCCCCCCCCCEEEEEECCCEEEECCCCCCCEEEEEECCCCCCCCCCE
VNMFCPESTIVHIDIDASEINKNKKVAYPIRANVKDALQVLNSALAAKGWERKSSGYTRT
EEEECCCCEEEEEECCHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
PEWFGVIDSWKKQYPFSYEDRKGYIAPQAVIEELYRQTADKDPIICTGVGQHQMFAAQFF
CHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHH
KFDKPRRLATSGGLGTMGYGLPASMGACLAYPDRLVVNIDGDGSMLMNIQELATIHVERL
HCCCCCCEECCCCCCCCCCCCCHHCCHHEECCCEEEEEECCCCCEEEEHHHHHHHHHCCC
PVKCIILNNQHLGMVVQWEDLKYDSNRAQTFLADPHDNYDPTHKTEDVIYPNYPLICAGF
CEEEEEECCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCEECCCCCEEEECC
GVKCERVLRIEELPAAITRMIESPEAYVLDVMVPHDVHVLPMILGGMSYKDVILERIAGD
CCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHCCC
GSAKKASELGKEIPTAL
CCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
STNDKTSSAPTKTRMTGAEVLVECLVREGVDVVFAYPGGASMPIHQALSHQPKIRTILP
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHCCCCCEEEECC
RHEQGGAFGAEGYGRVTGKVGVCISTSGPGATNMITSIADAYLDSTPLVAITAQVMRSLI
CCCCCCCCCCCCCCEEECEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
GRGAFQETDVFGMTAPIVKHSYLVTEPEELPRIIKEAFYIASTGRPGPVLIDMPKDVQEA
CCCCCCCCCCCCCCHHHHHCCEEEECHHHHHHHHHHHHEEEECCCCCCEEEECCCHHHHH
VFTPDFDMEMDIPGYNPVLPVPADKLEELIPLIENARRPVIYAGGGIISAEASGDLLEFA
HCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCHHHHHH
ERSQIPVATTLMGIGAMPETHPLSLRWLGMHGAVFANNAVNEADLVIALGARFDDRVTGA
HHCCCCHHHHHHHCCCCCCCCCCEEEEEECCCEEEECCCCCCCEEEEEECCCCCCCCCCE
VNMFCPESTIVHIDIDASEINKNKKVAYPIRANVKDALQVLNSALAAKGWERKSSGYTRT
EEEECCCCEEEEEECCHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
PEWFGVIDSWKKQYPFSYEDRKGYIAPQAVIEELYRQTADKDPIICTGVGQHQMFAAQFF
CHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHH
KFDKPRRLATSGGLGTMGYGLPASMGACLAYPDRLVVNIDGDGSMLMNIQELATIHVERL
HCCCCCCEECCCCCCCCCCCCCHHCCHHEECCCEEEEEECCCCCEEEEHHHHHHHHHCCC
PVKCIILNNQHLGMVVQWEDLKYDSNRAQTFLADPHDNYDPTHKTEDVIYPNYPLICAGF
CEEEEEECCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCEECCCCCEEEECC
GVKCERVLRIEELPAAITRMIESPEAYVLDVMVPHDVHVLPMILGGMSYKDVILERIAGD
CCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHCCC
GSAKKASELGKEIPTAL
CCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8366043; 12948626 [H]