Definition | Akkermansia muciniphila ATCC BAA-835, complete genome. |
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Accession | NC_010655 |
Length | 2,664,102 |
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The map label for this gene is ilvB [H]
Identifier: 187736138
GI number: 187736138
Start: 1991873
End: 1993726
Strand: Direct
Name: ilvB [H]
Synonym: Amuc_1650
Alternate gene names: 187736138
Gene position: 1991873-1993726 (Clockwise)
Preceding gene: 187736137
Following gene: 187736139
Centisome position: 74.77
GC content: 57.23
Gene sequence:
>1854_bases ATGAGCACAAACGACAAAACATCATCCGCCCCGACGAAAACCCGCATGACAGGAGCTGAAGTGCTCGTGGAATGCCTCGT GCGTGAAGGTGTAGACGTCGTCTTTGCCTATCCTGGCGGCGCCAGCATGCCGATTCATCAGGCCCTGAGCCATCAGCCCA AGATACGGACCATCCTGCCCCGCCATGAACAGGGCGGGGCATTCGGCGCGGAAGGCTATGGCCGCGTTACGGGCAAGGTG GGCGTTTGCATTTCCACTTCCGGCCCCGGCGCCACCAACATGATTACCTCCATTGCGGATGCTTATCTGGACTCCACGCC TCTGGTGGCGATTACGGCTCAGGTCATGCGCTCCTTGATTGGACGCGGCGCCTTCCAGGAAACAGACGTATTCGGCATGA CCGCCCCTATCGTGAAGCACAGCTATCTGGTGACGGAACCGGAAGAACTGCCCCGTATCATCAAGGAAGCCTTCTACATC GCTTCCACGGGCCGTCCGGGCCCTGTGCTGATTGACATGCCCAAGGACGTGCAGGAGGCCGTGTTCACACCGGACTTTGA CATGGAGATGGATATTCCCGGCTACAACCCCGTGCTGCCCGTCCCTGCGGACAAGCTGGAAGAACTCATCCCGTTGATTG AAAACGCCAGGCGGCCTGTCATTTACGCCGGCGGCGGCATCATTTCTGCGGAAGCTTCCGGGGATCTTCTGGAATTTGCG GAACGTTCCCAGATTCCTGTGGCGACCACCCTGATGGGCATTGGCGCCATGCCGGAAACCCACCCTCTTTCCCTGCGTTG GCTGGGCATGCACGGAGCCGTGTTTGCGAATAACGCCGTGAATGAAGCGGATCTGGTTATTGCCCTGGGCGCCCGGTTTG ACGACCGCGTAACAGGCGCCGTCAATATGTTCTGTCCGGAATCCACGATCGTTCACATTGATATCGACGCCAGCGAGATC AATAAAAACAAGAAGGTGGCGTATCCCATCCGCGCAAACGTGAAGGACGCCCTCCAGGTGCTCAACTCCGCTCTGGCCGC AAAAGGCTGGGAGCGCAAATCCTCCGGCTACACCCGCACTCCTGAATGGTTCGGCGTGATTGACAGTTGGAAAAAACAGT ACCCCTTCTCCTATGAGGACCGCAAGGGGTATATCGCCCCGCAGGCTGTCATTGAGGAGCTCTACCGCCAGACGGCGGAC AAGGACCCCATCATCTGCACGGGGGTGGGCCAGCATCAGATGTTTGCCGCTCAATTCTTCAAATTTGACAAGCCCCGCCG TCTGGCCACTTCCGGCGGTTTGGGAACCATGGGCTATGGACTTCCCGCCTCCATGGGAGCGTGCCTGGCTTATCCGGACA GACTGGTCGTGAATATTGACGGGGACGGTTCCATGCTCATGAATATTCAGGAGCTGGCAACCATTCATGTGGAGCGTCTG CCCGTCAAATGCATTATTCTGAACAACCAGCACCTGGGCATGGTGGTCCAATGGGAAGATTTGAAGTATGATTCCAACCG GGCCCAAACCTTCCTGGCGGACCCGCACGACAATTATGATCCTACCCATAAAACGGAAGATGTCATCTACCCGAACTATC CGCTTATTTGTGCCGGATTCGGCGTCAAGTGCGAGCGTGTGCTTCGCATAGAGGAGCTTCCGGCGGCTATCACCCGGATG ATTGAATCCCCTGAGGCCTATGTCCTGGACGTCATGGTTCCCCATGATGTGCATGTGCTGCCGATGATTCTGGGGGGCAT GAGCTACAAGGATGTGATTCTGGAACGTATTGCCGGGGATGGTTCCGCCAAAAAGGCGTCTGAACTGGGCAAGGAAATCC CGACTGCCCTGTAA
Upstream 100 bases:
>100_bases TTCTCCATGCCCTTCTTCCTTTTAAGGAAAAGGCTTCACATTGCGCCCGGAATGCGTTAGAACCTTTTTTCCTATTGAAC AAATAAAATATTATTTGCAC
Downstream 100 bases:
>100_bases GAGCGAGGCAAGCTTCTTCTATTGAGCCTTAAACAGGAGCCGTCCGTAAGGGCGGCTCCTGTTGCATGGCGGCGCAAGTG GAATGCAGGTCAGTTGACTG
Product: acetolactate synthase, large subunit, biosynthetic type
Products: NA
Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]
Number of amino acids: Translated: 617; Mature: 616
Protein sequence:
>617_residues MSTNDKTSSAPTKTRMTGAEVLVECLVREGVDVVFAYPGGASMPIHQALSHQPKIRTILPRHEQGGAFGAEGYGRVTGKV GVCISTSGPGATNMITSIADAYLDSTPLVAITAQVMRSLIGRGAFQETDVFGMTAPIVKHSYLVTEPEELPRIIKEAFYI ASTGRPGPVLIDMPKDVQEAVFTPDFDMEMDIPGYNPVLPVPADKLEELIPLIENARRPVIYAGGGIISAEASGDLLEFA ERSQIPVATTLMGIGAMPETHPLSLRWLGMHGAVFANNAVNEADLVIALGARFDDRVTGAVNMFCPESTIVHIDIDASEI NKNKKVAYPIRANVKDALQVLNSALAAKGWERKSSGYTRTPEWFGVIDSWKKQYPFSYEDRKGYIAPQAVIEELYRQTAD KDPIICTGVGQHQMFAAQFFKFDKPRRLATSGGLGTMGYGLPASMGACLAYPDRLVVNIDGDGSMLMNIQELATIHVERL PVKCIILNNQHLGMVVQWEDLKYDSNRAQTFLADPHDNYDPTHKTEDVIYPNYPLICAGFGVKCERVLRIEELPAAITRM IESPEAYVLDVMVPHDVHVLPMILGGMSYKDVILERIAGDGSAKKASELGKEIPTAL
Sequences:
>Translated_617_residues MSTNDKTSSAPTKTRMTGAEVLVECLVREGVDVVFAYPGGASMPIHQALSHQPKIRTILPRHEQGGAFGAEGYGRVTGKV GVCISTSGPGATNMITSIADAYLDSTPLVAITAQVMRSLIGRGAFQETDVFGMTAPIVKHSYLVTEPEELPRIIKEAFYI ASTGRPGPVLIDMPKDVQEAVFTPDFDMEMDIPGYNPVLPVPADKLEELIPLIENARRPVIYAGGGIISAEASGDLLEFA ERSQIPVATTLMGIGAMPETHPLSLRWLGMHGAVFANNAVNEADLVIALGARFDDRVTGAVNMFCPESTIVHIDIDASEI NKNKKVAYPIRANVKDALQVLNSALAAKGWERKSSGYTRTPEWFGVIDSWKKQYPFSYEDRKGYIAPQAVIEELYRQTAD KDPIICTGVGQHQMFAAQFFKFDKPRRLATSGGLGTMGYGLPASMGACLAYPDRLVVNIDGDGSMLMNIQELATIHVERL PVKCIILNNQHLGMVVQWEDLKYDSNRAQTFLADPHDNYDPTHKTEDVIYPNYPLICAGFGVKCERVLRIEELPAAITRM IESPEAYVLDVMVPHDVHVLPMILGGMSYKDVILERIAGDGSAKKASELGKEIPTAL >Mature_616_residues STNDKTSSAPTKTRMTGAEVLVECLVREGVDVVFAYPGGASMPIHQALSHQPKIRTILPRHEQGGAFGAEGYGRVTGKVG VCISTSGPGATNMITSIADAYLDSTPLVAITAQVMRSLIGRGAFQETDVFGMTAPIVKHSYLVTEPEELPRIIKEAFYIA STGRPGPVLIDMPKDVQEAVFTPDFDMEMDIPGYNPVLPVPADKLEELIPLIENARRPVIYAGGGIISAEASGDLLEFAE RSQIPVATTLMGIGAMPETHPLSLRWLGMHGAVFANNAVNEADLVIALGARFDDRVTGAVNMFCPESTIVHIDIDASEIN KNKKVAYPIRANVKDALQVLNSALAAKGWERKSSGYTRTPEWFGVIDSWKKQYPFSYEDRKGYIAPQAVIEELYRQTADK DPIICTGVGQHQMFAAQFFKFDKPRRLATSGGLGTMGYGLPASMGACLAYPDRLVVNIDGDGSMLMNIQELATIHVERLP VKCIILNNQHLGMVVQWEDLKYDSNRAQTFLADPHDNYDPTHKTEDVIYPNYPLICAGFGVKCERVLRIEELPAAITRMI ESPEAYVLDVMVPHDVHVLPMILGGMSYKDVILERIAGDGSAKKASELGKEIPTAL
Specific function: Valine and isoleucine biosynthesis; first step. [C]
COG id: COG0028
COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the TPP enzyme family [H]
Homologues:
Organism=Homo sapiens, GI93004078, Length=503, Percent_Identity=24.4532803180915, Blast_Score=138, Evalue=2e-32, Organism=Homo sapiens, GI21361361, Length=519, Percent_Identity=22.5433526011561, Blast_Score=131, Evalue=2e-30, Organism=Escherichia coli, GI87081685, Length=586, Percent_Identity=40.1023890784983, Blast_Score=439, Evalue=1e-124, Organism=Escherichia coli, GI1790104, Length=598, Percent_Identity=40.8026755852843, Blast_Score=436, Evalue=1e-123, Organism=Escherichia coli, GI1786717, Length=572, Percent_Identity=32.5174825174825, Blast_Score=280, Evalue=3e-76, Organism=Escherichia coli, GI1788716, Length=487, Percent_Identity=26.8993839835729, Blast_Score=165, Evalue=8e-42, Organism=Escherichia coli, GI1787096, Length=577, Percent_Identity=24.9566724436742, Blast_Score=149, Evalue=4e-37, Organism=Caenorhabditis elegans, GI17542570, Length=550, Percent_Identity=26.3636363636364, Blast_Score=156, Evalue=3e-38, Organism=Caenorhabditis elegans, GI17531299, Length=581, Percent_Identity=25.3012048192771, Blast_Score=135, Evalue=5e-32, Organism=Caenorhabditis elegans, GI17531301, Length=581, Percent_Identity=25.3012048192771, Blast_Score=135, Evalue=5e-32, Organism=Saccharomyces cerevisiae, GI6323755, Length=601, Percent_Identity=40.5990016638935, Blast_Score=424, Evalue=1e-119, Organism=Saccharomyces cerevisiae, GI6321524, Length=512, Percent_Identity=22.8515625, Blast_Score=96, Evalue=2e-20, Organism=Saccharomyces cerevisiae, GI6323073, Length=513, Percent_Identity=23.1968810916179, Blast_Score=91, Evalue=5e-19, Organism=Saccharomyces cerevisiae, GI6320816, Length=495, Percent_Identity=23.4343434343434, Blast_Score=89, Evalue=3e-18, Organism=Saccharomyces cerevisiae, GI6323163, Length=498, Percent_Identity=24.0963855421687, Blast_Score=86, Evalue=2e-17, Organism=Drosophila melanogaster, GI19922626, Length=557, Percent_Identity=23.8779174147217, Blast_Score=139, Evalue=8e-33,
Paralogues:
None
Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012846 - InterPro: IPR012000 - InterPro: IPR012001 - InterPro: IPR000399 - InterPro: IPR011766 [H]
Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]
EC number: =2.2.1.6 [H]
Molecular weight: Translated: 67308; Mature: 67177
Theoretical pI: Translated: 5.19; Mature: 5.19
Prosite motif: PS00187 TPP_ENZYMES
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.3 %Cys (Translated Protein) 3.7 %Met (Translated Protein) 5.0 %Cys+Met (Translated Protein) 1.3 %Cys (Mature Protein) 3.6 %Met (Mature Protein) 4.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSTNDKTSSAPTKTRMTGAEVLVECLVREGVDVVFAYPGGASMPIHQALSHQPKIRTILP CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHCCCCCEEEECC RHEQGGAFGAEGYGRVTGKVGVCISTSGPGATNMITSIADAYLDSTPLVAITAQVMRSLI CCCCCCCCCCCCCCEEECEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH GRGAFQETDVFGMTAPIVKHSYLVTEPEELPRIIKEAFYIASTGRPGPVLIDMPKDVQEA CCCCCCCCCCCCCCHHHHHCCEEEECHHHHHHHHHHHHEEEECCCCCCEEEECCCHHHHH VFTPDFDMEMDIPGYNPVLPVPADKLEELIPLIENARRPVIYAGGGIISAEASGDLLEFA HCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCHHHHHH ERSQIPVATTLMGIGAMPETHPLSLRWLGMHGAVFANNAVNEADLVIALGARFDDRVTGA HHCCCCHHHHHHHCCCCCCCCCCEEEEEECCCEEEECCCCCCCEEEEEECCCCCCCCCCE VNMFCPESTIVHIDIDASEINKNKKVAYPIRANVKDALQVLNSALAAKGWERKSSGYTRT EEEECCCCEEEEEECCHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCC PEWFGVIDSWKKQYPFSYEDRKGYIAPQAVIEELYRQTADKDPIICTGVGQHQMFAAQFF CHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHH KFDKPRRLATSGGLGTMGYGLPASMGACLAYPDRLVVNIDGDGSMLMNIQELATIHVERL HCCCCCCEECCCCCCCCCCCCCHHCCHHEECCCEEEEEECCCCCEEEEHHHHHHHHHCCC PVKCIILNNQHLGMVVQWEDLKYDSNRAQTFLADPHDNYDPTHKTEDVIYPNYPLICAGF CEEEEEECCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCEECCCCCEEEECC GVKCERVLRIEELPAAITRMIESPEAYVLDVMVPHDVHVLPMILGGMSYKDVILERIAGD CCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHCCC GSAKKASELGKEIPTAL CCHHHHHHHHHHCCCCC >Mature Secondary Structure STNDKTSSAPTKTRMTGAEVLVECLVREGVDVVFAYPGGASMPIHQALSHQPKIRTILP CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHCCCCCEEEECC RHEQGGAFGAEGYGRVTGKVGVCISTSGPGATNMITSIADAYLDSTPLVAITAQVMRSLI CCCCCCCCCCCCCCEEECEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH GRGAFQETDVFGMTAPIVKHSYLVTEPEELPRIIKEAFYIASTGRPGPVLIDMPKDVQEA CCCCCCCCCCCCCCHHHHHCCEEEECHHHHHHHHHHHHEEEECCCCCCEEEECCCHHHHH VFTPDFDMEMDIPGYNPVLPVPADKLEELIPLIENARRPVIYAGGGIISAEASGDLLEFA HCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCHHHHHH ERSQIPVATTLMGIGAMPETHPLSLRWLGMHGAVFANNAVNEADLVIALGARFDDRVTGA HHCCCCHHHHHHHCCCCCCCCCCEEEEEECCCEEEECCCCCCCEEEEEECCCCCCCCCCE VNMFCPESTIVHIDIDASEINKNKKVAYPIRANVKDALQVLNSALAAKGWERKSSGYTRT EEEECCCCEEEEEECCHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCC PEWFGVIDSWKKQYPFSYEDRKGYIAPQAVIEELYRQTADKDPIICTGVGQHQMFAAQFF CHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHH KFDKPRRLATSGGLGTMGYGLPASMGACLAYPDRLVVNIDGDGSMLMNIQELATIHVERL HCCCCCCEECCCCCCCCCCCCCHHCCHHEECCCEEEEEECCCCCEEEEHHHHHHHHHCCC PVKCIILNNQHLGMVVQWEDLKYDSNRAQTFLADPHDNYDPTHKTEDVIYPNYPLICAGF CEEEEEECCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCEECCCCCEEEECC GVKCERVLRIEELPAAITRMIESPEAYVLDVMVPHDVHVLPMILGGMSYKDVILERIAGD CCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHCCC GSAKKASELGKEIPTAL CCHHHHHHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8366043; 12948626 [H]