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The map label for this gene is glyA [H]

Identifier: 187736119

GI number: 187736119

Start: 1963498

End: 1965198

Strand: Reverse

Name: glyA [H]

Synonym: Amuc_1630

Alternate gene names: 187736119

Gene position: 1965198-1963498 (Counterclockwise)

Preceding gene: 187736120

Following gene: 187736113

Centisome position: 73.77

GC content: 58.79

Gene sequence:

>1701_bases
ATGAGCACCACCATGAATACGACATACAAAATTGCCATCGGCGCGGATCACGCCGGAGTCGATCTCAAGGAAACCGTAGC
AGAACTCCTCAAGGCATGGGGTCATGAAGTGACCGACATGGGAACCATGACCAAAAATTCCTGTGATTATTCCGACTACG
CCAATGCAGTCGCAAGCAGCATTGCTGACGGCACCAACGACCGCGGCATCCTTATCTGCCGGTCCGGCATCGGCATGAGC
ATTGCCGCCAACCGCTGGGTGGGCGTCCGCGCCGCCCTCTGCCGCACGGCCCCTGCTGCGGCCCTTTCCCGCCAGCACAA
TGATTCCAACCTGCTCTGCCTGGCTTCCGCCTATGTGGACAATGAAAGTGTGGAAGACGTCCTGGACGCCTGGCTGCATG
CTGACTTTGAAGGCGGACGCCATGAACGCCGCGTCGTTAAATCCTCCGGTAGCCCCCTGCAATGGACGGACCCGGAACTG
GCGGGCCTCATCCAGGAGGAAGGACGCCGGGAAAGCAACAACATTGAGCTGATTGCCTCCGAAAATTTCACCTCTCCCTC
CGTCCGGGAAGCCCAGGGCTCCCTGCTGACCAACAAATACGCGGAAGGCTATCCCGGCAAGCGCTGGTATGGCGGTTGCG
AGGTGGTGGACAAAGTGGAACAGCTCGCCATTGACCGCGTGCTGAAAATTTTCGGCGGGGATCATGCCAACGTGCAGCCC
CACTCCGGTTCCCAGGCCAACATGGCCGTTTACTTCTCTGTTCTGAAGCCGGGCGACACCATTCTCACGATGGATCTCTC
CCACGGCGGCCACCTCACCCACGGACACCGGGCCAACTTCTCCGGCAAACTGTACAATGTGGTTCACTACGGCGTATCCC
AGGAAACGGAAGCTATTGACTATGATGCTTTGGAAAAACTGGCTCTGGAGGTAAAGCCGCAAATGATCACGGCGGGAGCA
AGCGCCTACTCACGCACAATCGACTTTGAACGCATGGGCCAGATTGCCAGGGCCTGCGGTGCCTACCTGTTCGTGGACAT
GGCCCACATCGCGGGCCTGGTGGCCGGGGGGCAGCACCCGAATCCGGTTCCCCATGCGGACTTCGTCTCCTCCACCACGC
ATAAATCCCTGCGCGGCCCCCGCGGCGGCTTCGTCATCTGCAAGGAGGAATACGCCAAAAAACTGGATGCAGCCGTCTTC
CCCGGAATGCAGGGCGGCCCCCTCATGCACATCATTGCCGCCAAGGCGGCCTGTTTCGGAGAAGCTCTGAAGCCCGAATT
CAAGGACTATGCGGCCCAGGTTGTCAAAAACGCCAAGGCCATGGCGGCCAAAATGGCGGAACTCGGCTTCCGCGTCGTCT
CCAACGGTACGGACAACCACGTATTCATGGTAGACCTCCGCAACAAAGGCATTAACGGTGCAGATGCGCAGGAAGCCCTG
GACCGCGTAGGCATCACCGTAAACAAGAACGCCATCCCGTTTGACACGGGTTCTCCCATGAAACCTTCCGGCATCCGCAT
CGGTACGCCTGCCGTAACCACTCGCGGCATGAAGGAAAAAGACGTGGAACAGGTGGCTGAATTCATTGCGCGTGCGCTGG
CCTTGTACGTAGGTGACCAGGTATGCCCGAATCCGGAAGGCTTCTCCCAGCTTAAGGAAGAAGTTTCCGCGTTTAACCGC
AACTTCCGCCTGCCTCATTAA

Upstream 100 bases:

>100_bases
TTCCGAGGCAATTCCGGGAGCCGTGCCTCCCGAACAGCCCGAAATGAATCCGGGGCTTGCCAGCCGGAGGGAAATAAGGC
AGTATTTTTGCCCGTCAGCA

Downstream 100 bases:

>100_bases
CATCTCCTGCGTATAAACGCTTTTCAGGCCGTTCCGCCTTTACCGCGGAACGGCCTTTTCATCAAAAATCCGTATTTACG
GCCCCCGATACGCGCGGCCA

Product: sugar-phosphate isomerase, RpiB/LacA/LacB family

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 566; Mature: 565

Protein sequence:

>566_residues
MSTTMNTTYKIAIGADHAGVDLKETVAELLKAWGHEVTDMGTMTKNSCDYSDYANAVASSIADGTNDRGILICRSGIGMS
IAANRWVGVRAALCRTAPAAALSRQHNDSNLLCLASAYVDNESVEDVLDAWLHADFEGGRHERRVVKSSGSPLQWTDPEL
AGLIQEEGRRESNNIELIASENFTSPSVREAQGSLLTNKYAEGYPGKRWYGGCEVVDKVEQLAIDRVLKIFGGDHANVQP
HSGSQANMAVYFSVLKPGDTILTMDLSHGGHLTHGHRANFSGKLYNVVHYGVSQETEAIDYDALEKLALEVKPQMITAGA
SAYSRTIDFERMGQIARACGAYLFVDMAHIAGLVAGGQHPNPVPHADFVSSTTHKSLRGPRGGFVICKEEYAKKLDAAVF
PGMQGGPLMHIIAAKAACFGEALKPEFKDYAAQVVKNAKAMAAKMAELGFRVVSNGTDNHVFMVDLRNKGINGADAQEAL
DRVGITVNKNAIPFDTGSPMKPSGIRIGTPAVTTRGMKEKDVEQVAEFIARALALYVGDQVCPNPEGFSQLKEEVSAFNR
NFRLPH

Sequences:

>Translated_566_residues
MSTTMNTTYKIAIGADHAGVDLKETVAELLKAWGHEVTDMGTMTKNSCDYSDYANAVASSIADGTNDRGILICRSGIGMS
IAANRWVGVRAALCRTAPAAALSRQHNDSNLLCLASAYVDNESVEDVLDAWLHADFEGGRHERRVVKSSGSPLQWTDPEL
AGLIQEEGRRESNNIELIASENFTSPSVREAQGSLLTNKYAEGYPGKRWYGGCEVVDKVEQLAIDRVLKIFGGDHANVQP
HSGSQANMAVYFSVLKPGDTILTMDLSHGGHLTHGHRANFSGKLYNVVHYGVSQETEAIDYDALEKLALEVKPQMITAGA
SAYSRTIDFERMGQIARACGAYLFVDMAHIAGLVAGGQHPNPVPHADFVSSTTHKSLRGPRGGFVICKEEYAKKLDAAVF
PGMQGGPLMHIIAAKAACFGEALKPEFKDYAAQVVKNAKAMAAKMAELGFRVVSNGTDNHVFMVDLRNKGINGADAQEAL
DRVGITVNKNAIPFDTGSPMKPSGIRIGTPAVTTRGMKEKDVEQVAEFIARALALYVGDQVCPNPEGFSQLKEEVSAFNR
NFRLPH
>Mature_565_residues
STTMNTTYKIAIGADHAGVDLKETVAELLKAWGHEVTDMGTMTKNSCDYSDYANAVASSIADGTNDRGILICRSGIGMSI
AANRWVGVRAALCRTAPAAALSRQHNDSNLLCLASAYVDNESVEDVLDAWLHADFEGGRHERRVVKSSGSPLQWTDPELA
GLIQEEGRRESNNIELIASENFTSPSVREAQGSLLTNKYAEGYPGKRWYGGCEVVDKVEQLAIDRVLKIFGGDHANVQPH
SGSQANMAVYFSVLKPGDTILTMDLSHGGHLTHGHRANFSGKLYNVVHYGVSQETEAIDYDALEKLALEVKPQMITAGAS
AYSRTIDFERMGQIARACGAYLFVDMAHIAGLVAGGQHPNPVPHADFVSSTTHKSLRGPRGGFVICKEEYAKKLDAAVFP
GMQGGPLMHIIAAKAACFGEALKPEFKDYAAQVVKNAKAMAAKMAELGFRVVSNGTDNHVFMVDLRNKGINGADAQEALD
RVGITVNKNAIPFDTGSPMKPSGIRIGTPAVTTRGMKEKDVEQVAEFIARALALYVGDQVCPNPEGFSQLKEEVSAFNRN
FRLPH

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI261862352, Length=452, Percent_Identity=42.2566371681416, Blast_Score=352, Evalue=8e-97,
Organism=Homo sapiens, GI261862350, Length=452, Percent_Identity=42.2566371681416, Blast_Score=352, Evalue=8e-97,
Organism=Homo sapiens, GI261862348, Length=452, Percent_Identity=42.2566371681416, Blast_Score=352, Evalue=8e-97,
Organism=Homo sapiens, GI19923315, Length=449, Percent_Identity=42.3162583518931, Blast_Score=351, Evalue=9e-97,
Organism=Homo sapiens, GI261862346, Length=445, Percent_Identity=41.7977528089888, Blast_Score=338, Evalue=1e-92,
Organism=Homo sapiens, GI22547186, Length=460, Percent_Identity=41.304347826087, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI22547189, Length=445, Percent_Identity=40.2247191011236, Blast_Score=303, Evalue=2e-82,
Organism=Escherichia coli, GI1788902, Length=380, Percent_Identity=61.0526315789474, Blast_Score=457, Evalue=1e-129,
Organism=Escherichia coli, GI1790528, Length=136, Percent_Identity=48.5294117647059, Blast_Score=130, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI25144732, Length=400, Percent_Identity=44.75, Blast_Score=350, Evalue=8e-97,
Organism=Caenorhabditis elegans, GI25144729, Length=400, Percent_Identity=44.75, Blast_Score=350, Evalue=1e-96,
Organism=Saccharomyces cerevisiae, GI6323087, Length=404, Percent_Identity=45.5445544554455, Blast_Score=360, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6319739, Length=423, Percent_Identity=43.7352245862884, Blast_Score=359, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24640005, Length=455, Percent_Identity=43.956043956044, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI221329721, Length=455, Percent_Identity=43.956043956044, Blast_Score=371, Evalue=1e-103,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 61102; Mature: 60971

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTMNTTYKIAIGADHAGVDLKETVAELLKAWGHEVTDMGTMTKNSCDYSDYANAVASS
CCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHH
IADGTNDRGILICRSGIGMSIAANRWVGVRAALCRTAPAAALSRQHNDSNLLCLASAYVD
HCCCCCCCEEEEEECCCCCEEECCCCHHHHHHHHHCCHHHHHHCCCCCCCEEEEEEECCC
NESVEDVLDAWLHADFEGGRHERRVVKSSGSPLQWTDPELAGLIQEEGRRESNNIELIAS
CCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEC
ENFTSPSVREAQGSLLTNKYAEGYPGKRWYGGCEVVDKVEQLAIDRVLKIFGGDHANVQP
CCCCCCCHHHHHCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
HSGSQANMAVYFSVLKPGDTILTMDLSHGGHLTHGHRANFSGKLYNVVHYGVSQETEAID
CCCCCCCEEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCC
YDALEKLALEVKPQMITAGASAYSRTIDFERMGQIARACGAYLFVDMAHIAGLVAGGQHP
HHHHHHHHHHCCCHHEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NPVPHADFVSSTTHKSLRGPRGGFVICKEEYAKKLDAAVFPGMQGGPLMHIIAAKAACFG
CCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
EALKPEFKDYAAQVVKNAKAMAAKMAELGFRVVSNGTDNHVFMVDLRNKGINGADAQEAL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEEEECCCCCCCCCHHHHH
DRVGITVNKNAIPFDTGSPMKPSGIRIGTPAVTTRGMKEKDVEQVAEFIARALALYVGDQ
HHCCEEECCCCCCCCCCCCCCCCCEEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
VCPNPEGFSQLKEEVSAFNRNFRLPH
CCCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
STTMNTTYKIAIGADHAGVDLKETVAELLKAWGHEVTDMGTMTKNSCDYSDYANAVASS
CCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHH
IADGTNDRGILICRSGIGMSIAANRWVGVRAALCRTAPAAALSRQHNDSNLLCLASAYVD
HCCCCCCCEEEEEECCCCCEEECCCCHHHHHHHHHCCHHHHHHCCCCCCCEEEEEEECCC
NESVEDVLDAWLHADFEGGRHERRVVKSSGSPLQWTDPELAGLIQEEGRRESNNIELIAS
CCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEC
ENFTSPSVREAQGSLLTNKYAEGYPGKRWYGGCEVVDKVEQLAIDRVLKIFGGDHANVQP
CCCCCCCHHHHHCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
HSGSQANMAVYFSVLKPGDTILTMDLSHGGHLTHGHRANFSGKLYNVVHYGVSQETEAID
CCCCCCCEEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCC
YDALEKLALEVKPQMITAGASAYSRTIDFERMGQIARACGAYLFVDMAHIAGLVAGGQHP
HHHHHHHHHHCCCHHEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NPVPHADFVSSTTHKSLRGPRGGFVICKEEYAKKLDAAVFPGMQGGPLMHIIAAKAACFG
CCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
EALKPEFKDYAAQVVKNAKAMAAKMAELGFRVVSNGTDNHVFMVDLRNKGINGADAQEAL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEEEECCCCCCCCCHHHHH
DRVGITVNKNAIPFDTGSPMKPSGIRIGTPAVTTRGMKEKDVEQVAEFIARALALYVGDQ
HHCCEEECCCCCCCCCCCCCCCCCEEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
VCPNPEGFSQLKEEVSAFNRNFRLPH
CCCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]