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The map label for this gene is yugK [H]

Identifier: 187736056

GI number: 187736056

Start: 1890176

End: 1891363

Strand: Reverse

Name: yugK [H]

Synonym: Amuc_1566

Alternate gene names: 187736056

Gene position: 1891363-1890176 (Counterclockwise)

Preceding gene: 187736058

Following gene: 187736055

Centisome position: 70.99

GC content: 57.07

Gene sequence:

>1188_bases
ATGCTCAATTTCGTTTACGATAACAAAACCACTCTTATTTTCGGAAAAGGCACCCACCATGAAACGGGAACCCTTCTCAA
GCCGTTAGGCAAAAAAATCCTGCTTCATTACGGTAGCGGCAGCATCAGACGTTCCGGTCTTTACGATGCCGTCACGGCGT
CCTTAAAAGCCGCCGGCGTGGAGTATGAAGAACTGGGAGGCGTCCAGGCAAACCCTACGCTGCCCCTGGTGTATGAAGGC
ATCCGCCTCTGCCGGGAACACGGCCTGGGCCTCGTGCTGGCCGTGGGAGGAGGCAGCGTGATTGACTCCGCCAAAGCGAT
TGCGCTGGGCGTTCCCCATGAAGGGGACGTATGGGAACTATACCTTTCCAAAAAACAGCCTCAGTCCGACCCTCTGCCCG
TCGCAACCGTGCTGACCATTCCCGCCGCGGGCAGCGAGAGCAGCCCGAATACGGTCATCACCAATGAAGAGACCAGAAGA
AAACTGGGGTACGGTTCCCCCAAACTGCGCCCCGTATTCAGCATTATCAACCCGGAATTGTTCTTTACGCTCCCGCACCG
CCAGATGGCCAATGGCGTCAGCGACATGATGAGCCACATTTTTGAGCGCTATTTCACCAGAACCCTGCATACGGACCTTT
CCGACAGCCTTTGTGAGGCCACCCTGCGCACCATCATGAAAAACGCCCGCATCCTGAACGGGAACCTGAATGATTACAAC
GCCTGGGCGGAAATCGCGTTTTCCGGCAACATCGCCCACAACAACCTGTTGGGGGTAGGCCGCGAACAGGACTGGGGCTG
CCACGCCATGGAACACGAATTGAGCGCACTGTACCATGTGGACCACGGCGCAGGCCTGGCCGTCGTCACCCCGGCCTGGA
TGAAGTATGTTTCCCCCAAACACCAGGAAATATTCGTGCAGTTCGCCGTCAATGTGATGGGAGTGGAAGGTTCCTTCCGG
GAACCGTCAGCCATCATCCGGGAAGGTATTTCCCGCCTGGAACGTTTTTACCGGGAATTAGGGCTTCCGACGACTATGGA
AGAACTGAACATCCTTCCCGGGGATTTCCCCCTGATGGCGGAACAGGCCGTCAGTGTGCGCGGCCCCGTCGGCGGACTGG
AAAAGCTGGATGTCCGGGACATCCAGGCCATCTACCGACTGGGTTGCAGTAATCTGCAGCACGCATGA

Upstream 100 bases:

>100_bases
ATCCTCCGGAACAGCATCCCCCCCTGGAAAGGGGAACAGGCCATACAAAAATCTTGAGAAGGGGGCGGAAGGGCCGTAGC
GTTGCCGTATCATTCCCGCC

Downstream 100 bases:

>100_bases
CGAAAGGGGAAAAACGTCTGATCATGGAATACCCCTTCCCTCACTCCCGGCCTTGTTGACAGCGTTAAGACAATCTCCCT
TTTCCCGCAGCCTACTTGCA

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MLNFVYDNKTTLIFGKGTHHETGTLLKPLGKKILLHYGSGSIRRSGLYDAVTASLKAAGVEYEELGGVQANPTLPLVYEG
IRLCREHGLGLVLAVGGGSVIDSAKAIALGVPHEGDVWELYLSKKQPQSDPLPVATVLTIPAAGSESSPNTVITNEETRR
KLGYGSPKLRPVFSIINPELFFTLPHRQMANGVSDMMSHIFERYFTRTLHTDLSDSLCEATLRTIMKNARILNGNLNDYN
AWAEIAFSGNIAHNNLLGVGREQDWGCHAMEHELSALYHVDHGAGLAVVTPAWMKYVSPKHQEIFVQFAVNVMGVEGSFR
EPSAIIREGISRLERFYRELGLPTTMEELNILPGDFPLMAEQAVSVRGPVGGLEKLDVRDIQAIYRLGCSNLQHA

Sequences:

>Translated_395_residues
MLNFVYDNKTTLIFGKGTHHETGTLLKPLGKKILLHYGSGSIRRSGLYDAVTASLKAAGVEYEELGGVQANPTLPLVYEG
IRLCREHGLGLVLAVGGGSVIDSAKAIALGVPHEGDVWELYLSKKQPQSDPLPVATVLTIPAAGSESSPNTVITNEETRR
KLGYGSPKLRPVFSIINPELFFTLPHRQMANGVSDMMSHIFERYFTRTLHTDLSDSLCEATLRTIMKNARILNGNLNDYN
AWAEIAFSGNIAHNNLLGVGREQDWGCHAMEHELSALYHVDHGAGLAVVTPAWMKYVSPKHQEIFVQFAVNVMGVEGSFR
EPSAIIREGISRLERFYRELGLPTTMEELNILPGDFPLMAEQAVSVRGPVGGLEKLDVRDIQAIYRLGCSNLQHA
>Mature_395_residues
MLNFVYDNKTTLIFGKGTHHETGTLLKPLGKKILLHYGSGSIRRSGLYDAVTASLKAAGVEYEELGGVQANPTLPLVYEG
IRLCREHGLGLVLAVGGGSVIDSAKAIALGVPHEGDVWELYLSKKQPQSDPLPVATVLTIPAAGSESSPNTVITNEETRR
KLGYGSPKLRPVFSIINPELFFTLPHRQMANGVSDMMSHIFERYFTRTLHTDLSDSLCEATLRTIMKNARILNGNLNDYN
AWAEIAFSGNIAHNNLLGVGREQDWGCHAMEHELSALYHVDHGAGLAVVTPAWMKYVSPKHQEIFVQFAVNVMGVEGSFR
EPSAIIREGISRLERFYRELGLPTTMEELNILPGDFPLMAEQAVSVRGPVGGLEKLDVRDIQAIYRLGCSNLQHA

Specific function: Unknown

COG id: COG1979

COG function: function code C; Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=339, Percent_Identity=24.188790560472, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1789386, Length=365, Percent_Identity=32.0547945205479, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1789163, Length=392, Percent_Identity=28.5714285714286, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1787493, Length=347, Percent_Identity=27.3775216138329, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI48994951, Length=330, Percent_Identity=25.7575757575758, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082107, Length=332, Percent_Identity=25.6024096385542, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17537053, Length=396, Percent_Identity=23.2323232323232, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321181, Length=361, Percent_Identity=26.3157894736842, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: 1.1.-.- [C]

Molecular weight: Translated: 43357; Mature: 43357

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNFVYDNKTTLIFGKGTHHETGTLLKPLGKKILLHYGSGSIRRSGLYDAVTASLKAAGV
CCEEEECCCEEEEEECCCCCCCCHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCC
EYEELGGVQANPTLPLVYEGIRLCREHGLGLVLAVGGGSVIDSAKAIALGVPHEGDVWEL
CHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHCCCCEEEEECCCCCCEEEE
YLSKKQPQSDPLPVATVLTIPAAGSESSPNTVITNEETRRKLGYGSPKLRPVFSIINPEL
EECCCCCCCCCCCEEEEEEEECCCCCCCCCEEEECHHHHHHCCCCCCCCHHHHHHCCCEE
FFTLPHRQMANGVSDMMSHIFERYFTRTLHTDLSDSLCEATLRTIMKNARILNGNLNDYN
EEEECHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEECCCCCCC
AWAEIAFSGNIAHNNLLGVGREQDWGCHAMEHELSALYHVDHGAGLAVVTPAWMKYVSPK
CEEEEEEECCCCCCCCEECCCCCCCCCHHHHHHHHHHEEECCCCCEEEECHHHHHHCCCC
HQEIFVQFAVNVMGVEGSFREPSAIIREGISRLERFYRELGLPTTMEELNILPGDFPLMA
HHHHHEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCHHH
EQAVSVRGPVGGLEKLDVRDIQAIYRLGCSNLQHA
HHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLNFVYDNKTTLIFGKGTHHETGTLLKPLGKKILLHYGSGSIRRSGLYDAVTASLKAAGV
CCEEEECCCEEEEEECCCCCCCCHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCC
EYEELGGVQANPTLPLVYEGIRLCREHGLGLVLAVGGGSVIDSAKAIALGVPHEGDVWEL
CHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHCCCCEEEEECCCCCCEEEE
YLSKKQPQSDPLPVATVLTIPAAGSESSPNTVITNEETRRKLGYGSPKLRPVFSIINPEL
EECCCCCCCCCCCEEEEEEEECCCCCCCCCEEEECHHHHHHCCCCCCCCHHHHHHCCCEE
FFTLPHRQMANGVSDMMSHIFERYFTRTLHTDLSDSLCEATLRTIMKNARILNGNLNDYN
EEEECHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEECCCCCCC
AWAEIAFSGNIAHNNLLGVGREQDWGCHAMEHELSALYHVDHGAGLAVVTPAWMKYVSPK
CEEEEEEECCCCCCCCEECCCCCCCCCHHHHHHHHHHEEECCCCCEEEECHHHHHHCCCC
HQEIFVQFAVNVMGVEGSFREPSAIIREGISRLERFYRELGLPTTMEELNILPGDFPLMA
HHHHHEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCHHH
EQAVSVRGPVGGLEKLDVRDIQAIYRLGCSNLQHA
HHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377 [H]