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The map label for this gene is trpA [H]

Identifier: 187736026

GI number: 187736026

Start: 1838487

End: 1839275

Strand: Direct

Name: trpA [H]

Synonym: Amuc_1536

Alternate gene names: 187736026

Gene position: 1838487-1839275 (Clockwise)

Preceding gene: 187736025

Following gene: 187736027

Centisome position: 69.01

GC content: 58.94

Gene sequence:

>789_bases
ATGAATAATATGCAGAAATCACCGTTGCAGAAAGCCGTGGAGAGGGCCCATGCCCTCGGCAGGCGTGCCGTTATCCCTTT
CATTACCGCCGGATTCCCGGACAAGGAATCCTTCTGGACGCACTTGTCCCGTATTGACGAAGCCGGGGCGGATATTATTG
AGATAGGAGTTCCCTTCTCGGATCCCGTAGCGGACGGCCCGGTTATTGAACAGGCATCCCGGGATGCCCTGGCCCGCGGC
GTCAGCCTGAAATGGATTCTGGACGGTCTGAAAGCCCGCAAGGGCGGTTTTTCAGCCGAACTGGTGCTGATGGGATACGT
AAATCCCTTTTACCAGTATGGCCTGGAACAGCTTGCCCTGGATGCGGAGGAGGCGGGCGTCAGCGGTTTCATCGTACCGG
ATATGCCGCTGGAGGAATCCGGAATGTTCCGGGAGGCTTTCAGCCCCCATGGCCTGACGCTCGTCACTCTGGTGGCTCCC
AATACTTCCGTGGAACGCATGCGGGAATACAAGCCTTATACTTCCGGCTTCGTTTATGTGGTCTCCGTGCTGGGAACCAC
CGGTGGGAAAGCCAACCTGGAGCGGAGCGTTACGGAAACCATGCGCCGTGCCCGGTCCGTTTTTGATGTGCCGCTGGCGC
TGGGCTTCGGGCTTCAGACGCCGGACCAGCTGGAGACGCTGCCTGAAGATGCCCGGCCGGATGCCGCCGTGCTTGGGAGC
GCTCTGCTCAGGCACATTGGAGAAGGGAAGGACGCCGGGGAATTTTTGGAAAAATGGACCAGAGGTTGA

Upstream 100 bases:

>100_bases
CTGCCGCAGGGGGGGGACGTCCTGGTCAATCTCTCCGGCCGCGGAGACAAGGACCTGGGAATCGTTAAAAAATATTTGAA
TCTTTAAGCCGCATTCTTCC

Downstream 100 bases:

>100_bases
ACTGGACGTTTCTCTCTGGTTTTTAAGGATGGGCCTGCACAACTTATTGTGCAGGCTCTTTTTATTTTATCTGGTAATGA
ACGGAGAAAATACGGATTCG

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MNNMQKSPLQKAVERAHALGRRAVIPFITAGFPDKESFWTHLSRIDEAGADIIEIGVPFSDPVADGPVIEQASRDALARG
VSLKWILDGLKARKGGFSAELVLMGYVNPFYQYGLEQLALDAEEAGVSGFIVPDMPLEESGMFREAFSPHGLTLVTLVAP
NTSVERMREYKPYTSGFVYVVSVLGTTGGKANLERSVTETMRRARSVFDVPLALGFGLQTPDQLETLPEDARPDAAVLGS
ALLRHIGEGKDAGEFLEKWTRG

Sequences:

>Translated_262_residues
MNNMQKSPLQKAVERAHALGRRAVIPFITAGFPDKESFWTHLSRIDEAGADIIEIGVPFSDPVADGPVIEQASRDALARG
VSLKWILDGLKARKGGFSAELVLMGYVNPFYQYGLEQLALDAEEAGVSGFIVPDMPLEESGMFREAFSPHGLTLVTLVAP
NTSVERMREYKPYTSGFVYVVSVLGTTGGKANLERSVTETMRRARSVFDVPLALGFGLQTPDQLETLPEDARPDAAVLGS
ALLRHIGEGKDAGEFLEKWTRG
>Mature_262_residues
MNNMQKSPLQKAVERAHALGRRAVIPFITAGFPDKESFWTHLSRIDEAGADIIEIGVPFSDPVADGPVIEQASRDALARG
VSLKWILDGLKARKGGFSAELVLMGYVNPFYQYGLEQLALDAEEAGVSGFIVPDMPLEESGMFREAFSPHGLTLVTLVAP
NTSVERMREYKPYTSGFVYVVSVLGTTGGKANLERSVTETMRRARSVFDVPLALGFGLQTPDQLETLPEDARPDAAVLGS
ALLRHIGEGKDAGEFLEKWTRG

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=204, Percent_Identity=31.8627450980392, Blast_Score=120, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6321412, Length=249, Percent_Identity=37.3493975903614, Blast_Score=168, Evalue=9e-43,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 28525; Mature: 28525

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNMQKSPLQKAVERAHALGRRAVIPFITAGFPDKESFWTHLSRIDEAGADIIEIGVPFS
CCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCC
DPVADGPVIEQASRDALARGVSLKWILDGLKARKGGFSAELVLMGYVNPFYQYGLEQLAL
CCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHHHHHH
DAEEAGVSGFIVPDMPLEESGMFREAFSPHGLTLVTLVAPNTSVERMREYKPYTSGFVYV
CHHHCCCCEEECCCCCCCCCCCHHHHCCCCCEEEEEEECCCCHHHHHHHCCCCCCHHHHH
VSVLGTTGGKANLERSVTETMRRARSVFDVPLALGFGLQTPDQLETLPEDARPDAAVLGS
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCHHHHHHH
ALLRHIGEGKDAGEFLEKWTRG
HHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MNNMQKSPLQKAVERAHALGRRAVIPFITAGFPDKESFWTHLSRIDEAGADIIEIGVPFS
CCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCC
DPVADGPVIEQASRDALARGVSLKWILDGLKARKGGFSAELVLMGYVNPFYQYGLEQLAL
CCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHHHHHH
DAEEAGVSGFIVPDMPLEESGMFREAFSPHGLTLVTLVAPNTSVERMREYKPYTSGFVYV
CHHHCCCCEEECCCCCCCCCCCHHHHCCCCCEEEEEEECCCCHHHHHHHCCCCCCHHHHH
VSVLGTTGGKANLERSVTETMRRARSVFDVPLALGFGLQTPDQLETLPEDARPDAAVLGS
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCHHHHHHH
ALLRHIGEGKDAGEFLEKWTRG
HHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA