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The map label for this gene is trpE [H]

Identifier: 187736021

GI number: 187736021

Start: 1832918

End: 1834309

Strand: Direct

Name: trpE [H]

Synonym: Amuc_1531

Alternate gene names: 187736021

Gene position: 1832918-1834309 (Clockwise)

Preceding gene: 187736020

Following gene: 187736022

Centisome position: 68.8

GC content: 58.62

Gene sequence:

>1392_bases
ATGATCACTCTCCAACAGCGCAGCCGCCGCCTGAGCGCCGATCTGGAGACCCCTATCAGCCTGTTTCTGAGCCTGACTCA
GAACAAAATTCCCGGACTTCTACTGGAAAGCGCGGAAGTGGACGGCAGATGGGGGCGCTACAGCATCATCGCCTGCGATT
ATCTGATGACCGTTTCCTGTGTGGACGCCAGGCTTTCCCTTTCCATCAAAGACGACCGTCTGGCTTCCCTGAAGGAGCTG
GAAGGCATGCCTTACCTGGATGGACTGCGCTCTCTGATGCAACGTCTGGAGCTGGTGGGGGACGATATGAGGCAGGCTCC
CATTACGCGGGCTTTGTACGGCTATTTCGGGTATGAAACCGCCGCCCTGTTCCAGCCCAGGCTGGCGCAGGCCATTCCGG
CTTCTTCCGCAGAGTCCTGCCTGGTGCTGGCCGGCACCGTGATTGTTTTTGACCATTTGTACAATCGCCTTACCCAACTC
AGCCTGGGTGAACACCGGGATTTGTCCCATGCCCCGCTCCATGGGGCGGAGGAACCTTCCGTCGGGGAAGTTTGCCGCAC
ACCGGACCAGGCAGCCTACATGAAGGGGGTAGAGCATATCAAGGAGCTGCTGCATGACGGGGAAGCCATCCAGGTGGTGC
TTTCCTCCCAGGCTTCCGCGGAGTTCCACGGAGACGCTTTCATGCTGTACCGCCGCATGCGCAGCATTAATCCTTCCCCA
TACATGTTTTTCATGCGCCTGCCGGAGGTGACGCTGTTCGGATCTTCTCCGGAACTGATGGTGCGCTGCACAGACGGCAA
GCTTCAGCTTTCCCCCATTGCCGGAACGCGCAGGCGCGGCAGGGATGACGAGGAGGATGCAGCTCTGGCTGCCGATCTCC
TGAAAGATCCGAAGGAATGTTCGGAACATGTCATGCTGGTGGATCTGGGCCGCAACGACCTGGGCCGTGTCGCCAAGCCC
GGTTCCGTGAAACTGGAACGCCTGATGGAGATTGAACGTTTTTCCCATGTGATGCATATGACTTCCCGCGTGACCGCCCA
GGTGAACGACGGGTTGGACGTCTTGGACATTCTTGGCGCTGCCTTCCCGGCCGGGACGGTTAGCGGAGCCCCCAAGGTGC
GCGCCATGGAAATCCTGGCGGAGGAAGAGCCTCTGCCGCGCGGACCGTACGCCGGATGCATCGGATGGCTGGGATTGGAC
AAAAACGGCGTCCACATGGATTCCGGCATCACCATCCGCAGCATGTGGGTGAAGGATGGGCGCATCCACTGGCAGACGGG
AGCCGGCATCGTATATGATTCCGATCCGGCCGCGGAATGGCAGGAATGCATGAACAAGGGTAAGATTATTGACGTTATTT
TGAAAGGAGAAGACCATGTTTCTGTTCATTGA

Upstream 100 bases:

>100_bases
TTCAGCTATGACCATTTTTCAAGAACTGCTTTGATTCCTCCGAGAGTCAAAGCAGTTTTTTTATTTTCAACTTACATCAT
CATCCATGCAAACACCATCC

Downstream 100 bases:

>100_bases
TAATTACGATTCGTTTTCGTGGAATCTGGTGCAGGCGTTTTATGCCCTGGGACGCAAGCCCGTGGTGCATGCGAATGACG
ATTCTCGTATTCTGGAACTG

Product: Anthranilate synthase

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MITLQQRSRRLSADLETPISLFLSLTQNKIPGLLLESAEVDGRWGRYSIIACDYLMTVSCVDARLSLSIKDDRLASLKEL
EGMPYLDGLRSLMQRLELVGDDMRQAPITRALYGYFGYETAALFQPRLAQAIPASSAESCLVLAGTVIVFDHLYNRLTQL
SLGEHRDLSHAPLHGAEEPSVGEVCRTPDQAAYMKGVEHIKELLHDGEAIQVVLSSQASAEFHGDAFMLYRRMRSINPSP
YMFFMRLPEVTLFGSSPELMVRCTDGKLQLSPIAGTRRRGRDDEEDAALAADLLKDPKECSEHVMLVDLGRNDLGRVAKP
GSVKLERLMEIERFSHVMHMTSRVTAQVNDGLDVLDILGAAFPAGTVSGAPKVRAMEILAEEEPLPRGPYAGCIGWLGLD
KNGVHMDSGITIRSMWVKDGRIHWQTGAGIVYDSDPAAEWQECMNKGKIIDVILKGEDHVSVH

Sequences:

>Translated_463_residues
MITLQQRSRRLSADLETPISLFLSLTQNKIPGLLLESAEVDGRWGRYSIIACDYLMTVSCVDARLSLSIKDDRLASLKEL
EGMPYLDGLRSLMQRLELVGDDMRQAPITRALYGYFGYETAALFQPRLAQAIPASSAESCLVLAGTVIVFDHLYNRLTQL
SLGEHRDLSHAPLHGAEEPSVGEVCRTPDQAAYMKGVEHIKELLHDGEAIQVVLSSQASAEFHGDAFMLYRRMRSINPSP
YMFFMRLPEVTLFGSSPELMVRCTDGKLQLSPIAGTRRRGRDDEEDAALAADLLKDPKECSEHVMLVDLGRNDLGRVAKP
GSVKLERLMEIERFSHVMHMTSRVTAQVNDGLDVLDILGAAFPAGTVSGAPKVRAMEILAEEEPLPRGPYAGCIGWLGLD
KNGVHMDSGITIRSMWVKDGRIHWQTGAGIVYDSDPAAEWQECMNKGKIIDVILKGEDHVSVH
>Mature_463_residues
MITLQQRSRRLSADLETPISLFLSLTQNKIPGLLLESAEVDGRWGRYSIIACDYLMTVSCVDARLSLSIKDDRLASLKEL
EGMPYLDGLRSLMQRLELVGDDMRQAPITRALYGYFGYETAALFQPRLAQAIPASSAESCLVLAGTVIVFDHLYNRLTQL
SLGEHRDLSHAPLHGAEEPSVGEVCRTPDQAAYMKGVEHIKELLHDGEAIQVVLSSQASAEFHGDAFMLYRRMRSINPSP
YMFFMRLPEVTLFGSSPELMVRCTDGKLQLSPIAGTRRRGRDDEEDAALAADLLKDPKECSEHVMLVDLGRNDLGRVAKP
GSVKLERLMEIERFSHVMHMTSRVTAQVNDGLDVLDILGAAFPAGTVSGAPKVRAMEILAEEEPLPRGPYAGCIGWLGLD
KNGVHMDSGITIRSMWVKDGRIHWQTGAGIVYDSDPAAEWQECMNKGKIIDVILKGEDHVSVH

Specific function: Catalyzes The Biosynthesis Of 4-Amino-4-Deoxychorismate (Adc) From Chorismate And Glutamine. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=436, Percent_Identity=31.4220183486239, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1787518, Length=512, Percent_Identity=31.4453125, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI87082077, Length=274, Percent_Identity=28.4671532846715, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786809, Length=259, Percent_Identity=25.8687258687259, Blast_Score=85, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6320935, Length=472, Percent_Identity=33.0508474576271, Blast_Score=223, Evalue=4e-59,
Organism=Saccharomyces cerevisiae, GI6324361, Length=396, Percent_Identity=24.7474747474747, Blast_Score=115, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 51231; Mature: 51231

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITLQQRSRRLSADLETPISLFLSLTQNKIPGLLLESAEVDGRWGRYSIIACDYLMTVSC
CCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEEHHHHHHHHH
VDARLSLSIKDDRLASLKELEGMPYLDGLRSLMQRLELVGDDMRQAPITRALYGYFGYET
HCEEEEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHH
AALFQPRLAQAIPASSAESCLVLAGTVIVFDHLYNRLTQLSLGEHRDLSHAPLHGAEEPS
HHHHCHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
VGEVCRTPDQAAYMKGVEHIKELLHDGEAIQVVLSSQASAEFHGDAFMLYRRMRSINPSP
HHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCC
YMFFMRLPEVTLFGSSPELMVRCTDGKLQLSPIAGTRRRGRDDEEDAALAADLLKDPKEC
EEEEEECCCEEEECCCCCEEEEECCCEEEEECCCCCHHCCCCCHHHHHHHHHHHCCHHHH
SEHVMLVDLGRNDLGRVAKPGSVKLERLMEIERFSHVMHMTSRVTAQVNDGLDVLDILGA
CCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHC
AFPAGTVSGAPKVRAMEILAEEEPLPRGPYAGCIGWLGLDKNGVHMDSGITIRSMWVKDG
CCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHEEECCCCCCCEECCCCEEEEEEEECC
RIHWQTGAGIVYDSDPAAEWQECMNKGKIIDVILKGEDHVSVH
EEEEEECCEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure
MITLQQRSRRLSADLETPISLFLSLTQNKIPGLLLESAEVDGRWGRYSIIACDYLMTVSC
CCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEEHHHHHHHHH
VDARLSLSIKDDRLASLKELEGMPYLDGLRSLMQRLELVGDDMRQAPITRALYGYFGYET
HCEEEEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHH
AALFQPRLAQAIPASSAESCLVLAGTVIVFDHLYNRLTQLSLGEHRDLSHAPLHGAEEPS
HHHHCHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
VGEVCRTPDQAAYMKGVEHIKELLHDGEAIQVVLSSQASAEFHGDAFMLYRRMRSINPSP
HHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCC
YMFFMRLPEVTLFGSSPELMVRCTDGKLQLSPIAGTRRRGRDDEEDAALAADLLKDPKEC
EEEEEECCCEEEECCCCCEEEEECCCEEEEECCCCCHHCCCCCHHHHHHHHHHHCCHHHH
SEHVMLVDLGRNDLGRVAKPGSVKLERLMEIERFSHVMHMTSRVTAQVNDGLDVLDILGA
CCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHC
AFPAGTVSGAPKVRAMEILAEEEPLPRGPYAGCIGWLGLDKNGVHMDSGITIRSMWVKDG
CCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHEEECCCCCCCEECCCCEEEEEEEECC
RIHWQTGAGIVYDSDPAAEWQECMNKGKIIDVILKGEDHVSVH
EEEEEECCEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7685830; 10360571 [H]