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The map label for this gene is hisB

Identifier: 187735965

GI number: 187735965

Start: 1765737

End: 1766327

Strand: Direct

Name: hisB

Synonym: Amuc_1474

Alternate gene names: 187735965

Gene position: 1765737-1766327 (Clockwise)

Preceding gene: 187735964

Following gene: 187735966

Centisome position: 66.28

GC content: 57.87

Gene sequence:

>591_bases
ATGAGGAACGCTTCTTGCAAACGGGTCACGGGTGAAACGGACATCAGCATGGAACTGAACCTGGACGGCACGGGATGCGC
CGCCGTCGCAACGGGGCATGCGTTTTTTGACCATATGCTGGATTTACTGGCCCGCCATTCCCTGATGGACCTGACCCTTC
AGGCCCGCGGAGACCTGGAAGTAGACGCCCACCACACGGTGGAGGATGTGGGAATCGTTCTGGGGGAATGCATTAAAAAT
GCACTGGGGGACAAAAAGGGCATTGTTCGCTACGGCTGTTCCTACCTGCCCATGGATGAAACTCTTACGCGCGTGGTGAT
GGATTTGAGCAACCGTCCGTATGTAGCTTTCCGTATTCCGGAAGGCGGTCTGCCGGATGCCCCCAACTTTCCGCTGACCC
TTTGCGAGGAATTCTGCCGTGCGCTGGCCAATAACCTGCGTTGCAACCTGCATGTGGAAGTGCTTTACGGCAGGGATGGC
CACCACATTGCGGAATCTGTCTTCAAGGGCATCGCCCACGCGTTGCGGCAGGCTGCGGCGATTGATCCCCGAGCCGCCGG
GACGCTGCCTTCAACCAAGGGAATGCTGTAA

Upstream 100 bases:

>100_bases
TTTGACGGTCTGCATGTTTTTGCGGGGAGAAGAGGGCAAATCTTTCCCCATGCGATATTTCCTGCTTTCTTCCGCCGCGT
CTTCAGTATAGAAGTGTTGC

Downstream 100 bases:

>100_bases
AATACATGAAACTTGGCGTGATTGATTACGGTGCGGGCAATCTCCGCAGTGTGCTGAACACCTTTGAGGCCGCCGGCGTG
ACCGGTCATCTGGTGCGTAC

Product: Imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MRNASCKRVTGETDISMELNLDGTGCAAVATGHAFFDHMLDLLARHSLMDLTLQARGDLEVDAHHTVEDVGIVLGECIKN
ALGDKKGIVRYGCSYLPMDETLTRVVMDLSNRPYVAFRIPEGGLPDAPNFPLTLCEEFCRALANNLRCNLHVEVLYGRDG
HHIAESVFKGIAHALRQAAAIDPRAAGTLPSTKGML

Sequences:

>Translated_196_residues
MRNASCKRVTGETDISMELNLDGTGCAAVATGHAFFDHMLDLLARHSLMDLTLQARGDLEVDAHHTVEDVGIVLGECIKN
ALGDKKGIVRYGCSYLPMDETLTRVVMDLSNRPYVAFRIPEGGLPDAPNFPLTLCEEFCRALANNLRCNLHVEVLYGRDG
HHIAESVFKGIAHALRQAAAIDPRAAGTLPSTKGML
>Mature_196_residues
MRNASCKRVTGETDISMELNLDGTGCAAVATGHAFFDHMLDLLARHSLMDLTLQARGDLEVDAHHTVEDVGIVLGECIKN
ALGDKKGIVRYGCSYLPMDETLTRVVMDLSNRPYVAFRIPEGGLPDAPNFPLTLCEEFCRALANNLRCNLHVEVLYGRDG
HHIAESVFKGIAHALRQAAAIDPRAAGTLPSTKGML

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=195, Percent_Identity=41.5384615384615, Blast_Score=147, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6324776, Length=222, Percent_Identity=39.6396396396396, Blast_Score=140, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_AKKM8 (B2UL23)

Other databases:

- EMBL:   CP001071
- RefSeq:   YP_001878077.1
- ProteinModelPortal:   B2UL23
- SMR:   B2UL23
- GeneID:   6274464
- GenomeReviews:   CP001071_GR
- KEGG:   amu:Amuc_1474
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21300; Mature: 21300

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNASCKRVTGETDISMELNLDGTGCAAVATGHAFFDHMLDLLARHSLMDLTLQARGDLE
CCCCCCCEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEE
VDAHHTVEDVGIVLGECIKNALGDKKGIVRYGCSYLPMDETLTRVVMDLSNRPYVAFRIP
ECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECC
EGGLPDAPNFPLTLCEEFCRALANNLRCNLHVEVLYGRDGHHIAESVFKGIAHALRQAAA
CCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHC
IDPRAAGTLPSTKGML
CCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRNASCKRVTGETDISMELNLDGTGCAAVATGHAFFDHMLDLLARHSLMDLTLQARGDLE
CCCCCCCEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEE
VDAHHTVEDVGIVLGECIKNALGDKKGIVRYGCSYLPMDETLTRVVMDLSNRPYVAFRIP
ECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECC
EGGLPDAPNFPLTLCEEFCRALANNLRCNLHVEVLYGRDGHHIAESVFKGIAHALRQAAA
CCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHC
IDPRAAGTLPSTKGML
CCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA