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The map label for this gene is prs [H]

Identifier: 187735962

GI number: 187735962

Start: 1762416

End: 1763345

Strand: Direct

Name: prs [H]

Synonym: Amuc_1471

Alternate gene names: 187735962

Gene position: 1762416-1763345 (Clockwise)

Preceding gene: 187735959

Following gene: 187735963

Centisome position: 66.15

GC content: 57.2

Gene sequence:

>930_bases
ATGAAGATTATCAGCGGTACAGCACACAGAGAACTTGCGGAGCGCATTGCGCAAAGCGTAGGCATTCAGTTGACGAACGT
CACGGTGAATACTTTCCCCGATGGGGAAAGTTTTGTAAAGATAAATGAAAACATCCGGGGCAAGGATGTTTTCCTCATTC
AGCCCACCTGCCCTCCCACGAACCATAATATTATGGAATTGTGCGTGATGGTGGACGCCGCCCGCCGCGCCAGTGCCGGA
CGCATCACGGCTGTTGTTCCTTTCTTCGGGTATGCCCGCCAGGATCGCAAGGACCAGCCCCGCGTTCCCATTACCGCCAA
GTTGGTGGCCAATCTGCTGACGGCCGCCGGAGTGGACCGCGTGCTGACTATGGATCTCCATGCCGCCCAGATCCAGGGAT
TCTTTGATATTCCGGTGGATCACCTGTACGCCGCCCCCGTTTTAATCCGTCACCTGCGCGAACATTATGTTAAAGACCTC
AAGAAACTGGTCGTCGTCTCCCCGGACGTGGGCGGCGTGAAAATGGCTCGCGCGTATTCCGACGCGCTGGGTGCGGAATT
GGCCATTGTTGCCAAGCACCGCGTCAACGCCACCCATGTGGAAGCCATGAATGTCATTGGTGACGTGGAAGGGCGCGATG
CCGTTCTGATTGACGACATGACGGAAACCGCCGGCACCCTGTGCGCTGCCGCCAATATCCTGAAGGAACGGGGAGCCCAG
CGCGTGTTCGCCTGCGTTTCTCACGGCGTGCTGGGGGACATGGCCCGCGAACGGATTTCCGGTTCCTGCATTGAACGCGT
TCTTACCTCCGACACCGTTCCCATGGCCTATGGCCCCAAAGTGGACTGTGTCAGCGTGGGAGACCTGCTGGGCCATGCCG
TGCAGCGCATACATGACGGAGAATCCGTATCATCATTATTTGACATTTAG

Upstream 100 bases:

>100_bases
AACGGGGGAATCCATCATGGAGAAAAATCAAATTGTGAGAATTAAGTATTGCGATTATGCGGGCCTGTGTTCAGAATGCG
TCCGCTTTTCAGTTTCCGGT

Downstream 100 bases:

>100_bases
ACAATTTTAGTGCAGAGTCCTGCGCCCTGACCTGAGTACCGGTTTACGCGGGTTCGGAAATCCCGGCGGGGCCTCTGCCT
GAACCCGATTAGGAAACATC

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MKIISGTAHRELAERIAQSVGIQLTNVTVNTFPDGESFVKINENIRGKDVFLIQPTCPPTNHNIMELCVMVDAARRASAG
RITAVVPFFGYARQDRKDQPRVPITAKLVANLLTAAGVDRVLTMDLHAAQIQGFFDIPVDHLYAAPVLIRHLREHYVKDL
KKLVVVSPDVGGVKMARAYSDALGAELAIVAKHRVNATHVEAMNVIGDVEGRDAVLIDDMTETAGTLCAAANILKERGAQ
RVFACVSHGVLGDMARERISGSCIERVLTSDTVPMAYGPKVDCVSVGDLLGHAVQRIHDGESVSSLFDI

Sequences:

>Translated_309_residues
MKIISGTAHRELAERIAQSVGIQLTNVTVNTFPDGESFVKINENIRGKDVFLIQPTCPPTNHNIMELCVMVDAARRASAG
RITAVVPFFGYARQDRKDQPRVPITAKLVANLLTAAGVDRVLTMDLHAAQIQGFFDIPVDHLYAAPVLIRHLREHYVKDL
KKLVVVSPDVGGVKMARAYSDALGAELAIVAKHRVNATHVEAMNVIGDVEGRDAVLIDDMTETAGTLCAAANILKERGAQ
RVFACVSHGVLGDMARERISGSCIERVLTSDTVPMAYGPKVDCVSVGDLLGHAVQRIHDGESVSSLFDI
>Mature_309_residues
MKIISGTAHRELAERIAQSVGIQLTNVTVNTFPDGESFVKINENIRGKDVFLIQPTCPPTNHNIMELCVMVDAARRASAG
RITAVVPFFGYARQDRKDQPRVPITAKLVANLLTAAGVDRVLTMDLHAAQIQGFFDIPVDHLYAAPVLIRHLREHYVKDL
KKLVVVSPDVGGVKMARAYSDALGAELAIVAKHRVNATHVEAMNVIGDVEGRDAVLIDDMTETAGTLCAAANILKERGAQ
RVFACVSHGVLGDMARERISGSCIERVLTSDTVPMAYGPKVDCVSVGDLLGHAVQRIHDGESVSSLFDI

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=311, Percent_Identity=45.016077170418, Blast_Score=302, Evalue=3e-82,
Organism=Homo sapiens, GI4506129, Length=309, Percent_Identity=44.6601941747573, Blast_Score=296, Evalue=1e-80,
Organism=Homo sapiens, GI28557709, Length=311, Percent_Identity=44.3729903536978, Blast_Score=296, Evalue=2e-80,
Organism=Homo sapiens, GI84875539, Length=312, Percent_Identity=44.2307692307692, Blast_Score=291, Evalue=5e-79,
Organism=Homo sapiens, GI4506133, Length=338, Percent_Identity=34.6153846153846, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI194018537, Length=337, Percent_Identity=34.4213649851632, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI310128524, Length=147, Percent_Identity=31.2925170068027, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI310115209, Length=147, Percent_Identity=31.2925170068027, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI310118259, Length=147, Percent_Identity=31.2925170068027, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI310119946, Length=147, Percent_Identity=31.2925170068027, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1787458, Length=314, Percent_Identity=50.9554140127389, Blast_Score=313, Evalue=8e-87,
Organism=Caenorhabditis elegans, GI25149168, Length=311, Percent_Identity=43.0868167202572, Blast_Score=288, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17554702, Length=311, Percent_Identity=43.0868167202572, Blast_Score=287, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI17554704, Length=309, Percent_Identity=43.042071197411, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI71989924, Length=311, Percent_Identity=43.0868167202572, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17570245, Length=338, Percent_Identity=30.7692307692308, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6321776, Length=312, Percent_Identity=43.9102564102564, Blast_Score=271, Evalue=6e-74,
Organism=Saccharomyces cerevisiae, GI6319403, Length=310, Percent_Identity=43.8709677419355, Blast_Score=267, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6320946, Length=310, Percent_Identity=44.1935483870968, Blast_Score=263, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6322667, Length=203, Percent_Identity=41.871921182266, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6324511, Length=87, Percent_Identity=50.5747126436782, Blast_Score=92, Evalue=9e-20,
Organism=Drosophila melanogaster, GI21355239, Length=311, Percent_Identity=45.9807073954984, Blast_Score=298, Evalue=4e-81,
Organism=Drosophila melanogaster, GI45551540, Length=334, Percent_Identity=42.814371257485, Blast_Score=285, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24651458, Length=352, Percent_Identity=30.9659090909091, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24651456, Length=352, Percent_Identity=30.9659090909091, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI281362873, Length=352, Percent_Identity=30.9659090909091, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24651454, Length=352, Percent_Identity=30.9659090909091, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24651462, Length=371, Percent_Identity=29.6495956873315, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24651464, Length=371, Percent_Identity=29.6495956873315, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI45552010, Length=371, Percent_Identity=29.6495956873315, Blast_Score=179, Evalue=2e-45,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 33424; Mature: 33424

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIISGTAHRELAERIAQSVGIQLTNVTVNTFPDGESFVKINENIRGKDVFLIQPTCPPT
CCCCCCHHHHHHHHHHHHHHCEEEEEEEEEECCCCCCEEEECCCCCCCEEEEEECCCCCC
NHNIMELCVMVDAARRASAGRITAVVPFFGYARQDRKDQPRVPITAKLVANLLTAAGVDR
CCHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCC
VLTMDLHAAQIQGFFDIPVDHLYAAPVLIRHLREHYVKDLKKLVVVSPDVGGVKMARAYS
EEEECHHHHHHCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHH
DALGAELAIVAKHRVNATHVEAMNVIGDVEGRDAVLIDDMTETAGTLCAAANILKERGAQ
HHHCCEEEEEEHHCCCHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCHH
RVFACVSHGVLGDMARERISGSCIERVLTSDTVPMAYGPKVDCVSVGDLLGHAVQRIHDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCC
ESVSSLFDI
CHHHHHHCC
>Mature Secondary Structure
MKIISGTAHRELAERIAQSVGIQLTNVTVNTFPDGESFVKINENIRGKDVFLIQPTCPPT
CCCCCCHHHHHHHHHHHHHHCEEEEEEEEEECCCCCCEEEECCCCCCCEEEEEECCCCCC
NHNIMELCVMVDAARRASAGRITAVVPFFGYARQDRKDQPRVPITAKLVANLLTAAGVDR
CCHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCC
VLTMDLHAAQIQGFFDIPVDHLYAAPVLIRHLREHYVKDLKKLVVVSPDVGGVKMARAYS
EEEECHHHHHHCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHH
DALGAELAIVAKHRVNATHVEAMNVIGDVEGRDAVLIDDMTETAGTLCAAANILKERGAQ
HHHCCEEEEEEHHCCCHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCHH
RVFACVSHGVLGDMARERISGSCIERVLTSDTVPMAYGPKVDCVSVGDLLGHAVQRIHDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCC
ESVSSLFDI
CHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA