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The map label for this gene is uvrA [H]

Identifier: 187735943

GI number: 187735943

Start: 1743347

End: 1745848

Strand: Reverse

Name: uvrA [H]

Synonym: Amuc_1452

Alternate gene names: 187735943

Gene position: 1745848-1743347 (Counterclockwise)

Preceding gene: 187735944

Following gene: 187735942

Centisome position: 65.53

GC content: 62.35

Gene sequence:

>2502_bases
ATGAATCTTCCCATCTCCATCCGCGGCGCGCGCCAGCACAACCTCCGGAACCTGAATCTGGATCTTCCGTCCAACAAGCT
CATCGTATTCTGCGGCCCTTCCGGCTCCGGAAAATCTTCCCTGGCGTTTGATACGCTTTTTTCCGAATCCCGCAGGCGTT
TTCTGGACTGCCTGTCGGCACGCTCCAGGCAGGGCATGGATCAACCGGAAAAACCGGAAGTGGACAGCATTACCGGGCTG
CCCCCGGCCCTGTGCCTGGAGCAATCCGCCAGGCAGCAGAGTTCCCGCACCCTGCTGGGGAGCATCACGGAAATTCTGGA
CTACCTGCGCATCCTTTACGCGGCTGCCGGCACGCCCCATGACCCGGAGACAGGAAAGGAACTGGAACGCAAGAGCCCGG
ACCGGATTACGGAAGAACTCGTTTCCCTGCCGGAACACACGCGCCTGATTCTGACCGCTCCGGCGGAAAACCTGCTGGCC
CAGGATCCCGCAGCGACGCTGGCCGACTTCCAGCGGCAGGGCTTCCTCCGGGTTTACTGGAACGGAGAAATGCGGGATAT
TGAAGAAATAAGTTCCCCCGTCCCCCCGCCTCCAGACGCGGCCCTGGTCATTGACCGCCTCATCGTCAGAGGGGAAAATA
CGGCCTCGCGCATTGCGGATTCCCTGCAAACGGCTCTCCGTATCAATCCGGACGAGGTGCGGGCCATCATCACCATACCG
GGAGAGGAAGCCTCAATCCGGGCCTTCCACACCCGCTACCGCAATCCGGAAACAGGCTTCCTTCTGCCCCAGCTTACGCC
CCGCCATTTTTCCTTCAACTCCCCGCTGGGGGCATGCCCCTCCTGCCGGGGAACCGGCCTGAATGAACAGGAAAACGGTC
CGTGCCGCGCCTGCGGAGGCCAGCGTCTTTCCCCTCTGGCCCTGGCCGTCACCATGCCTGCGCCGGACCGGGCCTACAAT
CTCGCGGAACTGACGGCTCTTCCTCTGGAAGATATGGCAGGAGAACTGGAACGACTGAAAACGCCCCCCTCCCTGGCGGC
GGCATTGACCCCGCTCATGGAGGAAATCAACAAACGCGTGCGCTTCCTGAATGAGCTGGGACTCTCCTACCTGTCCCTGG
ACCGCCAGGCAAACACCCTCTCCGGAGGCGAACTGCAGAGGGCGCGCCTGGCTTCCCAGCTGGGAGGCGGCCTTTCCGGA
GTCCTTTACATCCTGGACGAACCCACGGCCGGACTGCACCCCGCCGATACGGACCGCCTGCTCCGCGCTCTCCGGACGCT
CCGGAACCAGGGCAACACAGTACTGGTCGTAGAGCATGATGAACAAATTCTAACCGCGGCGGATCACCTGGTGGACATGG
GCCCCGGCTCCGGAACCAACGGAGGCCGTATTCTGGCGCAGGGCTCCCTTGCTGAGATACTGGGAAATTCAGGAAGCCCC
ACCGGGGAATGGCTTTCAGGCAAGCGAAACATGCCCGCCTCCGGACGCAAGACGGCTCCTGCGGGGCGTCTGGTACTGAC
CGGTGCGGACAAGCACAACCTCAACAACGTCACTCTGAATATCCCGGTCGGCACACTGACCTGCATCTCCGGCCCTTCCG
GTTCAGGGAAATCCACCCTTGTCCGGGACTGCCTCATCCCCGCAGTCAGGCAAGATCTCTCCGGGAAAAAGGGTATTCCG
CGCCGCGTGCAGGGAACGGAACACTTCAACCGCCTCGTCGTCATCGACCAGTCGCCCATCGGCAAAACGCCGCGCTCCAC
ACCGGCCACCGCTACCGGCCTGCTCCAGGTGCTGCGCCCCCTTTACGCACAGCTCCCCCTTTCCAAGCAGAGGGGATATA
CGGCGGCGCGCTTTTCCCCCAACATTCGCGGAGGCCGCTGTGAACGGTGCCAGGGAACGGGCATGATTGAAGTGGACATG
AACTTTCTGGGAAACGTGGCAATGCCCTGCGACGCCTGCCAGGGGCAGTGCTACAACAGGGAAACGCTGGAAGTCACCTG
GAAAGGGAAATCCATTGCCCAGGCGCTGGCCCTGACCGTGGACGAAGCGGCGGAATTCTTTTCCTCCCTGCCCAGAGCCG
CCGCCATCCTGAAAAGCATGCAGGACGTAGGGCTGGGATACCTCAATCTCAACCGCAGGGCGGACACCCTTTCCGGCGGA
GAATCCCAGCGCATAAAAATAGCTGCGGAACTGGCCAAAGCCCCGGCCTGGAAACTGGAGGAAGACGGGAAACGGGCCCT
GTTCATTCTGGACGAACCCACCAGCGGCCTCCACTTCAATGAAGTGGCCCTTCTCCTGGCAGCCCTTTTCCGCCTGAGGG
ATGCCGGACACACCATCCTCTGCGTGGAACACCACAAGGACCTGCTCAATGCCGCGGACTACCTGGTGGACATGGGCCCC
GGAGCCGGCAGGCACGGCGGCAATATCGTGGCCGAGGGCTCCCCCGCAGATGTAGCGTCCAATCCGGAAGCGCCCACTTC
TCCCTGGCTCGTCCCCCGTTAA

Upstream 100 bases:

>100_bases
ATCCACCGGCACGCCAAATTCCTGGGAGATATCACGGCGCGCCGCCTCATCATTGAGGAAGGCGGCACGCACCAGGGAGC
CTTTACCCGCCTTACGTGAC

Downstream 100 bases:

>100_bases
CAACGGCAGCCCCTGAAAATCATTCATCTGTCCTGTCCCCCGGACATCCCGTTCCCGGCGTCTTCGGAAAAAAATCTGCC
TCTCCGGGGTTTATTCGCCT

Product: excinuclease ABC, A subunit

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 833; Mature: 833

Protein sequence:

>833_residues
MNLPISIRGARQHNLRNLNLDLPSNKLIVFCGPSGSGKSSLAFDTLFSESRRRFLDCLSARSRQGMDQPEKPEVDSITGL
PPALCLEQSARQQSSRTLLGSITEILDYLRILYAAAGTPHDPETGKELERKSPDRITEELVSLPEHTRLILTAPAENLLA
QDPAATLADFQRQGFLRVYWNGEMRDIEEISSPVPPPPDAALVIDRLIVRGENTASRIADSLQTALRINPDEVRAIITIP
GEEASIRAFHTRYRNPETGFLLPQLTPRHFSFNSPLGACPSCRGTGLNEQENGPCRACGGQRLSPLALAVTMPAPDRAYN
LAELTALPLEDMAGELERLKTPPSLAAALTPLMEEINKRVRFLNELGLSYLSLDRQANTLSGGELQRARLASQLGGGLSG
VLYILDEPTAGLHPADTDRLLRALRTLRNQGNTVLVVEHDEQILTAADHLVDMGPGSGTNGGRILAQGSLAEILGNSGSP
TGEWLSGKRNMPASGRKTAPAGRLVLTGADKHNLNNVTLNIPVGTLTCISGPSGSGKSTLVRDCLIPAVRQDLSGKKGIP
RRVQGTEHFNRLVVIDQSPIGKTPRSTPATATGLLQVLRPLYAQLPLSKQRGYTAARFSPNIRGGRCERCQGTGMIEVDM
NFLGNVAMPCDACQGQCYNRETLEVTWKGKSIAQALALTVDEAAEFFSSLPRAAAILKSMQDVGLGYLNLNRRADTLSGG
ESQRIKIAAELAKAPAWKLEEDGKRALFILDEPTSGLHFNEVALLLAALFRLRDAGHTILCVEHHKDLLNAADYLVDMGP
GAGRHGGNIVAEGSPADVASNPEAPTSPWLVPR

Sequences:

>Translated_833_residues
MNLPISIRGARQHNLRNLNLDLPSNKLIVFCGPSGSGKSSLAFDTLFSESRRRFLDCLSARSRQGMDQPEKPEVDSITGL
PPALCLEQSARQQSSRTLLGSITEILDYLRILYAAAGTPHDPETGKELERKSPDRITEELVSLPEHTRLILTAPAENLLA
QDPAATLADFQRQGFLRVYWNGEMRDIEEISSPVPPPPDAALVIDRLIVRGENTASRIADSLQTALRINPDEVRAIITIP
GEEASIRAFHTRYRNPETGFLLPQLTPRHFSFNSPLGACPSCRGTGLNEQENGPCRACGGQRLSPLALAVTMPAPDRAYN
LAELTALPLEDMAGELERLKTPPSLAAALTPLMEEINKRVRFLNELGLSYLSLDRQANTLSGGELQRARLASQLGGGLSG
VLYILDEPTAGLHPADTDRLLRALRTLRNQGNTVLVVEHDEQILTAADHLVDMGPGSGTNGGRILAQGSLAEILGNSGSP
TGEWLSGKRNMPASGRKTAPAGRLVLTGADKHNLNNVTLNIPVGTLTCISGPSGSGKSTLVRDCLIPAVRQDLSGKKGIP
RRVQGTEHFNRLVVIDQSPIGKTPRSTPATATGLLQVLRPLYAQLPLSKQRGYTAARFSPNIRGGRCERCQGTGMIEVDM
NFLGNVAMPCDACQGQCYNRETLEVTWKGKSIAQALALTVDEAAEFFSSLPRAAAILKSMQDVGLGYLNLNRRADTLSGG
ESQRIKIAAELAKAPAWKLEEDGKRALFILDEPTSGLHFNEVALLLAALFRLRDAGHTILCVEHHKDLLNAADYLVDMGP
GAGRHGGNIVAEGSPADVASNPEAPTSPWLVPR
>Mature_833_residues
MNLPISIRGARQHNLRNLNLDLPSNKLIVFCGPSGSGKSSLAFDTLFSESRRRFLDCLSARSRQGMDQPEKPEVDSITGL
PPALCLEQSARQQSSRTLLGSITEILDYLRILYAAAGTPHDPETGKELERKSPDRITEELVSLPEHTRLILTAPAENLLA
QDPAATLADFQRQGFLRVYWNGEMRDIEEISSPVPPPPDAALVIDRLIVRGENTASRIADSLQTALRINPDEVRAIITIP
GEEASIRAFHTRYRNPETGFLLPQLTPRHFSFNSPLGACPSCRGTGLNEQENGPCRACGGQRLSPLALAVTMPAPDRAYN
LAELTALPLEDMAGELERLKTPPSLAAALTPLMEEINKRVRFLNELGLSYLSLDRQANTLSGGELQRARLASQLGGGLSG
VLYILDEPTAGLHPADTDRLLRALRTLRNQGNTVLVVEHDEQILTAADHLVDMGPGSGTNGGRILAQGSLAEILGNSGSP
TGEWLSGKRNMPASGRKTAPAGRLVLTGADKHNLNNVTLNIPVGTLTCISGPSGSGKSTLVRDCLIPAVRQDLSGKKGIP
RRVQGTEHFNRLVVIDQSPIGKTPRSTPATATGLLQVLRPLYAQLPLSKQRGYTAARFSPNIRGGRCERCQGTGMIEVDM
NFLGNVAMPCDACQGQCYNRETLEVTWKGKSIAQALALTVDEAAEFFSSLPRAAAILKSMQDVGLGYLNLNRRADTLSGG
ESQRIKIAAELAKAPAWKLEEDGKRALFILDEPTSGLHFNEVALLLAALFRLRDAGHTILCVEHHKDLLNAADYLVDMGP
GAGRHGGNIVAEGSPADVASNPEAPTSPWLVPR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=553, Percent_Identity=47.377938517179, Blast_Score=489, Evalue=1e-139,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR003593
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 89851; Mature: 89851

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLPISIRGARQHNLRNLNLDLPSNKLIVFCGPSGSGKSSLAFDTLFSESRRRFLDCLSA
CCCCEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RSRQGMDQPEKPEVDSITGLPPALCLEQSARQQSSRTLLGSITEILDYLRILYAAAGTPH
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DPETGKELERKSPDRITEELVSLPEHTRLILTAPAENLLAQDPAATLADFQRQGFLRVYW
CCCCCHHHHHCCHHHHHHHHHCCCCCCEEEEECCHHHHHHCCCHHHHHHHHHCCCEEEEE
NGEMRDIEEISSPVPPPPDAALVIDRLIVRGENTASRIADSLQTALRINPDEVRAIITIP
CCCCHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHEEEEEEEC
GEEASIRAFHTRYRNPETGFLLPQLTPRHFSFNSPLGACPSCRGTGLNEQENGPCRACGG
CCCCHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
QRLSPLALAVTMPAPDRAYNLAELTALPLEDMAGELERLKTPPSLAAALTPLMEEINKRV
CCCCCEEEEEECCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
RFLNELGLSYLSLDRQANTLSGGELQRARLASQLGGGLSGVLYILDEPTAGLHPADTDRL
HHHHHHCHHHEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHH
LRALRTLRNQGNTVLVVEHDEQILTAADHLVDMGPGSGTNGGRILAQGSLAEILGNSGSP
HHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHCCCCCC
TGEWLSGKRNMPASGRKTAPAGRLVLTGADKHNLNNVTLNIPVGTLTCISGPSGSGKSTL
CCHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCEEEEECCCCCCCCHHH
VRDCLIPAVRQDLSGKKGIPRRVQGTEHFNRLVVIDQSPIGKTPRSTPATATGLLQVLRP
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
LYAQLPLSKQRGYTAARFSPNIRGGRCERCQGTGMIEVDMNFLGNVAMPCDACQGQCYNR
HHHHCCCCHHCCCEEEECCCCCCCCCCCCCCCCCEEEECHHHHCCCCCCCHHHCCCCCCC
ETLEVTWKGKSIAQALALTVDEAAEFFSSLPRAAAILKSMQDVGLGYLNLNRRADTLSGG
CEEEEEECCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEECCCCCCCCCCC
ESQRIKIAAELAKAPAWKLEEDGKRALFILDEPTSGLHFNEVALLLAALFRLRDAGHTIL
CCCEEEHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEE
CVEHHKDLLNAADYLVDMGPGAGRHGGNIVAEGSPADVASNPEAPTSPWLVPR
EEHHHHHHHHHHHHHEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNLPISIRGARQHNLRNLNLDLPSNKLIVFCGPSGSGKSSLAFDTLFSESRRRFLDCLSA
CCCCEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RSRQGMDQPEKPEVDSITGLPPALCLEQSARQQSSRTLLGSITEILDYLRILYAAAGTPH
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DPETGKELERKSPDRITEELVSLPEHTRLILTAPAENLLAQDPAATLADFQRQGFLRVYW
CCCCCHHHHHCCHHHHHHHHHCCCCCCEEEEECCHHHHHHCCCHHHHHHHHHCCCEEEEE
NGEMRDIEEISSPVPPPPDAALVIDRLIVRGENTASRIADSLQTALRINPDEVRAIITIP
CCCCHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHEEEEEEEC
GEEASIRAFHTRYRNPETGFLLPQLTPRHFSFNSPLGACPSCRGTGLNEQENGPCRACGG
CCCCHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
QRLSPLALAVTMPAPDRAYNLAELTALPLEDMAGELERLKTPPSLAAALTPLMEEINKRV
CCCCCEEEEEECCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
RFLNELGLSYLSLDRQANTLSGGELQRARLASQLGGGLSGVLYILDEPTAGLHPADTDRL
HHHHHHCHHHEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHH
LRALRTLRNQGNTVLVVEHDEQILTAADHLVDMGPGSGTNGGRILAQGSLAEILGNSGSP
HHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHCCCCCC
TGEWLSGKRNMPASGRKTAPAGRLVLTGADKHNLNNVTLNIPVGTLTCISGPSGSGKSTL
CCHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCEEEEECCCCCCCCHHH
VRDCLIPAVRQDLSGKKGIPRRVQGTEHFNRLVVIDQSPIGKTPRSTPATATGLLQVLRP
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
LYAQLPLSKQRGYTAARFSPNIRGGRCERCQGTGMIEVDMNFLGNVAMPCDACQGQCYNR
HHHHCCCCHHCCCEEEECCCCCCCCCCCCCCCCCEEEECHHHHCCCCCCCHHHCCCCCCC
ETLEVTWKGKSIAQALALTVDEAAEFFSSLPRAAAILKSMQDVGLGYLNLNRRADTLSGG
CEEEEEECCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEECCCCCCCCCCC
ESQRIKIAAELAKAPAWKLEEDGKRALFILDEPTSGLHFNEVALLLAALFRLRDAGHTIL
CCCEEEHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEE
CVEHHKDLLNAADYLVDMGPGAGRHGGNIVAEGSPADVASNPEAPTSPWLVPR
EEHHHHHHHHHHHHHEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8675016 [H]