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The map label for this gene is mro [H]

Identifier: 187735802

GI number: 187735802

Start: 1587603

End: 1588562

Strand: Reverse

Name: mro [H]

Synonym: Amuc_1309

Alternate gene names: 187735802

Gene position: 1588562-1587603 (Counterclockwise)

Preceding gene: 187735803

Following gene: 187735799

Centisome position: 59.63

GC content: 60.31

Gene sequence:

>960_bases
ATGATCTTCGGCACCTTACCCGGCGGCGCACCTGTAGAATTGTTTGAACTGTCTTCCGACAAGCTGACGGTACGCATCAG
CAACTACGGGGGGCGCATCATCTCCGTCGTCAAGGACGGCATGGACATGATCGTAGGGCCCAAGCACTTTGAAGACATGC
TGAAAGACACCTGTTATTGCGGTGCGATTTGCGGCCGTGTCGCGAATCGCATCGCAAAAGGCAGGTTCTCCATTGACGGG
GATTCCCGCACCGTGGCCGTCAACAACGGCCCCAACCACCTGCACGGCGGCATCCAGGGGTTCGACAGCAAAGTCTGGCA
GGTGCAGGAAGCCGGGCGCAATACGCTGGTGCTGACCCTGCACTCCGCAGACGGTGAGGAAAATTACCCCGGCAACCTGG
AAGTGGTAGCCACCTACACCGTGGTGGAAGAAACCCTTCATCTCCGCCTGGAAGCGTATGCGGACGCAGCCACAATCGTC
AACCTCACCAACCACGCTTACTGGAACCTGTCCGGCAAACCCACCATTGATTCCATGACCCTGGAGATACGGGCCTCCGC
CTATACTCCGGTGGATGCGACCAATATCCCCGACGGCCGTATTCTTCCCGTGGAAGGAACGGACTTTGACCTGCGGAAAG
CAGCCCTGCTGGGGGAACGCAACTCCGCCGCCCACCCGGACACCGCCGCCGGACTGGACCACAACTACGTGCTGGATTCC
GAACCGGGCGACAAAATCGCCGCCATCCTTCTTGATCCGGAATCCCGGCACCGCCTGATTGTGGCGACGGATGCTCCCGG
CCTCCAGGTATATACCGGGGAATACCTGCCCCAGGCGCGCCAGGGAATAGCGCTGGAAGCCCAGGGCTTCCCCAATGCCG
TCAATACCCCCCACTTCCCCAGCGTCATTCTGCGTCCCGGCCAATCCTCCACGCGCAGCATTACCTGGACTGTCAGATAG

Upstream 100 bases:

>100_bases
TTCAGGTCGGGCAGCGCGTGCGCGTGATCATCGGCAACAACGGTTCCCGCGTGCTGGCCTATTAATTGGACATCCACTAC
TGACCAAGCTATATACCGGC

Downstream 100 bases:

>100_bases
GCGGCATGCCTGAATCCCGTTTCCGAACAAAAAACGGCGCTTCGACAACGCCCGCAACGGGCTTTCCTGTGCAGGCACGC
GGCATCAGGAGGCCGCGTAA

Product: Aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MIFGTLPGGAPVELFELSSDKLTVRISNYGGRIISVVKDGMDMIVGPKHFEDMLKDTCYCGAICGRVANRIAKGRFSIDG
DSRTVAVNNGPNHLHGGIQGFDSKVWQVQEAGRNTLVLTLHSADGEENYPGNLEVVATYTVVEETLHLRLEAYADAATIV
NLTNHAYWNLSGKPTIDSMTLEIRASAYTPVDATNIPDGRILPVEGTDFDLRKAALLGERNSAAHPDTAAGLDHNYVLDS
EPGDKIAAILLDPESRHRLIVATDAPGLQVYTGEYLPQARQGIALEAQGFPNAVNTPHFPSVILRPGQSSTRSITWTVR

Sequences:

>Translated_319_residues
MIFGTLPGGAPVELFELSSDKLTVRISNYGGRIISVVKDGMDMIVGPKHFEDMLKDTCYCGAICGRVANRIAKGRFSIDG
DSRTVAVNNGPNHLHGGIQGFDSKVWQVQEAGRNTLVLTLHSADGEENYPGNLEVVATYTVVEETLHLRLEAYADAATIV
NLTNHAYWNLSGKPTIDSMTLEIRASAYTPVDATNIPDGRILPVEGTDFDLRKAALLGERNSAAHPDTAAGLDHNYVLDS
EPGDKIAAILLDPESRHRLIVATDAPGLQVYTGEYLPQARQGIALEAQGFPNAVNTPHFPSVILRPGQSSTRSITWTVR
>Mature_319_residues
MIFGTLPGGAPVELFELSSDKLTVRISNYGGRIISVVKDGMDMIVGPKHFEDMLKDTCYCGAICGRVANRIAKGRFSIDG
DSRTVAVNNGPNHLHGGIQGFDSKVWQVQEAGRNTLVLTLHSADGEENYPGNLEVVATYTVVEETLHLRLEAYADAATIV
NLTNHAYWNLSGKPTIDSMTLEIRASAYTPVDATNIPDGRILPVEGTDFDLRKAALLGERNSAAHPDTAAGLDHNYVLDS
EPGDKIAAILLDPESRHRLIVATDAPGLQVYTGEYLPQARQGIALEAQGFPNAVNTPHFPSVILRPGQSSTRSITWTVR

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=334, Percent_Identity=41.9161676646707, Blast_Score=228, Evalue=8e-60,
Organism=Escherichia coli, GI1786971, Length=327, Percent_Identity=32.1100917431193, Blast_Score=167, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17557428, Length=291, Percent_Identity=30.5841924398625, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI115533334, Length=291, Percent_Identity=30.5841924398625, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6319493, Length=319, Percent_Identity=30.4075235109718, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6324399, Length=321, Percent_Identity=28.0373831775701, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6322004, Length=322, Percent_Identity=29.5031055900621, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24659048, Length=333, Percent_Identity=36.036036036036, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24583720, Length=330, Percent_Identity=32.4242424242424, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24668282, Length=332, Percent_Identity=30.1204819277108, Blast_Score=147, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24668278, Length=328, Percent_Identity=31.4024390243902, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24641876, Length=327, Percent_Identity=26.9113149847095, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 34502; Mature: 34502

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFGTLPGGAPVELFELSSDKLTVRISNYGGRIISVVKDGMDMIVGPKHFEDMLKDTCYC
CEEEECCCCCCEEEEEECCCEEEEEEECCCCEEEEEECCCHHEEECCHHHHHHHHHHHHH
GAICGRVANRIAKGRFSIDGDSRTVAVNNGPNHLHGGIQGFDSKVWQVQEAGRNTLVLTL
HHHHHHHHHHHHCCEEEECCCCEEEEECCCCCHHCCCCCCCCHHHEEHHHCCCCEEEEEE
HSADGEENYPGNLEVVATYTVVEETLHLRLEAYADAATIVNLTNHAYWNLSGKPTIDSMT
ECCCCCCCCCCCEEEEEEEEEEHHHHHEEEEECCCEEEEEEECCCEEEECCCCCCCCEEE
LEIRASAYTPVDATNIPDGRILPVEGTDFDLRKAALLGERNSAAHPDTAAGLDHNYVLDS
EEEEECCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHCCCCCCCCCCHHCCCCCCEEECC
EPGDKIAAILLDPESRHRLIVATDAPGLQVYTGEYLPQARQGIALEAQGFPNAVNTPHFP
CCCCEEEEEEECCCCCCEEEEEECCCCEEEEECCCCCHHHCCEEEEECCCCCCCCCCCCC
SVILRPGQSSTRSITWTVR
EEEECCCCCCCEEEEEEEC
>Mature Secondary Structure
MIFGTLPGGAPVELFELSSDKLTVRISNYGGRIISVVKDGMDMIVGPKHFEDMLKDTCYC
CEEEECCCCCCEEEEEECCCEEEEEEECCCCEEEEEECCCHHEEECCHHHHHHHHHHHHH
GAICGRVANRIAKGRFSIDGDSRTVAVNNGPNHLHGGIQGFDSKVWQVQEAGRNTLVLTL
HHHHHHHHHHHHCCEEEECCCCEEEEECCCCCHHCCCCCCCCHHHEEHHHCCCCEEEEEE
HSADGEENYPGNLEVVATYTVVEETLHLRLEAYADAATIVNLTNHAYWNLSGKPTIDSMT
ECCCCCCCCCCCEEEEEEEEEEHHHHHEEEEECCCEEEEEEECCCEEEECCCCCCCCEEE
LEIRASAYTPVDATNIPDGRILPVEGTDFDLRKAALLGERNSAAHPDTAAGLDHNYVLDS
EEEEECCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHCCCCCCCCCCHHCCCCCCEEECC
EPGDKIAAILLDPESRHRLIVATDAPGLQVYTGEYLPQARQGIALEAQGFPNAVNTPHFP
CCCCEEEEEEECCCCCCEEEEEECCCCEEEEECCCCCHHHCCEEEEECCCCCCCCCCCCC
SVILRPGQSSTRSITWTVR
EEEECCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]