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The map label for this gene is prtC [H]

Identifier: 187735782

GI number: 187735782

Start: 1560701

End: 1561972

Strand: Direct

Name: prtC [H]

Synonym: Amuc_1288

Alternate gene names: 187735782

Gene position: 1560701-1561972 (Clockwise)

Preceding gene: 187735781

Following gene: 187735783

Centisome position: 58.58

GC content: 60.61

Gene sequence:

>1272_bases
ATGCCTTTTCAAAACCGGATAGAAATCATGGCCCCGGCGGGGTCGTTTGAATCTCTGGCGGCCGCCTTGCAGGGCGGAGC
GGACTCCGTGTACTTCGGAGTAGGAAAGCTGAACATGCGTTCCCGCGCCACGGTCAATTTTTCGGAAGAAGATTTGCCGG
AAATCGTCGAGCGTTGCCATGAGGCGGGCGCCAAAGCTTATCTGACACTGAATATCATTGTGTACGATGAAGAGCTGGAG
GCGGTGCATGCCCTGTGCGACGCCGCCCGGAAAGCCGGTGTGGATGCCGTCATCGCTTCCGACCTGGCGGTGATTTCTTA
TGCGCGTTCCATTGGGCTGGAAGTCCATATGTCCGTGCAGGCCAACGTCTGCAACATGGCCTCCGTCAAATTTTACGCGC
AGTACGCGGATGTGGTGGTGCTGGCCCGGGAACTCACCCTGGCGCAAATCAGGCATATCATTGAATCCATCCGGAAGGAG
GGCGTGAAAGGCCCCTCCGGGGAGCTGCTGCGGGTGGAAATTTTCGCCCATGGGGCGTTATGTGTGGCCGTGTCCGGCAA
ATGCCACATGAGCCTGGCGGCCTACAACTCCTCCGCCAACCGGGGGGCCTGCTTCCAGAACTGCCGCCGCGCCTACCGCG
TGACGGATGAGGAAACGGGCAATGAACTGGTGATAGACAACAAATACGTGATGTCTCCCAAGGACCTGTGTACCATTCCG
GTGCTGGACCAGCTTCTGGACGCGGGCGTTTCCGTGCTGAAGCTGGAAGGGCGCGGCCGTTCCTCGGATTACGTCAGGAC
GGTTACCTCCGTGTACCGGGAAGCCGCGCGGGCATGCCAGGACGGAACCTTTTCCGCGGACAGGGCGGAAGCGTGGATGA
AACGGCTGGAATCCGTTTTCAACCGGGGATTCTGGCAAGGCGGCTATTACCTGGGCGTGAAGTGGGGGGAATGGAGCGGT
TCCGCCAACAGCCGCGCTGCCCTGTTGAAGATCCACATTGCCAGGGTAGAGAACTTTTATAAGAAGAACGGGGTGGCGGC
CCTGTTCCTGGAAGCCGGCGGCCTGTCCGCGGGGCAGACCATCCTCATAACAGGCCCCACTACGGGAGCCGTCCGCATGG
AAGTGGCAGCCATGCGGAGGGAGACGGCAGAGGGCATGGAGCCCGTAGAAGCCGCTCAAAAGGGAGAAACCGTCTATCTG
GCGGTTCCCGAACAGGTGCGCCGCCGGGACAAGGTGTACCTGCTGCGCCCCCGGATGCTGGAGGATGCCTGA

Upstream 100 bases:

>100_bases
CCCGGACCGCCTGTGCAATATTCACATGTCCATTGTTAAATGCTTTCCCGAGGGAAGAATTTCCGTCATTCTGATGGAAG
AACCCGGAGGACTTTGACCC

Downstream 100 bases:

>100_bases
ATGTCCGGTTGTCCCTTTCTTCCTCTGCCTGCCTTTTCCAAAGACCGGGAATCGACGGCAGGATGATTTTAATTTTTCCG
TTTCCTGCCCGGCTGGGCCG

Product: peptidase U32

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MPFQNRIEIMAPAGSFESLAAALQGGADSVYFGVGKLNMRSRATVNFSEEDLPEIVERCHEAGAKAYLTLNIIVYDEELE
AVHALCDAARKAGVDAVIASDLAVISYARSIGLEVHMSVQANVCNMASVKFYAQYADVVVLARELTLAQIRHIIESIRKE
GVKGPSGELLRVEIFAHGALCVAVSGKCHMSLAAYNSSANRGACFQNCRRAYRVTDEETGNELVIDNKYVMSPKDLCTIP
VLDQLLDAGVSVLKLEGRGRSSDYVRTVTSVYREAARACQDGTFSADRAEAWMKRLESVFNRGFWQGGYYLGVKWGEWSG
SANSRAALLKIHIARVENFYKKNGVAALFLEAGGLSAGQTILITGPTTGAVRMEVAAMRRETAEGMEPVEAAQKGETVYL
AVPEQVRRRDKVYLLRPRMLEDA

Sequences:

>Translated_423_residues
MPFQNRIEIMAPAGSFESLAAALQGGADSVYFGVGKLNMRSRATVNFSEEDLPEIVERCHEAGAKAYLTLNIIVYDEELE
AVHALCDAARKAGVDAVIASDLAVISYARSIGLEVHMSVQANVCNMASVKFYAQYADVVVLARELTLAQIRHIIESIRKE
GVKGPSGELLRVEIFAHGALCVAVSGKCHMSLAAYNSSANRGACFQNCRRAYRVTDEETGNELVIDNKYVMSPKDLCTIP
VLDQLLDAGVSVLKLEGRGRSSDYVRTVTSVYREAARACQDGTFSADRAEAWMKRLESVFNRGFWQGGYYLGVKWGEWSG
SANSRAALLKIHIARVENFYKKNGVAALFLEAGGLSAGQTILITGPTTGAVRMEVAAMRRETAEGMEPVEAAQKGETVYL
AVPEQVRRRDKVYLLRPRMLEDA
>Mature_422_residues
PFQNRIEIMAPAGSFESLAAALQGGADSVYFGVGKLNMRSRATVNFSEEDLPEIVERCHEAGAKAYLTLNIIVYDEELEA
VHALCDAARKAGVDAVIASDLAVISYARSIGLEVHMSVQANVCNMASVKFYAQYADVVVLARELTLAQIRHIIESIRKEG
VKGPSGELLRVEIFAHGALCVAVSGKCHMSLAAYNSSANRGACFQNCRRAYRVTDEETGNELVIDNKYVMSPKDLCTIPV
LDQLLDAGVSVLKLEGRGRSSDYVRTVTSVYREAARACQDGTFSADRAEAWMKRLESVFNRGFWQGGYYLGVKWGEWSGS
ANSRAALLKIHIARVENFYKKNGVAALFLEAGGLSAGQTILITGPTTGAVRMEVAAMRRETAEGMEPVEAAQKGETVYLA
VPEQVRRRDKVYLLRPRMLEDA

Specific function: Expresses collagenase activity. Hydrolyzes type I collagen. May play a role in virulence [H]

COG id: COG0826

COG function: function code O; Collagenase and related proteases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase U32 family [H]

Homologues:

Organism=Escherichia coli, GI87081910, Length=320, Percent_Identity=33.125, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1789548, Length=328, Percent_Identity=30.4878048780488, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1788397, Length=452, Percent_Identity=26.7699115044248, Blast_Score=128, Evalue=9e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001539 [H]

Pfam domain/function: PF01136 Peptidase_U32 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 46266; Mature: 46135

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU ; PS01276 PEPTIDASE_U32

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFQNRIEIMAPAGSFESLAAALQGGADSVYFGVGKLNMRSRATVNFSEEDLPEIVERCH
CCCCCCEEEEECCCCHHHHHHHHCCCCCEEEEEECCCCCCCCEEECCCCCHHHHHHHHHH
EAGAKAYLTLNIIVYDEELEAVHALCDAARKAGVDAVIASDLAVISYARSIGLEVHMSVQ
HCCCEEEEEEEEEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCEEEEEEEE
ANVCNMASVKFYAQYADVVVLARELTLAQIRHIIESIRKEGVKGPSGELLRVEIFAHGAL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCEE
CVAVSGKCHMSLAAYNSSANRGACFQNCRRAYRVTDEETGNELVIDNKYVMSPKDLCTIP
EEEECCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCEEEECCHHHEEHH
VLDQLLDAGVSVLKLEGRGRSSDYVRTVTSVYREAARACQDGTFSADRAEAWMKRLESVF
HHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
NRGFWQGGYYLGVKWGEWSGSANSRAALLKIHIARVENFYKKNGVAALFLEAGGLSAGQT
HCCCCCCCEEEEEEEECCCCCCCCCEEEEEEEHHHHHHHHHHCCCEEEEEECCCCCCCCE
ILITGPTTGAVRMEVAAMRRETAEGMEPVEAAQKGETVYLAVPEQVRRRDKVYLLRPRML
EEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEEECCHHHHCCCCEEEECCHHC
EDA
CCC
>Mature Secondary Structure 
PFQNRIEIMAPAGSFESLAAALQGGADSVYFGVGKLNMRSRATVNFSEEDLPEIVERCH
CCCCCEEEEECCCCHHHHHHHHCCCCCEEEEEECCCCCCCCEEECCCCCHHHHHHHHHH
EAGAKAYLTLNIIVYDEELEAVHALCDAARKAGVDAVIASDLAVISYARSIGLEVHMSVQ
HCCCEEEEEEEEEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCEEEEEEEE
ANVCNMASVKFYAQYADVVVLARELTLAQIRHIIESIRKEGVKGPSGELLRVEIFAHGAL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCEE
CVAVSGKCHMSLAAYNSSANRGACFQNCRRAYRVTDEETGNELVIDNKYVMSPKDLCTIP
EEEECCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCEEEECCHHHEEHH
VLDQLLDAGVSVLKLEGRGRSSDYVRTVTSVYREAARACQDGTFSADRAEAWMKRLESVF
HHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
NRGFWQGGYYLGVKWGEWSGSANSRAALLKIHIARVENFYKKNGVAALFLEAGGLSAGQT
HCCCCCCCEEEEEEEECCCCCCCCCEEEEEEEHHHHHHHHHHCCCEEEEEECCCCCCCCE
ILITGPTTGAVRMEVAAMRRETAEGMEPVEAAQKGETVYLAVPEQVRRRDKVYLLRPRML
EEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEEECCHHHHCCCCEEEECCHHC
EDA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12949112 [H]