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The map label for this gene is fklB [H]

Identifier: 187735776

GI number: 187735776

Start: 1544185

End: 1545018

Strand: Direct

Name: fklB [H]

Synonym: Amuc_1282

Alternate gene names: 187735776

Gene position: 1544185-1545018 (Clockwise)

Preceding gene: 187735775

Following gene: 187735777

Centisome position: 57.96

GC content: 55.28

Gene sequence:

>834_bases
ATGAAGATGAAACCTTCCATCGCCCTGTTTGCCGCTTCCGCTCTTCTGGCGGGTGTGGCAGGCGCGCAAGAAAAGGCCGC
CGAAGCTCCGGCAGCCGACCAACCCAAACAAGAGAAAGAAATTACTGTGTCTCCCGAACAGATGAAAAAGGACCTGGGCT
ATTTTCTGGGTTTCCAGAGCGGTCAGCAACTTGGTTCCATTCCTACCCTGACCTTTGACGACCTGGACCAGGAATCCTTC
CTGCAGGGCATCAAGGACGGCATGGTCCGCAAGCCCGCCAAGGACCAGGAACAGCTGAAACCCGCCCTGGATGCGTTCCA
GAAGCAAATTGACGAACGCATTTCCGCCAAGGCCAAGGCCAATTTGGAGGCCAGCAGGAAATTCATGGAGGAAAACGGCA
AAAAAGAAGGCGTCACCACAACGAAGTCCGGCCTCCAGTACAAGGTTGTGAACAAGGGCGGCGAAGAAAAATTTGATGAA
AAGAAGTTCAAGAACCCCATGTTCAAGGTGAAGTACAAGGGCACGCTGCTGGACGGCACCGTGTTTGACGACACCAAGGG
CAAGTCCGTGGAACTTCCTCTCCAGGTCATCCCCGGTTTTGCCGAAGCGCTGACCACGATGCCCGTCGGCTCCAAATGGA
TTGTCTACATTCCTTCCGAGCTGGCTTACGGGGAAAACACTCCCGGCGCTCCGATTGAACCCAATTCCCCGCTCATCTTT
GATCTGGAACTGGACGGCATTTCGGAAGCCCCTGCTCCCCAGGGAGGCCCCATGAGCATTTCTCCGGAACAACTTCAGGA
GATGCTTAAGCAGAGCGGCGCCCAGCAGCAGTAA

Upstream 100 bases:

>100_bases
TGCCGGGAGAGGATGACAGGATGACCGATTCTCTTGTCTTGTGATATGAACGGAATCCGTTAAAAAGGAGTCCTCTTTTC
AAAGAAAGGATAAAAATACC

Downstream 100 bases:

>100_bases
GGAAAAAATAATTCAAGTCAGGGCCGTTCCCGGGAGGGAGCGGCCTTTTTGTTTCTATCCGTACCGCTTTCATCAGGAAA
GCGAATGGGCAGACTGGGAA

Product: peptidylprolyl isomerase FKBP-type

Products: NA

Alternate protein names: FKBP22; PPIase; Rotamase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MKMKPSIALFAASALLAGVAGAQEKAAEAPAADQPKQEKEITVSPEQMKKDLGYFLGFQSGQQLGSIPTLTFDDLDQESF
LQGIKDGMVRKPAKDQEQLKPALDAFQKQIDERISAKAKANLEASRKFMEENGKKEGVTTTKSGLQYKVVNKGGEEKFDE
KKFKNPMFKVKYKGTLLDGTVFDDTKGKSVELPLQVIPGFAEALTTMPVGSKWIVYIPSELAYGENTPGAPIEPNSPLIF
DLELDGISEAPAPQGGPMSISPEQLQEMLKQSGAQQQ

Sequences:

>Translated_277_residues
MKMKPSIALFAASALLAGVAGAQEKAAEAPAADQPKQEKEITVSPEQMKKDLGYFLGFQSGQQLGSIPTLTFDDLDQESF
LQGIKDGMVRKPAKDQEQLKPALDAFQKQIDERISAKAKANLEASRKFMEENGKKEGVTTTKSGLQYKVVNKGGEEKFDE
KKFKNPMFKVKYKGTLLDGTVFDDTKGKSVELPLQVIPGFAEALTTMPVGSKWIVYIPSELAYGENTPGAPIEPNSPLIF
DLELDGISEAPAPQGGPMSISPEQLQEMLKQSGAQQQ
>Mature_277_residues
MKMKPSIALFAASALLAGVAGAQEKAAEAPAADQPKQEKEITVSPEQMKKDLGYFLGFQSGQQLGSIPTLTFDDLDQESF
LQGIKDGMVRKPAKDQEQLKPALDAFQKQIDERISAKAKANLEASRKFMEENGKKEGVTTTKSGLQYKVVNKGGEEKFDE
KKFKNPMFKVKYKGTLLDGTVFDDTKGKSVELPLQVIPGFAEALTTMPVGSKWIVYIPSELAYGENTPGAPIEPNSPLIF
DLELDGISEAPAPQGGPMSISPEQLQEMLKQSGAQQQ

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm. Periplasm. Note=According to PubMed:7610040 it is periplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI87082390, Length=199, Percent_Identity=42.2110552763819, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1789745, Length=192, Percent_Identity=35.4166666666667, Blast_Score=91, Evalue=7e-20,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 30115; Mature: 30115

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMKPSIALFAASALLAGVAGAQEKAAEAPAADQPKQEKEITVSPEQMKKDLGYFLGFQS
CCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCEEECHHHHHHHHHHHHCCCC
GQQLGSIPTLTFDDLDQESFLQGIKDGMVRKPAKDQEQLKPALDAFQKQIDERISAKAKA
CCHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
NLEASRKFMEENGKKEGVTTTKSGLQYKVVNKGGEEKFDEKKFKNPMFKVKYKGTLLDGT
CHHHHHHHHHHCCCCCCCEECCCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCEEECCE
VFDDTKGKSVELPLQVIPGFAEALTTMPVGSKWIVYIPSELAYGENTPGAPIEPNSPLIF
EECCCCCCEEECHHHHHCCHHHHHHHCCCCCEEEEEECCHHCCCCCCCCCCCCCCCCEEE
DLELDGISEAPAPQGGPMSISPEQLQEMLKQSGAQQQ
EEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKMKPSIALFAASALLAGVAGAQEKAAEAPAADQPKQEKEITVSPEQMKKDLGYFLGFQS
CCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCEEECHHHHHHHHHHHHCCCC
GQQLGSIPTLTFDDLDQESFLQGIKDGMVRKPAKDQEQLKPALDAFQKQIDERISAKAKA
CCHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
NLEASRKFMEENGKKEGVTTTKSGLQYKVVNKGGEEKFDEKKFKNPMFKVKYKGTLLDGT
CHHHHHHHHHHCCCCCCCEECCCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCEEECCE
VFDDTKGKSVELPLQVIPGFAEALTTMPVGSKWIVYIPSELAYGENTPGAPIEPNSPLIF
EECCCCCCEEECHHHHHCCHHHHHHHCCCCCEEEEEECCHHCCCCCCCCCCCCCCCCEEE
DLELDGISEAPAPQGGPMSISPEQLQEMLKQSGAQQQ
EEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 8703024; 9298646 [H]