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The map label for this gene is hmrM [H]

Identifier: 187735626

GI number: 187735626

Start: 1353001

End: 1354338

Strand: Reverse

Name: hmrM [H]

Synonym: Amuc_1131

Alternate gene names: 187735626

Gene position: 1354338-1353001 (Counterclockwise)

Preceding gene: 187735627

Following gene: 187735620

Centisome position: 50.84

GC content: 53.51

Gene sequence:

>1338_bases
ATGAATAATCCTTCTTTTACTTCCTATCAAAAGATATGGCTCATGTCATACCCCCTCATGATCAGCCTGATCATTGAGCA
TATGATCGGCCTGACGGATGCCGTCTTCCTGGGGCGCGTGGGGGACGTGGCGCTGGGAGCATGCGCTCTGGGCGGCGTGT
ATTACATGGCCATGTTCATGCTGGCATTCGGCTTCGGCTTTGGCGCACAAATCATCATTGCGCGCCGCAACGGGGAACGC
CGTTACAACAGGATTGCCCCCACCATGGTTCAGGGCTGTTATTTCATGCTGGTCCTGGCGGTAGCCCTTTTCGCCGCATC
CCAATATTTTTCCCCCATCATCCTGCGGGACATCATTGAATCTCCACAGGTGTACGGGGCCACGGCGGATTACCTGCACT
GGCGCACCTACGGTATTTTTTTCTCTTTCCTCTGCGTCATGTTCCGAGCCTATTACGTGGGGATTACCCAGACGAAAATT
CTGACGGTCAATTCCATTGTCATGCTCCTGAGCAATGTCGCGTTAAATTACTGCCTCATTTTCGGGAAAGGCGGCTTTCC
CGCCGCAGGCATAGCAGGGGCGGCCATTGCCTCCAGCGTATCGGAAGCAGTCTCCCTTCTCTTTTTCATCATCTACACAA
GCATGACGGCGGATAAACGGAAGTACGGCTTCCGCCGGGCATTCACACTCCGCCCCCATCTGCTGAAGGGAATGCTGTCC
ATTTCCGGATGGACCATGGTGCAATCTTTTATTTCCGTCTCCATCTGGTTTATTTTTTTCCTGGCGATTGAACATTTGGG
GGAACGCCCGCTGGCCGTTACCAACATCGTCCGCAATATTTCCGCCCTGCTGATCATGGTGATCAGCGCTTTTGCCACCA
CGGCAGGAGCTCTCATCAGCAACCAGATTGGAGCGGGAGAACAGCGCTGCCTGTTCAAAACCTGCGGCATGACTCTCAAA
CTGACATACGCCATCCTGATCCCCCTGCTCATCATACTGTGCCTGTTTCCGGAGTCCGTCCTCCGTGCCTTCACGGATAG
TCCGTCCCTGATTGCCGCCAGCGTCAATTCCGTGTATGTGATGGCTTCTTCCACACTGATCATGGCTCCGTCATTCATCC
TGTTCAATGCCGTATCCGGCACAGGCAATACCAAGGCGGGATTCATCATGGAAATGATTTCCCTGGCCGTTTACACGGCC
GTCATTTATTACGGCATCATCAGGCTCAAGCCGGATGTGGCTCTCTGCTGGTTTTCCGAACACGTTTACGGCGTTACCCT
GATCTTCCTGGCATGGTGGTACCTCAAGAGCGGGAAATGGAGAGGCAAAAAGGTTTAG

Upstream 100 bases:

>100_bases
AGCAAACGCATTTCTTTCTTGCAAGAAAACATTTTAATTCAAAAATATTTGGCCTTTAGCGCCTGCCCTTGGCGGACCAT
GCCCGCAGGCTGCCCCCGCT

Downstream 100 bases:

>100_bases
GAGGAACAAGAACGGGGAACGGCACGAAATAAAGTCCGCTTTCATCCAGGCGTCTCCAACGCTCTCCCATTCTCAAAAAA
TGCCCTGGTTGGAGAAAAGG

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter; Na(+)/drug antiporter [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MNNPSFTSYQKIWLMSYPLMISLIIEHMIGLTDAVFLGRVGDVALGACALGGVYYMAMFMLAFGFGFGAQIIIARRNGER
RYNRIAPTMVQGCYFMLVLAVALFAASQYFSPIILRDIIESPQVYGATADYLHWRTYGIFFSFLCVMFRAYYVGITQTKI
LTVNSIVMLLSNVALNYCLIFGKGGFPAAGIAGAAIASSVSEAVSLLFFIIYTSMTADKRKYGFRRAFTLRPHLLKGMLS
ISGWTMVQSFISVSIWFIFFLAIEHLGERPLAVTNIVRNISALLIMVISAFATTAGALISNQIGAGEQRCLFKTCGMTLK
LTYAILIPLLIILCLFPESVLRAFTDSPSLIAASVNSVYVMASSTLIMAPSFILFNAVSGTGNTKAGFIMEMISLAVYTA
VIYYGIIRLKPDVALCWFSEHVYGVTLIFLAWWYLKSGKWRGKKV

Sequences:

>Translated_445_residues
MNNPSFTSYQKIWLMSYPLMISLIIEHMIGLTDAVFLGRVGDVALGACALGGVYYMAMFMLAFGFGFGAQIIIARRNGER
RYNRIAPTMVQGCYFMLVLAVALFAASQYFSPIILRDIIESPQVYGATADYLHWRTYGIFFSFLCVMFRAYYVGITQTKI
LTVNSIVMLLSNVALNYCLIFGKGGFPAAGIAGAAIASSVSEAVSLLFFIIYTSMTADKRKYGFRRAFTLRPHLLKGMLS
ISGWTMVQSFISVSIWFIFFLAIEHLGERPLAVTNIVRNISALLIMVISAFATTAGALISNQIGAGEQRCLFKTCGMTLK
LTYAILIPLLIILCLFPESVLRAFTDSPSLIAASVNSVYVMASSTLIMAPSFILFNAVSGTGNTKAGFIMEMISLAVYTA
VIYYGIIRLKPDVALCWFSEHVYGVTLIFLAWWYLKSGKWRGKKV
>Mature_445_residues
MNNPSFTSYQKIWLMSYPLMISLIIEHMIGLTDAVFLGRVGDVALGACALGGVYYMAMFMLAFGFGFGAQIIIARRNGER
RYNRIAPTMVQGCYFMLVLAVALFAASQYFSPIILRDIIESPQVYGATADYLHWRTYGIFFSFLCVMFRAYYVGITQTKI
LTVNSIVMLLSNVALNYCLIFGKGGFPAAGIAGAAIASSVSEAVSLLFFIIYTSMTADKRKYGFRRAFTLRPHLLKGMLS
ISGWTMVQSFISVSIWFIFFLAIEHLGERPLAVTNIVRNISALLIMVISAFATTAGALISNQIGAGEQRCLFKTCGMTLK
LTYAILIPLLIILCLFPESVLRAFTDSPSLIAASVNSVYVMASSTLIMAPSFILFNAVSGTGNTKAGFIMEMISLAVYTA
VIYYGIIRLKPDVALCWFSEHVYGVTLIFLAWWYLKSGKWRGKKV

Specific function: Multidrug efflux pump that functions as a Na(+)/drug antiporter. Confers resistance to norfloxacin, acriflavine, doxorubicin, ethidium bromide, tetraphenylphosphonium chloride, daunomycin, berberine and sodium deoxycholate [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49207; Mature: 49207

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNPSFTSYQKIWLMSYPLMISLIIEHMIGLTDAVFLGRVGDVALGACALGGVYYMAMFM
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LAFGFGFGAQIIIARRNGERRYNRIAPTMVQGCYFMLVLAVALFAASQYFSPIILRDIIE
HHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHC
SPQVYGATADYLHWRTYGIFFSFLCVMFRAYYVGITQTKILTVNSIVMLLSNVALNYCLI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEE
FGKGGFPAAGIAGAAIASSVSEAVSLLFFIIYTSMTADKRKYGFRRAFTLRPHLLKGMLS
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHEEECCHHHHHHHHH
ISGWTMVQSFISVSIWFIFFLAIEHLGERPLAVTNIVRNISALLIMVISAFATTAGALIS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NQIGAGEQRCLFKTCGMTLKLTYAILIPLLIILCLFPESVLRAFTDSPSLIAASVNSVYV
HCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEECCCCEEE
MASSTLIMAPSFILFNAVSGTGNTKAGFIMEMISLAVYTAVIYYGIIRLKPDVALCWFSE
EECCHHHHCCHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEEHHH
HVYGVTLIFLAWWYLKSGKWRGKKV
HHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNNPSFTSYQKIWLMSYPLMISLIIEHMIGLTDAVFLGRVGDVALGACALGGVYYMAMFM
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LAFGFGFGAQIIIARRNGERRYNRIAPTMVQGCYFMLVLAVALFAASQYFSPIILRDIIE
HHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHC
SPQVYGATADYLHWRTYGIFFSFLCVMFRAYYVGITQTKILTVNSIVMLLSNVALNYCLI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEE
FGKGGFPAAGIAGAAIASSVSEAVSLLFFIIYTSMTADKRKYGFRRAFTLRPHLLKGMLS
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHEEECCHHHHHHHHH
ISGWTMVQSFISVSIWFIFFLAIEHLGERPLAVTNIVRNISALLIMVISAFATTAGALIS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NQIGAGEQRCLFKTCGMTLKLTYAILIPLLIILCLFPESVLRAFTDSPSLIAASVNSVYV
HCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEECCCCEEE
MASSTLIMAPSFILFNAVSGTGNTKAGFIMEMISLAVYTAVIYYGIIRLKPDVALCWFSE
EECCHHHHCCHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEEHHH
HVYGVTLIFLAWWYLKSGKWRGKKV
HHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]