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The map label for this gene is galK [H]

Identifier: 187735470

GI number: 187735470

Start: 1156686

End: 1157864

Strand: Direct

Name: galK [H]

Synonym: Amuc_0969

Alternate gene names: 187735470

Gene position: 1156686-1157864 (Clockwise)

Preceding gene: 187735469

Following gene: 187735471

Centisome position: 43.42

GC content: 57.17

Gene sequence:

>1179_bases
ATGGATTTAGTTCAGCGAGAAATCTCTAAAGAAACGGTGACTCCGTATTTCATCGAGTATTTCGGTCAGGCGCCTACTCA
TGTGGCAGCGGCACCGGGACGTGTGAACCTTATTGGTGAGCACACGGATTATAATAACGGTTTTGTGATGCCTATGGCGC
TTGATAACCATTGTGTTGTGGCTGTGGCTCCCTCCCCCGTGGGCAAACACCGCTTTTGCGGTTCCCTGGGTGACCAGATC
CATGAAATTGCAGTGGAAGACGCCTTGGTTCCCGGCGAACCGTTCTGGTCCAATTATGTCCGCGGCGTTTTGGCCAACCT
GCACAGGCGCGGCATAGAAATCGGGCCTGTGGATATGCTGATTGACAGCAATGTGCCCCGCGGCGGCGGCCTCTCCTCCA
GTGCCGCTCTTGAAGTTGCCGTCTGTACGGCGCTCGCCGCTTTTGCCGGCGTTGAAATAGATCCCAAGGAAGTAGCCCTC
ATTGGGCAGGCCGTGGAACATGAATTCGTGAACGTTCCCTGCGGCATCATGGACCAGTTTATTTCCGCCAACGGCAAGAA
GGGCATGGCTCTCAAGCTGGATTGCGCCACGCTGGAATATGAGCTGGTTCCGATGAACAATGAATCCGTCTCCGTGCTGG
TTCTGGACAGCGCTGTGAAGCATTCCCTGGCGGACGGAGCTTATGGACAGCGCCGCAAGCAGTGTGAGGAAGCTTCTTCC
ATCATGGGCGTACCCTCCCTGCGGGAAGCTACGCTGGAGCTGCTGGAATCCTTCAGGGAACAGCTTGGCGATGTGCGCTA
TCGCCGCGCCCGCCACGTCATTGGAGAAAATGCGCGCGTGAACGCTTTTGCGAACGCCCTTGCCCGCGGCGATTGGGATG
AGGCCGGCGTAGCCATGCGCGGCAGCCATGCTTCCCTGCGGGACGACTATGAAGTTTCCTGTGCTGAGGTGGATACCCTT
GTTTCACTTTGTGACCGCATTCCCTCCGCATCCTCCATTTACGGCGCGCGCATGACGGGCGGCGGGTTTGGCGGATGCAT
TGTGGCCCTGGTGAAGACGGAGGATGTGGAAAAGGTGGCCCAGGAGCTTCTGGACGGCTACTGCCAGGAAACGGGCATTG
AAACTACGTATCTTGTAACCCGTGCCGGAGAAGGCGCCCGTGTTTTGTACCAAGCTTAA

Upstream 100 bases:

>100_bases
GGATGGAATTGGTGTATTCTGTGGAAAATGAAAAAAATTATTGCCGGACAGAGACTTTAATCTTGAGGTGCGGAAAGGGA
TGGGGCAGAATCAATCTACT

Downstream 100 bases:

>100_bases
TCCATACTGATGATGAAAACACTAGCAACCATATTCGGGGCGCTCGCCCTGATGACGTGGGGCGCAGCTGCCCAGGAGGG
TCCCGTACCTGCAACGGCGG

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MDLVQREISKETVTPYFIEYFGQAPTHVAAAPGRVNLIGEHTDYNNGFVMPMALDNHCVVAVAPSPVGKHRFCGSLGDQI
HEIAVEDALVPGEPFWSNYVRGVLANLHRRGIEIGPVDMLIDSNVPRGGGLSSSAALEVAVCTALAAFAGVEIDPKEVAL
IGQAVEHEFVNVPCGIMDQFISANGKKGMALKLDCATLEYELVPMNNESVSVLVLDSAVKHSLADGAYGQRRKQCEEASS
IMGVPSLREATLELLESFREQLGDVRYRRARHVIGENARVNAFANALARGDWDEAGVAMRGSHASLRDDYEVSCAEVDTL
VSLCDRIPSASSIYGARMTGGGFGGCIVALVKTEDVEKVAQELLDGYCQETGIETTYLVTRAGEGARVLYQA

Sequences:

>Translated_392_residues
MDLVQREISKETVTPYFIEYFGQAPTHVAAAPGRVNLIGEHTDYNNGFVMPMALDNHCVVAVAPSPVGKHRFCGSLGDQI
HEIAVEDALVPGEPFWSNYVRGVLANLHRRGIEIGPVDMLIDSNVPRGGGLSSSAALEVAVCTALAAFAGVEIDPKEVAL
IGQAVEHEFVNVPCGIMDQFISANGKKGMALKLDCATLEYELVPMNNESVSVLVLDSAVKHSLADGAYGQRRKQCEEASS
IMGVPSLREATLELLESFREQLGDVRYRRARHVIGENARVNAFANALARGDWDEAGVAMRGSHASLRDDYEVSCAEVDTL
VSLCDRIPSASSIYGARMTGGGFGGCIVALVKTEDVEKVAQELLDGYCQETGIETTYLVTRAGEGARVLYQA
>Mature_392_residues
MDLVQREISKETVTPYFIEYFGQAPTHVAAAPGRVNLIGEHTDYNNGFVMPMALDNHCVVAVAPSPVGKHRFCGSLGDQI
HEIAVEDALVPGEPFWSNYVRGVLANLHRRGIEIGPVDMLIDSNVPRGGGLSSSAALEVAVCTALAAFAGVEIDPKEVAL
IGQAVEHEFVNVPCGIMDQFISANGKKGMALKLDCATLEYELVPMNNESVSVLVLDSAVKHSLADGAYGQRRKQCEEASS
IMGVPSLREATLELLESFREQLGDVRYRRARHVIGENARVNAFANALARGDWDEAGVAMRGSHASLRDDYEVSCAEVDTL
VSLCDRIPSASSIYGARMTGGGFGGCIVALVKTEDVEKVAQELLDGYCQETGIETTYLVTRAGEGARVLYQA

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=380, Percent_Identity=43.421052631579, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI48527957, Length=440, Percent_Identity=27.2727272727273, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI4503897, Length=440, Percent_Identity=27.2727272727273, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1786972, Length=379, Percent_Identity=43.5356200527704, Blast_Score=301, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI71989053, Length=419, Percent_Identity=26.0143198090692, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320212, Length=228, Percent_Identity=27.1929824561404, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319494, Length=261, Percent_Identity=26.8199233716475, Blast_Score=73, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24661292, Length=416, Percent_Identity=29.3269230769231, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI21355577, Length=416, Percent_Identity=29.3269230769231, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24661285, Length=416, Percent_Identity=29.3269230769231, Blast_Score=111, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 42148; Mature: 42148

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLVQREISKETVTPYFIEYFGQAPTHVAAAPGRVNLIGEHTDYNNGFVMPMALDNHCVV
CCHHHHHHHHHCCCHHHHHHHCCCCCEEECCCCCEEEEECCCCCCCCEEEEEEECCCEEE
AVAPSPVGKHRFCGSLGDQIHEIAVEDALVPGEPFWSNYVRGVLANLHRRGIEIGPVDML
EECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEECCEEEE
IDSNVPRGGGLSSSAALEVAVCTALAAFAGVEIDPKEVALIGQAVEHEFVNVPCGIMDQF
EECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHH
ISANGKKGMALKLDCATLEYELVPMNNESVSVLVLDSAVKHSLADGAYGQRRKQCEEASS
HCCCCCCCCEEEEEEEEEEEEEEECCCCCEEEEEECHHHHHHHCCCCCHHHHHHHHHHHH
IMGVPSLREATLELLESFREQLGDVRYRRARHVIGENARVNAFANALARGDWDEAGVAMR
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEE
GSHASLRDDYEVSCAEVDTLVSLCDRIPSASSIYGARMTGGGFGGCIVALVKTEDVEKVA
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCEEEEEEECCHHHHHHH
QELLDGYCQETGIETTYLVTRAGEGARVLYQA
HHHHHHHHHHCCCCEEEEEEECCCCCEEEEEC
>Mature Secondary Structure
MDLVQREISKETVTPYFIEYFGQAPTHVAAAPGRVNLIGEHTDYNNGFVMPMALDNHCVV
CCHHHHHHHHHCCCHHHHHHHCCCCCEEECCCCCEEEEECCCCCCCCEEEEEEECCCEEE
AVAPSPVGKHRFCGSLGDQIHEIAVEDALVPGEPFWSNYVRGVLANLHRRGIEIGPVDML
EECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEECCEEEE
IDSNVPRGGGLSSSAALEVAVCTALAAFAGVEIDPKEVALIGQAVEHEFVNVPCGIMDQF
EECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHH
ISANGKKGMALKLDCATLEYELVPMNNESVSVLVLDSAVKHSLADGAYGQRRKQCEEASS
HCCCCCCCCEEEEEEEEEEEEEEECCCCCEEEEEECHHHHHHHCCCCCHHHHHHHHHHHH
IMGVPSLREATLELLESFREQLGDVRYRRARHVIGENARVNAFANALARGDWDEAGVAMR
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEE
GSHASLRDDYEVSCAEVDTLVSLCDRIPSASSIYGARMTGGGFGGCIVALVKTEDVEKVA
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCEEEEEEECCHHHHHHH
QELLDGYCQETGIETTYLVTRAGEGARVLYQA
HHHHHHHHHHCCCCEEEEEEECCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA