| Definition | Akkermansia muciniphila ATCC BAA-835, complete genome. |
|---|---|
| Accession | NC_010655 |
| Length | 2,664,102 |
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The map label for this gene is ppiB [H]
Identifier: 187735450
GI number: 187735450
Start: 1130150
End: 1130743
Strand: Reverse
Name: ppiB [H]
Synonym: Amuc_0949
Alternate gene names: 187735450
Gene position: 1130743-1130150 (Counterclockwise)
Preceding gene: 187735451
Following gene: 187735449
Centisome position: 42.44
GC content: 60.27
Gene sequence:
>594_bases ATGAAAAAATATCTCACCCTTCTGTTGTGTTCCCTGTGCGCCCTGGCGTGCTTCAGCGCCTCCGCGGAATCCACAGCCGG CCTCAAGGACGTCAATGTCGTCATCTCCACTACCAAAGGGGATATTGAACTGGCCCTTTACCCCTCCAAGGCGCCCGTCA CCGTAGCCAACTTCCTGAACCTCGCCAGCAGAGGGTACTACAAGGGCATCACCTTCCACCGCGTGATTCCGAATTTCATG ATCCAGGGCGGCGATCCCACCGGCACGGGCATGGGAGGCCCCGGCTACAGTTTTGAAGACGAGTTTTCCCCGGACCTCAG GCATGACGGCCCCGGCGTGCTTTCCATGGCGAACGCGGGCCCCGGCACCAACGGTTCCCAATTTTTCATCACCCATGTGG CCACGCCCCATCTGGACGGCCGCCATACGGTCTTCGGGAAGGTGCTGAAAGGGCAGGACGTCGTCAACTCCATTGTCCGG GGGGACAAAATCAAGGACATCCGCATTCTGGACAAGAACGCCGCAGCTGCCGTGCTGAAAGCGGAAGCCGCCCGCGTAAC CCGGTGGAACAAGGCCCTGGACGCCGCCAGATAA
Upstream 100 bases:
>100_bases TCCCGCATTGGCGCGCCCCGCGCCATTCTCCCGTCAGGGCGCGCGATTTACTTGCAACCCTGCTTTTATTCGGGCAACAT AGGGGGGAAAACAAGAAGCC
Downstream 100 bases:
>100_bases CCAGGAAGCTGCCAGCGGCATGAACGATCTCCGGTGCGCCGCCGCCCATTCCCGGTTTTCCGCAGGAAGCGGAGGCCAGG CGGGAAGACGCGGACGAACG
Product: Peptidylprolyl isomerase
Products: NA
Alternate protein names: PPIase; Rotamase [H]
Number of amino acids: Translated: 197; Mature: 197
Protein sequence:
>197_residues MKKYLTLLLCSLCALACFSASAESTAGLKDVNVVISTTKGDIELALYPSKAPVTVANFLNLASRGYYKGITFHRVIPNFM IQGGDPTGTGMGGPGYSFEDEFSPDLRHDGPGVLSMANAGPGTNGSQFFITHVATPHLDGRHTVFGKVLKGQDVVNSIVR GDKIKDIRILDKNAAAAVLKAEAARVTRWNKALDAAR
Sequences:
>Translated_197_residues MKKYLTLLLCSLCALACFSASAESTAGLKDVNVVISTTKGDIELALYPSKAPVTVANFLNLASRGYYKGITFHRVIPNFM IQGGDPTGTGMGGPGYSFEDEFSPDLRHDGPGVLSMANAGPGTNGSQFFITHVATPHLDGRHTVFGKVLKGQDVVNSIVR GDKIKDIRILDKNAAAAVLKAEAARVTRWNKALDAAR >Mature_197_residues MKKYLTLLLCSLCALACFSASAESTAGLKDVNVVISTTKGDIELALYPSKAPVTVANFLNLASRGYYKGITFHRVIPNFM IQGGDPTGTGMGGPGYSFEDEFSPDLRHDGPGVLSMANAGPGTNGSQFFITHVATPHLDGRHTVFGKVLKGQDVVNSIVR GDKIKDIRILDKNAAAAVLKAEAARVTRWNKALDAAR
Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]
COG id: COG0652
COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family
Gene ontology:
Cell location: Periplasmic Protein [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 PPIase cyclophilin-type domain [H]
Homologues:
Organism=Homo sapiens, GI24308049, Length=128, Percent_Identity=60.9375, Blast_Score=156, Evalue=1e-38, Organism=Homo sapiens, GI7706339, Length=130, Percent_Identity=57.6923076923077, Blast_Score=150, Evalue=5e-37, Organism=Homo sapiens, GI19557636, Length=133, Percent_Identity=49.6240601503759, Blast_Score=135, Evalue=2e-32, Organism=Homo sapiens, GI64276486, Length=119, Percent_Identity=48.7394957983193, Blast_Score=122, Evalue=2e-28, Organism=Homo sapiens, GI10863927, Length=144, Percent_Identity=49.3055555555556, Blast_Score=118, Evalue=3e-27, Organism=Homo sapiens, GI4758950, Length=191, Percent_Identity=45.0261780104712, Blast_Score=116, Evalue=1e-26, Organism=Homo sapiens, GI22547212, Length=129, Percent_Identity=51.937984496124, Blast_Score=115, Evalue=3e-26, Organism=Homo sapiens, GI7657473, Length=129, Percent_Identity=51.937984496124, Blast_Score=115, Evalue=3e-26, Organism=Homo sapiens, GI4505991, Length=169, Percent_Identity=47.9289940828402, Blast_Score=115, Evalue=4e-26, Organism=Homo sapiens, GI22547215, Length=147, Percent_Identity=50.3401360544218, Blast_Score=114, Evalue=5e-26, Organism=Homo sapiens, GI5031987, Length=126, Percent_Identity=53.968253968254, Blast_Score=111, Evalue=4e-25, Organism=Homo sapiens, GI45439316, Length=131, Percent_Identity=48.0916030534351, Blast_Score=111, Evalue=4e-25, Organism=Homo sapiens, GI303305009, Length=159, Percent_Identity=44.6540880503145, Blast_Score=110, Evalue=6e-25, Organism=Homo sapiens, GI5174637, Length=126, Percent_Identity=50, Blast_Score=110, Evalue=9e-25, Organism=Homo sapiens, GI4826932, Length=143, Percent_Identity=48.2517482517483, Blast_Score=109, Evalue=2e-24, Organism=Homo sapiens, GI310129267, Length=126, Percent_Identity=49.2063492063492, Blast_Score=108, Evalue=4e-24, Organism=Homo sapiens, GI310120620, Length=126, Percent_Identity=49.2063492063492, Blast_Score=108, Evalue=4e-24, Organism=Homo sapiens, GI310127646, Length=133, Percent_Identity=42.8571428571429, Blast_Score=106, Evalue=1e-23, Organism=Homo sapiens, GI310114371, Length=133, Percent_Identity=42.8571428571429, Blast_Score=106, Evalue=1e-23, Organism=Homo sapiens, GI310119221, Length=133, Percent_Identity=42.8571428571429, Blast_Score=106, Evalue=1e-23, Organism=Homo sapiens, GI6631100, Length=153, Percent_Identity=45.7516339869281, Blast_Score=105, Evalue=2e-23, Organism=Homo sapiens, GI256017253, Length=125, Percent_Identity=48.8, Blast_Score=105, Evalue=3e-23, Organism=Homo sapiens, GI221139811, Length=125, Percent_Identity=48.8, Blast_Score=105, Evalue=3e-23, Organism=Homo sapiens, GI256017251, Length=125, Percent_Identity=48.8, Blast_Score=105, Evalue=3e-23, Organism=Homo sapiens, GI310110104, Length=133, Percent_Identity=47.3684210526316, Blast_Score=104, Evalue=4e-23, Organism=Homo sapiens, GI42560244, Length=134, Percent_Identity=46.2686567164179, Blast_Score=104, Evalue=5e-23, Organism=Homo sapiens, GI178057341, Length=126, Percent_Identity=47.6190476190476, Blast_Score=103, Evalue=1e-22, Organism=Homo sapiens, GI20911035, Length=137, Percent_Identity=40.8759124087591, Blast_Score=100, Evalue=9e-22, Organism=Homo sapiens, GI209417936, Length=126, Percent_Identity=47.6190476190476, Blast_Score=100, Evalue=9e-22, Organism=Homo sapiens, GI30102944, Length=126, Percent_Identity=47.6190476190476, Blast_Score=100, Evalue=9e-22, Organism=Homo sapiens, GI219842199, Length=126, Percent_Identity=47.6190476190476, Blast_Score=100, Evalue=9e-22, Organism=Homo sapiens, GI310132444, Length=144, Percent_Identity=44.4444444444444, Blast_Score=100, Evalue=1e-21, Organism=Homo sapiens, GI310113152, Length=144, Percent_Identity=44.4444444444444, Blast_Score=100, Evalue=1e-21, Organism=Homo sapiens, GI150418007, Length=126, Percent_Identity=47.6190476190476, Blast_Score=100, Evalue=1e-21, Organism=Homo sapiens, GI5454154, Length=134, Percent_Identity=45.5223880597015, Blast_Score=98, Evalue=5e-21, Organism=Homo sapiens, GI169214050, Length=143, Percent_Identity=40.5594405594406, Blast_Score=97, Evalue=1e-20, Organism=Homo sapiens, GI239751853, Length=143, Percent_Identity=40.5594405594406, Blast_Score=96, Evalue=2e-20, Organism=Homo sapiens, GI113428306, Length=143, Percent_Identity=40.5594405594406, Blast_Score=96, Evalue=2e-20, Organism=Homo sapiens, GI169164185, Length=126, Percent_Identity=46.031746031746, Blast_Score=95, Evalue=4e-20, Organism=Homo sapiens, GI169163623, Length=126, Percent_Identity=46.031746031746, Blast_Score=95, Evalue=4e-20, Organism=Homo sapiens, GI169163387, Length=144, Percent_Identity=43.75, Blast_Score=95, Evalue=4e-20, Organism=Homo sapiens, GI310127745, Length=123, Percent_Identity=43.0894308943089, Blast_Score=93, Evalue=1e-19, Organism=Homo sapiens, GI310119290, Length=123, Percent_Identity=43.0894308943089, Blast_Score=93, Evalue=1e-19, Organism=Homo sapiens, GI310114540, Length=123, Percent_Identity=43.0894308943089, Blast_Score=92, Evalue=2e-19, Organism=Homo sapiens, GI27735045, Length=143, Percent_Identity=37.7622377622378, Blast_Score=82, Evalue=2e-16, Organism=Homo sapiens, GI14277126, Length=151, Percent_Identity=35.7615894039735, Blast_Score=81, Evalue=7e-16, Organism=Homo sapiens, GI289803023, Length=167, Percent_Identity=31.1377245508982, Blast_Score=71, Evalue=6e-13, Organism=Escherichia coli, GI1789763, Length=165, Percent_Identity=38.7878787878788, Blast_Score=90, Evalue=1e-19, Organism=Escherichia coli, GI1786736, Length=137, Percent_Identity=35.7664233576642, Blast_Score=67, Evalue=7e-13, Organism=Caenorhabditis elegans, GI17539496, Length=148, Percent_Identity=55.4054054054054, Blast_Score=151, Evalue=2e-37, Organism=Caenorhabditis elegans, GI17506311, Length=129, Percent_Identity=55.8139534883721, Blast_Score=139, Evalue=1e-33, Organism=Caenorhabditis elegans, GI71980590, Length=131, Percent_Identity=49.618320610687, Blast_Score=132, Evalue=1e-31, Organism=Caenorhabditis elegans, GI71980594, Length=131, Percent_Identity=49.618320610687, Blast_Score=132, Evalue=1e-31, Organism=Caenorhabditis elegans, GI17532641, Length=135, Percent_Identity=48.1481481481481, Blast_Score=131, Evalue=3e-31, Organism=Caenorhabditis elegans, GI71997782, Length=121, Percent_Identity=48.7603305785124, Blast_Score=125, Evalue=1e-29, Organism=Caenorhabditis elegans, GI17552780, Length=165, Percent_Identity=46.6666666666667, Blast_Score=122, Evalue=1e-28, Organism=Caenorhabditis elegans, GI17506307, Length=132, Percent_Identity=53.7878787878788, Blast_Score=118, Evalue=2e-27, Organism=Caenorhabditis elegans, GI17559074, Length=151, Percent_Identity=47.682119205298, Blast_Score=117, Evalue=3e-27, Organism=Caenorhabditis elegans, GI17552782, Length=133, Percent_Identity=49.6240601503759, Blast_Score=113, Evalue=8e-26, Organism=Caenorhabditis elegans, GI17552784, Length=134, Percent_Identity=47.7611940298507, Blast_Score=112, Evalue=1e-25, Organism=Caenorhabditis elegans, GI17565860, Length=135, Percent_Identity=49.6296296296296, Blast_Score=112, Evalue=2e-25, Organism=Caenorhabditis elegans, GI17566266, Length=133, Percent_Identity=49.6240601503759, Blast_Score=111, Evalue=2e-25, Organism=Caenorhabditis elegans, GI17551282, Length=132, Percent_Identity=50, Blast_Score=110, Evalue=4e-25, Organism=Caenorhabditis elegans, GI17551284, Length=132, Percent_Identity=50, Blast_Score=110, Evalue=4e-25, Organism=Caenorhabditis elegans, GI17539498, Length=126, Percent_Identity=48.4126984126984, Blast_Score=102, Evalue=1e-22, Organism=Caenorhabditis elegans, GI17532643, Length=131, Percent_Identity=48.0916030534351, Blast_Score=100, Evalue=5e-22, Organism=Caenorhabditis elegans, GI32563659, Length=154, Percent_Identity=37.6623376623377, Blast_Score=96, Evalue=1e-20, Organism=Caenorhabditis elegans, GI115533296, Length=147, Percent_Identity=34.0136054421769, Blast_Score=68, Evalue=3e-12, Organism=Saccharomyces cerevisiae, GI6320510, Length=171, Percent_Identity=49.1228070175439, Blast_Score=121, Evalue=8e-29, Organism=Saccharomyces cerevisiae, GI6323562, Length=132, Percent_Identity=53.7878787878788, Blast_Score=121, Evalue=9e-29, Organism=Saccharomyces cerevisiae, GI6321848, Length=172, Percent_Identity=44.1860465116279, Blast_Score=111, Evalue=1e-25, Organism=Saccharomyces cerevisiae, GI6320359, Length=126, Percent_Identity=52.3809523809524, Blast_Score=110, Evalue=1e-25, Organism=Saccharomyces cerevisiae, GI6323246, Length=137, Percent_Identity=48.1751824817518, Blast_Score=109, Evalue=3e-25, Organism=Saccharomyces cerevisiae, GI6322492, Length=177, Percent_Identity=37.2881355932203, Blast_Score=85, Evalue=7e-18, Organism=Drosophila melanogaster, GI17986117, Length=157, Percent_Identity=49.6815286624204, Blast_Score=149, Evalue=8e-37, Organism=Drosophila melanogaster, GI19922376, Length=157, Percent_Identity=45.2229299363057, Blast_Score=146, Evalue=1e-35, Organism=Drosophila melanogaster, GI19922912, Length=130, Percent_Identity=59.2307692307692, Blast_Score=134, Evalue=5e-32, Organism=Drosophila melanogaster, GI20130249, Length=162, Percent_Identity=49.3827160493827, Blast_Score=119, Evalue=1e-27, Organism=Drosophila melanogaster, GI21357249, Length=137, Percent_Identity=43.0656934306569, Blast_Score=117, Evalue=3e-27, Organism=Drosophila melanogaster, GI24652460, Length=133, Percent_Identity=41.3533834586466, Blast_Score=115, Evalue=2e-26, Organism=Drosophila melanogaster, GI45549139, Length=126, Percent_Identity=52.3809523809524, Blast_Score=112, Evalue=2e-25, Organism=Drosophila melanogaster, GI24664125, Length=126, Percent_Identity=52.3809523809524, Blast_Score=108, Evalue=3e-24, Organism=Drosophila melanogaster, GI21357783, Length=126, Percent_Identity=52.3809523809524, Blast_Score=108, Evalue=3e-24, Organism=Drosophila melanogaster, GI24650807, Length=134, Percent_Identity=46.2686567164179, Blast_Score=107, Evalue=4e-24, Organism=Drosophila melanogaster, GI17647301, Length=128, Percent_Identity=48.4375, Blast_Score=102, Evalue=1e-22, Organism=Drosophila melanogaster, GI17136360, Length=129, Percent_Identity=44.9612403100775, Blast_Score=102, Evalue=2e-22, Organism=Drosophila melanogaster, GI21355677, Length=156, Percent_Identity=38.4615384615385, Blast_Score=97, Evalue=6e-21, Organism=Drosophila melanogaster, GI24586038, Length=140, Percent_Identity=43.5714285714286, Blast_Score=97, Evalue=8e-21, Organism=Drosophila melanogaster, GI24661775, Length=118, Percent_Identity=38.135593220339, Blast_Score=68, Evalue=3e-12, Organism=Drosophila melanogaster, GI21355237, Length=118, Percent_Identity=38.135593220339, Blast_Score=68, Evalue=3e-12, Organism=Drosophila melanogaster, GI24661771, Length=118, Percent_Identity=38.135593220339, Blast_Score=68, Evalue=3e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR015891 - InterPro: IPR020892 - InterPro: IPR002130 [H]
Pfam domain/function: PF00160 Pro_isomerase [H]
EC number: =5.2.1.8 [H]
Molecular weight: Translated: 20968; Mature: 20968
Theoretical pI: Translated: 9.44; Mature: 9.44
Prosite motif: PS50072 CSA_PPIASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 2.0 %Met (Translated Protein) 3.6 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 2.0 %Met (Mature Protein) 3.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKKYLTLLLCSLCALACFSASAESTAGLKDVNVVISTTKGDIELALYPSKAPVTVANFLN CHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCHHHHHHH LASRGYYKGITFHRVIPNFMIQGGDPTGTGMGGPGYSFEDEFSPDLRHDGPGVLSMANAG HHHCCCCCCCHHHHHCCHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCC PGTNGSQFFITHVATPHLDGRHTVFGKVLKGQDVVNSIVRGDKIKDIRILDKNAAAAVLK CCCCCCEEEEEEECCCCCCCCHHHHHHHHCCHHHHHHHHCCCCCCEEEEECCCHHHHHHH AEAARVTRWNKALDAAR HHHHHHHHHHHHHHCCC >Mature Secondary Structure MKKYLTLLLCSLCALACFSASAESTAGLKDVNVVISTTKGDIELALYPSKAPVTVANFLN CHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCHHHHHHH LASRGYYKGITFHRVIPNFMIQGGDPTGTGMGGPGYSFEDEFSPDLRHDGPGVLSMANAG HHHCCCCCCCHHHHHCCHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCC PGTNGSQFFITHVATPHLDGRHTVFGKVLKGQDVVNSIVRGDKIKDIRILDKNAAAAVLK CCCCCCEEEEEEECCCCCCCCHHHHHHHHCCHHHHHHHHCCCCCCEEEEECCCHHHHHHH AEAARVTRWNKALDAAR HHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9317025; 9665876 [H]