Click here to switch to the map view.

The map label for this gene is mscL [H]

Identifier: 187735373

GI number: 187735373

Start: 1041128

End: 1041541

Strand: Reverse

Name: mscL [H]

Synonym: Amuc_0871

Alternate gene names: 187735373

Gene position: 1041541-1041128 (Counterclockwise)

Preceding gene: 187735377

Following gene: 187735372

Centisome position: 39.1

GC content: 54.11

Gene sequence:

>414_bases
ATGGCTCATTTTTTCAACCTCAAAGGCTTTCTGGAAGAATTCAAGGCATTCGCCCTTAAAGGGAACGTTATTGACCTGGC
GGTGGCCGTCGTCATCGGCGGCGCATTCAACAAAATCGTCTCCGTCTTCGTTTCCAGCATCATCACCCCCATCATCGGCT
ACCTTACTTCCGGGGTCAACCTGGCATACCTGGTGCTGAAGCTGGGCGATGTGGAATTAAAATACGGGGAATTGCTTCAG
GCGACCATTGACTTCCTCATCATCGCCTTCTCCGTCTTTGTAGCCATCAAGCTGATCGGAGCCCTGAGGCGCAAGAGCGA
AGAAGCTCCGGCCGCCCCTGCTCCCAAGCCGGATGACGTCGTCCTCCTGGAACAGATCCGGGACATCCTGCAAAAACAGG
CGGACGCCAAATAA

Upstream 100 bases:

>100_bases
CCCCGGAAGACAGTCACATCTTTGTCCGCCGCCCATTCATTTTTCTTTTCTTTTATCATTTTAACGGCAGAATAACCACC
GCAACCAGCAATAATCCACT

Downstream 100 bases:

>100_bases
GCCCTTTTGAACGGTTCATGCCGGTTCCATACGGGACCGGCATATTTTTTCCTCTTTACTTGTTCCGCCGCAGACGGGAA
AGTGATTGCATGACTTCTCC

Product: large conductance mechanosensitive channel protein

Products: non-specific ion/solute [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 137; Mature: 136

Protein sequence:

>137_residues
MAHFFNLKGFLEEFKAFALKGNVIDLAVAVVIGGAFNKIVSVFVSSIITPIIGYLTSGVNLAYLVLKLGDVELKYGELLQ
ATIDFLIIAFSVFVAIKLIGALRRKSEEAPAAPAPKPDDVVLLEQIRDILQKQADAK

Sequences:

>Translated_137_residues
MAHFFNLKGFLEEFKAFALKGNVIDLAVAVVIGGAFNKIVSVFVSSIITPIIGYLTSGVNLAYLVLKLGDVELKYGELLQ
ATIDFLIIAFSVFVAIKLIGALRRKSEEAPAAPAPKPDDVVLLEQIRDILQKQADAK
>Mature_136_residues
AHFFNLKGFLEEFKAFALKGNVIDLAVAVVIGGAFNKIVSVFVSSIITPIIGYLTSGVNLAYLVLKLGDVELKYGELLQA
TIDFLIIAFSVFVAIKLIGALRRKSEEAPAAPAPKPDDVVLLEQIRDILQKQADAK

Specific function: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell [H]

COG id: COG1970

COG function: function code M; Large-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscL family [H]

Homologues:

Organism=Escherichia coli, GI1789686, Length=132, Percent_Identity=46.969696969697, Blast_Score=118, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001185
- InterPro:   IPR015089 [H]

Pfam domain/function: PF01741 MscL [H]

EC number: NA

Molecular weight: Translated: 14847; Mature: 14716

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS01327 MSCL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHFFNLKGFLEEFKAFALKGNVIDLAVAVVIGGAFNKIVSVFVSSIITPIIGYLTSGVN
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LAYLVLKLGDVELKYGELLQATIDFLIIAFSVFVAIKLIGALRRKSEEAPAAPAPKPDDV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
VLLEQIRDILQKQADAK
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AHFFNLKGFLEEFKAFALKGNVIDLAVAVVIGGAFNKIVSVFVSSIITPIIGYLTSGVN
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LAYLVLKLGDVELKYGELLQATIDFLIIAFSVFVAIKLIGALRRKSEEAPAAPAPKPDDV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
VLLEQIRDILQKQADAK
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: non-specific ion/solute [Cytoplasm] [C]

Specific reaction: non-specific ion/solute [Cytoplasm] = non-specific ion/solute [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA