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The map label for this gene is nedA [H]

Identifier: 187735348

GI number: 187735348

Start: 1007089

End: 1009203

Strand: Direct

Name: nedA [H]

Synonym: Amuc_0846

Alternate gene names: 187735348

Gene position: 1007089-1009203 (Clockwise)

Preceding gene: 187735344

Following gene: 187735349

Centisome position: 37.8

GC content: 58.72

Gene sequence:

>2115_bases
ATGAATTTAAACCAGTTGATTAAGGCGGCCGTATTGGGAGGGGCCCTGTGCACGGCCTGTTTTGCAGGAGCCGGGCCGAA
GGGCTGTTTAACGCCGTTAAAGCCTGTTCCTTCCGCGGAGCAGCTTGAATGGCATGACATGGAGATGTATGCCTTTGTCC
ATTTTACGATTAATACCTTTACTGGAAAAGAGTGGGGCTATGGAGACGAAAAGCCGGAGCTGTTTCATCCTTCCGATTTC
GATGCGGATGATCTTGTCAGGACGCTGGCGGACGCCGGGTTCAAAGGGGTGGTGCTGACCTGCAAGCATCATGACGGTTT
TTGCCTGTGGCCCACAAAGACGACCCTCCATAGTGTAGCGGCTTCTCCGTGGAAGCAGGGGAAGGGCGATGTGGTGAAGG
AGGTGTCCCGCGCGTGCGGAAAGTATGGCGTCAGGTTCGGTGTTTATCTGTCTCCGTGGGACCGCAATGCCGCCTCTTAC
GGAACGCCGGATTATATCCGGATGTACCGTCAGCAGTTGAAAGAGCTGGCGACGGGATACGGTTCCATTTTCCTGGCTTG
GTTTGACGGAGCGAACGGAGGGGATGGGTATTACGGAGGAGCGCGGGAAAGGCGTTCTATCGACCGGAGCGCGTATTACG
ACTGGAAGGCAACTTGGGGTGAGTTGAAGAAACGGCAGCCCGGAGCCGTCATCTTTTCCGACGTAGGGCCGGATGTCCGC
TGGGTAGGCAATGAAAGCGGCTATGCGGGTTATCCCTGCTGGGCCACATACACCCCCGTTCCGCTGCAAGCCGGGACGGA
ACCCGCGCCCGGCACCGTGCGCTACCGGCTGGGCACGGAAGGCACCATGGACGGCAAGTACTGGATTCCTGCGGAGGTGG
ATGTTTCCATTCGTCCGGGCTGGTTCTGGCATGAGCATGAAAATTCCCGCGTCCGGACGCCGGAAAATCTGCTGAAGTTG
TATTTTGACAGCGTAGGCAGAGGGGCCAATTTGAATTTGAATGTGCCGCCGGACCGCCGCGGCCGCATTCATGAAGAGGA
TAAAAAGTCTCTGGCGGGCTTCCGTGTGCTGCTGGATGAGTTGTATTCCCGCAACTTCGCCTCCGGTGCACAGGCTGAGT
CCTCCTCTTCTTGGAAGGGGCACGGTGCGGAACAGGTTCTGGACCGGAAACGGACGACGTACTGGGTGGCCGCTCCGGAA
GATAAGCATCCCTGCGTGGTATTGAAATTGCCGGAGCCCGCGGCGTTTGACGTCATCCGGCTGGCAGAGCCCATCCAACT
GGGGCAGAGGGTGCGCAAATTCCGTGTGGAGGTGCGTGAGAACGGCCAGTGGAGCAAGTGGACGGAGGGGGCCAGCATAG
GGGCCAGAGTTCTTCTGAAAGGAAGGCCCGTGACGGCGGATGGAGTGCGCGTGGTGCTGGAACAATCCCGGGCCGTTCCG
GCCCTGTGCGAGGTTTCTTTATGGAAGTATCCCGTCATCCTGAATGCTCCGGCGGTGAATTATGACCGCAATGGACGGGT
GACCCTGGCTTCCGCGGAGAACGTAGTGATCAGGTACACCACGGATGGAACGGAACCCGGTCCGCAGTCCGCCATGTACA
GGAATCCTTTCTTTCTCCCTGCCGGGGGGACGGTGAAAGCGGCGGCCGAATATCGCGGCAGAAAATCTTCCGTAACCACT
CAGATTATTCCTGTCCCCACGCGGGACTGGAAAGTGGTGGCCGGGGAAAGAAGCGCCGCCGCTCCGGAACTGGCTATTGA
CGGAGATTCTTCCACCCTCTGGCATACGCATGCCGCCCAGGGAGAGCTGGCGCCTCCGCAGGCGCTGGAGATCGACATGG
GGCGTCCGGTTAACGTTGCCGCCGTTATCTATACGCCGCGCAGGGATTCCTCAACGGGAACGGTTGACCGCTATGCCGTC
TATTTGAGCATGGATGGGAACACATGGGGGGCTCCCGCTGCGGAGGGGGAGTTCTCTAATATCCGCGCCAATCCCGTTCC
GCAGCGGATTGACCTGAAAGCGCCTGTCAAAGCACGTTATCTGCGTTTTGTAGGCAAGCGGGTGGTGGAAGGCAGCCATG
TTGCCGTTGCCGAGCTGGGCGTATTGGGAAAATAA

Upstream 100 bases:

>100_bases
CGCAGAGAGGAAGAGAGACTAAAAGGCCTGCATGACTTGATCGGAAAGAATAAGACCGCCAGGAACGTACGAGGAGTTAA
AACGATAGTGATTGTTGGTA

Downstream 100 bases:

>100_bases
GCGGTTTCCTTTTTTTATTATCGTAGTCCTCCGGCGTTTTCTTGACGGATGGAGGGAAGAGGGGCAAGATGGCACGCATG
GAACAAGTCAGTCTCATGGA

Product: coagulation factor 5/8 type domain protein

Products: NA

Alternate protein names: Neuraminidase [H]

Number of amino acids: Translated: 704; Mature: 704

Protein sequence:

>704_residues
MNLNQLIKAAVLGGALCTACFAGAGPKGCLTPLKPVPSAEQLEWHDMEMYAFVHFTINTFTGKEWGYGDEKPELFHPSDF
DADDLVRTLADAGFKGVVLTCKHHDGFCLWPTKTTLHSVAASPWKQGKGDVVKEVSRACGKYGVRFGVYLSPWDRNAASY
GTPDYIRMYRQQLKELATGYGSIFLAWFDGANGGDGYYGGARERRSIDRSAYYDWKATWGELKKRQPGAVIFSDVGPDVR
WVGNESGYAGYPCWATYTPVPLQAGTEPAPGTVRYRLGTEGTMDGKYWIPAEVDVSIRPGWFWHEHENSRVRTPENLLKL
YFDSVGRGANLNLNVPPDRRGRIHEEDKKSLAGFRVLLDELYSRNFASGAQAESSSSWKGHGAEQVLDRKRTTYWVAAPE
DKHPCVVLKLPEPAAFDVIRLAEPIQLGQRVRKFRVEVRENGQWSKWTEGASIGARVLLKGRPVTADGVRVVLEQSRAVP
ALCEVSLWKYPVILNAPAVNYDRNGRVTLASAENVVIRYTTDGTEPGPQSAMYRNPFFLPAGGTVKAAAEYRGRKSSVTT
QIIPVPTRDWKVVAGERSAAAPELAIDGDSSTLWHTHAAQGELAPPQALEIDMGRPVNVAAVIYTPRRDSSTGTVDRYAV
YLSMDGNTWGAPAAEGEFSNIRANPVPQRIDLKAPVKARYLRFVGKRVVEGSHVAVAELGVLGK

Sequences:

>Translated_704_residues
MNLNQLIKAAVLGGALCTACFAGAGPKGCLTPLKPVPSAEQLEWHDMEMYAFVHFTINTFTGKEWGYGDEKPELFHPSDF
DADDLVRTLADAGFKGVVLTCKHHDGFCLWPTKTTLHSVAASPWKQGKGDVVKEVSRACGKYGVRFGVYLSPWDRNAASY
GTPDYIRMYRQQLKELATGYGSIFLAWFDGANGGDGYYGGARERRSIDRSAYYDWKATWGELKKRQPGAVIFSDVGPDVR
WVGNESGYAGYPCWATYTPVPLQAGTEPAPGTVRYRLGTEGTMDGKYWIPAEVDVSIRPGWFWHEHENSRVRTPENLLKL
YFDSVGRGANLNLNVPPDRRGRIHEEDKKSLAGFRVLLDELYSRNFASGAQAESSSSWKGHGAEQVLDRKRTTYWVAAPE
DKHPCVVLKLPEPAAFDVIRLAEPIQLGQRVRKFRVEVRENGQWSKWTEGASIGARVLLKGRPVTADGVRVVLEQSRAVP
ALCEVSLWKYPVILNAPAVNYDRNGRVTLASAENVVIRYTTDGTEPGPQSAMYRNPFFLPAGGTVKAAAEYRGRKSSVTT
QIIPVPTRDWKVVAGERSAAAPELAIDGDSSTLWHTHAAQGELAPPQALEIDMGRPVNVAAVIYTPRRDSSTGTVDRYAV
YLSMDGNTWGAPAAEGEFSNIRANPVPQRIDLKAPVKARYLRFVGKRVVEGSHVAVAELGVLGK
>Mature_704_residues
MNLNQLIKAAVLGGALCTACFAGAGPKGCLTPLKPVPSAEQLEWHDMEMYAFVHFTINTFTGKEWGYGDEKPELFHPSDF
DADDLVRTLADAGFKGVVLTCKHHDGFCLWPTKTTLHSVAASPWKQGKGDVVKEVSRACGKYGVRFGVYLSPWDRNAASY
GTPDYIRMYRQQLKELATGYGSIFLAWFDGANGGDGYYGGARERRSIDRSAYYDWKATWGELKKRQPGAVIFSDVGPDVR
WVGNESGYAGYPCWATYTPVPLQAGTEPAPGTVRYRLGTEGTMDGKYWIPAEVDVSIRPGWFWHEHENSRVRTPENLLKL
YFDSVGRGANLNLNVPPDRRGRIHEEDKKSLAGFRVLLDELYSRNFASGAQAESSSSWKGHGAEQVLDRKRTTYWVAAPE
DKHPCVVLKLPEPAAFDVIRLAEPIQLGQRVRKFRVEVRENGQWSKWTEGASIGARVLLKGRPVTADGVRVVLEQSRAVP
ALCEVSLWKYPVILNAPAVNYDRNGRVTLASAENVVIRYTTDGTEPGPQSAMYRNPFFLPAGGTVKAAAEYRGRKSSVTT
QIIPVPTRDWKVVAGERSAAAPELAIDGDSSTLWHTHAAQGELAPPQALEIDMGRPVNVAAVIYTPRRDSSTGTVDRYAV
YLSMDGNTWGAPAAEGEFSNIRANPVPQRIDLKAPVKARYLRFVGKRVVEGSHVAVAELGVLGK

Specific function: To release sialic acids for use as carbon and energy sources for this non-pathogenic bacterium while in pathogenic microorganisms, sialidases have been suggested to be pathogenic factors [H]

COG id: COG3669

COG function: function code G; Alpha-L-fucosidase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 F5/8 type C domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018905
- InterPro:   IPR002860
- InterPro:   IPR000421
- InterPro:   IPR008979
- InterPro:   IPR013783
- InterPro:   IPR014756
- InterPro:   IPR011040
- InterPro:   IPR006311 [H]

Pfam domain/function: PF02012 BNR; PF00754 F5_F8_type_C; PF10633 NPCBM_assoc [H]

EC number: =3.2.1.18 [H]

Molecular weight: Translated: 77597; Mature: 77597

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS50022 FA58C_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLNQLIKAAVLGGALCTACFAGAGPKGCLTPLKPVPSAEQLEWHDMEMYAFVHFTINTF
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEEE
TGKEWGYGDEKPELFHPSDFDADDLVRTLADAGFKGVVLTCKHHDGFCLWPTKTTLHSVA
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCEEECCCHHHHHHHH
ASPWKQGKGDVVKEVSRACGKYGVRFGVYLSPWDRNAASYGTPDYIRMYRQQLKELATGY
CCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
GSIFLAWFDGANGGDGYYGGARERRSIDRSAYYDWKATWGELKKRQPGAVIFSDVGPDVR
CEEEEEEECCCCCCCCCCCCCHHHHCCCHHHEECHHCCHHHHHCCCCCEEEEECCCCCEE
WVGNESGYAGYPCWATYTPVPLQAGTEPAPGTVRYRLGTEGTMDGKYWIPAEVDVSIRPG
EECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEECCEEEEEECCC
WFWHEHENSRVRTPENLLKLYFDSVGRGANLNLNVPPDRRGRIHEEDKKSLAGFRVLLDE
EEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
LYSRNFASGAQAESSSSWKGHGAEQVLDRKRTTYWVAAPEDKHPCVVLKLPEPAAFDVIR
HHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCEEEEECCCCCHHHHHH
LAEPIQLGQRVRKFRVEVRENGQWSKWTEGASIGARVLLKGRPVTADGVRVVLEQSRAVP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCC
ALCEVSLWKYPVILNAPAVNYDRNGRVTLASAENVVIRYTTDGTEPGPQSAMYRNPFFLP
HHHHHHHHCCCEEEECCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCCCCCCEEEC
AGGTVKAAAEYRGRKSSVTTQIIPVPTRDWKVVAGERSAAAPELAIDGDSSTLWHTHAAQ
CCCCEEHHHHHCCCCCCCEEEEEECCCCCCEEEECCCCCCCCEEEEECCCCEEEEEECCC
GELAPPQALEIDMGRPVNVAAVIYTPRRDSSTGTVDRYAVYLSMDGNTWGAPAAEGEFSN
CCCCCCCEEEECCCCCCEEEEEEEECCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCC
IRANPVPQRIDLKAPVKARYLRFVGKRVVEGSHVAVAELGVLGK
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCC
>Mature Secondary Structure
MNLNQLIKAAVLGGALCTACFAGAGPKGCLTPLKPVPSAEQLEWHDMEMYAFVHFTINTF
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEEE
TGKEWGYGDEKPELFHPSDFDADDLVRTLADAGFKGVVLTCKHHDGFCLWPTKTTLHSVA
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCEEECCCHHHHHHHH
ASPWKQGKGDVVKEVSRACGKYGVRFGVYLSPWDRNAASYGTPDYIRMYRQQLKELATGY
CCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
GSIFLAWFDGANGGDGYYGGARERRSIDRSAYYDWKATWGELKKRQPGAVIFSDVGPDVR
CEEEEEEECCCCCCCCCCCCCHHHHCCCHHHEECHHCCHHHHHCCCCCEEEEECCCCCEE
WVGNESGYAGYPCWATYTPVPLQAGTEPAPGTVRYRLGTEGTMDGKYWIPAEVDVSIRPG
EECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEECCEEEEEECCC
WFWHEHENSRVRTPENLLKLYFDSVGRGANLNLNVPPDRRGRIHEEDKKSLAGFRVLLDE
EEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
LYSRNFASGAQAESSSSWKGHGAEQVLDRKRTTYWVAAPEDKHPCVVLKLPEPAAFDVIR
HHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCEEEEECCCCCHHHHHH
LAEPIQLGQRVRKFRVEVRENGQWSKWTEGASIGARVLLKGRPVTADGVRVVLEQSRAVP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCC
ALCEVSLWKYPVILNAPAVNYDRNGRVTLASAENVVIRYTTDGTEPGPQSAMYRNPFFLP
HHHHHHHHCCCEEEECCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCCCCCCEEEC
AGGTVKAAAEYRGRKSSVTTQIIPVPTRDWKVVAGERSAAAPELAIDGDSSTLWHTHAAQ
CCCCEEHHHHHCCCCCCCEEEEEECCCCCCEEEECCCCCCCCEEEEECCCCEEEEEECCC
GELAPPQALEIDMGRPVNVAAVIYTPRRDSSTGTVDRYAVYLSMDGNTWGAPAAEGEFSN
CCCCCCCEEEECCCCCCEEEEEEEECCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCC
IRANPVPQRIDLKAPVKARYLRFVGKRVVEGSHVAVAELGVLGK
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1400240; 8591030 [H]