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The map label for this gene is argH [H]

Identifier: 187735343

GI number: 187735343

Start: 1000759

End: 1002135

Strand: Reverse

Name: argH [H]

Synonym: Amuc_0841

Alternate gene names: 187735343

Gene position: 1002135-1000759 (Counterclockwise)

Preceding gene: 187735345

Following gene: 187735342

Centisome position: 37.62

GC content: 59.26

Gene sequence:

>1377_bases
ATGTGGGTCATGTGGAAAGGCAGATTTTCTAAACCCACCGCTGATCTGGTTCAACGCTACGGCGAATCCGTCTCCTACGA
CTGGAGGCTTTTCCGCCAGGACATTGCCGGATCCATCGCCCATGCGCGGGCCCAGCTCAAGGCTGGCCTGCTTTCGCAGG
AAGAATTCAACGCCATTGAATCCGGCCTGAAAGACATCCTGAAAGACATTGAAGCAGGCAACTTCTCGTGGAGCCGGGAA
CTGGAGGACGTGCACATGAACATTGAAAGCGAACTCACCCGGCGCATCGGCGCTCCGGGCGCCAAGCTGCATACCGCACG
CTCCCGCAATGACCAGGTAGCTACGGACACGCGGCTTTACTGCCGGGCGGAAATCGATGAAATTCTGGGAAAAGTGCGCC
ATCTGCAGCGCGCGCTGGTCATGAAGGCGAAGGAATACGCGGATGCCATGATGCCGGGCTATACTCACCTGCAGCGCGCC
CAGCCCGTCACCATGGGCCATCACCTGCTGGCTTACGTGGAAATGCTGGACCGGGATGCGGACCGCCTCAAGGACTGCCG
CAGGCGCCTGAACGTCTCCCCGCTCGGTTCCGGAGCCATCGCCGGTTCCACCATCTGCCTGGACCGCCACGGAATTGCCG
TGGAACTGGGTTTTGACGCAGTTACAGAAAACTCCATGGATGCGATTGCCGACCGGGATTACATCATGGAAATCCTTTTT
GACCTGGCCGTGGTCGGAGCCCATCTCTCCCGCATGAGCGAGGACGTCATCCTGTGGTGCACGGCGGAATTCGGCTTCGC
TTCCTTGTCCGACGCCCATACGACAGGTTCATCCCTGATGCCCCAGAAAAAAAATCCGGACGTCGCGGAACTCACACGCG
GAAAAACGGGGCGGCTGTACGGTAACCTCACCGCCGTTATGGTGGCTGTCAAAGGGCTTCCCCTGACTTACAACCGCGAC
CTCCAGGAAGACAAGGAACCCCTGTTCGATTCCATTGATACGGTTAAACTGGCCCTGGACGTCAATGCGGAAATGATAGC
CGCCATGACGGTGAACACGGCCAGGGCCAGGGAAGCGGCGTCCGACCCCATGCTGCTGGCCACGGACCTGGCGGATTATC
TGGTGCGCCGCGGGGTCCCCTTCCGGAAGGCCCATGAGCTGGTCGGGAAGGCAGTCGCCATGAGCATCTCCACGGGTACG
CCGCTCAACAAGCTGAGCGACGAACAATTCGCCTCCATTTCAAATGCATATGGAACAGACGCGCGCGACGTATTTGAATT
GACAAAAGCCTTCGCCCAGCGTACCAACCCGGGGGCTCCCAATTCCGACAACACCCGCCGCCGCATCGCCTACTGGGAAG
GCATCCTTTCCAAGTAA

Upstream 100 bases:

>100_bases
CCACTCCGGTTTTCCAGGCATGCGGATTTTTCCCAGTTCCGCGGAATCTGCCTCCATTACCCATTTCAGGCTTTCAAAAC
GGAAGCTCCTGGGGCACAAC

Downstream 100 bases:

>100_bases
CGCCGCCTGCGGAGGCGGACGGGAACGAAGAGAGCCTGCCGTCCGTCTCCGCGGGGCGCCTCCGGGTGCAGGAAGGGGAC
GCTTCAACCCCGCCGGCGGC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MWVMWKGRFSKPTADLVQRYGESVSYDWRLFRQDIAGSIAHARAQLKAGLLSQEEFNAIESGLKDILKDIEAGNFSWSRE
LEDVHMNIESELTRRIGAPGAKLHTARSRNDQVATDTRLYCRAEIDEILGKVRHLQRALVMKAKEYADAMMPGYTHLQRA
QPVTMGHHLLAYVEMLDRDADRLKDCRRRLNVSPLGSGAIAGSTICLDRHGIAVELGFDAVTENSMDAIADRDYIMEILF
DLAVVGAHLSRMSEDVILWCTAEFGFASLSDAHTTGSSLMPQKKNPDVAELTRGKTGRLYGNLTAVMVAVKGLPLTYNRD
LQEDKEPLFDSIDTVKLALDVNAEMIAAMTVNTARAREAASDPMLLATDLADYLVRRGVPFRKAHELVGKAVAMSISTGT
PLNKLSDEQFASISNAYGTDARDVFELTKAFAQRTNPGAPNSDNTRRRIAYWEGILSK

Sequences:

>Translated_458_residues
MWVMWKGRFSKPTADLVQRYGESVSYDWRLFRQDIAGSIAHARAQLKAGLLSQEEFNAIESGLKDILKDIEAGNFSWSRE
LEDVHMNIESELTRRIGAPGAKLHTARSRNDQVATDTRLYCRAEIDEILGKVRHLQRALVMKAKEYADAMMPGYTHLQRA
QPVTMGHHLLAYVEMLDRDADRLKDCRRRLNVSPLGSGAIAGSTICLDRHGIAVELGFDAVTENSMDAIADRDYIMEILF
DLAVVGAHLSRMSEDVILWCTAEFGFASLSDAHTTGSSLMPQKKNPDVAELTRGKTGRLYGNLTAVMVAVKGLPLTYNRD
LQEDKEPLFDSIDTVKLALDVNAEMIAAMTVNTARAREAASDPMLLATDLADYLVRRGVPFRKAHELVGKAVAMSISTGT
PLNKLSDEQFASISNAYGTDARDVFELTKAFAQRTNPGAPNSDNTRRRIAYWEGILSK
>Mature_458_residues
MWVMWKGRFSKPTADLVQRYGESVSYDWRLFRQDIAGSIAHARAQLKAGLLSQEEFNAIESGLKDILKDIEAGNFSWSRE
LEDVHMNIESELTRRIGAPGAKLHTARSRNDQVATDTRLYCRAEIDEILGKVRHLQRALVMKAKEYADAMMPGYTHLQRA
QPVTMGHHLLAYVEMLDRDADRLKDCRRRLNVSPLGSGAIAGSTICLDRHGIAVELGFDAVTENSMDAIADRDYIMEILF
DLAVVGAHLSRMSEDVILWCTAEFGFASLSDAHTTGSSLMPQKKNPDVAELTRGKTGRLYGNLTAVMVAVKGLPLTYNRD
LQEDKEPLFDSIDTVKLALDVNAEMIAAMTVNTARAREAASDPMLLATDLADYLVRRGVPFRKAHELVGKAVAMSISTGT
PLNKLSDEQFASISNAYGTDARDVFELTKAFAQRTNPGAPNSDNTRRRIAYWEGILSK

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=430, Percent_Identity=45.3488372093023, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI68303542, Length=430, Percent_Identity=45.3488372093023, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI68303547, Length=430, Percent_Identity=43.0232558139535, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI68303549, Length=430, Percent_Identity=42.5581395348837, Blast_Score=345, Evalue=4e-95,
Organism=Homo sapiens, GI19743875, Length=232, Percent_Identity=28.0172413793103, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1790398, Length=449, Percent_Identity=45.8797327394209, Blast_Score=403, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17553882, Length=223, Percent_Identity=29.5964125560538, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI32565146, Length=216, Percent_Identity=30.0925925925926, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6321806, Length=439, Percent_Identity=43.5079726651481, Blast_Score=373, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6324993, Length=240, Percent_Identity=26.25, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221473854, Length=443, Percent_Identity=39.5033860045147, Blast_Score=319, Evalue=2e-87,
Organism=Drosophila melanogaster, GI78706858, Length=443, Percent_Identity=39.5033860045147, Blast_Score=319, Evalue=2e-87,
Organism=Drosophila melanogaster, GI78710009, Length=224, Percent_Identity=28.125, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24640179, Length=224, Percent_Identity=27.2321428571429, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24640177, Length=224, Percent_Identity=27.2321428571429, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 50842; Mature: 50842

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWVMWKGRFSKPTADLVQRYGESVSYDWRLFRQDIAGSIAHARAQLKAGLLSQEEFNAIE
CEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SGLKDILKDIEAGNFSWSRELEDVHMNIESELTRRIGAPGAKLHTARSRNDQVATDTRLY
HHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCEECCCCCCCCCCCCHHHH
CRAEIDEILGKVRHLQRALVMKAKEYADAMMPGYTHLQRAQPVTMGHHLLAYVEMLDRDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHCCH
DRLKDCRRRLNVSPLGSGAIAGSTICLDRHGIAVELGFDAVTENSMDAIADRDYIMEILF
HHHHHHHHHCCCCCCCCCCCCCCEEEEECCCEEEEECCHHHCCCCHHHHHHHHHHHHHHH
DLAVVGAHLSRMSEDVILWCTAEFGFASLSDAHTTGSSLMPQKKNPDVAELTRGKTGRLY
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHH
GNLTAVMVAVKGLPLTYNRDLQEDKEPLFDSIDTVKLALDVNAEMIAAMTVNTARAREAA
HHHHHHHHHHHCCCEEECCCCHHHHHHHHCCCCCEEEEEECCHHEEEEEEHHHHHHHHHC
SDPMLLATDLADYLVRRGVPFRKAHELVGKAVAMSISTGTPLNKLSDEQFASISNAYGTD
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEECCCCCHHHCCHHHHHHHHHHCCCC
ARDVFELTKAFAQRTNPGAPNSDNTRRRIAYWEGILSK
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MWVMWKGRFSKPTADLVQRYGESVSYDWRLFRQDIAGSIAHARAQLKAGLLSQEEFNAIE
CEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SGLKDILKDIEAGNFSWSRELEDVHMNIESELTRRIGAPGAKLHTARSRNDQVATDTRLY
HHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCEECCCCCCCCCCCCHHHH
CRAEIDEILGKVRHLQRALVMKAKEYADAMMPGYTHLQRAQPVTMGHHLLAYVEMLDRDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHCCH
DRLKDCRRRLNVSPLGSGAIAGSTICLDRHGIAVELGFDAVTENSMDAIADRDYIMEILF
HHHHHHHHHCCCCCCCCCCCCCCEEEEECCCEEEEECCHHHCCCCHHHHHHHHHHHHHHH
DLAVVGAHLSRMSEDVILWCTAEFGFASLSDAHTTGSSLMPQKKNPDVAELTRGKTGRLY
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHH
GNLTAVMVAVKGLPLTYNRDLQEDKEPLFDSIDTVKLALDVNAEMIAAMTVNTARAREAA
HHHHHHHHHHHCCCEEECCCCHHHHHHHHCCCCCEEEEEECCHHEEEEEEHHHHHHHHHC
SDPMLLATDLADYLVRRGVPFRKAHELVGKAVAMSISTGTPLNKLSDEQFASISNAYGTD
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEECCCCCHHHCCHHHHHHHHHHCCCC
ARDVFELTKAFAQRTNPGAPNSDNTRRRIAYWEGILSK
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA