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The map label for this gene is typA [H]

Identifier: 187735228

GI number: 187735228

Start: 852109

End: 853944

Strand: Reverse

Name: typA [H]

Synonym: Amuc_0722

Alternate gene names: 187735228

Gene position: 853944-852109 (Counterclockwise)

Preceding gene: 187735230

Following gene: 187735223

Centisome position: 32.05

GC content: 55.56

Gene sequence:

>1836_bases
ATGTCAGATCCTTCCAAGTTCCGCAATCTCGCCATCATCGCTCACGTTGACCATGGGAAGACGACCCTGGTTGACCAACT
TTTGCAGGCGGGAGGCGCCTACCGGGCCAACCAGGCCGTGCAGGAACGCGCCATGGATTCCATGGATCTGGAACGTGAAA
AAGGCATCACGATCAAGGCCAAGAATACATCCATCCTCTGGAATGGATACACGATCAACATTGTGGATACTCCCGGACAC
GCGGATTTCGGCGGGGAAGTGGAGCGCGTGATGAAAATGGTGGATGGCGTGCTTCTGGTGGTGGACGCTTTTGAAGGGCC
GCAGGCCCAGACGCGTTTTGTGCTCCGCAAGGCCCTTCAGGAAGGGCTGATGCCCATTGTCGTCATTAACAAGATCGACC
GTCCGCATGCCGATCCCGCCGCCGTGCATGACCAGGTGCTGGAGCTTTTTCTGGAGCTGGGCGCCACGGATGAACAATTT
GAAGCCCCTTTCGTGTACGGTTCCGCCCGCGACGGTTACTTCATGAATTCCATGGAGGGGGAACCTCCTGTGGACTGCAC
TCCTCTTTTATTCAAGATTGTGGAACATATCCCCGCTCCGAAGGATGCCGATCCGGAGGGTGAATTCAAGATGCTCGTTT
CCAATATTGACTGGGACGATTATGTGGGCCGTGTGGCTATCGGCCGCATTACCTCCGGCACTGTGAAGAAAGGGGACACC
GTGTGGCTCCATCAGAGCGACGGCTCCTGCATTTCCGGAAAAGTGACCCGCATGTTTGAATATTCCGGCCTGAGCACTAC
GGATTCGGCCATCGGCGTGGCAGGCAACATCGTAGGGGTGGCGGGGTTTGAAAACGTCAATATCGGGGAAACCTTGGGCG
GTTCCGCGGATACGGAGCCCCTTCCATTCGTGGCGATTGATCCTCCTACCATTTCCATGGAATTTTCCATCAACAACGGG
CCTTTCGGAGGGCGCGACGGCAAGAATGTGACTTCCCGCGTGATACGCGACCGCCTGATGAGGGAAATGCGGACGAATAT
TTCCATCCAGGTGGAGGATACGGACAAGGCCGGCGTTTTCTCCGTTTCCGCCCGCGGCGCCATGCAGATCGCCGTGCTGG
TGGAGACTATGCGCCGTGAAAATTATGAACTGTGCGTTTCCCGTCCCACCGTGATCATGAAGAGGGATGAAAACGACCGC
CTTACGGAACCGTATGAAACGATGTACGTAGAAGTTCCGGACGAACATGCCAACGGCGTCATGAAGCTTCTTCACGCCCG
CAAGGGACAGATGGAAGACATGGTATGCAGGGAAGGCACGGGCCATACTTTTATTCAGGCTTATATTCCCACCCGCGGTA
TTATCGGTTTTGAATTTGAGCTGGTCAATCTGACGTCCGGCCACGGTATTTTCTCCCACCTGTTCCGGGATTACGGGCCT
TATGCCGGGGACATCACCACGCGTACCACCGGCACCCTGGTTTCCATGGAGACGGGCGTTTCCACTCCGTTCGCGCTGGT
AGCGCTGGAAGAACGCGGGCGTCTGTTTGTGGGGCCGCAGGAAGATATTTACGAAGGCCAGATTGTAGGCGAAAACCCGC
GGCAGATGGATATGCCGGTCAACCCGTGCAAGGAAAAGCATTTGAACAATATCCGCTCAGCCACGAAGGGAGACGGCATC
CAGCTTTCCCCTCCCGTCATTTTTTCTCTGGAACGTGCCATTGAGTACATTGAACCTGATGAACTGGTGGAGGCTACGCC
TCATTTTATCCGTCTGCGCAAGCGCATCCTGAACGCCAATGACCGCGTAAGGGAATCCCGCAAAGCAGGAAATTAA

Upstream 100 bases:

>100_bases
GGCGATGGCGGCAGGGAGGCTTGCAAACGCTGAAAATATAGTCGGTATTCATGGAGCAGACTTGACATTTATTTTCCGGT
GTTTTTAGCTCTCGCGCGCA

Downstream 100 bases:

>100_bases
GGTTCCTGGAGCGCTGGGGAAAGGCTTCTGTGTTCAAAGCGGCGCCGGGGTAGGGCCGCGCTGCCGGGTTCCCTGCGGTC
CGCTGAGCGGAGGAATGGCC

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 611; Mature: 610

Protein sequence:

>611_residues
MSDPSKFRNLAIIAHVDHGKTTLVDQLLQAGGAYRANQAVQERAMDSMDLEREKGITIKAKNTSILWNGYTINIVDTPGH
ADFGGEVERVMKMVDGVLLVVDAFEGPQAQTRFVLRKALQEGLMPIVVINKIDRPHADPAAVHDQVLELFLELGATDEQF
EAPFVYGSARDGYFMNSMEGEPPVDCTPLLFKIVEHIPAPKDADPEGEFKMLVSNIDWDDYVGRVAIGRITSGTVKKGDT
VWLHQSDGSCISGKVTRMFEYSGLSTTDSAIGVAGNIVGVAGFENVNIGETLGGSADTEPLPFVAIDPPTISMEFSINNG
PFGGRDGKNVTSRVIRDRLMREMRTNISIQVEDTDKAGVFSVSARGAMQIAVLVETMRRENYELCVSRPTVIMKRDENDR
LTEPYETMYVEVPDEHANGVMKLLHARKGQMEDMVCREGTGHTFIQAYIPTRGIIGFEFELVNLTSGHGIFSHLFRDYGP
YAGDITTRTTGTLVSMETGVSTPFALVALEERGRLFVGPQEDIYEGQIVGENPRQMDMPVNPCKEKHLNNIRSATKGDGI
QLSPPVIFSLERAIEYIEPDELVEATPHFIRLRKRILNANDRVRESRKAGN

Sequences:

>Translated_611_residues
MSDPSKFRNLAIIAHVDHGKTTLVDQLLQAGGAYRANQAVQERAMDSMDLEREKGITIKAKNTSILWNGYTINIVDTPGH
ADFGGEVERVMKMVDGVLLVVDAFEGPQAQTRFVLRKALQEGLMPIVVINKIDRPHADPAAVHDQVLELFLELGATDEQF
EAPFVYGSARDGYFMNSMEGEPPVDCTPLLFKIVEHIPAPKDADPEGEFKMLVSNIDWDDYVGRVAIGRITSGTVKKGDT
VWLHQSDGSCISGKVTRMFEYSGLSTTDSAIGVAGNIVGVAGFENVNIGETLGGSADTEPLPFVAIDPPTISMEFSINNG
PFGGRDGKNVTSRVIRDRLMREMRTNISIQVEDTDKAGVFSVSARGAMQIAVLVETMRRENYELCVSRPTVIMKRDENDR
LTEPYETMYVEVPDEHANGVMKLLHARKGQMEDMVCREGTGHTFIQAYIPTRGIIGFEFELVNLTSGHGIFSHLFRDYGP
YAGDITTRTTGTLVSMETGVSTPFALVALEERGRLFVGPQEDIYEGQIVGENPRQMDMPVNPCKEKHLNNIRSATKGDGI
QLSPPVIFSLERAIEYIEPDELVEATPHFIRLRKRILNANDRVRESRKAGN
>Mature_610_residues
SDPSKFRNLAIIAHVDHGKTTLVDQLLQAGGAYRANQAVQERAMDSMDLEREKGITIKAKNTSILWNGYTINIVDTPGHA
DFGGEVERVMKMVDGVLLVVDAFEGPQAQTRFVLRKALQEGLMPIVVINKIDRPHADPAAVHDQVLELFLELGATDEQFE
APFVYGSARDGYFMNSMEGEPPVDCTPLLFKIVEHIPAPKDADPEGEFKMLVSNIDWDDYVGRVAIGRITSGTVKKGDTV
WLHQSDGSCISGKVTRMFEYSGLSTTDSAIGVAGNIVGVAGFENVNIGETLGGSADTEPLPFVAIDPPTISMEFSINNGP
FGGRDGKNVTSRVIRDRLMREMRTNISIQVEDTDKAGVFSVSARGAMQIAVLVETMRRENYELCVSRPTVIMKRDENDRL
TEPYETMYVEVPDEHANGVMKLLHARKGQMEDMVCREGTGHTFIQAYIPTRGIIGFEFELVNLTSGHGIFSHLFRDYGPY
AGDITTRTTGTLVSMETGVSTPFALVALEERGRLFVGPQEDIYEGQIVGENPRQMDMPVNPCKEKHLNNIRSATKGDGIQ
LSPPVIFSLERAIEYIEPDELVEATPHFIRLRKRILNANDRVRESRKAGN

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=521, Percent_Identity=27.6391554702495, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI94966754, Length=134, Percent_Identity=44.7761194029851, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI18390331, Length=146, Percent_Identity=41.7808219178082, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI4503483, Length=150, Percent_Identity=37.3333333333333, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI25306287, Length=132, Percent_Identity=40.9090909090909, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI25306283, Length=132, Percent_Identity=40.9090909090909, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI19923640, Length=132, Percent_Identity=40.9090909090909, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI310132016, Length=112, Percent_Identity=40.1785714285714, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI310110807, Length=112, Percent_Identity=40.1785714285714, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI310123363, Length=112, Percent_Identity=40.1785714285714, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI217272894, Length=140, Percent_Identity=35, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI217272892, Length=140, Percent_Identity=35, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI34147630, Length=245, Percent_Identity=32.6530612244898, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI94966752, Length=65, Percent_Identity=52.3076923076923, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI53729339, Length=277, Percent_Identity=28.158844765343, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI53729337, Length=277, Percent_Identity=28.158844765343, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI48994988, Length=603, Percent_Identity=48.7562189054726, Blast_Score=562, Evalue=1e-161,
Organism=Escherichia coli, GI1788922, Length=506, Percent_Identity=28.2608695652174, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1789738, Length=151, Percent_Identity=39.0728476821192, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1790835, Length=152, Percent_Identity=30.9210526315789, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI2367247, Length=380, Percent_Identity=26.5789473684211, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790412, Length=245, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789737, Length=245, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17557151, Length=244, Percent_Identity=36.4754098360656, Blast_Score=151, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI17556745, Length=136, Percent_Identity=41.9117647058824, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71988819, Length=128, Percent_Identity=42.1875, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71988811, Length=128, Percent_Identity=42.1875, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17533571, Length=144, Percent_Identity=40.9722222222222, Blast_Score=112, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17506493, Length=162, Percent_Identity=35.1851851851852, Blast_Score=108, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17552882, Length=141, Percent_Identity=39.0070921985816, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI25141371, Length=244, Percent_Identity=26.2295081967213, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17556456, Length=276, Percent_Identity=26.4492753623188, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71994658, Length=143, Percent_Identity=34.2657342657343, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323320, Length=484, Percent_Identity=27.4793388429752, Blast_Score=157, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6324707, Length=150, Percent_Identity=42.6666666666667, Blast_Score=121, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6320593, Length=150, Percent_Identity=42.6666666666667, Blast_Score=121, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6323098, Length=151, Percent_Identity=42.3841059602649, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324166, Length=147, Percent_Identity=39.4557823129252, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322359, Length=133, Percent_Identity=39.8496240601504, Blast_Score=97, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6324761, Length=282, Percent_Identity=31.9148936170213, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI78706572, Length=517, Percent_Identity=27.852998065764, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24582462, Length=146, Percent_Identity=41.7808219178082, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24585709, Length=154, Percent_Identity=37.012987012987, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24585711, Length=154, Percent_Identity=37.012987012987, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24585713, Length=154, Percent_Identity=37.012987012987, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI28574573, Length=138, Percent_Identity=41.304347826087, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21357743, Length=140, Percent_Identity=40, Blast_Score=102, Evalue=9e-22,
Organism=Drosophila melanogaster, GI221458488, Length=139, Percent_Identity=43.1654676258993, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI281363316, Length=237, Percent_Identity=30.379746835443, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17864358, Length=237, Percent_Identity=30.379746835443, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28572034, Length=272, Percent_Identity=27.9411764705882, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19921738, Length=255, Percent_Identity=30.1960784313725, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 67554; Mature: 67422

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPSKFRNLAIIAHVDHGKTTLVDQLLQAGGAYRANQAVQERAMDSMDLEREKGITIKA
CCCHHHHCCEEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHCCCEEEE
KNTSILWNGYTINIVDTPGHADFGGEVERVMKMVDGVLLVVDAFEGPQAQTRFVLRKALQ
CCCEEEECCEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHH
EGLMPIVVINKIDRPHADPAAVHDQVLELFLELGATDEQFEAPFVYGSARDGYFMNSMEG
HCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEECCCCC
EPPVDCTPLLFKIVEHIPAPKDADPEGEFKMLVSNIDWDDYVGRVAIGRITSGTVKKGDT
CCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHCCEEEEECCCCCCCCCCE
VWLHQSDGSCISGKVTRMFEYSGLSTTDSAIGVAGNIVGVAGFENVNIGETLGGSADTEP
EEEECCCCCEECCCEEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCC
LPFVAIDPPTISMEFSINNGPFGGRDGKNVTSRVIRDRLMREMRTNISIQVEDTDKAGVF
CCEEEECCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEE
SVSARGAMQIAVLVETMRRENYELCVSRPTVIMKRDENDRLTEPYETMYVEVPDEHANGV
EEECCCHHHHHHHHHHHHCCCCEEEECCCEEEEEECCCCCCCCCCEEEEEECCCHHHHHH
MKLLHARKGQMEDMVCREGTGHTFIQAYIPTRGIIGFEFELVNLTSGHGIFSHLFRDYGP
HHHHHHHCCCHHHHHHCCCCCCEEEEEECCCCCEEEEEEEEEEECCCCHHHHHHHHHHCC
YAGDITTRTTGTLVSMETGVSTPFALVALEERGRLFVGPQEDIYEGQIVGENPRQMDMPV
CCCCCEECCCCEEEEECCCCCCCEEEEEEECCCCEEECCCCCCCCCEEECCCCCCCCCCC
NPCKEKHLNNIRSATKGDGIQLSPPVIFSLERAIEYIEPDELVEATPHFIRLRKRILNAN
CHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHCCC
DRVRESRKAGN
HHHHHHHCCCC
>Mature Secondary Structure 
SDPSKFRNLAIIAHVDHGKTTLVDQLLQAGGAYRANQAVQERAMDSMDLEREKGITIKA
CCHHHHCCEEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHCCCEEEE
KNTSILWNGYTINIVDTPGHADFGGEVERVMKMVDGVLLVVDAFEGPQAQTRFVLRKALQ
CCCEEEECCEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHH
EGLMPIVVINKIDRPHADPAAVHDQVLELFLELGATDEQFEAPFVYGSARDGYFMNSMEG
HCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEECCCCC
EPPVDCTPLLFKIVEHIPAPKDADPEGEFKMLVSNIDWDDYVGRVAIGRITSGTVKKGDT
CCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHCCEEEEECCCCCCCCCCE
VWLHQSDGSCISGKVTRMFEYSGLSTTDSAIGVAGNIVGVAGFENVNIGETLGGSADTEP
EEEECCCCCEECCCEEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCC
LPFVAIDPPTISMEFSINNGPFGGRDGKNVTSRVIRDRLMREMRTNISIQVEDTDKAGVF
CCEEEECCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEE
SVSARGAMQIAVLVETMRRENYELCVSRPTVIMKRDENDRLTEPYETMYVEVPDEHANGV
EEECCCHHHHHHHHHHHHCCCCEEEECCCEEEEEECCCCCCCCCCEEEEEECCCHHHHHH
MKLLHARKGQMEDMVCREGTGHTFIQAYIPTRGIIGFEFELVNLTSGHGIFSHLFRDYGP
HHHHHHHCCCHHHHHHCCCCCCEEEEEECCCCCEEEEEEEEEEECCCCHHHHHHHHHHCC
YAGDITTRTTGTLVSMETGVSTPFALVALEERGRLFVGPQEDIYEGQIVGENPRQMDMPV
CCCCCEECCCCEEEEECCCCCCCEEEEEEECCCCEEECCCCCCCCCEEECCCCCCCCCCC
NPCKEKHLNNIRSATKGDGIQLSPPVIFSLERAIEYIEPDELVEATPHFIRLRKRILNAN
CHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHCCC
DRVRESRKAGN
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]