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The map label for this gene is serA [H]

Identifier: 187735211

GI number: 187735211

Start: 830557

End: 832128

Strand: Direct

Name: serA [H]

Synonym: Amuc_0705

Alternate gene names: 187735211

Gene position: 830557-832128 (Clockwise)

Preceding gene: 187735210

Following gene: 187735212

Centisome position: 31.18

GC content: 58.08

Gene sequence:

>1572_bases
ATGAACAAGGTCCTTATTCCTACCAAACTCTCCGACGTAGCGGCCAACACGCTTAAAACGGCCGGCTATGAAGTCATCCA
GGACGCTGATACGCCTCTGGAAAAACAGGTAGCCGCCCATCCGGATGCCGTGGCTCTGATCGTCCGCAGCGAAAAAGTCA
CTCCGGAAATCATGGACGCCCTTCCTTCCCTGAAGCTGGTCGTCCGCGCCGGAGCCGGTTACGACAACATTGACATTGTG
TACGCCCGCAAAAAAAACGTGGACGTCATGAATACCCCCGGGGCCAACTCCAATGCTGTGGCGGAAGAAGTCATGGCCAT
GATTCTGGCCTACTACCGCCACATCGTCCAGGCGGACGCCACCACCCGGGAAGGCCTGTGGGAAAAGAAAAAATACATGG
GCAGCGAGCTGACCAAAAAGACGGTGGGCATCATCGGCCTGGGCAACATCGGCCGCAACCTCGTCAAGCGTCTGCAGGGA
TTTGAACCCATTCTGCTGGGCTACGATCACTTTCTGGCACGCCAGCGCGCCCTGAACATCGGCGTCACCCCTACCAGCAT
TGAAGATATTTTCTCCCAGTGCGACATTATTACCCTGCACGTTCCGGGCGGCCCCTCCACCCACCACATGGTGAACGCGG
AGCTCATTGGAAAAATGAAAGACGGAGCAGTACTCATCAACTGCTCCCGCTACGGCGTGGTGGATGAAGAAGCGCTGGCC
GCCGCCAAGGCCGCAGGCAAAAACATCGGCTACCTGACGGACGTACATCCCAAGGACGCGCCCGGAGAGAAGCCTTCCGC
CCCCATTGCGGATTTGATTCTTCCCCACCTGGGAGCCAACACCCGGGAGGCCAATACGAAAGCGGCCAAACGCGCCGCAG
AACAGATGATCGCCTACTTTTCCGACGGCGACACCTCCTGCGTGGTGAACGGGGAATCCCCCAGCGGCCTCAATCCGGCC
CATCTTCAACTGGCGTTTCTGCTCGCCTCCCTGGCGCGCAAGGCCGGCGGCAACAAGCCCATCCGCCGCGTGGAATGCAC
TTTTTACGGCAACCTGCGCATTTTCCGCAAATGGTTTACGGCCCCCATTCTGGAAGGCCTTCTGCCGCATGCGGAAAAAG
GGCTCATGCCTGCCGCCGCGGAAGAATCCCTGCGGGAGCACGGCATCGTTTTCAAAGCGAGGGAACCCAAAGACGACAAA
CCTTATGAAGATTCCATCACGCTGGACGTGGCCATGGAAGAGGAAGAGGAATATTTCCACACCAGCGTGCGCGGCGTGGT
GACGGAAGGCATCCCCATGGTCTCCCGCCTGAACAATTTCAACGGATTGTACGCGGACCTGCGCGGCACGACATTATGCC
TGCGCTACAAGGACCGCCCGGGTATTATCGCCCTCATCGGCTCCGCCCTGTCTTCCAATGGAATCAACATTGACAACATC
GCCGCCCCGGCCGACCACGCCACCAGGGAGGCCCTGACCGTGATTAAGACCAACCAGCCGGTTTCCGATGAACTGCTGGA
TAAAATCGCGAAAGAGATAGATGCCATCTCTGCGTTTTCCCTGAATCTTTAA

Upstream 100 bases:

>100_bases
GGAGAAATCATGCCTCCCAAATCCACCTGGTTTGAACCCAAGCTGCGCAGCGGGCTTTTTATCCATACCATTGAACAATA
ATCTTTTCCACCGTACCAAC

Downstream 100 bases:

>100_bases
CAGGGAAAGACGCATTTCCGGAAACCTGCTTTTCAGACCGCCCGCTTCCTTCATCTCCGGAGGGAAGCGGGCGGTTCTTA
TTTCTGCCATGTTGACAAGG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MNKVLIPTKLSDVAANTLKTAGYEVIQDADTPLEKQVAAHPDAVALIVRSEKVTPEIMDALPSLKLVVRAGAGYDNIDIV
YARKKNVDVMNTPGANSNAVAEEVMAMILAYYRHIVQADATTREGLWEKKKYMGSELTKKTVGIIGLGNIGRNLVKRLQG
FEPILLGYDHFLARQRALNIGVTPTSIEDIFSQCDIITLHVPGGPSTHHMVNAELIGKMKDGAVLINCSRYGVVDEEALA
AAKAAGKNIGYLTDVHPKDAPGEKPSAPIADLILPHLGANTREANTKAAKRAAEQMIAYFSDGDTSCVVNGESPSGLNPA
HLQLAFLLASLARKAGGNKPIRRVECTFYGNLRIFRKWFTAPILEGLLPHAEKGLMPAAAEESLREHGIVFKAREPKDDK
PYEDSITLDVAMEEEEEYFHTSVRGVVTEGIPMVSRLNNFNGLYADLRGTTLCLRYKDRPGIIALIGSALSSNGINIDNI
AAPADHATREALTVIKTNQPVSDELLDKIAKEIDAISAFSLNL

Sequences:

>Translated_523_residues
MNKVLIPTKLSDVAANTLKTAGYEVIQDADTPLEKQVAAHPDAVALIVRSEKVTPEIMDALPSLKLVVRAGAGYDNIDIV
YARKKNVDVMNTPGANSNAVAEEVMAMILAYYRHIVQADATTREGLWEKKKYMGSELTKKTVGIIGLGNIGRNLVKRLQG
FEPILLGYDHFLARQRALNIGVTPTSIEDIFSQCDIITLHVPGGPSTHHMVNAELIGKMKDGAVLINCSRYGVVDEEALA
AAKAAGKNIGYLTDVHPKDAPGEKPSAPIADLILPHLGANTREANTKAAKRAAEQMIAYFSDGDTSCVVNGESPSGLNPA
HLQLAFLLASLARKAGGNKPIRRVECTFYGNLRIFRKWFTAPILEGLLPHAEKGLMPAAAEESLREHGIVFKAREPKDDK
PYEDSITLDVAMEEEEEYFHTSVRGVVTEGIPMVSRLNNFNGLYADLRGTTLCLRYKDRPGIIALIGSALSSNGINIDNI
AAPADHATREALTVIKTNQPVSDELLDKIAKEIDAISAFSLNL
>Mature_523_residues
MNKVLIPTKLSDVAANTLKTAGYEVIQDADTPLEKQVAAHPDAVALIVRSEKVTPEIMDALPSLKLVVRAGAGYDNIDIV
YARKKNVDVMNTPGANSNAVAEEVMAMILAYYRHIVQADATTREGLWEKKKYMGSELTKKTVGIIGLGNIGRNLVKRLQG
FEPILLGYDHFLARQRALNIGVTPTSIEDIFSQCDIITLHVPGGPSTHHMVNAELIGKMKDGAVLINCSRYGVVDEEALA
AAKAAGKNIGYLTDVHPKDAPGEKPSAPIADLILPHLGANTREANTKAAKRAAEQMIAYFSDGDTSCVVNGESPSGLNPA
HLQLAFLLASLARKAGGNKPIRRVECTFYGNLRIFRKWFTAPILEGLLPHAEKGLMPAAAEESLREHGIVFKAREPKDDK
PYEDSITLDVAMEEEEEYFHTSVRGVVTEGIPMVSRLNNFNGLYADLRGTTLCLRYKDRPGIIALIGSALSSNGINIDNI
AAPADHATREALTVIKTNQPVSDELLDKIAKEIDAISAFSLNL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=380, Percent_Identity=34.7368421052632, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI4557497, Length=265, Percent_Identity=30.9433962264151, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI61743967, Length=265, Percent_Identity=30.9433962264151, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI145580578, Length=264, Percent_Identity=29.1666666666667, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI4557499, Length=264, Percent_Identity=29.1666666666667, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI145580575, Length=264, Percent_Identity=29.1666666666667, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI6912396, Length=298, Percent_Identity=30.5369127516779, Blast_Score=105, Evalue=8e-23,
Organism=Escherichia coli, GI1789279, Length=320, Percent_Identity=31.25, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI87082289, Length=274, Percent_Identity=29.1970802919708, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1787645, Length=199, Percent_Identity=30.1507537688442, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1788660, Length=225, Percent_Identity=32.4444444444444, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=303, Percent_Identity=36.3036303630363, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI25147481, Length=220, Percent_Identity=29.0909090909091, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320925, Length=325, Percent_Identity=28.3076923076923, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6322116, Length=324, Percent_Identity=28.3950617283951, Blast_Score=126, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6324055, Length=297, Percent_Identity=30.6397306397306, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324964, Length=267, Percent_Identity=29.9625468164794, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324980, Length=197, Percent_Identity=28.4263959390863, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921140, Length=320, Percent_Identity=35, Blast_Score=181, Evalue=8e-46,
Organism=Drosophila melanogaster, GI24646446, Length=224, Percent_Identity=32.1428571428571, Blast_Score=116, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24646448, Length=224, Percent_Identity=32.1428571428571, Blast_Score=116, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24646452, Length=224, Percent_Identity=32.1428571428571, Blast_Score=116, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24646450, Length=224, Percent_Identity=32.1428571428571, Blast_Score=116, Evalue=5e-26,
Organism=Drosophila melanogaster, GI62472511, Length=224, Percent_Identity=32.1428571428571, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI28571528, Length=276, Percent_Identity=30.0724637681159, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI28574286, Length=250, Percent_Identity=25.6, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI45552429, Length=255, Percent_Identity=24.7058823529412, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28574284, Length=255, Percent_Identity=24.7058823529412, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45551003, Length=255, Percent_Identity=24.7058823529412, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24585514, Length=255, Percent_Identity=24.7058823529412, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28574282, Length=255, Percent_Identity=24.7058823529412, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24585516, Length=247, Percent_Identity=25.5060728744939, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56677; Mature: 56677

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVLIPTKLSDVAANTLKTAGYEVIQDADTPLEKQVAAHPDAVALIVRSEKVTPEIMDA
CCCEECCCCHHHHHHHHHHHCCHHHHHCCCCCHHHHHHCCCCEEEEEEECCCCCHHHHHH
LPSLKLVVRAGAGYDNIDIVYARKKNVDVMNTPGANSNAVAEEVMAMILAYYRHIVQADA
CCCEEEEEEECCCCCCEEEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCC
TTREGLWEKKKYMGSELTKKTVGIIGLGNIGRNLVKRLQGFEPILLGYDHFLARQRALNI
CHHHHHHHHHHHHHHHHHHHHHCEEEECHHHHHHHHHHCCCCCEEECHHHHHHHHHHCCC
GVTPTSIEDIFSQCDIITLHVPGGPSTHHMVNAELIGKMKDGAVLINCSRYGVVDEEALA
CCCCCHHHHHHHCCCEEEEECCCCCCCCEEECHHHHCCCCCCEEEEEECCCCCCCHHHHH
AAKAAGKNIGYLTDVHPKDAPGEKPSAPIADLILPHLGANTREANTKAAKRAAEQMIAYF
HHHHCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
SDGDTSCVVNGESPSGLNPAHLQLAFLLASLARKAGGNKPIRRVECTFYGNLRIFRKWFT
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHH
APILEGLLPHAEKGLMPAAAEESLREHGIVFKAREPKDDKPYEDSITLDVAMEEEEEYFH
HHHHHHHCCHHHCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEEECCHHHHHH
TSVRGVVTEGIPMVSRLNNFNGLYADLRGTTLCLRYKDRPGIIALIGSALSSNGINIDNI
HHHHHHHHCCCHHHHHHCCCCCEEEECCCCEEEEEECCCCCEEEEEEHHHCCCCCCCCCC
AAPADHATREALTVIKTNQPVSDELLDKIAKEIDAISAFSLNL
CCCCCHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHEECCC
>Mature Secondary Structure
MNKVLIPTKLSDVAANTLKTAGYEVIQDADTPLEKQVAAHPDAVALIVRSEKVTPEIMDA
CCCEECCCCHHHHHHHHHHHCCHHHHHCCCCCHHHHHHCCCCEEEEEEECCCCCHHHHHH
LPSLKLVVRAGAGYDNIDIVYARKKNVDVMNTPGANSNAVAEEVMAMILAYYRHIVQADA
CCCEEEEEEECCCCCCEEEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCC
TTREGLWEKKKYMGSELTKKTVGIIGLGNIGRNLVKRLQGFEPILLGYDHFLARQRALNI
CHHHHHHHHHHHHHHHHHHHHHCEEEECHHHHHHHHHHCCCCCEEECHHHHHHHHHHCCC
GVTPTSIEDIFSQCDIITLHVPGGPSTHHMVNAELIGKMKDGAVLINCSRYGVVDEEALA
CCCCCHHHHHHHCCCEEEEECCCCCCCCEEECHHHHCCCCCCEEEEEECCCCCCCHHHHH
AAKAAGKNIGYLTDVHPKDAPGEKPSAPIADLILPHLGANTREANTKAAKRAAEQMIAYF
HHHHCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
SDGDTSCVVNGESPSGLNPAHLQLAFLLASLARKAGGNKPIRRVECTFYGNLRIFRKWFT
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHH
APILEGLLPHAEKGLMPAAAEESLREHGIVFKAREPKDDKPYEDSITLDVAMEEEEEYFH
HHHHHHHCCHHHCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEEECCHHHHHH
TSVRGVVTEGIPMVSRLNNFNGLYADLRGTTLCLRYKDRPGIIALIGSALSSNGINIDNI
HHHHHHHHCCCHHHHHHCCCCCEEEECCCCEEEEEECCCCCEEEEEEHHHCCCCCCCCCC
AAPADHATREALTVIKTNQPVSDELLDKIAKEIDAISAFSLNL
CCCCCHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]