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The map label for this gene is argH [H]

Identifier: 186476934

GI number: 186476934

Start: 2449844

End: 2451250

Strand: Direct

Name: argH [H]

Synonym: Bphy_2183

Alternate gene names: 186476934

Gene position: 2449844-2451250 (Clockwise)

Preceding gene: 186476933

Following gene: 186476935

Centisome position: 70.41

GC content: 64.61

Gene sequence:

>1407_bases
ATGACGTCCCAACTGCATAAAAAAGGCGAAGCCTGGTCGGCTCGCTTCTCCGAGCCGATGTCGGAACTCGTCAAGCGCTA
CACGTCGTCGGTATTCTTCGACAAGCGTCTCGCGCTCGTCGACATCGAAGGCTCGCTCGCGCACGCGTCGATGCTGGCCG
CGCAAAAGATCATCAGCGCCGACGACCTCGCCGCGATCCAGCGCGGCATGGCGCAGATCCAGGGTGAAATCGAGCGCGGC
GAGTTCGAATGGCAGCTCGATCTCGAAGACGTGCACCTGAACATCGAAGCGCGGCTCACCGCCCTGATCGGCGACGCAGG
CAAGCGCCTGCACACGGGCCGCTCGCGCAACGACCAGGTCGCGACCGACATCCGCCTGTGGCTGCGCGGAGAAATCGACC
GTATCGGCGATCTGCTGAAGGGCCTGCGCAGCGCGCTGCTCGATCTTGCAGAACAGAACGCGGACACGATCATGCCGGGC
TTCACGCACCTGCAGGTCGCACAGCCAGTGACGTTCGGCCATCACCTGCTCGCCTACGTCGAAATGTTCTCACGTGACGC
CGAGCGCATGCTCGACACCCGCAAGCGCGTGAACCGCCTGCCTCTCGGCGCAGCGGCGCTCGCCGGCACCAGCTACCCGA
TCGACCGTCACGCCGTCGCGAAGACGCTCGGCTTCGACGGCATTTGCGCGAACTCGCTCGACGCCGTGTCCGATCGCGAC
TTCGCGATCGAATTCACGGCCGCTTCGGCGCTCGTGATGACGCATGTGTCGCGCTTCTCGGAAGAACTCGTGCTGTGGAT
GAGCCCGCGCGTCGGCTTCATCGATATTGCCGACCGCTTCTGCACCGGCTCGTCGATCATGCCGCAGAAGAAGAACCCCG
ACGTGCCCGAACTCGCACGCGGCAAGACGGGCCGCGTCAACGGCCACCTGATGGCGCTGCTCACGCTGATGAAGGGCCAG
CCGCTCGCATACAACAAGGACAATCAGGAAGACAAGGAACCGCTGTTCGATACCGTCGACACCGTCGCCGATACGCTGCG
CATCTTCGCGGAGATGGTCGCGGGCATCACGGTGAAGTCGGAGAACATGCGCGGCGCAGCGCTGCAAGGCTTCTCGACGG
CAACCGATCTCGCCGATTACCTCGTCAAGCGCGGCCTGCCGTTCCGCGACGCGCACGAAGCCGTCGCGCACGCAGTGAAG
GTGTGCGACGATCGCGGCTGCGATCTGTCGGATCTGACGCTCGACGAAATGAAGGCGGAATTGCCGAACGTCGCTGCGCT
GCTGGGCGACGACGTGTTCGGCTATCTCACGCTCGAAGGATCGGTTGCAAGCCGGAATCATGCGGGCGGCACGGCGCCGG
ATCAGGTGCGCGCTGCCATCGCGGCTGCACGGGCTGCCCTCGGCTAA

Upstream 100 bases:

>100_bases
GCGCCGCGGGTGTTAAAATCGTTGTCTCCTTCAAGGCGGCGCAGCACCAGGCACCCGTGCCGCGCCGTCCGCGTCTTCAC
CTCGCATACTGCCCATCACC

Downstream 100 bases:

>100_bases
CGCATTTTCCTGCCGATGCTCAAAGGCGAACTCTCTTGCGAGGGTTCGCCTTTTTTGTTGGTGGCGCAAACAAGCAGCGA
CGAATGGCCGCCCTGCCCCG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIEGSLAHASMLAAQKIISADDLAAIQRGMAQIQGEIERG
EFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGDLLKGLRSALLDLAEQNADTIMPG
FTHLQVAQPVTFGHHLLAYVEMFSRDAERMLDTRKRVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRD
FAIEFTAASALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQ
PLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKSENMRGAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVK
VCDDRGCDLSDLTLDEMKAELPNVAALLGDDVFGYLTLEGSVASRNHAGGTAPDQVRAAIAAARAALG

Sequences:

>Translated_468_residues
MTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIEGSLAHASMLAAQKIISADDLAAIQRGMAQIQGEIERG
EFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGDLLKGLRSALLDLAEQNADTIMPG
FTHLQVAQPVTFGHHLLAYVEMFSRDAERMLDTRKRVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRD
FAIEFTAASALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQ
PLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKSENMRGAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVK
VCDDRGCDLSDLTLDEMKAELPNVAALLGDDVFGYLTLEGSVASRNHAGGTAPDQVRAAIAAARAALG
>Mature_467_residues
TSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIEGSLAHASMLAAQKIISADDLAAIQRGMAQIQGEIERGE
FEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGDLLKGLRSALLDLAEQNADTIMPGF
THLQVAQPVTFGHHLLAYVEMFSRDAERMLDTRKRVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRDF
AIEFTAASALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQP
LAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKSENMRGAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVKV
CDDRGCDLSDLTLDEMKAELPNVAALLGDDVFGYLTLEGSVASRNHAGGTAPDQVRAAIAAARAALG

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=461, Percent_Identity=40.1301518438178, Blast_Score=355, Evalue=6e-98,
Organism=Homo sapiens, GI68303542, Length=461, Percent_Identity=40.1301518438178, Blast_Score=355, Evalue=6e-98,
Organism=Homo sapiens, GI68303547, Length=461, Percent_Identity=37.9609544468547, Blast_Score=325, Evalue=6e-89,
Organism=Homo sapiens, GI68303549, Length=461, Percent_Identity=37.3101952277657, Blast_Score=311, Evalue=9e-85,
Organism=Escherichia coli, GI1790398, Length=458, Percent_Identity=45.4148471615721, Blast_Score=400, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6321806, Length=459, Percent_Identity=40.958605664488, Blast_Score=342, Evalue=8e-95,
Organism=Drosophila melanogaster, GI221473854, Length=445, Percent_Identity=38.6516853932584, Blast_Score=311, Evalue=5e-85,
Organism=Drosophila melanogaster, GI78706858, Length=445, Percent_Identity=38.6516853932584, Blast_Score=311, Evalue=5e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51070; Mature: 50939

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIEGSLAHASMLAAQKIISA
CCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCH
DDLAAIQRGMAQIQGEIERGEFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQV
HHHHHHHHHHHHHHCCCCCCCEEEEEEHHHEEEEHHHHHHHHHHHHHHHHCCCCCCCCCH
ATDIRLWLRGEIDRIGDLLKGLRSALLDLAEQNADTIMPGFTHLQVAQPVTFGHHLLAYV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHH
EMFSRDAERMLDTRKRVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRD
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
FAIEFTAASALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR
EEEEEHHHHHHHHHHHHHHHHHEEEEECCCCCEEEHHHHHCCCCCCCCCCCCCCCCHHHC
GKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKS
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEC
ENMRGAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVKVCDDRGCDLSDLTLDEMKAE
CCCCCHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
LPNVAALLGDDVFGYLTLEGSVASRNHAGGTAPDQVRAAIAAARAALG
CCHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIEGSLAHASMLAAQKIISA
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCH
DDLAAIQRGMAQIQGEIERGEFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQV
HHHHHHHHHHHHHHCCCCCCCEEEEEEHHHEEEEHHHHHHHHHHHHHHHHCCCCCCCCCH
ATDIRLWLRGEIDRIGDLLKGLRSALLDLAEQNADTIMPGFTHLQVAQPVTFGHHLLAYV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHH
EMFSRDAERMLDTRKRVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRD
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
FAIEFTAASALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR
EEEEEHHHHHHHHHHHHHHHHHEEEEECCCCCEEEHHHHHCCCCCCCCCCCCCCCCHHHC
GKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKS
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEC
ENMRGAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVKVCDDRGCDLSDLTLDEMKAE
CCCCCHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
LPNVAALLGDDVFGYLTLEGSVASRNHAGGTAPDQVRAAIAAARAALG
CCHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA