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The map label for this gene is paaH [H]

Identifier: 186476738

GI number: 186476738

Start: 2233897

End: 2235477

Strand: Direct

Name: paaH [H]

Synonym: Bphy_1983

Alternate gene names: 186476738

Gene position: 2233897-2235477 (Clockwise)

Preceding gene: 186476736

Following gene: 186476739

Centisome position: 64.21

GC content: 64.71

Gene sequence:

>1581_bases
ATGTCACCGTACACCTCTCGCCAGTACAGCATCGAGACTGTCGGCATCGTCGGCACGGGTGCGATGGGACGCGGCATCGC
CCAGATCGCCGCGCTCGCGGGCCTCCAGGTCAGGCTCTACGACACGAACGCCGCAGCGGTCGGCGCGGCGCGCGACTATC
TGTCCGACACCTTCTCGAAGCTCGTTCCCAAAGGCAAGCTAGACAGTTCGCGTTCGCTCGCGGCGCTTGCCTGCGTGACG
GGCGCCAACGCCATCGAAGAACTGAAGGACTGCGATCTCGTCGTCGAAGCAATCGTCGAAAAGCTCGACGTGAAGCGCGC
GCTCTTCAAGGAGCTGGAAGGCATCGTCAGCGAACGTTGCATACTCGCGTCGAACACGTCGTCGCTGTCGATCACGGCAA
TTGCTGCCGCATGCACGGACCCGTCGCGTGTGCTCGGCTATCACTTCTTCAATCCGGTGCCGCTGATGAAGGTCGTCGAA
GTGATCGACGGTTTGCGCAGCGATCCCGCCGCCGGCAACGCGCTGATGGATCTCGCACGCCGCATGGGCCATACGCCCGT
GCGCGCGAAAGACATGCCTGGCTTCATCGTGAATCACGCGGGCCGCGGCATGAACACGGAAGGCCTGCGAGTAGCGGATG
AAGGTGTTGCGAGTTTCGTCGACATCGACCGCATCATGCGCGAGCAGGCGGGCTTCCGGCTCGGACCGTTCGAGCTGCTC
GACCTGACCGCGCTCGACGTGTCGCATCCCGTGATGGAATCGATCTATCACCAGTTCTACGAAGAGGCGCGCTTCACGCC
GTCGCCGATCACAGGCACGCGCCTCGCGGGCGGCCTGATCGGACGCAAGGCGGGAGAAGGCTTCTATGTCTACGTCGATG
GCAAGCAGCAGGCGCCCGCCGAAGCCCCGGCACCAACTGAACTGCCGAAGCGCGTGTGGGTCAGCGCGCGTGGGCCCGCT
GCACGCGATGCCGTAGTCGCGCTGATTGCAAGGGCCGGCGTCGCCGTCGACCAAGGTGCGACGCCCGGCGCCGATTCGCT
GATCGTCGTGACGCCGCTGGGTTTCGATGCAACGACAGCCGCCGTCGATGAAGGTCTCGATGCGAGCCGCGTCGTCGCCA
TCGACACGCTCTTCCCGCTCGTCGAAGCACAACGCCGCACGTTGATGACAACGCCCGCGACGACGCGCGCCGCGCGTGAT
ACCGCGCACGCCCTGTTCGCACACGACGGCGTACCCGTCACCGTGATCCGCGATTCGACGGGCTTCGTGGCGCAGCGTGT
CGTCGCGACGATCGTCAACATTGGTTGCGATATTGCGCAGCGGCAGATCGCGTCGCCGGAAGACATCGATCTCGCCGTCA
CGCTCGGCCTCGGTTATCCACGCGGACCGCTGGCACTCGGCGATGCGCTCGGCGCGCAGACCATCCTGACGATTCTGCGC
AACATGTTCAAGGTGCTCGGCGATCCGCGCTATCGTCCTTCACCGTGGCTCGCACGCCGCGCGCAACTCGGTATGCCGCT
CACGCAACGCGATGCCACCGACAATGACGACAACAACTACGACACTCAGGAGCACGCATAA

Upstream 100 bases:

>100_bases
CGCTTTGCCGTTCGCCGCGCACGTTGACAATGCGGCGGGCCAGCGCGATGAATTTGGAACGCACGTACTATTTTAGAACA
ATCATGGAGTGAGTCACATC

Downstream 100 bases:

>100_bases
TGGCCGCCGAACTGCTCGCCTCGCGCCCGACCGAAAGCGAATCGACGCTCGTGTTGACACTCTCGAACCCAGGGGCGCGC
AACGCGATGCACCCGGACAT

Product: 3-hydroxy-acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MSPYTSRQYSIETVGIVGTGAMGRGIAQIAALAGLQVRLYDTNAAAVGAARDYLSDTFSKLVPKGKLDSSRSLAALACVT
GANAIEELKDCDLVVEAIVEKLDVKRALFKELEGIVSERCILASNTSSLSITAIAAACTDPSRVLGYHFFNPVPLMKVVE
VIDGLRSDPAAGNALMDLARRMGHTPVRAKDMPGFIVNHAGRGMNTEGLRVADEGVASFVDIDRIMREQAGFRLGPFELL
DLTALDVSHPVMESIYHQFYEEARFTPSPITGTRLAGGLIGRKAGEGFYVYVDGKQQAPAEAPAPTELPKRVWVSARGPA
ARDAVVALIARAGVAVDQGATPGADSLIVVTPLGFDATTAAVDEGLDASRVVAIDTLFPLVEAQRRTLMTTPATTRAARD
TAHALFAHDGVPVTVIRDSTGFVAQRVVATIVNIGCDIAQRQIASPEDIDLAVTLGLGYPRGPLALGDALGAQTILTILR
NMFKVLGDPRYRPSPWLARRAQLGMPLTQRDATDNDDNNYDTQEHA

Sequences:

>Translated_526_residues
MSPYTSRQYSIETVGIVGTGAMGRGIAQIAALAGLQVRLYDTNAAAVGAARDYLSDTFSKLVPKGKLDSSRSLAALACVT
GANAIEELKDCDLVVEAIVEKLDVKRALFKELEGIVSERCILASNTSSLSITAIAAACTDPSRVLGYHFFNPVPLMKVVE
VIDGLRSDPAAGNALMDLARRMGHTPVRAKDMPGFIVNHAGRGMNTEGLRVADEGVASFVDIDRIMREQAGFRLGPFELL
DLTALDVSHPVMESIYHQFYEEARFTPSPITGTRLAGGLIGRKAGEGFYVYVDGKQQAPAEAPAPTELPKRVWVSARGPA
ARDAVVALIARAGVAVDQGATPGADSLIVVTPLGFDATTAAVDEGLDASRVVAIDTLFPLVEAQRRTLMTTPATTRAARD
TAHALFAHDGVPVTVIRDSTGFVAQRVVATIVNIGCDIAQRQIASPEDIDLAVTLGLGYPRGPLALGDALGAQTILTILR
NMFKVLGDPRYRPSPWLARRAQLGMPLTQRDATDNDDNNYDTQEHA
>Mature_525_residues
SPYTSRQYSIETVGIVGTGAMGRGIAQIAALAGLQVRLYDTNAAAVGAARDYLSDTFSKLVPKGKLDSSRSLAALACVTG
ANAIEELKDCDLVVEAIVEKLDVKRALFKELEGIVSERCILASNTSSLSITAIAAACTDPSRVLGYHFFNPVPLMKVVEV
IDGLRSDPAAGNALMDLARRMGHTPVRAKDMPGFIVNHAGRGMNTEGLRVADEGVASFVDIDRIMREQAGFRLGPFELLD
LTALDVSHPVMESIYHQFYEEARFTPSPITGTRLAGGLIGRKAGEGFYVYVDGKQQAPAEAPAPTELPKRVWVSARGPAA
RDAVVALIARAGVAVDQGATPGADSLIVVTPLGFDATTAAVDEGLDASRVVAIDTLFPLVEAQRRTLMTTPATTRAARDT
AHALFAHDGVPVTVIRDSTGFVAQRVVATIVNIGCDIAQRQIASPEDIDLAVTLGLGYPRGPLALGDALGAQTILTILRN
MFKVLGDPRYRPSPWLARRAQLGMPLTQRDATDNDDNNYDTQEHA

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=293, Percent_Identity=38.5665529010239, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI296179427, Length=310, Percent_Identity=37.4193548387097, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI20127408, Length=360, Percent_Identity=29.4444444444444, Blast_Score=149, Evalue=8e-36,
Organism=Homo sapiens, GI68989263, Length=292, Percent_Identity=28.0821917808219, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI261878539, Length=292, Percent_Identity=28.0821917808219, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI115430219, Length=238, Percent_Identity=29.4117647058824, Blast_Score=110, Evalue=4e-24,
Organism=Escherichia coli, GI1787661, Length=498, Percent_Identity=36.9477911646586, Blast_Score=274, Evalue=1e-74,
Organism=Escherichia coli, GI1788682, Length=266, Percent_Identity=33.4586466165414, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1790281, Length=336, Percent_Identity=27.9761904761905, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17549919, Length=293, Percent_Identity=39.9317406143345, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17553560, Length=290, Percent_Identity=38.6206896551724, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=33.4494773519164, Blast_Score=171, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI71985923, Length=288, Percent_Identity=29.8611111111111, Blast_Score=141, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17508953, Length=370, Percent_Identity=31.0810810810811, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17508951, Length=370, Percent_Identity=31.0810810810811, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI25144276, Length=322, Percent_Identity=32.2981366459627, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI71985930, Length=313, Percent_Identity=27.7955271565495, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17558304, Length=298, Percent_Identity=29.8657718120805, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI19921000, Length=327, Percent_Identity=29.0519877675841, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24583077, Length=327, Percent_Identity=29.0519877675841, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24583079, Length=327, Percent_Identity=29.0519877675841, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI45549573, Length=242, Percent_Identity=32.6446280991736, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI20129993, Length=241, Percent_Identity=27.8008298755187, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 56017; Mature: 55885

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPYTSRQYSIETVGIVGTGAMGRGIAQIAALAGLQVRLYDTNAAAVGAARDYLSDTFSK
CCCCCCCCEEEEEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHH
LVPKGKLDSSRSLAALACVTGANAIEELKDCDLVVEAIVEKLDVKRALFKELEGIVSERC
HCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
ILASNTSSLSITAIAAACTDPSRVLGYHFFNPVPLMKVVEVIDGLRSDPAAGNALMDLAR
EEECCCCCEEEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHH
RMGHTPVRAKDMPGFIVNHAGRGMNTEGLRVADEGVASFVDIDRIMREQAGFRLGPFELL
HHCCCCCCCCCCCCCEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
DLTALDVSHPVMESIYHQFYEEARFTPSPITGTRLAGGLIGRKAGEGFYVYVDGKQQAPA
HHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCC
EAPAPTELPKRVWVSARGPAARDAVVALIARAGVAVDQGATPGADSLIVVTPLGFDATTA
CCCCCCCCCHHHEEECCCCCHHHHHHHHHHHCCCEECCCCCCCCCCEEEEEECCCCCHHH
AVDEGLDASRVVAIDTLFPLVEAQRRTLMTTPATTRAARDTAHALFAHDGVPVTVIRDST
HHHCCCCCCCEEEHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCC
GFVAQRVVATIVNIGCDIAQRQIASPEDIDLAVTLGLGYPRGPLALGDALGAQTILTILR
CHHHHHHHHHHHHHCCHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
NMFKVLGDPRYRPSPWLARRAQLGMPLTQRDATDNDDNNYDTQEHA
HHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SPYTSRQYSIETVGIVGTGAMGRGIAQIAALAGLQVRLYDTNAAAVGAARDYLSDTFSK
CCCCCCCEEEEEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHH
LVPKGKLDSSRSLAALACVTGANAIEELKDCDLVVEAIVEKLDVKRALFKELEGIVSERC
HCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
ILASNTSSLSITAIAAACTDPSRVLGYHFFNPVPLMKVVEVIDGLRSDPAAGNALMDLAR
EEECCCCCEEEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHH
RMGHTPVRAKDMPGFIVNHAGRGMNTEGLRVADEGVASFVDIDRIMREQAGFRLGPFELL
HHCCCCCCCCCCCCCEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
DLTALDVSHPVMESIYHQFYEEARFTPSPITGTRLAGGLIGRKAGEGFYVYVDGKQQAPA
HHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCC
EAPAPTELPKRVWVSARGPAARDAVVALIARAGVAVDQGATPGADSLIVVTPLGFDATTA
CCCCCCCCCHHHEEECCCCCHHHHHHHHHHHCCCEECCCCCCCCCCEEEEEECCCCCHHH
AVDEGLDASRVVAIDTLFPLVEAQRRTLMTTPATTRAARDTAHALFAHDGVPVTVIRDST
HHHCCCCCCCEEEHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCC
GFVAQRVVATIVNIGCDIAQRQIASPEDIDLAVTLGLGYPRGPLALGDALGAQTILTILR
CHHHHHHHHHHHHHCCHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
NMFKVLGDPRYRPSPWLARRAQLGMPLTQRDATDNDDNNYDTQEHA
HHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]