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The map label for this gene is rfbD [H]

Identifier: 186476724

GI number: 186476724

Start: 2211427

End: 2212347

Strand: Direct

Name: rfbD [H]

Synonym: Bphy_1969

Alternate gene names: 186476724

Gene position: 2211427-2212347 (Clockwise)

Preceding gene: 186476723

Following gene: 186476729

Centisome position: 63.56

GC content: 67.64

Gene sequence:

>921_bases
ATGTTCAAGGTTGCCGTCATCGGCGCGTCGGGTCTGCTGGGGCGCACGATTGCGGGCGAGCTCGTGCGGCAGCAGGACTG
GCAGATCGTGCAGACGACATTCAGCCGCCCGATGCCCGAAAGCGTACCGCTCGATATTCGTGACGCTAGCGCGGTCGATC
AGTTCGTCGAGCGCGAGCGGCCGAACGCCATCGTCATCGCGGCAGCCGAGCGGCGACCGGATGTGTGCGAAAACAATCCG
GCGCTCGCGCGTGCGCTGAACGTGGACGCCGTGCGCGCGATCGCATCGGCTGCACGCCGGCACGACGCGTGGGTGCTGTC
CATTTCCACCGACTATGTGTTCGACGGCACGGCGCCGCCCTATCGCTACGACGCGACGCCGTCGCCCATCAACGCCTACG
GCCGCAGCAAGCTCGAAGGCGAGCGGGCGCTGGCCGACGCGGCCGATCTGGGCTGCGTGCTGCGCCTGCCGCTGCTGTTC
GGGCCGATCGTCGACTGGCAGGAATCGGCCGTGACGAGTCTCGTGCCCGCGATCGCAGCATCGGCGTCGGCGCCCGCATC
ATCCGGAGCGAAACCCGCCGTGATGGACGCGTGGGCGATCCGCTATCCGACCTATACGCTCGACGTCGCCGTCGTCGTGC
GTCAGTTGCTGGAACGGCACGCGCGTGGCGAAGCGATATGCGGGACAGTGCAATGGTCCGGTGACGAGCCGATGACGAAG
TACGAGATCGCCCAACGTCTCGCGCACGCATTGCAGATGGACGCGCAACTGACGCCGCAGCACACGCCGACGGACGCCAC
GCCGCGCCCGTACAACTGCCAGCTCGATTCGGCACGGCTCGAGGCGCTCGGCATCGGCCGACGCACGCCCTTCGATACGG
CGATCCGCGAGGTTTTTGCGCTGTTTCCGTGGCGCGGTTAG

Upstream 100 bases:

>100_bases
CGTCCAGTCGGGCGCGTCAGCAGACACGCTCAAGGCCGCCATCGACGAAGCCGGCTACACGGTCGTCGGCGTCAACAGCA
ACTGAATGGGGAACGCGCGC

Downstream 100 bases:

>100_bases
ATGTCAGTGGAAATCGCGGCTCGTCGATTGCAGGCCGCCAAGCAGATGCGACATATCGACGAGCCGTTGCGCCACCAGAT
GCCGCACTTCGCCCTCGCAT

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MFKVAVIGASGLLGRTIAGELVRQQDWQIVQTTFSRPMPESVPLDIRDASAVDQFVERERPNAIVIAAAERRPDVCENNP
ALARALNVDAVRAIASAARRHDAWVLSISTDYVFDGTAPPYRYDATPSPINAYGRSKLEGERALADAADLGCVLRLPLLF
GPIVDWQESAVTSLVPAIAASASAPASSGAKPAVMDAWAIRYPTYTLDVAVVVRQLLERHARGEAICGTVQWSGDEPMTK
YEIAQRLAHALQMDAQLTPQHTPTDATPRPYNCQLDSARLEALGIGRRTPFDTAIREVFALFPWRG

Sequences:

>Translated_306_residues
MFKVAVIGASGLLGRTIAGELVRQQDWQIVQTTFSRPMPESVPLDIRDASAVDQFVERERPNAIVIAAAERRPDVCENNP
ALARALNVDAVRAIASAARRHDAWVLSISTDYVFDGTAPPYRYDATPSPINAYGRSKLEGERALADAADLGCVLRLPLLF
GPIVDWQESAVTSLVPAIAASASAPASSGAKPAVMDAWAIRYPTYTLDVAVVVRQLLERHARGEAICGTVQWSGDEPMTK
YEIAQRLAHALQMDAQLTPQHTPTDATPRPYNCQLDSARLEALGIGRRTPFDTAIREVFALFPWRG
>Mature_306_residues
MFKVAVIGASGLLGRTIAGELVRQQDWQIVQTTFSRPMPESVPLDIRDASAVDQFVERERPNAIVIAAAERRPDVCENNP
ALARALNVDAVRAIASAARRHDAWVLSISTDYVFDGTAPPYRYDATPSPINAYGRSKLEGERALADAADLGCVLRLPLLF
GPIVDWQESAVTSLVPAIAASASAPASSGAKPAVMDAWAIRYPTYTLDVAVVVRQLLERHARGEAICGTVQWSGDEPMTK
YEIAQRLAHALQMDAQLTPQHTPTDATPRPYNCQLDSARLEALGIGRRTPFDTAIREVFALFPWRG

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI11034825, Length=304, Percent_Identity=43.0921052631579, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI33519455, Length=304, Percent_Identity=43.0921052631579, Blast_Score=237, Evalue=1e-62,
Organism=Escherichia coli, GI1788352, Length=118, Percent_Identity=38.9830508474576, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 33330; Mature: 33330

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKVAVIGASGLLGRTIAGELVRQQDWQIVQTTFSRPMPESVPLDIRDASAVDQFVERER
CEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCC
PNAIVIAAAERRPDVCENNPALARALNVDAVRAIASAARRHDAWVLSISTDYVFDGTAPP
CCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEECCCCCC
YRYDATPSPINAYGRSKLEGERALADAADLGCVLRLPLLFGPIVDWQESAVTSLVPAIAA
CCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
SASAPASSGAKPAVMDAWAIRYPTYTLDVAVVVRQLLERHARGEAICGTVQWSGDEPMTK
CCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHH
YEIAQRLAHALQMDAQLTPQHTPTDATPRPYNCQLDSARLEALGIGRRTPFDTAIREVFA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHH
LFPWRG
HCCCCC
>Mature Secondary Structure
MFKVAVIGASGLLGRTIAGELVRQQDWQIVQTTFSRPMPESVPLDIRDASAVDQFVERER
CEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCC
PNAIVIAAAERRPDVCENNPALARALNVDAVRAIASAARRHDAWVLSISTDYVFDGTAPP
CCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEECCCCCC
YRYDATPSPINAYGRSKLEGERALADAADLGCVLRLPLLFGPIVDWQESAVTSLVPAIAA
CCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
SASAPASSGAKPAVMDAWAIRYPTYTLDVAVVVRQLLERHARGEAICGTVQWSGDEPMTK
CCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHH
YEIAQRLAHALQMDAQLTPQHTPTDATPRPYNCQLDSARLEALGIGRRTPFDTAIREVFA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHH
LFPWRG
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1710759; 11677609 [H]