Click here to switch to the map view.

The map label for this gene is fabR [H]

Identifier: 186476031

GI number: 186476031

Start: 1427610

End: 1428290

Strand: Reverse

Name: fabR [H]

Synonym: Bphy_1272

Alternate gene names: 186476031

Gene position: 1428290-1427610 (Counterclockwise)

Preceding gene: 186476033

Following gene: 186476027

Centisome position: 41.05

GC content: 62.11

Gene sequence:

>681_bases
ATGGCATCGGCCGGATCGCATCTCTTTAGATCGTTTAAACGGACGCTCATGCAACCCGCATTGGACCCGCAACTCGCGCC
CGGCAAGCGCAAACTGATCGAGGCAGCGTTGCGGCTCACAGCCCGTGGCCGCAGCTTCACGAGTCTGGGCCTTCGCGAAC
TCGCGCGAGAGGCCGAACTCAATCCGAATACGTTCTACCGGCACTTCGACACGCTCGACGATCTTGCCCGCGAAGCCGGC
GAATGGATCGGCCTCCGTTTGCGGCCGATGCTGCGGCGTGAACGCTGGCTCGCTGCACACGACGAGCCGCATAGCGTGCC
CCGTCGCGCGTGTGCTGCCTTCTTTGCGTTTGCGCTCGACAACCGCGAGGCGTTTCTGAGTGCGCTGGCCGAGTATCACG
GCACGTCGCCCGTGCTGCGCGAGGCCGTGCGCGCGAATCTGAACGAGGTGTCGACGGAGATGGCGGAGGACGTCTTGCAA
TTGAATCTGATGCCCACGCTGTCGCGCGAGACCGTCGAGGAAATCTGCACGCAGATCGTGCTGCAGCTGTTTCATCTGTC
GCACGAATTTATCGGCAATGTTGCACAGCGCGCGTCGCTGATCGATTACGCGGAGCGCTTCATTGCGAGGCTGTTTGCGG
GTGCCGTCGTGCTGTCGCAGCATGAAGGGCATAGCGGATAA

Upstream 100 bases:

>100_bases
TGATTTGGTCTGCATCCGTCTACGACGGTTTAAGCGCAGGGTAGACAAGTGTACACATGACGTCAAGATCGTTGTACAGT
GCTCGCTCGAAGGTCGAGAC

Downstream 100 bases:

>100_bases
GCGCAAGCATGTTGCCCGTTGACGCGCATGAAAAAGGGCTCCGTGAGGAGCCCTTCGCGTTTGTCGCCGTTCAACCCGGC
GAGCGCAGTCAGATCGTCAG

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MASAGSHLFRSFKRTLMQPALDPQLAPGKRKLIEAALRLTARGRSFTSLGLRELAREAELNPNTFYRHFDTLDDLAREAG
EWIGLRLRPMLRRERWLAAHDEPHSVPRRACAAFFAFALDNREAFLSALAEYHGTSPVLREAVRANLNEVSTEMAEDVLQ
LNLMPTLSRETVEEICTQIVLQLFHLSHEFIGNVAQRASLIDYAERFIARLFAGAVVLSQHEGHSG

Sequences:

>Translated_226_residues
MASAGSHLFRSFKRTLMQPALDPQLAPGKRKLIEAALRLTARGRSFTSLGLRELAREAELNPNTFYRHFDTLDDLAREAG
EWIGLRLRPMLRRERWLAAHDEPHSVPRRACAAFFAFALDNREAFLSALAEYHGTSPVLREAVRANLNEVSTEMAEDVLQ
LNLMPTLSRETVEEICTQIVLQLFHLSHEFIGNVAQRASLIDYAERFIARLFAGAVVLSQHEGHSG
>Mature_225_residues
ASAGSHLFRSFKRTLMQPALDPQLAPGKRKLIEAALRLTARGRSFTSLGLRELAREAELNPNTFYRHFDTLDDLAREAGE
WIGLRLRPMLRRERWLAAHDEPHSVPRRACAAFFAFALDNREAFLSALAEYHGTSPVLREAVRANLNEVSTEMAEDVLQL
NLMPTLSRETVEEICTQIVLQLFHLSHEFIGNVAQRASLIDYAERFIARLFAGAVVLSQHEGHSG

Specific function: Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, fabR directly influences the physical properties of the membrane bilayer [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI145693209, Length=159, Percent_Identity=38.3647798742138, Blast_Score=81, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 25490; Mature: 25359

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASAGSHLFRSFKRTLMQPALDPQLAPGKRKLIEAALRLTARGRSFTSLGLRELAREAEL
CCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
NPNTFYRHFDTLDDLAREAGEWIGLRLRPMLRRERWLAAHDEPHSVPRRACAAFFAFALD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
NREAFLSALAEYHGTSPVLREAVRANLNEVSTEMAEDVLQLNLMPTLSRETVEEICTQIV
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LQLFHLSHEFIGNVAQRASLIDYAERFIARLFAGAVVLSQHEGHSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ASAGSHLFRSFKRTLMQPALDPQLAPGKRKLIEAALRLTARGRSFTSLGLRELAREAEL
CCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
NPNTFYRHFDTLDDLAREAGEWIGLRLRPMLRRERWLAAHDEPHSVPRRACAAFFAFALD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
NREAFLSALAEYHGTSPVLREAVRANLNEVSTEMAEDVLQLNLMPTLSRETVEEICTQIV
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LQLFHLSHEFIGNVAQRASLIDYAERFIARLFAGAVVLSQHEGHSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA