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The map label for this gene is yphC [C]

Identifier: 183222638

GI number: 183222638

Start: 3405194

End: 3406234

Strand: Direct

Name: yphC [C]

Synonym: LEPBI_I3293

Alternate gene names: 183222638

Gene position: 3405194-3406234 (Clockwise)

Preceding gene: 183222637

Following gene: 183222640

Centisome position: 94.6

GC content: 42.56

Gene sequence:

>1041_bases
ATGAAAGCCGCCGTATTACCTTCGGGATCGAGATCCCTAGAAATCCAAGAATTAGACCTTCCACCACTCCCACCAAACCA
AGTCAAGGTGAAAGTAAAAGCATGTGGGATCTGCGGATCAGACATTCATTTCATTTTACATGGAAAAATGAAGGCCACGT
ATTCTCCTTGTGTACCTGGTCACGAAACTTCAGGAGTTGTCGCAGAGATTGGAGACCAAGTCACTAAATTTAAATTAGGT
GACCGAGTGGTAGTGAGTGCGGGGACATCTTGCGGAAAATGCAAACATTGTTTGGCAGGAAGAGAAAATCTTTGCGAAAA
TATCGGCGTCATTGGGTTCAACCAAAGAGGAGGATTTGCAGAATTCATCCAAACAGAAGAAAGGTACCTTCATTTATTAC
CAGAAGAAATTCCGTTTGCCGAGGGAGCCATCCTTGCTGATGCCGTATCCACTCCCTACCATGCTATCAAATACCAAGGT
GAATTAAAAGCAGGCGAATCGGTGGCCATCATCGGATGTGGTGGACTCGGAATCCATGCAGTGGCAATTGCTAAAGCCCT
TGGAGCGGCAAAAATTTATGCCATAGATATTGATAGTGGAAGTTTAGAAAATGCAAAAGCATATGGTGCCGACGAACTAA
TATTAGTCGAAAAGAATATGCAAGTTGGGAAAGTTTTAAAAGAAAAGTCGGGTGGGATCGATCTATTATGCGACTTTACT
GGTTACATGCCAAATATTGAAAGTAGTGTTCGTGCCATGAACCGAGGAGGAAGGATTGTCCTTGTGGGGATTGGAAGGAA
TAAACTCGAAATCCCGATGCCATTTTTTCTTATCGAAAGGCAAATCCGAATCACAGGGTCTTATGGTTCGGATCGACGGG
CCATTCCAGAACTCATCCAACTCTATCAGGAAAAAAAATTGAATCTCACTAAATCCATCAGTGGGATTCATAAACTGGAA
GATACGAACGAATTCTTACATGCGTTAGAAGAAAAAAAAGGGAATCCCATTCGTTTCATCATCAACCCTGAGTTATCATA
A

Upstream 100 bases:

>100_bases
ATTTGAAATATTATTTAAACGATACCATAGAGCTCACTTTAGAACAACTCAGTGAAACTGATTCGAGTGATATGTTATCA
GAACTTGATGGAATTATGTT

Downstream 100 bases:

>100_bases
AAACGAAACGAATCACTTTTTTTTGTCCTAGTCGAAGGACATCGACATAGGAACAACATGTTTTGTCTGATACCATCTGT
TGTAGATTGGGAAACCTTTG

Product: putative zinc-binding alcohol dehydrogenase

Products: NA

Alternate protein names: ADH-HT [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKAAVLPSGSRSLEIQELDLPPLPPNQVKVKVKACGICGSDIHFILHGKMKATYSPCVPGHETSGVVAEIGDQVTKFKLG
DRVVVSAGTSCGKCKHCLAGRENLCENIGVIGFNQRGGFAEFIQTEERYLHLLPEEIPFAEGAILADAVSTPYHAIKYQG
ELKAGESVAIIGCGGLGIHAVAIAKALGAAKIYAIDIDSGSLENAKAYGADELILVEKNMQVGKVLKEKSGGIDLLCDFT
GYMPNIESSVRAMNRGGRIVLVGIGRNKLEIPMPFFLIERQIRITGSYGSDRRAIPELIQLYQEKKLNLTKSISGIHKLE
DTNEFLHALEEKKGNPIRFIINPELS

Sequences:

>Translated_346_residues
MKAAVLPSGSRSLEIQELDLPPLPPNQVKVKVKACGICGSDIHFILHGKMKATYSPCVPGHETSGVVAEIGDQVTKFKLG
DRVVVSAGTSCGKCKHCLAGRENLCENIGVIGFNQRGGFAEFIQTEERYLHLLPEEIPFAEGAILADAVSTPYHAIKYQG
ELKAGESVAIIGCGGLGIHAVAIAKALGAAKIYAIDIDSGSLENAKAYGADELILVEKNMQVGKVLKEKSGGIDLLCDFT
GYMPNIESSVRAMNRGGRIVLVGIGRNKLEIPMPFFLIERQIRITGSYGSDRRAIPELIQLYQEKKLNLTKSISGIHKLE
DTNEFLHALEEKKGNPIRFIINPELS
>Mature_346_residues
MKAAVLPSGSRSLEIQELDLPPLPPNQVKVKVKACGICGSDIHFILHGKMKATYSPCVPGHETSGVVAEIGDQVTKFKLG
DRVVVSAGTSCGKCKHCLAGRENLCENIGVIGFNQRGGFAEFIQTEERYLHLLPEEIPFAEGAILADAVSTPYHAIKYQG
ELKAGESVAIIGCGGLGIHAVAIAKALGAAKIYAIDIDSGSLENAKAYGADELILVEKNMQVGKVLKEKSGGIDLLCDFT
GYMPNIESSVRAMNRGGRIVLVGIGRNKLEIPMPFFLIERQIRITGSYGSDRRAIPELIQLYQEKKLNLTKSISGIHKLE
DTNEFLHALEEKKGNPIRFIINPELS

Specific function: Thermophilic NAD(+)-dependent alcohol dehydrogenase. Bears mainly an ethanol-dehydrogenase activity [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=341, Percent_Identity=27.5659824046921, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI4501929, Length=368, Percent_Identity=28.5326086956522, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI4501933, Length=372, Percent_Identity=27.1505376344086, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI34577061, Length=368, Percent_Identity=27.445652173913, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI156523966, Length=369, Percent_Identity=26.5582655826558, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI71565154, Length=371, Percent_Identity=25.6064690026954, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=26.0387811634349, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI71743840, Length=367, Percent_Identity=25.3405994550409, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI262073058, Length=367, Percent_Identity=25.3405994550409, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI71565152, Length=372, Percent_Identity=26.8817204301075, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI194239674, Length=262, Percent_Identity=28.6259541984733, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI13236495, Length=262, Percent_Identity=28.6259541984733, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI194239676, Length=174, Percent_Identity=31.6091954022989, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI87082125, Length=334, Percent_Identity=29.940119760479, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1790045, Length=334, Percent_Identity=28.1437125748503, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1788073, Length=330, Percent_Identity=26.969696969697, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI87081918, Length=334, Percent_Identity=30.5389221556886, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1788407, Length=298, Percent_Identity=29.5302013422819, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1787863, Length=272, Percent_Identity=30.5147058823529, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786552, Length=367, Percent_Identity=26.9754768392371, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI226510992, Length=290, Percent_Identity=30, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1786518, Length=300, Percent_Identity=30.6666666666667, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1790718, Length=272, Percent_Identity=30.1470588235294, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87082401, Length=313, Percent_Identity=28.4345047923323, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1788075, Length=334, Percent_Identity=24.5508982035928, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786825, Length=244, Percent_Identity=26.6393442622951, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562876, Length=348, Percent_Identity=33.9080459770115, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17562878, Length=345, Percent_Identity=31.5942028985507, Blast_Score=147, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI25146526, Length=374, Percent_Identity=27.5401069518717, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI71997431, Length=376, Percent_Identity=27.3936170212766, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71988145, Length=346, Percent_Identity=25.7225433526012, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17565904, Length=329, Percent_Identity=26.7477203647416, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17562582, Length=339, Percent_Identity=27.1386430678466, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17562584, Length=325, Percent_Identity=25.5384615384615, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323099, Length=325, Percent_Identity=30.4615384615385, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319258, Length=355, Percent_Identity=29.0140845070423, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320033, Length=373, Percent_Identity=25.4691689008043, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6322619, Length=325, Percent_Identity=29.5384615384615, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6319955, Length=325, Percent_Identity=29.2307692307692, Blast_Score=125, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6323961, Length=327, Percent_Identity=29.6636085626911, Blast_Score=116, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6324486, Length=316, Percent_Identity=29.746835443038, Blast_Score=112, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6319621, Length=334, Percent_Identity=28.7425149700599, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6323729, Length=319, Percent_Identity=28.5266457680251, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319257, Length=357, Percent_Identity=25.2100840336134, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6319949, Length=305, Percent_Identity=30.1639344262295, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6323980, Length=307, Percent_Identity=29.3159609120521, Blast_Score=86, Evalue=7e-18,
Organism=Drosophila melanogaster, GI17737895, Length=369, Percent_Identity=28.7262872628726, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI17737897, Length=343, Percent_Identity=28.2798833819242, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17137530, Length=343, Percent_Identity=27.6967930029155, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI45550770, Length=331, Percent_Identity=26.5861027190332, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI221457811, Length=331, Percent_Identity=26.5861027190332, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI45551930, Length=331, Percent_Identity=26.5861027190332, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37407; Mature: 37407

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVLPSGSRSLEIQELDLPPLPPNQVKVKVKACGICGSDIHFILHGKMKATYSPCVPG
CCCEECCCCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCCEEEEEECCEEECCCCCCCC
HETSGVVAEIGDQVTKFKLGDRVVVSAGTSCGKCKHCLAGRENLCENIGVIGFNQRGGFA
CCCCCHHHHHCCHHEEEECCCEEEEECCCCCHHHHHHHCCHHHHHHHCCEEEECCCCCHH
EFIQTEERYLHLLPEEIPFAEGAILADAVSTPYHAIKYQGELKAGESVAIIGCGGLGIHA
HHHHHHHHHHHHCCCCCCCCCCCEEEHHHCCCCEEEEECCCCCCCCEEEEEEECCCHHHH
VAIAKALGAAKIYAIDIDSGSLENAKAYGADELILVEKNMQVGKVLKEKSGGIDLLCDFT
HHHHHHHCCEEEEEEECCCCCCCCCHHCCCCEEEEEECCCHHHHHHHHCCCCEEEEEECC
GYMPNIESSVRAMNRGGRIVLVGIGRNKLEIPMPFFLIERQIRITGSYGSDRRAIPELIQ
CCCCCHHHHHHHHCCCCEEEEEECCCCEEECCCCEEEEEEEEEEEECCCCCCHHHHHHHH
LYQEKKLNLTKSISGIHKLEDTNEFLHALEEKKGNPIRFIINPELS
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
>Mature Secondary Structure
MKAAVLPSGSRSLEIQELDLPPLPPNQVKVKVKACGICGSDIHFILHGKMKATYSPCVPG
CCCEECCCCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCCEEEEEECCEEECCCCCCCC
HETSGVVAEIGDQVTKFKLGDRVVVSAGTSCGKCKHCLAGRENLCENIGVIGFNQRGGFA
CCCCCHHHHHCCHHEEEECCCEEEEECCCCCHHHHHHHCCHHHHHHHCCEEEECCCCCHH
EFIQTEERYLHLLPEEIPFAEGAILADAVSTPYHAIKYQGELKAGESVAIIGCGGLGIHA
HHHHHHHHHHHHCCCCCCCCCCCEEEHHHCCCCEEEEECCCCCCCCEEEEEEECCCHHHH
VAIAKALGAAKIYAIDIDSGSLENAKAYGADELILVEKNMQVGKVLKEKSGGIDLLCDFT
HHHHHHHCCEEEEEEECCCCCCCCCHHCCCCEEEEEECCCHHHHHHHHCCCCEEEEEECC
GYMPNIESSVRAMNRGGRIVLVGIGRNKLEIPMPFFLIERQIRITGSYGSDRRAIPELIQ
CCCCCHHHHHHHHCCCCEEEEEECCCCEEECCCCEEEEEEEEEEEECCCCCCHHHHHHHH
LYQEKKLNLTKSISGIHKLEDTNEFLHALEEKKGNPIRFIINPELS
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8020473 [H]