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The map label for this gene is dxs [C]

Identifier: 183222315

GI number: 183222315

Start: 3071182

End: 3072147

Strand: Reverse

Name: dxs [C]

Synonym: LEPBI_I2967

Alternate gene names: 183222315

Gene position: 3072147-3071182 (Counterclockwise)

Preceding gene: 183222316

Following gene: 183222314

Centisome position: 85.35

GC content: 44.72

Gene sequence:

>966_bases
ATGGGAGCACCTAGCCAATCCACAGCGGACAAAAAAGCAACAAGAGATGCATATGGCGAAGCCTTAGTTGAGTTAGGTGC
ATCTAGACAAGATGTGGTGGTTTTAGATGCGGACCTTTCTGGTTCCACTAAAACTGCTGACTTCAAAAAAAAGTATCCAG
AAAGGTTTTTTAATGTAGGGGTCGCTGAACAAAACTTAGTTGGTCATGCGGCGGGCCTTGCGCTCTCTGGATTTGTTCCT
TTTGCATCTAGTTTTGCTATGTTTTTATCTGGTCGCGCTTGGGAAGTTGTCCGTAATAGTGTCGTTTACCCAAAGTTAAA
CGTGAAATTAGTGGCTTCTCATGGTGGGATCACTGTGGGAGAAGACGGTGCCTCCCACCAATGTATCGAAGACTTTGCTA
TCATGCGTGTGATCCCTGAGATGACCGTCATCTGTCCTTCTGATTTTAATGAAACCAAACAAGTGATCCATGCCATTGCC
GATTACAAAGGCCCTGTGTATGTGAGAGTGGGTCGACCTGCCATTCCTGTCATCGAACGAGAAAACTACAAATTCCAAAT
CGGAAAGGCAGAAGTGATCTCGGAAGGAAAGGATGTTTGTATCATCGCCAATGGAGTGATGGTCAACGAAGCAATGATTG
CCGTTGGACTTCTCAAAGAAAAAGGAATTCATGCAAGCTTACTCAATATGGCAACCATCAAACCTTTGGACAAAGAAGCC
ATCGTTGCCAAAGCGAAAGAGTGTGGTGCGATTGTGACTTGCGAAGAACACAATGTCATCGGTGGCCTTGGTTCTGCAGT
CTCTGAACTTTTATCGGAAGAATATCCCGTACCAGTCATCAAAGTAGGGATGAAGGATACTTTTGGAAAATCAGGAACAT
GGAGTGGGCTCCTTGATTATTTTGGTCTCCGCGCAAAGGATGTTGTGACTCACGCGGAACTTGCGATTTCCAAAAAGAAA
AAATAG

Upstream 100 bases:

>100_bases
CTTACCAAGAAACAGCAGCATATGGTCACTTCGGAAGAACAGGAAGTACATTCACTTGGGAAAAAACTGACAAAGCAGAC
GCTTTGAAAAAAGGATAATT

Downstream 100 bases:

>100_bases
GTTTAGGGCTTCGGTGATGACCGGTTCCGGAGCTACCCAACCTTCGATTCTAGAAGAAACAGAAATCAAACCCACGAAAC
ATGACGGCCCTTGGAAGGTT

Product: putative transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MGAPSQSTADKKATRDAYGEALVELGASRQDVVVLDADLSGSTKTADFKKKYPERFFNVGVAEQNLVGHAAGLALSGFVP
FASSFAMFLSGRAWEVVRNSVVYPKLNVKLVASHGGITVGEDGASHQCIEDFAIMRVIPEMTVICPSDFNETKQVIHAIA
DYKGPVYVRVGRPAIPVIERENYKFQIGKAEVISEGKDVCIIANGVMVNEAMIAVGLLKEKGIHASLLNMATIKPLDKEA
IVAKAKECGAIVTCEEHNVIGGLGSAVSELLSEEYPVPVIKVGMKDTFGKSGTWSGLLDYFGLRAKDVVTHAELAISKKK
K

Sequences:

>Translated_321_residues
MGAPSQSTADKKATRDAYGEALVELGASRQDVVVLDADLSGSTKTADFKKKYPERFFNVGVAEQNLVGHAAGLALSGFVP
FASSFAMFLSGRAWEVVRNSVVYPKLNVKLVASHGGITVGEDGASHQCIEDFAIMRVIPEMTVICPSDFNETKQVIHAIA
DYKGPVYVRVGRPAIPVIERENYKFQIGKAEVISEGKDVCIIANGVMVNEAMIAVGLLKEKGIHASLLNMATIKPLDKEA
IVAKAKECGAIVTCEEHNVIGGLGSAVSELLSEEYPVPVIKVGMKDTFGKSGTWSGLLDYFGLRAKDVVTHAELAISKKK
K
>Mature_320_residues
GAPSQSTADKKATRDAYGEALVELGASRQDVVVLDADLSGSTKTADFKKKYPERFFNVGVAEQNLVGHAAGLALSGFVPF
ASSFAMFLSGRAWEVVRNSVVYPKLNVKLVASHGGITVGEDGASHQCIEDFAIMRVIPEMTVICPSDFNETKQVIHAIAD
YKGPVYVRVGRPAIPVIERENYKFQIGKAEVISEGKDVCIIANGVMVNEAMIAVGLLKEKGIHASLLNMATIKPLDKEAI
VAKAKECGAIVTCEEHNVIGGLGSAVSELLSEEYPVPVIKVGMKDTFGKSGTWSGLLDYFGLRAKDVVTHAELAISKKKK

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=313, Percent_Identity=38.3386581469649, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI4507521, Length=313, Percent_Identity=38.3386581469649, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI225637463, Length=312, Percent_Identity=38.4615384615385, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI225637459, Length=312, Percent_Identity=38.4615384615385, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI225637461, Length=312, Percent_Identity=38.4615384615385, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI133778974, Length=318, Percent_Identity=34.9056603773585, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI4557353, Length=263, Percent_Identity=25.0950570342205, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI34101272, Length=263, Percent_Identity=25.0950570342205, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1786622, Length=291, Percent_Identity=34.7079037800687, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI48994911, Length=325, Percent_Identity=25.8461538461538, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788808, Length=323, Percent_Identity=24.4582043343653, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17539652, Length=313, Percent_Identity=38.6581469648562, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6319593, Length=333, Percent_Identity=25.2252252252252, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6325331, Length=203, Percent_Identity=27.0935960591133, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24645119, Length=311, Percent_Identity=36.9774919614148, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI45551847, Length=311, Percent_Identity=36.9774919614148, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI45550715, Length=311, Percent_Identity=36.9774919614148, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24666278, Length=320, Percent_Identity=36.25, Blast_Score=171, Evalue=7e-43,
Organism=Drosophila melanogaster, GI21358145, Length=285, Percent_Identity=26.3157894736842, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24650940, Length=285, Percent_Identity=26.3157894736842, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 34400; Mature: 34269

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAPSQSTADKKATRDAYGEALVELGASRQDVVVLDADLSGSTKTADFKKKYPERFFNVG
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCC
VAEQNLVGHAAGLALSGFVPFASSFAMFLSGRAWEVVRNSVVYPKLNVKLVASHGGITVG
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCCEEEEEECCCEEEC
EDGASHQCIEDFAIMRVIPEMTVICPSDFNETKQVIHAIADYKGPVYVRVGRPAIPVIER
CCCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEC
ENYKFQIGKAEVISEGKDVCIIANGVMVNEAMIAVGLLKEKGIHASLLNMATIKPLDKEA
CCCEEEECCHHHHCCCCCEEEEECCEEEHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHH
IVAKAKECGAIVTCEEHNVIGGLGSAVSELLSEEYPVPVIKVGMKDTFGKSGTWSGLLDY
HHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHH
FGLRAKDVVTHAELAISKKKK
HCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GAPSQSTADKKATRDAYGEALVELGASRQDVVVLDADLSGSTKTADFKKKYPERFFNVG
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCC
VAEQNLVGHAAGLALSGFVPFASSFAMFLSGRAWEVVRNSVVYPKLNVKLVASHGGITVG
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCCEEEEEECCCEEEC
EDGASHQCIEDFAIMRVIPEMTVICPSDFNETKQVIHAIADYKGPVYVRVGRPAIPVIER
CCCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEC
ENYKFQIGKAEVISEGKDVCIIANGVMVNEAMIAVGLLKEKGIHASLLNMATIKPLDKEA
CCCEEEECCHHHHCCCCCEEEEECCEEEHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHH
IVAKAKECGAIVTCEEHNVIGGLGSAVSELLSEEYPVPVIKVGMKDTFGKSGTWSGLLDY
HHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHH
FGLRAKDVVTHAELAISKKKK
HCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]