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The map label for this gene is mtnC

Identifier: 183222308

GI number: 183222308

Start: 3062084

End: 3062827

Strand: Reverse

Name: mtnC

Synonym: LEPBI_I2960

Alternate gene names: 183222308

Gene position: 3062827-3062084 (Counterclockwise)

Preceding gene: 183222309

Following gene: 183222305

Centisome position: 85.09

GC content: 38.04

Gene sequence:

>744_bases
ATGCAGATCAAACACAATTTACTTGATATTGAAGGGACAACGGCACCAATCGCCTTTGTCCATCAAATCCTTTTCCCTTA
TGCTACAAAAAACATCCATCGTTTTTTAAAAGAATACCAACTAACGGAACTTCAGTGGAAAGAAGTCCAAACAGAATTCC
AAAAGGATACTTCTTCCGGCGATCCCTTATTCATAGAAAAATTCAGAATTAAAAATGTACCATCGGGCCTGATTGTGAAT
GAAGTTCCCAATACTCTTTCAAAAGACATGGTTTCAGTGTATTTTGAATATCTGATTGAAAAAGATCGTAAATTTGGTCC
GCTGAAAGAGATCCAAGGGAAAATTTGGAAAGAAGGATATGAATCGGGTGAAATCAAAAGTACAGTATTTGATGATGTCC
CCAAGTTTTTAAATGACGCAATTCAATCTGGAATCCAAAATCATGTTTACTCTTCAGGCTCCGTTGAGGCACAACATTTG
ATTTACCAATATTCTGTGTTAGGTGATTTGCGGCAGTATTTTACTATGTACTTTGATACAGCAGTGGGTGGAAAAAGGGA
AAAAACAAGTTATGAAAGGATCGCAAGTACACTTGCTGTATCTCCAAGTGAAATTCGTTTTTTTACGGACATTGTCGAGG
AAGCGGAAGCTGCAAATGCCACAGGTATGGATGTGGTGATTTTAAATCGACCAGGAAACCTGGCCCAAAAACCACATCCA
TTCCCGGTTTGGGAACATTTTTAA

Upstream 100 bases:

>100_bases
TATGAAAAAGATGAAGCAAACATGCATTTGATGATGAAACAGAATGTTTCCTAGGTTATCTTTTTGTCCTAAATAATTCA
ACGGTAACACAATAGATTCA

Downstream 100 bases:

>100_bases
GTAAAATACCAAATCCCAAACGAATACACAAAGATTAAACTTGAGAAAATCAATTTCCAAAAAAAATGGGCGCGCATTAA
ATTCATAAACACATACGAAA

Product: putative enolase-phosphatase E-1

Products: NA

Alternate protein names: 2,3-diketo-5-methylthio-1-phosphopentane phosphatase

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MQIKHNLLDIEGTTAPIAFVHQILFPYATKNIHRFLKEYQLTELQWKEVQTEFQKDTSSGDPLFIEKFRIKNVPSGLIVN
EVPNTLSKDMVSVYFEYLIEKDRKFGPLKEIQGKIWKEGYESGEIKSTVFDDVPKFLNDAIQSGIQNHVYSSGSVEAQHL
IYQYSVLGDLRQYFTMYFDTAVGGKREKTSYERIASTLAVSPSEIRFFTDIVEEAEAANATGMDVVILNRPGNLAQKPHP
FPVWEHF

Sequences:

>Translated_247_residues
MQIKHNLLDIEGTTAPIAFVHQILFPYATKNIHRFLKEYQLTELQWKEVQTEFQKDTSSGDPLFIEKFRIKNVPSGLIVN
EVPNTLSKDMVSVYFEYLIEKDRKFGPLKEIQGKIWKEGYESGEIKSTVFDDVPKFLNDAIQSGIQNHVYSSGSVEAQHL
IYQYSVLGDLRQYFTMYFDTAVGGKREKTSYERIASTLAVSPSEIRFFTDIVEEAEAANATGMDVVILNRPGNLAQKPHP
FPVWEHF
>Mature_247_residues
MQIKHNLLDIEGTTAPIAFVHQILFPYATKNIHRFLKEYQLTELQWKEVQTEFQKDTSSGDPLFIEKFRIKNVPSGLIVN
EVPNTLSKDMVSVYFEYLIEKDRKFGPLKEIQGKIWKEGYESGEIKSTVFDDVPKFLNDAIQSGIQNHVYSSGSVEAQHL
IYQYSVLGDLRQYFTMYFDTAVGGKREKTSYERIASTLAVSPSEIRFFTDIVEEAEAANATGMDVVILNRPGNLAQKPHP
FPVWEHF

Specific function: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone

COG id: COG4229

COG function: function code C; Predicted enolase-phosphatase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. MasA/mtnC family

Homologues:

Organism=Homo sapiens, GI10864017, Length=232, Percent_Identity=36.2068965517241, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI115533232, Length=234, Percent_Identity=34.6153846153846, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320797, Length=240, Percent_Identity=32.9166666666667, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI281360080, Length=229, Percent_Identity=41.9213973799127, Blast_Score=177, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24644163, Length=229, Percent_Identity=41.9213973799127, Blast_Score=177, Evalue=6e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNC_LEPBA (B0SFG5)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001963911.1
- ProteinModelPortal:   B0SFG5
- SMR:   B0SFG5
- GeneID:   6388751
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_2858
- HOGENOM:   HBG294242
- OMA:   TTDLNFI
- ProtClustDB:   CLSK866737
- BioCyc:   LBIF355278:LBF_2858-MONOMER
- HAMAP:   MF_01681
- InterPro:   IPR010041
- InterPro:   IPR023214
- Gene3D:   G3DSA:3.40.50.1000
- PANTHER:   PTHR20371
- TIGRFAMs:   TIGR01691

Pfam domain/function: SSF56784 SSF56784

EC number: =3.1.3.77

Molecular weight: Translated: 28335; Mature: 28335

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIKHNLLDIEGTTAPIAFVHQILFPYATKNIHRFLKEYQLTELQWKEVQTEFQKDTSSG
CCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DPLFIEKFRIKNVPSGLIVNEVPNTLSKDMVSVYFEYLIEKDRKFGPLKEIQGKIWKEGY
CCEEEEEEECCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
ESGEIKSTVFDDVPKFLNDAIQSGIQNHVYSSGSVEAQHLIYQYSVLGDLRQYFTMYFDT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AVGGKREKTSYERIASTLAVSPSEIRFFTDIVEEAEAANATGMDVVILNRPGNLAQKPHP
HCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCC
FPVWEHF
CCCCCCC
>Mature Secondary Structure
MQIKHNLLDIEGTTAPIAFVHQILFPYATKNIHRFLKEYQLTELQWKEVQTEFQKDTSSG
CCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DPLFIEKFRIKNVPSGLIVNEVPNTLSKDMVSVYFEYLIEKDRKFGPLKEIQGKIWKEGY
CCEEEEEEECCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
ESGEIKSTVFDDVPKFLNDAIQSGIQNHVYSSGSVEAQHLIYQYSVLGDLRQYFTMYFDT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AVGGKREKTSYERIASTLAVSPSEIRFFTDIVEEAEAANATGMDVVILNRPGNLAQKPHP
HCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCC
FPVWEHF
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA