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The map label for this gene is lpxD [H]

Identifier: 183221920

GI number: 183221920

Start: 2647076

End: 2648095

Strand: Reverse

Name: lpxD [H]

Synonym: LEPBI_I2559

Alternate gene names: 183221920

Gene position: 2648095-2647076 (Counterclockwise)

Preceding gene: 183221922

Following gene: 183221915

Centisome position: 73.56

GC content: 38.53

Gene sequence:

>1020_bases
ATGAAACTAAGAGAGTTAGCTGAACGATTGGAAGCAAATTTCACTGGGAACGGTGATTTGGAAGTAAATGGAATCAAAGA
TTTAGAACACCACTCATCTGTTGATCCGAATAGCATCTATTATGTGGCATCTAAAAAATATTTAAATAAACATAAAAAAG
CAGCTGATGTTAAAATTGCGCTAACGATTGATTCTCTTGCCTCTTCGTTTCCAAATGCCATCATCATTCCTGAAGAAGGT
TCGAAAGTGAAATTCATCCAAGTGATTTCATTTTTCGAAAGAAAACCAAACCATTTACCTTCTATTTCACAAAAAGCAAG
TATCCATCCTTCAGCAAAGATCGGTAAAAATGTTACCATTATGGACTTTGTCGTGATCCAAGAAAATGTTGTGATCGGTG
ATCATGTGGTTTTACACCCAAATGTTGTCATTGAATCGAACGTGGAAGTAGGAAATGATACTGAGATTAAATCTGGTGTT
GTGGTCTACTATAATTGCAAAATCGGGAAAAGAAATTTAATCCACGCTAACACAGTCATCGGTGCCGATGGATTTGGTTT
TTATGATTATGGCGGAATACGATACAAAGTCCCTCAAATTGGCAATGTCGTGATTGGAGATGATGTCGAGATGGGCGCAC
ATTGTACGGTAGATAGAGCGGCTTTAGAATCGACAACCATCGGAAATTTTACAAAATTTGATGATCACGTACATGTTGGT
CATAATTGTAGAGTGGGGAACTATGTGTACATTGCTGGAGCCACAGTGCTTGCAGGTTCTGTCACAATTGAAGATGGTTG
TTTTTTGGCGGGTCAATCCGCAGTCGCAGAACACCTAACGATGAAAAAAGGATCAATTCTATTGGGACTTTCTGGTCTAA
CGGAAGATTCAAAAGAAAAAACAGCATATTTTGGAATTCCCGCAAGGCCAGCACTCGAGATGCATCGCATTCACACTTCC
TTGCCAATGTTACCTGAAATTGCAAAGGAACACACAAAACGAAAAAACAAAGAGAATTAA

Upstream 100 bases:

>100_bases
TTTTAATCTTCGGTATGTTTTCAAATTTTCAGAAGGGAGGCTTTGAAAATTATGATTGAAATATGTCCCTTACCATTATT
TTCTCACTTAAGGTCTTAAA

Downstream 100 bases:

>100_bases
ATCATTATAAAGAGATTGATTCTATATTTTTTTTCAAAGACTGAAGATTTTCGTTCATTTGTGATTTGAGATTCATTTTG
ACAAGGCCTTCACTCAGTTT

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MKLRELAERLEANFTGNGDLEVNGIKDLEHHSSVDPNSIYYVASKKYLNKHKKAADVKIALTIDSLASSFPNAIIIPEEG
SKVKFIQVISFFERKPNHLPSISQKASIHPSAKIGKNVTIMDFVVIQENVVIGDHVVLHPNVVIESNVEVGNDTEIKSGV
VVYYNCKIGKRNLIHANTVIGADGFGFYDYGGIRYKVPQIGNVVIGDDVEMGAHCTVDRAALESTTIGNFTKFDDHVHVG
HNCRVGNYVYIAGATVLAGSVTIEDGCFLAGQSAVAEHLTMKKGSILLGLSGLTEDSKEKTAYFGIPARPALEMHRIHTS
LPMLPEIAKEHTKRKNKEN

Sequences:

>Translated_339_residues
MKLRELAERLEANFTGNGDLEVNGIKDLEHHSSVDPNSIYYVASKKYLNKHKKAADVKIALTIDSLASSFPNAIIIPEEG
SKVKFIQVISFFERKPNHLPSISQKASIHPSAKIGKNVTIMDFVVIQENVVIGDHVVLHPNVVIESNVEVGNDTEIKSGV
VVYYNCKIGKRNLIHANTVIGADGFGFYDYGGIRYKVPQIGNVVIGDDVEMGAHCTVDRAALESTTIGNFTKFDDHVHVG
HNCRVGNYVYIAGATVLAGSVTIEDGCFLAGQSAVAEHLTMKKGSILLGLSGLTEDSKEKTAYFGIPARPALEMHRIHTS
LPMLPEIAKEHTKRKNKEN
>Mature_339_residues
MKLRELAERLEANFTGNGDLEVNGIKDLEHHSSVDPNSIYYVASKKYLNKHKKAADVKIALTIDSLASSFPNAIIIPEEG
SKVKFIQVISFFERKPNHLPSISQKASIHPSAKIGKNVTIMDFVVIQENVVIGDHVVLHPNVVIESNVEVGNDTEIKSGV
VVYYNCKIGKRNLIHANTVIGADGFGFYDYGGIRYKVPQIGNVVIGDDVEMGAHCTVDRAALESTTIGNFTKFDDHVHVG
HNCRVGNYVYIAGATVLAGSVTIEDGCFLAGQSAVAEHLTMKKGSILLGLSGLTEDSKEKTAYFGIPARPALEMHRIHTS
LPMLPEIAKEHTKRKNKEN

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=311, Percent_Identity=29.903536977492, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1786378, Length=201, Percent_Identity=26.3681592039801, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 37059; Mature: 37059

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLRELAERLEANFTGNGDLEVNGIKDLEHHSSVDPNSIYYVASKKYLNKHKKAADVKIA
CCHHHHHHHHHCCCCCCCCEEECCCCCHHHHCCCCCCEEEEEECHHHHHHCCCCCCEEEE
LTIDSLASSFPNAIIIPEEGSKVKFIQVISFFERKPNHLPSISQKASIHPSAKIGKNVTI
EEEHHHHHHCCCEEEEECCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCEEE
MDFVVIQENVVIGDHVVLHPNVVIESNVEVGNDTEIKSGVVVYYNCKIGKRNLIHANTVI
EEEEEEECCEEECCEEEECCCEEEECCCCCCCCCCCCCCEEEEEEEECCCCCEEEECEEE
GADGFGFYDYGGIRYKVPQIGNVVIGDDVEMGAHCTVDRAALESTTIGNFTKFDDHVHVG
CCCCCCEECCCCEEEECCCCCCEEECCCCCCCCCEEECHHHHCCCCCCCCEECCCEEECC
HNCRVGNYVYIAGATVLAGSVTIEDGCFLAGQSAVAEHLTMKKGSILLGLSGLTEDSKEK
CCEEECCEEEEECCEEEEEEEEECCCEEEECCHHHHHHHHCCCCCEEEEECCCCCCCCCC
TAYFGIPARPALEMHRIHTSLPMLPEIAKEHTKRKNKEN
EEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKLRELAERLEANFTGNGDLEVNGIKDLEHHSSVDPNSIYYVASKKYLNKHKKAADVKIA
CCHHHHHHHHHCCCCCCCCEEECCCCCHHHHCCCCCCEEEEEECHHHHHHCCCCCCEEEE
LTIDSLASSFPNAIIIPEEGSKVKFIQVISFFERKPNHLPSISQKASIHPSAKIGKNVTI
EEEHHHHHHCCCEEEEECCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCEEE
MDFVVIQENVVIGDHVVLHPNVVIESNVEVGNDTEIKSGVVVYYNCKIGKRNLIHANTVI
EEEEEEECCEEECCEEEECCCEEEECCCCCCCCCCCCCCEEEEEEEECCCCCEEEECEEE
GADGFGFYDYGGIRYKVPQIGNVVIGDDVEMGAHCTVDRAALESTTIGNFTKFDDHVHVG
CCCCCCEECCCCEEEECCCCCCEEECCCCCCCCCEEECHHHHCCCCCCCCEECCCEEECC
HNCRVGNYVYIAGATVLAGSVTIEDGCFLAGQSAVAEHLTMKKGSILLGLSGLTEDSKEK
CCEEECCEEEEECCEEEEEEEEECCCEEEECCHHHHHHHHCCCCCEEEEECCCCCCCCCC
TAYFGIPARPALEMHRIHTSLPMLPEIAKEHTKRKNKEN
EEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA