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The map label for this gene is luxQ [H]

Identifier: 183221820

GI number: 183221820

Start: 2528788

End: 2530959

Strand: Reverse

Name: luxQ [H]

Synonym: LEPBI_I2451

Alternate gene names: 183221820

Gene position: 2530959-2528788 (Counterclockwise)

Preceding gene: 183221821

Following gene: 183221818

Centisome position: 70.31

GC content: 32.55

Gene sequence:

>2172_bases
ATGACTTTTTTGATCCAAAAAAAACTAGAGCCATTTTATTTTGGTTTCCTTTGGGTTATTTTATTATCTTTAATATTTTC
ATCTTTTTTCTTCTTCTTCCATCTTTTTGATAGCCGCAACAATTCAAGTCGTCTTGAGGAGAAGAAACAATGGGATTTAA
GCTTAAAAGAATATGCGTCTTCCTTAAAAGATGCTGAGACAGGAGTGAGAGGATACTTACTTTCTAAAGACCGAACATTT
TTAAATCCTTATCATAAAGCATTGATATTACTCCCTAATATCGAACAATATTTAATTGATCACTGTGAAAACGAAGATAA
AGCAGATTTGATAAGTCTTATAAATTTAAGCCACTCCAAGCTAAAGCATATAGAAAGTCACTTGCTTTCTTTTTCCCAAA
GAAATCCATCCAATCAAAGTTTAGTGATTGGGAATCAGAAAATGGCGGAATTTCGGTATCTATACGATAGTTTAACTTCG
CGCAAACAAAAGAGAGATCAGTTTGAAATAGAAAAACATAACAAATCTAGTGATAGGCTCTTGGTTGTTTCAGCGGGTTT
GTTTTTGCTCCTCTCGTTTTTGATTTTATGGATGATATTTATACTTAAAATAAGTATCAAATCTATCTCAGAAAAAGAGA
TGATAGAAGATCGATATTTCGAAATTGAAGATTTATACCAAAATTCGCCCGTTGGTTTTCATAGTTTAGATCCAGATGGA
TTTTTTTTAAGAGTGAATCGAACGGAATCTGAATGGTTTGGATATTCGGAAAAGGAATTGATTGGAAAAAAGAAATGGTC
AGACCTTTTGACTGAAAATAGTCGAAATATTTTTTTTCAAAACTTTCCAATATTCAAAAAACAAGGTTATATAAATAATT
TAATTTTTGAAGTGATCAAAAAGAATGGAGATTCAATTTTTGTCAATTTGTCATCAACAGCAATATTTGCACAAAATGGT
CTAATGATTCGCAGTCGATCTGTGTTAGTTGATGTAACACAATCGATCGTATATGAAAGAGAACTTTTATTGGCCAAAAA
AAAAGCGGAAGAAGCAAATAAAGCAAAGTCTGATTTTTTATCGAATATGAGTCATGAATTACGAACTCCACTCAATGCAG
TTATTGGAATTTCGTTATGGTTACTGGAAGAAAATCCAAAAACAGAACAGTTGGAAAATTTAAAAAATTTAAAGTTTTCA
AGTGAATCACTACTTTCTCTTATCAATGACATTTTAGATTTTAACAAAATTGAAGAAAGATTGGTTGAAATTGAAAGAAT
TGATTTCAACTTAAAAGATTTTTTAAAATCGATCACGACATCTTTTACGATGCGAGCAAAAGAAAAATTATTAATTTTTA
ATGAAGATATAAAAGATACGGTTCCAGAGTTCATACATTCAGATCCAACTCGTTTACTACAAATTTTGAATAATTTACTT
TCCAATGCGTTAAAATTTACACAAGTGGGTTCGATCACTCTTTACGTAAGTGCAATTCCAATGGATTCGGAGTCAGTATT
ATTAACATTTGAAGTAACCGATACCGGGATTGGAATCGAGCCAAATAAGTTCCAATCCGTTTTCGAAAAATTTACGCAAG
CAAATCAAGATACCACGAGAAAATTTGGAGGTTCAGGTTTAGGCCTAGCCATTTCAAAGGCATTGGTTGAGCTTCTGGGA
GGTCATTTAGTGCTTACCTCAGAAGTTGGCAAAGGATCAAAATTTTCATTTTCTCTTCCATGTAAAATTGGAAAGGCCAA
TGAATTTATTTCGATCAGCACGGCCAAAAACAATGATGCTCTGAAAGATAAAATTGTTTTAGTTGCGGATGACATTCAAA
TCAATCGATCAATAGTGATCCGTTTTTTGAATCGCTGGGGTATTCAAACTTTTGAAGCAACAAATGGATTGGAAGTATTA
GAAATACTGAAAAATCAGCATGTTGATTTGATTCTAATGGATCTTCATATGCCTGAGATGGATGGGTATATGTCAGCAAC
GGAAATTCGAAAGGTTTCCAATTGGAACCAAATTCCTATTCTTGCATTAACTGCTTCGGCGCAATTGGAAACTCGCGCGC
AAATAAAGTCAGTTGGAATGAATGACTATATTTCCAAACCGTTCAACCCAAATGATTTATTGAATCAACTACACTTCTGG
ATTGGTTCTTAA

Upstream 100 bases:

>100_bases
ATTGAAAAAGGTACCCGGTTTGATCTATATTTCCCTGCATGGAAGGCAATGGTTTAATCTATTGACAGATTCATTCATTC
GATTAAGAACATAGTTTCTT

Downstream 100 bases:

>100_bases
AAATTACAATGATACTTCAAAACTGGAATCCAATGACAATGCGAGTATGGTGATATCATCGTCGGATCTTTTTGATTTCT
GAAATTTTTCTATTTGTTCA

Product: putative two-component regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 723; Mature: 722

Protein sequence:

>723_residues
MTFLIQKKLEPFYFGFLWVILLSLIFSSFFFFFHLFDSRNNSSRLEEKKQWDLSLKEYASSLKDAETGVRGYLLSKDRTF
LNPYHKALILLPNIEQYLIDHCENEDKADLISLINLSHSKLKHIESHLLSFSQRNPSNQSLVIGNQKMAEFRYLYDSLTS
RKQKRDQFEIEKHNKSSDRLLVVSAGLFLLLSFLILWMIFILKISIKSISEKEMIEDRYFEIEDLYQNSPVGFHSLDPDG
FFLRVNRTESEWFGYSEKELIGKKKWSDLLTENSRNIFFQNFPIFKKQGYINNLIFEVIKKNGDSIFVNLSSTAIFAQNG
LMIRSRSVLVDVTQSIVYERELLLAKKKAEEANKAKSDFLSNMSHELRTPLNAVIGISLWLLEENPKTEQLENLKNLKFS
SESLLSLINDILDFNKIEERLVEIERIDFNLKDFLKSITTSFTMRAKEKLLIFNEDIKDTVPEFIHSDPTRLLQILNNLL
SNALKFTQVGSITLYVSAIPMDSESVLLTFEVTDTGIGIEPNKFQSVFEKFTQANQDTTRKFGGSGLGLAISKALVELLG
GHLVLTSEVGKGSKFSFSLPCKIGKANEFISISTAKNNDALKDKIVLVADDIQINRSIVIRFLNRWGIQTFEATNGLEVL
EILKNQHVDLILMDLHMPEMDGYMSATEIRKVSNWNQIPILALTASAQLETRAQIKSVGMNDYISKPFNPNDLLNQLHFW
IGS

Sequences:

>Translated_723_residues
MTFLIQKKLEPFYFGFLWVILLSLIFSSFFFFFHLFDSRNNSSRLEEKKQWDLSLKEYASSLKDAETGVRGYLLSKDRTF
LNPYHKALILLPNIEQYLIDHCENEDKADLISLINLSHSKLKHIESHLLSFSQRNPSNQSLVIGNQKMAEFRYLYDSLTS
RKQKRDQFEIEKHNKSSDRLLVVSAGLFLLLSFLILWMIFILKISIKSISEKEMIEDRYFEIEDLYQNSPVGFHSLDPDG
FFLRVNRTESEWFGYSEKELIGKKKWSDLLTENSRNIFFQNFPIFKKQGYINNLIFEVIKKNGDSIFVNLSSTAIFAQNG
LMIRSRSVLVDVTQSIVYERELLLAKKKAEEANKAKSDFLSNMSHELRTPLNAVIGISLWLLEENPKTEQLENLKNLKFS
SESLLSLINDILDFNKIEERLVEIERIDFNLKDFLKSITTSFTMRAKEKLLIFNEDIKDTVPEFIHSDPTRLLQILNNLL
SNALKFTQVGSITLYVSAIPMDSESVLLTFEVTDTGIGIEPNKFQSVFEKFTQANQDTTRKFGGSGLGLAISKALVELLG
GHLVLTSEVGKGSKFSFSLPCKIGKANEFISISTAKNNDALKDKIVLVADDIQINRSIVIRFLNRWGIQTFEATNGLEVL
EILKNQHVDLILMDLHMPEMDGYMSATEIRKVSNWNQIPILALTASAQLETRAQIKSVGMNDYISKPFNPNDLLNQLHFW
IGS
>Mature_722_residues
TFLIQKKLEPFYFGFLWVILLSLIFSSFFFFFHLFDSRNNSSRLEEKKQWDLSLKEYASSLKDAETGVRGYLLSKDRTFL
NPYHKALILLPNIEQYLIDHCENEDKADLISLINLSHSKLKHIESHLLSFSQRNPSNQSLVIGNQKMAEFRYLYDSLTSR
KQKRDQFEIEKHNKSSDRLLVVSAGLFLLLSFLILWMIFILKISIKSISEKEMIEDRYFEIEDLYQNSPVGFHSLDPDGF
FLRVNRTESEWFGYSEKELIGKKKWSDLLTENSRNIFFQNFPIFKKQGYINNLIFEVIKKNGDSIFVNLSSTAIFAQNGL
MIRSRSVLVDVTQSIVYERELLLAKKKAEEANKAKSDFLSNMSHELRTPLNAVIGISLWLLEENPKTEQLENLKNLKFSS
ESLLSLINDILDFNKIEERLVEIERIDFNLKDFLKSITTSFTMRAKEKLLIFNEDIKDTVPEFIHSDPTRLLQILNNLLS
NALKFTQVGSITLYVSAIPMDSESVLLTFEVTDTGIGIEPNKFQSVFEKFTQANQDTTRKFGGSGLGLAISKALVELLGG
HLVLTSEVGKGSKFSFSLPCKIGKANEFISISTAKNNDALKDKIVLVADDIQINRSIVIRFLNRWGIQTFEATNGLEVLE
ILKNQHVDLILMDLHMPEMDGYMSATEIRKVSNWNQIPILALTASAQLETRAQIKSVGMNDYISKPFNPNDLLNQLHFWI
GS

Specific function: At low cell density, in absence of autoinducer has a kinase activity, and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=526, Percent_Identity=30.2281368821293, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1788713, Length=397, Percent_Identity=34.0050377833753, Blast_Score=188, Evalue=1e-48,
Organism=Escherichia coli, GI87081816, Length=380, Percent_Identity=35.2631578947368, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1789149, Length=394, Percent_Identity=32.994923857868, Blast_Score=183, Evalue=3e-47,
Organism=Escherichia coli, GI145693157, Length=256, Percent_Identity=38.671875, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1788393, Length=231, Percent_Identity=29.8701298701299, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1786600, Length=253, Percent_Identity=28.8537549407115, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI87082128, Length=230, Percent_Identity=29.5652173913043, Blast_Score=93, Evalue=7e-20,
Organism=Escherichia coli, GI1790436, Length=250, Percent_Identity=28.8, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI1786912, Length=340, Percent_Identity=25.8823529411765, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1786783, Length=240, Percent_Identity=26.6666666666667, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788550, Length=111, Percent_Identity=34.2342342342342, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1787894, Length=228, Percent_Identity=28.5087719298246, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1790300, Length=346, Percent_Identity=23.6994219653179, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=209, Percent_Identity=27.7511961722488, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1788545, Length=331, Percent_Identity=24.1691842900302, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1789809, Length=114, Percent_Identity=32.4561403508772, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI1790346, Length=218, Percent_Identity=25.2293577981651, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI1790863, Length=108, Percent_Identity=30.5555555555556, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1790437, Length=108, Percent_Identity=34.2592592592593, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=74, Percent_Identity=47.2972972972973, Blast_Score=81, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 83055; Mature: 82923

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS50112 PAS ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFLIQKKLEPFYFGFLWVILLSLIFSSFFFFFHLFDSRNNSSRLEEKKQWDLSLKEYAS
CCEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHH
SLKDAETGVRGYLLSKDRTFLNPYHKALILLPNIEQYLIDHCENEDKADLISLINLSHSK
HHHHHHCCCCEEEEECCCCHHCCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHCCHHH
LKHIESHLLSFSQRNPSNQSLVIGNQKMAEFRYLYDSLTSRKQKRDQFEIEKHNKSSDRL
HHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEE
LVVSAGLFLLLSFLILWMIFILKISIKSISEKEMIEDRYFEIEDLYQNSPVGFHSLDPDG
EEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHCCCCCCCCCCCCCC
FFLRVNRTESEWFGYSEKELIGKKKWSDLLTENSRNIFFQNFPIFKKQGYINNLIFEVIK
EEEEEECCCHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHH
KNGDSIFVNLSSTAIFAQNGLMIRSRSVLVDVTQSIVYERELLLAKKKAEEANKAKSDFL
CCCCEEEEEECCEEEEECCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SNMSHELRTPLNAVIGISLWLLEENPKTEQLENLKNLKFSSESLLSLINDILDFNKIEER
HHHHHHHHCHHHHHHEEEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LVEIERIDFNLKDFLKSITTSFTMRAKEKLLIFNEDIKDTVPEFIHSDPTRLLQILNNLL
HHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHH
SNALKFTQVGSITLYVSAIPMDSESVLLTFEVTDTGIGIEPNKFQSVFEKFTQANQDTTR
HHHHHHHEECCEEEEEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHH
KFGGSGLGLAISKALVELLGGHLVLTSEVGKGSKFSFSLPCKIGKANEFISISTAKNNDA
HCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCEECCCCCEEEEEECCCCCC
LKDKIVLVADDIQINRSIVIRFLNRWGIQTFEATNGLEVLEILKNQHVDLILMDLHMPEM
CCCEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCCEEEEEECCCCC
DGYMSATEIRKVSNWNQIPILALTASAQLETRAQIKSVGMNDYISKPFNPNDLLNQLHFW
CCCCCHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHH
IGS
CCC
>Mature Secondary Structure 
TFLIQKKLEPFYFGFLWVILLSLIFSSFFFFFHLFDSRNNSSRLEEKKQWDLSLKEYAS
CEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHH
SLKDAETGVRGYLLSKDRTFLNPYHKALILLPNIEQYLIDHCENEDKADLISLINLSHSK
HHHHHHCCCCEEEEECCCCHHCCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHCCHHH
LKHIESHLLSFSQRNPSNQSLVIGNQKMAEFRYLYDSLTSRKQKRDQFEIEKHNKSSDRL
HHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEE
LVVSAGLFLLLSFLILWMIFILKISIKSISEKEMIEDRYFEIEDLYQNSPVGFHSLDPDG
EEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHCCCCCCCCCCCCCC
FFLRVNRTESEWFGYSEKELIGKKKWSDLLTENSRNIFFQNFPIFKKQGYINNLIFEVIK
EEEEEECCCHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHH
KNGDSIFVNLSSTAIFAQNGLMIRSRSVLVDVTQSIVYERELLLAKKKAEEANKAKSDFL
CCCCEEEEEECCEEEEECCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SNMSHELRTPLNAVIGISLWLLEENPKTEQLENLKNLKFSSESLLSLINDILDFNKIEER
HHHHHHHHCHHHHHHEEEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LVEIERIDFNLKDFLKSITTSFTMRAKEKLLIFNEDIKDTVPEFIHSDPTRLLQILNNLL
HHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHH
SNALKFTQVGSITLYVSAIPMDSESVLLTFEVTDTGIGIEPNKFQSVFEKFTQANQDTTR
HHHHHHHEECCEEEEEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHH
KFGGSGLGLAISKALVELLGGHLVLTSEVGKGSKFSFSLPCKIGKANEFISISTAKNNDA
HCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCEECCCCCEEEEEECCCCCC
LKDKIVLVADDIQINRSIVIRFLNRWGIQTFEATNGLEVLEILKNQHVDLILMDLHMPEM
CCCEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCCEEEEEECCCCC
DGYMSATEIRKVSNWNQIPILALTASAQLETRAQIKSVGMNDYISKPFNPNDLLNQLHFW
CCCCCHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHH
IGS
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA