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The map label for this gene is higB [H]

Identifier: 183221578

GI number: 183221578

Start: 2284740

End: 2285036

Strand: Direct

Name: higB [H]

Synonym: LEPBI_I2199

Alternate gene names: 183221578

Gene position: 2284740-2285036 (Clockwise)

Preceding gene: 183221577

Following gene: 183221579

Centisome position: 63.47

GC content: 28.62

Gene sequence:

>297_bases
GTGCATATTATCAGCTGGAAGAAATTGGATGATTTCATTGCAAAACACCCTAATTCTGAATCTTCATTAAAAAGCTGGTT
TAAAATCATTAAAAATACACATTTTAAGGACTTTAATGAATTGAAGAAAGTTTTCAATTCCGTGGACCAAGTTGGAAAAT
TTACAGTTTTTAATATAAGCGGAAATCACTTTCGATTGATTGCTGCTATTCATTTCAATAGGCAAAAAGTTTTTGTAAGA
AACATTTTAACACATTCTGAATATGATAAAGGTAAATGGAAAAGGGAAAATTTATGA

Upstream 100 bases:

>100_bases
TATACGAAATCGCAAAAATGTATGCCTCGGAACATGAGTAACACTTAAATTAATTAAAAAAACCATTGACATATCTCATT
TTGAGATATTCTCTGGACTA

Downstream 100 bases:

>100_bases
TTCTAGAAATTGAAAAAGTTAAGAATGTTTGGGATGATGTTAAAGATATTCTCTCTGTACCTCATACTGATAAACAATAT
AAAAAATTAGTTAAGGTTCT

Product: hypothetical protein

Products: NA

Alternate protein names: Endoribonuclease HigB; Toxin HigB [H]

Number of amino acids: Translated: 98; Mature: 98

Protein sequence:

>98_residues
MHIISWKKLDDFIAKHPNSESSLKSWFKIIKNTHFKDFNELKKVFNSVDQVGKFTVFNISGNHFRLIAAIHFNRQKVFVR
NILTHSEYDKGKWKRENL

Sequences:

>Translated_98_residues
MHIISWKKLDDFIAKHPNSESSLKSWFKIIKNTHFKDFNELKKVFNSVDQVGKFTVFNISGNHFRLIAAIHFNRQKVFVR
NILTHSEYDKGKWKRENL
>Mature_98_residues
MHIISWKKLDDFIAKHPNSESSLKSWFKIIKNTHFKDFNELKKVFNSVDQVGKFTVFNISGNHFRLIAAIHFNRQKVFVR
NILTHSEYDKGKWKRENL

Specific function: Part of a toxin-antitoxin (TA) module. A probable translation-dependent mRNA interferase [H]

COG id: COG4680

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HigB mRNA interferase family [H]

Homologues:

Organism=Escherichia coli, GI1789465, Length=92, Percent_Identity=38.0434782608696, Blast_Score=72, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018669 [H]

Pfam domain/function: PF09907 DUF2136 [H]

EC number: NA

Molecular weight: Translated: 11734; Mature: 11734

Theoretical pI: Translated: 10.81; Mature: 10.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIISWKKLDDFIAKHPNSESSLKSWFKIIKNTHFKDFNELKKVFNSVDQVGKFTVFNIS
CCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCEEEEEEC
GNHFRLIAAIHFNRQKVFVRNILTHSEYDKGKWKRENL
CCCEEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MHIISWKKLDDFIAKHPNSESSLKSWFKIIKNTHFKDFNELKKVFNSVDQVGKFTVFNIS
CCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCEEEEEEC
GNHFRLIAAIHFNRQKVFVRNILTHSEYDKGKWKRENL
CCCEEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]