BacMap

Definition	Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)' chromosome chromosome I, complete sequence.
Accession	NC_010602
Length	3,599,677

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The map label for this gene is ppiA [H]

Identifier: 183221503

GI number: 183221503

Start: 2214062

End: 2214583

Strand: Direct

Name: ppiA [H]

Synonym: LEPBI_I2121

Alternate gene names: 183221503

Gene position: 2214062-2214583 (Clockwise)

Preceding gene: 183221499

Following gene: 183221504

Centisome position: 61.51

GC content: 41.57

Gene sequence:

>522_bases
GTGAATGGTATGAGTACTTTACGCGCAGTGATCAAAACAAATAAAGGTGAAATCCGAATCGAACTTTTTCCCGAGAAAAC
ACCAAACACGGTTGCCAATTTTGTGAATTTGGCCCAAAGGAATTTTTATAATGGTTTAAAGTTCCACCGTGTCATCGAAG
ATTTTATGATCCAAGGTGGTTGTCCCCAAGGAACAGGAACGGGTGGTCCAGGTTATAAGTTTCGCGATGAGTTTGACTCT
AGTTTGAAACACAACAAACCAGGGATCCTTTCTATGGCAAATGCAGGCCCTGGCACCAACGGAAGTCAATTTTTTATTAC
CCATGTTGCAACACCTTGGCTCGATGGAAAACATTCTGTGTTTGGTGCTGTGGTGGATGCAAGTGACCAAGAAGTGGTCA
ATGCCATTCGCCAGGGAGATAAGATCGAAACCATCACCATCGAAGGCGATCCAACTTCTGTTTTAGAAATTGCAAAACCT
TATCTCGAAGAATGGAACCAAATTTTAGATTCTAAAAAATAA

Upstream 100 bases:

>100_bases
TCATCATAGTACCTCATCCAATCAAACACCAAGTATAATGGGAAAATGATAAGGAACTCAAACCTTTTTTCGACTTGCCA
GGGGAAATTGAAGAAATTGA

Downstream 100 bases:

>100_bases
AGATTGCCCCATTCCTCTCTGTTTCCAATGTCTAATCATTATGAAAGAGAAAGGAAAACCAATCAAACAAATCAAATTGG
CTTCCAGGATGATCTTCACC

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MNGMSTLRAVIKTNKGEIRIELFPEKTPNTVANFVNLAQRNFYNGLKFHRVIEDFMIQGGCPQGTGTGGPGYKFRDEFDS
SLKHNKPGILSMANAGPGTNGSQFFITHVATPWLDGKHSVFGAVVDASDQEVVNAIRQGDKIETITIEGDPTSVLEIAKP
YLEEWNQILDSKK

Sequences:

>Translated_173_residues
MNGMSTLRAVIKTNKGEIRIELFPEKTPNTVANFVNLAQRNFYNGLKFHRVIEDFMIQGGCPQGTGTGGPGYKFRDEFDS
SLKHNKPGILSMANAGPGTNGSQFFITHVATPWLDGKHSVFGAVVDASDQEVVNAIRQGDKIETITIEGDPTSVLEIAKP
YLEEWNQILDSKK
>Mature_173_residues
MNGMSTLRAVIKTNKGEIRIELFPEKTPNTVANFVNLAQRNFYNGLKFHRVIEDFMIQGGCPQGTGTGGPGYKFRDEFDS
SLKHNKPGILSMANAGPGTNGSQFFITHVATPWLDGKHSVFGAVVDASDQEVVNAIRQGDKIETITIEGDPTSVLEIAKP
YLEEWNQILDSKK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=131, Percent_Identity=54.9618320610687, Blast_Score=140, Evalue=7e-34,
Organism=Homo sapiens, GI7706339, Length=118, Percent_Identity=55.9322033898305, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI19557636, Length=124, Percent_Identity=52.4193548387097, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI4758950, Length=128, Percent_Identity=54.6875, Blast_Score=113, Evalue=8e-26,
Organism=Homo sapiens, GI64276486, Length=121, Percent_Identity=43.801652892562, Blast_Score=110, Evalue=4e-25,
Organism=Homo sapiens, GI4505991, Length=128, Percent_Identity=55.46875, Blast_Score=110, Evalue=8e-25,
Organism=Homo sapiens, GI10863927, Length=144, Percent_Identity=49.3055555555556, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI22547212, Length=170, Percent_Identity=44.1176470588235, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI7657473, Length=170, Percent_Identity=44.1176470588235, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI22547215, Length=170, Percent_Identity=44.1176470588235, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI5454154, Length=127, Percent_Identity=48.8188976377953, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI310127646, Length=146, Percent_Identity=44.5205479452055, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI310114371, Length=146, Percent_Identity=44.5205479452055, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI310119221, Length=146, Percent_Identity=44.5205479452055, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI45439316, Length=145, Percent_Identity=46.2068965517241, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI5031987, Length=121, Percent_Identity=50.4132231404959, Blast_Score=100, Evalue=4e-22,
Organism=Homo sapiens, GI256017253, Length=128, Percent_Identity=50.78125, Blast_Score=100, Evalue=5e-22,
Organism=Homo sapiens, GI221139811, Length=128, Percent_Identity=50.78125, Blast_Score=100, Evalue=5e-22,
Organism=Homo sapiens, GI256017251, Length=128, Percent_Identity=50.78125, Blast_Score=100, Evalue=5e-22,
Organism=Homo sapiens, GI4826932, Length=160, Percent_Identity=41.875, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI310129267, Length=130, Percent_Identity=47.6923076923077, Blast_Score=98, Evalue=3e-21,
Organism=Homo sapiens, GI310120620, Length=130, Percent_Identity=47.6923076923077, Blast_Score=98, Evalue=3e-21,
Organism=Homo sapiens, GI303305009, Length=121, Percent_Identity=49.5867768595041, Blast_Score=98, Evalue=3e-21,
Organism=Homo sapiens, GI5174637, Length=121, Percent_Identity=49.5867768595041, Blast_Score=98, Evalue=4e-21,
Organism=Homo sapiens, GI178057341, Length=116, Percent_Identity=52.5862068965517, Blast_Score=98, Evalue=4e-21,
Organism=Homo sapiens, GI310110104, Length=143, Percent_Identity=45.4545454545455, Blast_Score=96, Evalue=1e-20,
Organism=Homo sapiens, GI42560244, Length=136, Percent_Identity=47.0588235294118, Blast_Score=96, Evalue=1e-20,
Organism=Homo sapiens, GI209417936, Length=116, Percent_Identity=51.7241379310345, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI30102944, Length=116, Percent_Identity=51.7241379310345, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI219842199, Length=116, Percent_Identity=51.7241379310345, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI169164185, Length=161, Percent_Identity=41.6149068322981, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI169163623, Length=161, Percent_Identity=41.6149068322981, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI169163387, Length=161, Percent_Identity=41.6149068322981, Blast_Score=91, Evalue=4e-19,
Organism=Homo sapiens, GI239751853, Length=144, Percent_Identity=43.0555555555556, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI169214050, Length=144, Percent_Identity=43.0555555555556, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI113428306, Length=144, Percent_Identity=43.0555555555556, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI6631100, Length=136, Percent_Identity=44.1176470588235, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI310132444, Length=144, Percent_Identity=43.0555555555556, Blast_Score=87, Evalue=8e-18,
Organism=Homo sapiens, GI310113152, Length=144, Percent_Identity=43.0555555555556, Blast_Score=87, Evalue=8e-18,
Organism=Homo sapiens, GI20911035, Length=134, Percent_Identity=37.3134328358209, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI150418007, Length=122, Percent_Identity=49.1803278688525, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI310127745, Length=115, Percent_Identity=46.0869565217391, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI310119290, Length=115, Percent_Identity=46.0869565217391, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI310114540, Length=115, Percent_Identity=46.0869565217391, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI14277126, Length=130, Percent_Identity=41.5384615384615, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI27735045, Length=128, Percent_Identity=38.28125, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI289803023, Length=154, Percent_Identity=31.8181818181818, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1786736, Length=141, Percent_Identity=37.5886524822695, Blast_Score=70, Evalue=5e-14,
Organism=Escherichia coli, GI1789763, Length=138, Percent_Identity=34.7826086956522, Blast_Score=68, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17539496, Length=119, Percent_Identity=58.8235294117647, Blast_Score=140, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17506311, Length=153, Percent_Identity=49.0196078431373, Blast_Score=132, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71980594, Length=160, Percent_Identity=40, Blast_Score=120, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17552780, Length=121, Percent_Identity=58.6776859504132, Blast_Score=120, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17506307, Length=134, Percent_Identity=54.4776119402985, Blast_Score=120, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71980590, Length=145, Percent_Identity=42.0689655172414, Blast_Score=117, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17532641, Length=120, Percent_Identity=48.3333333333333, Blast_Score=117, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71997782, Length=127, Percent_Identity=44.0944881889764, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17565860, Length=152, Percent_Identity=48.6842105263158, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17559074, Length=135, Percent_Identity=49.6296296296296, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17539498, Length=151, Percent_Identity=47.0198675496689, Blast_Score=106, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17566266, Length=128, Percent_Identity=50, Blast_Score=106, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17552782, Length=137, Percent_Identity=47.4452554744526, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17532643, Length=125, Percent_Identity=52, Blast_Score=103, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17551282, Length=155, Percent_Identity=47.741935483871, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17551284, Length=155, Percent_Identity=47.741935483871, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17552784, Length=136, Percent_Identity=45.5882352941176, Blast_Score=97, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI32563659, Length=131, Percent_Identity=33.587786259542, Blast_Score=80, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI115533296, Length=131, Percent_Identity=35.8778625954198, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320359, Length=121, Percent_Identity=54.5454545454545, Blast_Score=112, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323562, Length=135, Percent_Identity=52.5925925925926, Blast_Score=110, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6320510, Length=124, Percent_Identity=52.4193548387097, Blast_Score=105, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6323246, Length=127, Percent_Identity=48.8188976377953, Blast_Score=103, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321848, Length=165, Percent_Identity=44.2424242424242, Blast_Score=99, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6322492, Length=147, Percent_Identity=38.0952380952381, Blast_Score=73, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17986117, Length=131, Percent_Identity=53.4351145038168, Blast_Score=140, Evalue=6e-34,
Organism=Drosophila melanogaster, GI19922376, Length=170, Percent_Identity=40.5882352941176, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI19922912, Length=119, Percent_Identity=57.9831932773109, Blast_Score=121, Evalue=3e-28,
Organism=Drosophila melanogaster, GI20130249, Length=130, Percent_Identity=52.3076923076923, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21357249, Length=121, Percent_Identity=42.1487603305785, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24652460, Length=126, Percent_Identity=42.8571428571429, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI17136360, Length=132, Percent_Identity=46.969696969697, Blast_Score=103, Evalue=8e-23,
Organism=Drosophila melanogaster, GI45549139, Length=121, Percent_Identity=52.8925619834711, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24586038, Length=131, Percent_Identity=48.0916030534351, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17647301, Length=136, Percent_Identity=48.5294117647059, Blast_Score=97, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24664125, Length=121, Percent_Identity=50.4132231404959, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21357783, Length=121, Percent_Identity=50.4132231404959, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24650807, Length=136, Percent_Identity=44.8529411764706, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21355677, Length=134, Percent_Identity=35.0746268656716, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24661775, Length=161, Percent_Identity=33.5403726708075, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21355237, Length=161, Percent_Identity=33.5403726708075, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24661771, Length=161, Percent_Identity=33.5403726708075, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 19028; Mature: 19028

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGMSTLRAVIKTNKGEIRIELFPEKTPNTVANFVNLAQRNFYNGLKFHRVIEDFMIQGG
CCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
CPQGTGTGGPGYKFRDEFDSSLKHNKPGILSMANAGPGTNGSQFFITHVATPWLDGKHSV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCCHH
FGAVVDASDQEVVNAIRQGDKIETITIEGDPTSVLEIAKPYLEEWNQILDSKK
HHEEECCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNGMSTLRAVIKTNKGEIRIELFPEKTPNTVANFVNLAQRNFYNGLKFHRVIEDFMIQGG
CCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
CPQGTGTGGPGYKFRDEFDSSLKHNKPGILSMANAGPGTNGSQFFITHVATPWLDGKHSV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCCHH
FGAVVDASDQEVVNAIRQGDKIETITIEGDPTSVLEIAKPYLEEWNQILDSKK
HHEEECCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9317025; 9665876 [H]