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The map label for this gene is lpxB [H]

Identifier: 183221444

GI number: 183221444

Start: 2150951

End: 2152069

Strand: Direct

Name: lpxB [H]

Synonym: LEPBI_I2062

Alternate gene names: 183221444

Gene position: 2150951-2152069 (Clockwise)

Preceding gene: 183221443

Following gene: 183221450

Centisome position: 59.75

GC content: 38.25

Gene sequence:

>1119_bases
TTGTTAGAACTCAAAATGATCGAACCCGAATTCCATTTTTATGGAGTTGGGGGAGAGGGAATGATCCAAAACGGCCTCGA
ATCTTTAGAAGAGATGGAAAATTTAAGTGTGATTGGATTTTCAGAAGCGATCAAAAAGTATAGTTTTCTTAAAAAAGTAT
TCCATCGTTTATTAGAGGAAACGTCACATAGGCCCACTCAACTTGCTGTATTAATTGATTATCCTGGATTTAACCTGCGT
CTAGCGGAGGAACTAAAAAAAAGAGGGATCCCAACAGTATTTTATGTTTCCCCGCAGATCTGGGCTTGGAAATTCAAACG
AATCTATTTTATCAAAGAACATATCGCTCTCATGCTCACACTGTTTCGATTTGAGGAAGAGATTTACCATGAATACGGTG
TGAATGCAAAATTTGTGGGCCACCCCATCACAAAACGAATCCCTGAAAAGTTAAAAAAAGAACCAAACATCCCAGAAAAA
TTACCAGACCCTCACCACGGTTATACGGTGGGACTATTACCCGGATCGAGAAAGGGAGAGATCCATCGACTCATTGATCC
CATCCTTGGGACGGCTGTATTACTCCACGAACAATGTAAGTTAGAAAAGAAAAAAATTGTATTTTTAGTACCGAACATCA
ATCAAAAAGAAGAAACGTTTTTATTACAAAAAATAGAAGCAATCAAACTTTCCCACCCCGACATCCAAATCCATTACCTA
TGGAATTCTTCGCTCCGCGTAATGGAAGCCAGTGACCTACTCCTCATTGCCTCTGGGACAGCTACATTAGAAGGATTGTA
TTTTGAAACACCGATGGTGATTTTATATAAAGTAAGTTTGTTTACATATTTCCTTGGATCACTCCTGATCAAGTCCAAGT
TCATTGGTTTAGCCAATATTCTTTGTGGAGAGGAAGTTTGCCGAGAGATCACTCAAAATGAATGTAGGCCAGAATACATA
GTGAAGGAAGCTTGGAAAATTCTTTCCAATACAAAATTACGAAACAAAATCAAAGGGATCTTAAGAGAAGCAAAAGAAAG
AGAATTGGGAACAATGAACGCATCCAAAAAAGCAGCCAAAGAAATCCAAAATCTAATCAAACTACTTCCTGCGGATTAA

Upstream 100 bases:

>100_bases
CTCAATGGTAGCCAAAAAAAAATCACACCGATCTAATACAAAAAAAAATATCCTAGTCATAGCAGGCGAACATTCCGGAG
ACCTCATCGGTGCGGATCTT

Downstream 100 bases:

>100_bases
CCTGACCACTCGATTTTCCCAAGTCCCAATCCAAGATTTGGATTTGATATCGGAATATAGGAAGTATCCTTTCACAGTCT
CTTCATCATAGGCTCGGATC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MLELKMIEPEFHFYGVGGEGMIQNGLESLEEMENLSVIGFSEAIKKYSFLKKVFHRLLEETSHRPTQLAVLIDYPGFNLR
LAEELKKRGIPTVFYVSPQIWAWKFKRIYFIKEHIALMLTLFRFEEEIYHEYGVNAKFVGHPITKRIPEKLKKEPNIPEK
LPDPHHGYTVGLLPGSRKGEIHRLIDPILGTAVLLHEQCKLEKKKIVFLVPNINQKEETFLLQKIEAIKLSHPDIQIHYL
WNSSLRVMEASDLLLIASGTATLEGLYFETPMVILYKVSLFTYFLGSLLIKSKFIGLANILCGEEVCREITQNECRPEYI
VKEAWKILSNTKLRNKIKGILREAKERELGTMNASKKAAKEIQNLIKLLPAD

Sequences:

>Translated_372_residues
MLELKMIEPEFHFYGVGGEGMIQNGLESLEEMENLSVIGFSEAIKKYSFLKKVFHRLLEETSHRPTQLAVLIDYPGFNLR
LAEELKKRGIPTVFYVSPQIWAWKFKRIYFIKEHIALMLTLFRFEEEIYHEYGVNAKFVGHPITKRIPEKLKKEPNIPEK
LPDPHHGYTVGLLPGSRKGEIHRLIDPILGTAVLLHEQCKLEKKKIVFLVPNINQKEETFLLQKIEAIKLSHPDIQIHYL
WNSSLRVMEASDLLLIASGTATLEGLYFETPMVILYKVSLFTYFLGSLLIKSKFIGLANILCGEEVCREITQNECRPEYI
VKEAWKILSNTKLRNKIKGILREAKERELGTMNASKKAAKEIQNLIKLLPAD
>Mature_372_residues
MLELKMIEPEFHFYGVGGEGMIQNGLESLEEMENLSVIGFSEAIKKYSFLKKVFHRLLEETSHRPTQLAVLIDYPGFNLR
LAEELKKRGIPTVFYVSPQIWAWKFKRIYFIKEHIALMLTLFRFEEEIYHEYGVNAKFVGHPITKRIPEKLKKEPNIPEK
LPDPHHGYTVGLLPGSRKGEIHRLIDPILGTAVLLHEQCKLEKKKIVFLVPNINQKEETFLLQKIEAIKLSHPDIQIHYL
WNSSLRVMEASDLLLIASGTATLEGLYFETPMVILYKVSLFTYFLGSLLIKSKFIGLANILCGEEVCREITQNECRPEYI
VKEAWKILSNTKLRNKIKGILREAKERELGTMNASKKAAKEIQNLIKLLPAD

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=361, Percent_Identity=33.5180055401662, Blast_Score=195, Evalue=4e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 42916; Mature: 42916

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELKMIEPEFHFYGVGGEGMIQNGLESLEEMENLSVIGFSEAIKKYSFLKKVFHRLLEE
CCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHH
TSHRPTQLAVLIDYPGFNLRLAEELKKRGIPTVFYVSPQIWAWKFKRIYFIKEHIALMLT
HCCCCEEEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHH
LFRFEEEIYHEYGVNAKFVGHPITKRIPEKLKKEPNIPEKLPDPHHGYTVGLLPGSRKGE
HHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCH
IHRLIDPILGTAVLLHEQCKLEKKKIVFLVPNINQKEETFLLQKIEAIKLSHPDIQIHYL
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHEECCCCEEEEEE
WNSSLRVMEASDLLLIASGTATLEGLYFETPMVILYKVSLFTYFLGSLLIKSKFIGLANI
ECCCEEEEECCCEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LCGEEVCREITQNECRPEYIVKEAWKILSNTKLRNKIKGILREAKERELGTMNASKKAAK
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
EIQNLIKLLPAD
HHHHHHHHCCCC
>Mature Secondary Structure
MLELKMIEPEFHFYGVGGEGMIQNGLESLEEMENLSVIGFSEAIKKYSFLKKVFHRLLEE
CCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHH
TSHRPTQLAVLIDYPGFNLRLAEELKKRGIPTVFYVSPQIWAWKFKRIYFIKEHIALMLT
HCCCCEEEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHH
LFRFEEEIYHEYGVNAKFVGHPITKRIPEKLKKEPNIPEKLPDPHHGYTVGLLPGSRKGE
HHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCH
IHRLIDPILGTAVLLHEQCKLEKKKIVFLVPNINQKEETFLLQKIEAIKLSHPDIQIHYL
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHEECCCCEEEEEE
WNSSLRVMEASDLLLIASGTATLEGLYFETPMVILYKVSLFTYFLGSLLIKSKFIGLANI
ECCCEEEEECCCEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LCGEEVCREITQNECRPEYIVKEAWKILSNTKLRNKIKGILREAKERELGTMNASKKAAK
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
EIQNLIKLLPAD
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA